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Anti-diabetic and anti-oxidant effects of Zingiber Officinale on alloxan-induced and insulin-resistant diabetic male rats
BO Iranloye, AP Arikawe, G Rotimi, AO Sogbade
Nigerian Journal of Physiological Sciences , 2011,
Abstract: This study was designed to investigate the hypoglycaemic and anti-oxidant effects of Zingiber officinale on experimentally induced diabetes mellitus using alloxan and insulin resistance. Aqueous extracts of raw ginger was administered orally at a chosen dose of 500mg/ml for a period of 4 weeks to alloxan-induced diabetic and insulin resistant diabetic rats. The experimental rats exhibited hyperglycaemia accompanied with weight loss to confirm their diabetic state. Ginger effectively reduced fasting blood glucose and malonydealdehyde levels in alloxan-induced diabetic and insulin resistant diabetic rats compared to control and ginger only treated rats. Furthermore, ginger increased serum insulin level and also enhanced insulin sensitivity in alloxan-induced diabetic and insulin resistant diabetic rats compared to control and ginger only treated rats. The results of the study clearly show that dietary ginger has hypoglycaemic effect, enhances insulin synthesis in male rats and has high antioxidant activity. One of the likely mechanisms is the action of malonydealdehyde, which acts as a scavenger of oxygen radicals.
Anti-Hyperglycemic and Hypolipidemic Effect of Ethanolic Extract of Chrysophyllum albidum Seed Cotyledon in Alloxan Induced-Diabetic Rats
O.S. Olorunnisola,S. Amao,L.O. Ehigie,A.F. Ajayi
Research Journal of Applied Sciences , 2012,
Abstract: The present study evaluate the anti-hyperglycemic and hypolipidemic effect of ethanolic extract prepared from Chrysophyllum albidum seed cotyledon in model of alloxan-induced diabetic rats. Results showed that the daily treatment of diabetic rats with ethanolic extract of Chrysophyllum albidum seed cotyledon twice daily for 7 days (100 and 200 mg kg 1 orally) significantly decreased (p<0.001) the blood glucose levels by 11.92 and 12.10%, respectively in the treated induced diabetic rats compared to the diabetic control rats. The 100 mg kg 1 dose of the extract showed insignificant decrease in the hepatic lipids (except HDL-cholesterol) concentrations, while the 200 mg kg 1 of the extract showed a significant decrease (p<0.001) in the hepatic lipids (except HDL-cholesterol) in the treated diabetic rats and treated non-diabetic rats. However, the various doses of the extract significantly increased (p<0.001) the HDL-cholesterol in treated diabetic rats while, there was no significant effect on the hepatic HDL-cholesterol in the treated non-diabetic rats. The results justify the popular use of Chrysophyllum albidum seed cotyledon, pointing out to the potential benefit of the plant ethanolic extract in alternative medicine in the treatment of diabetes mellitus.
Effects of Hydromethanolic leaves extract of Indigofera pulchra on blood glucose levels of normoglycemic and alloxan-induced diabetic Wistar rats  [cached]
Y Tanko,M M Abdelaziz,A B Adelaiye,M Y Fatihu
International Journal of Applied Research in Natural Products , 2008,
Abstract: Summary: The effects of the hydromethanolic extract of Indigofera pulchra on blood glucose levels of alloxan induced and normoglycemic Wistar rats has been investigated. Three doses of the extract (250mg/Kg, 500mg/Kg and 1000mg/Kg) were administered intraperitoneally. The dose of 1000mg/Kg of the extract did not significantly alter the blood glucose levels of Alloxan induced diabetic Wistar rats after 4, 8 and 24 hours of treatment. However, the doses of 500 mg/Kg of the extract did significantly (p<0.05) decrease the blood glucose levels of Alloxan diabetic Wistar rats at 4 and 24 hours while the dose of 250 mg/Kg of the extract did significantly (p<0.05) decrease the blood glucose levels of Alloxan diabetic Wistar rats at 4, 8 and 24 hours. In normoglycemic rats, the dose of 1000mg/Kg of the extract significantly (p<0.05) decrease the blood glucose levels at 8 and 24 hours only. Also the dose of 500 mg/kg significantly (p<0.05) decrease the blood glucose levels at 24 hours while the dose of 250 mg/kg significantly (p<0.05) in the blood glucose levels at 8 and 24 hours. The phytochemical screening revealed the presences of tannins, saponins, flavonoids and steroids. The median lethal dose (LD50) in rats was calculated to be 2,154.1 mg/kg bodyweight. In conclusion, the doses of the extract has shown both significant (p<0.05) hypoglycemic and anti-hyperglycemic effects in Wistar rats. Industrial relevance: The search for more effective and hypoglycemic agents has continue to be an area of research interest, because of the less side effects and easily affordable medicinal plants has, when compared to the synthetic drugs. Indigofera pulchra is a very virgin plant and promising base on these current findings. The phytochemical screening revealed the present of phenolic compounds, tannins steroids, saponins and alkaloids. Elucidation of those secondary metabolites would be more effective in the treatment of this illness.
