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Deformation of skull bone as intracranial pressure changing
X Yue, L Wang
African Journal of Biotechnology , 2009,
Abstract: Raised intracranial pressure (ICP), a serious and often fatal condition, is often not preventable. In the present study, the relationship was determined between cranial deformation and ICP change. To record the deformation of skull bone, strain foil was placed on the exterior surface of parietal skull. Prior to construction of finite-element model (FEM), using the rats, an in vivo study was undertaken. Three anesthetized adult rats were subjected to baseline recording followed by either experimental raising ICP. By using the ‘Ansys’ finite element processor, a three-dimensional FEM of a hollow sphere was constructed for human skull. The model was used to calculate the deformation of human skull with the intracranial pressure changing. The skull is a layered sphere constructed in a specially designed form with a Tabula externa, Tabula interna, and a porous Diploe sandwiched in between. The stress and strain deformations were well-proportional on the exterior surface of human skull. The deformation scope of human skull was theoretically from 1.0 to 3.4 with the changing ICP from 1.5 to 5.0 kPa. The cranium could move and human skull - dura mater system was deformed as the ICP fluctuates.
Increased Intracranial Pressure Following Removal of Intracranial Lesions
B. Ramamurthi
Acta Medica Iranica , 1964,
Abstract: Increased intracramal tension may 0 ise some days or ''leeks the problem may ari 1 of lrelUova "nt r a cra nial tumours or . lfter operation. , ""n" . " such increased tensicn raises the pOSS1- In the immed.',iate postoperat1ve perlOd" " f eopenino- Unrelieved tentorial -" d f c the dec1s10n or r O' l)ility of a clot rormattcn an ore ~ "e"ln .or the so called third day post " f thrombus Into a ma]()Ir v .' , herniation. extenslOn 0 a f h raised intracranial pressure,. th common causes 0 sue operative oede~a. are e dematous blockage of ventricular system may When the ventnclc' has been opened. oe have to be tackled by repeated ventricular puncture. the fear of this postoperative oedema is the reason In posterior fossa surgery. '. - ' h many neurosuTgeons leave the dura open. w y " ommoner in posterior fossa " " tracranial presurc1 1S c Late onset of mcreased in f ttbromae or after excision of " b-total removal 0 neuro . operations spec1ally after su ti t the site of surgery or adheslOns block- " cyst forma ion a tubercnlomas. The cause :s Following air studies. a shunt procedure or a ing the cerebrospinal flUld "pa~hWay. tentorial incision would be md1cated.
Pure extradural approach for skull base lesions.  [cached]
Gupta S,Khosla V,Sharma B
Neurology India , 1999,
Abstract: Lesions in the parasellar and paracavernous regions can be removed by various skull base approaches involving basal osteotomies. A major complication of intradural skull base approaches is CSF leak and associated meningitis. We have managed 5 patients with skull base lesions with a pure extradural approach using wide basal osteotomies. The operative techniques are described.
Ganglioglioma with lytic skull lesions: a case report
Gurkanlar,D.; Kocak,H.; Yucel,E.; Aciduman,A.; Gunaydin,A.; Ekinci,?.; Keskil,S.;
Neurocirugía , 2007, DOI: 10.4321/S1130-14732007000200006
Abstract: gangliogliomas represent only 0.4% of central nervous system neoplasms and 1.3% of brain tumors. they are benign neoplasms with low morbidity and mortality and the patients usually present with seizures, but there has been no adult ganglioglioma with lytic skull lesion. a 49-year-old right handed woman suffering from generalized epileptic seizures was admitted to our hospital. she had also left hemiparesis with 4/5 motor strength. magnetic resonance imaging and immunohistochemical studies revealed who grade ii ganglioglioma. skull x-ray showed the lytic skull lesions. we have to consider gangliogliomas in the differential diagnosis of lytic skull lesions.
Viscoelastic finite-element analysis of human skull - dura mater system as intracranial pressure changing
X Yue, L Wang, S Sun, L Tong
African Journal of Biotechnology , 2008,
Abstract: In the work, the dynamic characteristics of the human skull-dura mater system were studied. For the purpose of our analysis, we adopted a model consisted of a hollow sphere. By using the ‘Patran and Ansys’ finite element processor, a simplified three-dimensional finite element model (FEM) of a human skull was constructed. The model was used to calculate the deformation of human skull with the intracranial pressure changing. This required good representation of the complex anatomy of the skull. Four different entities are distinguished: Tabula externa, Tabula interna, and a porous Diploe sandwiched in between, and dura mater. A thin-walled skull was simulated by composite shell elements. The viscoelasticity of human skull-dura mater system was studied and analyzed by the finite-element Maxwell model. The 1/8 model consisted of 25224 nodes and 24150 three-dimensional 8-node isoparametric solid elements. The elastic-viscous mechanical characteristics must be used for the skull. The viscous strains account for about 40% of total strains of human skull and dura mater. And the range of strain errors is from 6.45 to 14.82% after ignoring the viscosity of skull and dura mater.
Sudden death of a swimmer in water caused by heterotopic intracranial ossification and anomaly of the skull base  [PDF]
Pilija Vladimir,Budakov Branislav,Gvozdenovi? Ljiljana,Savovi? Slobodan
Vojnosanitetski Pregled , 2011, DOI: 10.2298/vsp1101073p
Abstract: Background. Expression of immersion syndrome implies sudden and unexpected death of swimmer in water. A drowned swimmer is still a riddle for the forensic and clinical doctors. Pathophysiological mechanisms which cause immersion syndrome may be divided into vegetatively regulating and mechanical ones. Case report. We presented heterotopic intracranial ossification with the anomaly of the skull base bones development in a young man, a swimmer, drowned after entering water and where the circumstances required expertise in forensic medicine. Conclusion. Intracranial heterotopic ossification with or without a disorder in the development of skull bones may be one of the causes of immersion syndrome.
