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Sarcoidosis
Thami Gurvinder,Bedi Gursharan,Jaswal Ritu,Kanwar Amrinder
Indian Journal of Dermatology, Venereology and Leprology , 2000,
Abstract: Two cases of cutaneous sarcoidosis with itchy lesions are reported. Both patients had systemic involvement and were successfully treated with glucocorticoids
Sarcoidosis
Hilario Nunes, Diane Bouvry, Paul Soler, Dominique Valeyre
Orphanet Journal of Rare Diseases , 2007, DOI: 10.1186/1750-1172-2-46
Abstract: SarcoidosisSarcoidosis is a multisystemic disorder of unknown cause that is characterized by the formation of immune granulomas in involved organs [1-4].Sarcoidosis affects primarily young and middle-aged adults. A prevailing hypothesis is that various unidentified antigens, either infectious or environnemental, could trigger an exaggerated immune reaction in genetically susceptible hosts [2]. The clinical expression of sarcoidosis is protean, in particular as regards the number and sites of involved organs. The lung and the lymphatic system are predominantly affected but virtually virtually every organ may be affected. Skin, eyes, peripheral lymph nodes and liver are each involved in 10–25% of cases. The evolution and severity of the disease are highly variable. Whilst spontaneous resolution occurs in the majority of cases within 12–36 months, some patients experience a prolonged and serious course [3]. Pulmonary fibrosis is the most frequent severe manifestation, accounting for the major cause of morbidity and mortality in western countries [3]. Other severe manifestations of the disease consist of cardiac, neurological, ocular, kidney or laryngeal localizations. Sarcoidosis can also induce abnormal metabolism of vitamin D3 within granulomatous lesions and hypercalcemia [5]. Mortality attributable to sarcoidosis is estimated at between 0.5 and 5% [6] and results from lung, heart and central nervous system localizations [3].Although not always required, the mainstay of sarcoidosis treatment is systemic corticosteroids [7,8]. Corticosteroids impeed the formation of granulomas and, as a result, are largely efficient against most active clinical manifestations. However, treatment is merely suspensive with frequent relapses when withdrawal is too rapid. Furthermore, the adverse side effects of corticosteroids are substantial. Other immunosuppressive agents and aminoquinolins can be employed as sparing drugs or as alternative options to corticosteroid therapy in patient
Bullous Ichthyosiform Erythroderma With Unusual Presentation  [cached]
Ghosh Arghyaprasun,Dey Sunil Kumar,Mandal Kakali,Kundu Mousumi
Indian Journal of Dermatology , 2003,
Abstract: Bullous ichthyosiform erythroderma is a rare autosomal dominant disorder of keratinization resulting in increased epidermal cell transit time. We describe a teenager who had five members of his family similarly affected with sparing of face, neck and upper part of chest.
Cutaneous sarcoidosis  [cached]
Ghorpade A,Ramanan C
Indian Journal of Dermatology, Venereology and Leprology , 1996,
Abstract: Cutaneous sarcoidosis in a middle aged lady is reported. Though sarcoidosis is rare in our country, an awarenesss about this condition is required to prevent misdiagnosis.
Ichthyosiform mycosis fungoides with alopecia and atypical membranous nephropathy  [cached]
Zhou Qiang,Zhu Kejian,Yu Haiyan,Cheng Hao
Indian Journal of Dermatology, Venereology and Leprology , 2011,
Abstract: We describe here a rare case of variant of mycosis fungoides (MF): ichthyosiform MF with alopecia and atypical membranous nephropathy. The diagnosis was made based on the following findings: generalized ichthyosis-like eruption, alopecia, enlarged superficial lymph nodes, proteinuria, and hematuria, the histological features of the skin biopsy from both ichthyotic and alopecic lesions with immunohistochemical staining, and the renal biopsy examination with immunofluorescence. The histological examination of ichthyotic and alopecic lesions displayed a predominant infiltration of atypical lymphocytes in the upper dermis with the characteristics of epidermotropism and folliculotropism. Immunohistochemical studies demonstrated that most infiltrated atypical lymphocytes were CD3, CD4, and CD45RO positive, whereas negative for CD5, CD7, CD20, CD30, and CD56. A renal biopsy examination revealed atypical membranous nephropathy with deposition of immunoglobulin G (IgG), IgM, IgA, C1q, and C3. In this case atypical membranous nephropathy was involved, which is very uncommon and has never been presented in the literature to date. Although ichthyosiform MF usually features a relatively favorable course, diffuse alopecia and the renal involvement in this case might indicate aggressive disease and poor prognosis.
Tuberculous sarcoidosis
Shah J
Lung India , 2007,
Abstract: This presentation is to define tuberculous sarcoidosis as a distinct clinical en-tity quite separate from tuberculosis or sarcoidosis. Evidence is also presented to postulate that altered mycobacterial infection or its biodegraded products can reasonably be considered as the aetiologic cause of Tuberculous Sarcoidosis.
Cutaneous sarcoidosis
Mishra R,Indira C,Saxena U,Mukherjee A
Indian Journal of Dermatology, Venereology and Leprology , 1993,
Abstract: Two cases of sarcoidosis with cutaneous lesions as presenting complaints are reported. Clinicians should have a high index of suspicion for sarcoidosis since it mimics other granulomatous skin conditions.
Cutaneous Sarcoidosis
Rupali Bargotra , Jyotsna Suri, Yudhvir Gupta
JK Science : Journal of Medical Education & Research , 2010,
Abstract: We present a case of exclusive cutaneous sarcoidosis with no clinical or radiological evidence of diseaseanywhere else in the body.Exclusive cutaneous involvement is rare and is reported in about 4.5%patientsof sarcoidosis.
Sarcoidosis of the Breast
Hayrettin G??MEN,Funda CO?KUN,?aduman BALABAN ADIM,Esra UZASLAN
Trakya Universitesi Tip Fakultesi Dergisi , 2009,
Abstract: Sarcoidosis is a granulomatous disease which might affect many systems. Less than 1% of the cases suffer breast involvement. There are about 33 cases involving breast in the literature. In many cases, systemic symptoms mask breast involvement of sarcoidosis, that was generally recognized in result of surgical operation for malignancy. Breast and skin involvement together is rather rare in sarcoidosis. A 49-yearold female patient with mediastinoscopic diagnosis of sarcoidosis has been followed since 1999. Patient was treated with systemic corticosteroid twice due to skin involvement of sarcoidosis in 2002 and 2004. In 2006 macronodular lesions were found in both of her breast. Nodule excision and reduction mammoplasty were performed with pathological result of noncaseous granulomatous sarcoid inflammation. Patient was admitted as pulmonary sarcoidosis stage II with skin and breast involvement. Since lung, breast and skin involvement together is very rare in sarcoidosis we presented this case.
Cardiac Sarcoidosis
AA Bajomo
Nigerian Journal of Clinical Practice , 2003,
Abstract: Cardiac sarcoidosis is a rare complication which occurs in 1-5% of sarcoidosis. We report here a case seen in Olabisi Onnabanjo University Teaching Hospital, Sagamu, who presented with heart failure. Nigerian Journal of Clinical Practice Vol.6(2) 2003: 122-123
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