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Topical photodynamic therapy
Polja?ki Mirjana,Jovanovi? Marina,Matovi? Ljubinka,Lugonja Branislava
Archive of Oncology , 2006, DOI: 10.2298/aoo0602039p
Abstract: Topical photodynamic therapy is a therapeutic modality in development, thus arises grate interest among dermatologists worldwide. It is an effective therapy for actinic keratosis, superficial BCC and Bowenos disease. Treatment efficacy, good cosmetics, low risk of skin cancer, low invasiveness, low rate of adverse events, facility for treating multiple or large lesions, especially in poor healing sites and, for penile, digital and facial involvement, low general toxicity and possibility of repeating the treatments with the same efficiency, enable topical photodynamic therapy to become increasingly practiced treatment modality. Researching aimed topical photodynamic therapy to prove as a treatment modality for clinical use in other dermatoses, is in experimental phase. To answer the question when dermatologist should consider using topical photodynamic therapy treatment modatility, we are present available date.
Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy
Alexander L. Pan,David Fergusson,Robert Hong,Ramy A. Badawi
Case Reports in Cardiology , 2012, DOI: 10.1155/2012/524508
Abstract: Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result in increased estrogen levels similar to those documented with oral contraceptive use, there are no reported cases of spontaneous coronary dissection with topical hormonal replacement therapy. We describe a 53-year-old female who developed two spontaneous coronary dissections while on topical hormonal replacement therapy. The patient had no other risk factors for coronary dissection. After withdrawal from topical hormonal therapy, our patient has done well and has not had recurrent coronary artery dissections over a one-year follow-up period. The potential contributory role of topical hormonal therapy as a cause of spontaneous coronary dissection should be recognized.
Spontaneous Coronary Artery Dissection following Topical Hormone Replacement Therapy  [PDF]
Alexander L. Pan,David Fergusson,Robert Hong,Ramy A. Badawi
Case Reports in Cardiology , 2012, DOI: 10.1155/2012/524508
Abstract: Spontaneous coronary artery dissection is a rare condition, usually presenting as an acute coronary syndrome, and is often seen in states associated with high systemic estrogen levels such as pregnancy or oral contraceptive use. While topical hormonal replacement therapy may result in increased estrogen levels similar to those documented with oral contraceptive use, there are no reported cases of spontaneous coronary dissection with topical hormonal replacement therapy. We describe a 53-year-old female who developed two spontaneous coronary dissections while on topical hormonal replacement therapy. The patient had no other risk factors for coronary dissection. After withdrawal from topical hormonal therapy, our patient has done well and has not had recurrent coronary artery dissections over a one-year follow-up period. The potential contributory role of topical hormonal therapy as a cause of spontaneous coronary dissection should be recognized. 1. Introduction Spontaneous coronary artery dissection (SCAD) is a rare condition, usually presenting as an acute coronary syndrome (ACS) in young or middle-aged women, and is often associated with pregnancy or oral contraceptives. While topical hormonal therapy may result in increased estrogen levels similar to those documented with oral contraceptive use, SCAD occurring after topical hormone therapy has not been reported. We report a case of recurrent spontaneous coronary artery dissection in a 53-year-old woman who had been treated with topical hormone replacement therapy for 4 years. 2. Case Report A 53-year-old postmenopausal female, with a history of treated hypothyroidism, presented to our medical center with protracted severe left-sided substernal rest chest discomfort. The patient had been using topical hormonal replacement therapy with 2 compounded creams: Biest (80?:?20 of estriol?:?estradiol) 5?mg/day and topical progesterone 125?mg/day for the previous 4 years. An initial electrocardiogram demonstrated inverted T waves in the inferolateral leads but no ST elevations. The patient was treated with nitrates with the relief of her symptoms. Cardiac biomarkers were obtained and found to be abnormal with an increased troponin I—level of 0.16?ng/mL (normal range <0.05?ng/mL). The patient was treated with aspirin, low molecular weight heparin, and intravenous nitroglycerin. An echocardiogram documented a normal left ventricular systolic function and no segmental wall motion abnormalities. Coronary angiography revealed spontaneous coronary dissection in the posterior descending branch of the right coronary
Recent Advances In Topical Therapy In Dermatology  [cached]
Mohan Thappa Devinder
Indian Journal of Dermatology , 2003,
Abstract: With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.