A Case of Multiple Myeloma Diagnosed by Skin Lesions  [PDF]
Fatma Gülru Erdo?an,Burcu Tu?rul,Aysel Gürler,Aylin Ok?u Heper
Turkderm , 2010,
Abstract: Multiple myeloma, being a malignant proliferation of plasma cells in the bone marrow, has clinical spectrum varying from monoclonal gammopathy with unknown significance to plasma cell leukemia. The presenting symptoms have usually been bone pain, pathologic fractures or repeating infections. In patients with multiple myeloma, amyloid depositions may be seen in the skin. This form, defined as primary systemic amyloidosis, is characterized by light-chain amyloid fibril depositions. Our case applied with multiple, asymptomatic, yellowish papules localized on the face, trunk, oral and genital mucosa, gradually increasing during the last two years. He had no complaints, except for slight weight loss. In routine tests, the patient had no pathological laboratory findings, except high C-reactive protein levels. Further research revealed histopathologic and immunohistochemical findings consistent with amyloidosis. Upon these results, immunoglobulin G levels were measured and found high, and in protein electrophoresis, IgG monoclonal gammopathy was determined. The diagnosis of multiple myeloma is made by bone marrow biopsy. This patient is presented for being an asymptomatic case diagnosed by skin findings of amyloidosis.
Skull destruction from intracranial metastasis arising from pulmonary squamous cell carcinoma: a case report
Kader Imran,Strong Michael,George Mathew
Journal of Medical Case Reports , 2013, DOI: 10.1186/1752-1947-7-28
Abstract: Introduction Squamous cell carcinoma of the lung represents 30% of all non-small cell lung carcinomas. It arises from dysplasia of squamous epithelium of the bronchi and is strongly associated with cigarette smoking. Squamous cell carcinoma of the lung is known to produce metastases in the brain parenchyma. Case presentation We present the case of an 80-year-old indigenous Australian man with an unusual presentation of metastatic carcinoma of the lung. The case demonstrated a squamous cell carcinoma of the lung with an intracranial metastatic lesion destroying the parietal bone and extending into the extracranial soft tissue. A visible deformity as a result of the metastasis was evident on physical examination and computed tomography demonstrated extensive bone destruction. Conclusion The authors were unable to find a case of this occurring from a squamous cell carcinoma of the lung anywhere in the world literature. The case report demonstrates an unusual disease presentation with a rare intracranial metastasis invading through the skull.
Frontal skull craniotomy combined with moderate-dose radiotherapy effectively ameliorate a rare case of non-secretory, multiple myeloma with orbital involvement
Hui-Ling Ko, Ching-Lin Chen, Kwan-Hwa Chi
World Journal of Surgical Oncology , 2009, DOI: 10.1186/1477-7819-7-86
Abstract: A 43-year-old male subject with multiple myeloma and long-term survival presented with orbital involvement. The subject lacked the typical features and poor prognostic factors associated with multiple myeloma, such as renal failure, hypercalcemia, and paraprotein in the serum and urine. The orbital computed tomographic scan revealed the tumor encasing the optic nerve, but without prominent bony destruction. Therefore, a frontal skull craniotomy with an epidural entrance to the orbital space was performed, to completely extirpate the orbital mass. The surgical procedure was followed by moderate-dose radiation therapy. After 32 months of follow-up care, the subject is doing well with excellent local control.Although the effectiveness and applicability of this approach remains to be determined, this case report demonstrates that accurate and early detection combined with local surgical treatment and appropriate radio/chemotherapy, can be applied to effectively extend an orbital multiple myeloma patient's life.Multiple myeloma presents as a systemic, disseminated disease and represents an uncontrolled proliferation of plasma cells with the overproduction of proteins belonging to the immunoglobulin family, and accounts for 1% to 2% of all cancers [1]. The median age at diagnosis is the sixth decade, and there is a progressive increase in incidence with age, reaching a maximum in the seventh decade of life. Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells, leading to enhanced levels of paraprotein in serum and/or urine. The plasma cells proliferate in the bone marrow and frequently invade adjacent bone, causing skeletal destruction that results in bone pain and pathological fractures. Bone marrow involvement may be focal rather than diffuse, which requires repeated bone marrow examinations in order to obtain an accurate diagnosis [1].A report from the International Myeloma Working Group in 2003 [2], indicates that urine c
Metastatic Breast Cancer or Multiple Myeloma? Camouflage by Lytic Lesions
Bruce Hough,Adam Brufsky,Suzanne Lentzsch
Journal of Oncology , 2010, DOI: 10.1155/2010/509530
Abstract: We report a case of a female with stage I infiltrating ductal carcinoma who received adjuvant therapy including trastuzumab. One year later she developed lytic lesions and was retreated with trastuzumab that was held after she developed symptomatic heart failure. Lytic lesions were attributed to relapse of breast cancer, and cardiac failure attributed to prior trastuzumab therapy. After complications necessitated multiple hospitalizations, a further workup revealed that the lytic lesions were not metastatic breast cancer but multiple myeloma. Her advanced multiple myeloma was associated with systemic amyloidosis involving gut and heart, which ultimately led to her demise. This report addresses the pitfalls of overlapping symptoms and the question of which patients with suspected metastatic disease should undergo a biopsy.
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