New Formulation Strategies in Topical Antifungal Therapy  [PDF]
Sevgi Güng?r, M. Sedef Erdal, Buket Aksu
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.31A009
Abstract:

Fungal infections of the skin are one of the often faced with dermatological diseases in worldwide. Topical therapy is an attractive choice for the treatment of the cutaneous infections due to its advantageous such as targeting of drugs to the site of infection and reduction of the risk of systemic side effects. Currently, antifungal drugs are generally used as conventional cream and gel preparations in topical treatment. The efficiency of that treatment depends on the penetration of drugs through the target layers of the skin at the effective concentrations. However, stratum corneum, the outermost layer of the skin, is an effective barrier for penetration of drugs into deeper layers of the skin. The physicochemical characteristics of drug molecules and the types of the formulations are effective factors in topical drug delivery. Therefore, a number of formulation strategies have been investigated for delivering antifungal compounds through targeted site of the skin. This review article focuses on the new alternative formulation approaches to improve skin penetration of antifungal drugs.

Iatrogenic Cushing's syndrome due to topical steroid  [cached]
Nihal Hatipo?lu,Selim Kurto?lu,Mehmet Keskin,Mustafa Kendirci
Erciyes Medical Journal , 2007,
Abstract: Iatrogenic Cushing's syndrome due to the use of steroid medication is extremely common because of the widespread use of these medicines in the treatment of many diseases. Systemic absorption of topical glucocorticoids may result in hypothalamic-pituitary-adrenal axis dysfunction in children. In this study, two cases with Cushing stigmata were presented. They had been administered topical corticosteroid treatment because of diaper dermatitis. We suggest that physicians should be alert to the signs of Cushing's syndrome in patients on topical steroid therapy. In addition, these findings show that the use of topical steroids, especially during infancy, should be limited to a short period and less potent agents should be preferred.
Topical ketoconazole therapy in a recalcitrant case of seborrhoeic dermatitis
Baishya B
Indian Journal of Dermatology, Venereology and Leprology , 1996,
Abstract: Ketoconazole 2% cream and 2% shampoo were found to be effective in controlling seborrhoeic dermatitis in a recalcitrant case. This topical ketoconazole therapy seems to be better than other conventional topical preparations prescribed in seborrhoeic dermatitis.
Iatrogenic Cushing Syndrome Due to Topical Steroid Administration in an Infant
Filiz TUTUNCULER
Trakya Universitesi Tip Fakultesi Dergisi , 2010,
Abstract: Topical therapy with glucocorticoids is used commonly in chronic dermatoses. Although side effects are less common compared to systemic use, infants who are exposed to topical corticosteroids have greater risk for Cushing syndrome or adrenocortical insuffiency caused by suppression of hypothalamic-pituitary-adrenal axis because glucocorticoids are highly absorbed through the diaper area. However, the development of Cushing syndrome in an infant from topical steroid therapy is unusual. We present an infant with diaper dermatitis who developed iatrogenic Cushing syndrome due to prolonged clobetosel propionate use.
The Recurrence and Cosmetic Results After Topical Photodynamic Therapy  [PDF]
Can Ceylan,Fezal ?zdemir,Alican Kazand?
Turkderm , 2009,
Abstract: Background and Design: Photodynamic therapy (FDT) is a photochemotherapy modality which is used frequently and effectively in the treatment of actinic keratosis, Bowen disease and basal cell carcinomas. This study was performed to determine cure rates, cosmetic outcome and recurrence rates after aminolevulinic acid (ALA)-based photodynamic therapy for skin lesions showing complete response to treatment procedure. Material and Method: Sixty-eight patients (27 females and 41 males) with 78 lesions were included in the study. Among them, 25 were actinic keratosis (AK), 8 were actinic cheilitis (AC), 30 were basal cell carcinomas (BCC), 3 were Bowen disease, 10 were intraepidermal epithelioma (IEE), one lesion was parapsoriasis and one lesion was verruca plantaris. Six to 8 hours after topical administration of ALA (20%), the lesions were exposed to light from a broad-band light source. Skin biopsy specimens were obtained from 74 lesions for histopathological control. Results: At the end of the second month of treatment, fifty-six (72%) of seventy-eight lesions showed complete clinical response, whereas fourty-seven of 74 lesions (63.5%) exhibited complete histopathological clearance. A total of 9 recurrences (16%) was observed during a median follow-up of 36 months. Recurrence rates were 3 (14%) in AK, 1 (17%) in AC, 1 (8%) in superficial BCC, 3 (75%) nodular BCC and 1 (12.5%) in IEE. Cosmetic outcome was excellent and good in 42 lesions (89%), fair in 3 lesions (6%) and poor in 2 lesions (5%). Conclusion: Topical photodynamic therapy is a noninvasive, effective and cosmetic modality of treatment in the selected skin lesions, as an alternative to the conventional procedures.
Acrokeratosis Verruciformis And Topical Vitamin A Therapy  [cached]
Sharma Ashok Kumar
Indian Journal of Dermatology , 1997,
Abstract: A case of a 32 year old female having acrokeratosis verruciformis is reported. The lesions responded partially to topical vitamin A acid (tretinoin)
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