EVALUATION OF ANTI DIABETIC ACTIVITY OF MARSILEA MINUTA LINN AGAINST ALLOXAN INDUCED DIABETES IN ALBINO RATS  [PDF]
S.Madhu,V.Kannabirran,P.Royal Frank,M.Sathish Reddy
International Research Journal of Pharmacy , 2012,
Abstract: The present study was design with an aim to evaluate the Ethanolic leaf extract of Marsilea minuta Linn (EEMM). The study was performed on ethanolic extract of MM leaf in oral glucose tolerance test (OGTT) and alloxan-induced diabetes models in albino rats. Three weeks treatment of diabetic animals with EEMM (250 and 500 mg/kg) showed significant check in rise of blood glucose compared to untreated diabetic rats along with improved complete lipid profile. The fasting blood glucose, cholesterol, HDL cholesterol and serum triglyceride content were estimated in both normal and alloxan induced diabetic rats. The fasting blood glucose, cholesterol and serum triglyceride content were found to be significantly reduced (p<0.05) in EEMM treated rats and the extract also showed the potent elevation in the level of serum HDL cholesterol. On the basis of analysis of data obtained during the study, it may be concluded that EEMM leaf is having significant antihyperglycemic potential and can be further fractionated in order to get a responsible constituent for this very action.
Effects of Garcinia kola on the Lipid Profile of Alloxan-Induced Diabetic Wistar Rats  [cached]
E.K. Nwangwa
British Journal of Pharmacology and Toxicology , 2012,
Abstract: In this study, the effects of Garcinia kola on the lipid profile of alloxan-induced diabetic Wistar rats were studied. A total of twenty four (24) albino rats of wistar strain weighing between 100-150 g were made diabetic by single freshly prepared intraperitoneal injection of 150 mg/dL of alloxan monohydrate. Eight (8) weeks after confirmation of diabetes, the rats were randomly divided into four (4) experimental groups (n = 6). Group I (Control) rats were treated with 1ml of 5% ethanol, Group II ( diabetic rats received 1ml of 5% ethanol), Group III (Diabetic rats treated with 400 mg/kg of extract of Garcinia kola and 1mL of 5% ethanol) and Group IV, (Diabetic rats received 400 mg/kg of extract of Garcinia kola, 1 mL of 5% ethanol and 1 mL of honey).The extracts were administered twice daily for four (4) weeks. The blood glucose level and Lipid profile was analysed. The results shows that Garcinia kola has a significant (p<0.05) hypoglycaemic effect on diabetic rats and significantly (p<0.05) decreased the level of Total Cholesterol (TC), Low Density Lipoprotein (LDL) and Triglyceride (TG) and significantly (p<0.05) increase in the level of High density lipoprotein compared with the diabetic non-treated group. These findings if applied can be of help in the management of diabetic patients.
EFFECT OF AQUEOUS LEAVES EXTRACT OF CORDIA DICHOTOMA ON BLOOD GLUCOSE LEVELS OF NORMOGLYCEMIC & ALLOXAN-INDUCED DIABETIC WISTER RATS
Swami Gaurav
International Journal of Pharmaceutical Research and Development , 2010,
Abstract: The effect of the aqueous extract of alloxan induced and normoglycemic Wister rats has been investigated. Three doses of the extract (250 mg/kg; 500 mg/kg and 1000 mg/kg) were administered orally. The 500 mg/kg extract of Cordia Dichotoma did not show any significant change in the blood glucose levels in normoglycemic and 250 mg/kg did not show any significant change in the blood glucose levels in alloxan Induced Diabetic Wister rats, when compared to untreated control. The dose 500 & 1000 mg/kg of extract showed a significant (p<0.5) decrease in blood glucose levels after 4, 8 and 24 hours. In normoglycemic rats, the dose of 1000 mg/kg of the extract significantly (p<0.05) decrease the blood glucose levels at 8 and 24 hours. In conclusion, the doses of extract has shown both significant (p<0.05) hypoglycemic and antihyperglycemic effects in Wister rats.
Antidiabetic and Antioxidant Effects of Methanolic Extracts of Leaf and Seed of Tetracarpidium conophorum on Alloxan-Induced Diabetic Wistar Rats  [PDF]
Nankang G. Lepzem, Rachel Adetoro Togun
Journal of Biomedical Science and Engineering (JBiSE) , 2017, DOI: 10.4236/jbise.2017.108031
Abstract: Methanolic extracts of Tetracarpidium conophorum (TCME) leaf, seed or leaf + seed extract demonstrated high capacity for reversing hyperglycemia and oxidative stress comparable with the standard anti-diabetic drug, metformin, in alloxan-induced diabetic rats. The leaf + seed extracts showed the best activity among the extracts and also ameliorated oxidative stress-induced damage of pancreas and liver tissue to normal state.
Evaluation of Effect of Ethanolic Leaf Extract of Mucuna pruriens on Blood Glucose Levels in Alloxan-Induced Diabetic Wistar Rats  [cached]
E.D. Eze,A. Mohammed,K.Y. Musa,Y. Tanko
Asian Journal of Medical Sciences , 2012,
Abstract: Mucuna pruriens is used extensively for its medicinal value for the treatment of diabetes mellitus in Nigeria. This study investigated the anti-diabetic activity of Mucuna pruriens on the blood glucose levels and the histopathology of the pancreas. To achieve this, Acute toxicity studies of the plant extract was determined. Doses of 100, 200 and 400 mg/kg bw of the extract were administered orally daily for 21 days to alloxan-induced diabetic Wistar rats. Metformin was used as a standard anti-diabetic drug and given by gavage. The fasting blood glucose levels were determined at intervals of three days. Premininary phytochemical screening revealed the presence of flavonoids, saponin, tannins, cardiac glycosides, triterpenes and reducing sugars. The LD50 of the extract of Mucuna pruriens was found to be 2154 mg/kg. The study showed that there was a significant reduction (p<0.05) in the fasting blood sugar levels in alloxan-induced diabetic treated groups that received 100, 200 and 400 mg/kg of the extract orally, with a maximum reduction (p<0.01) of 161.83±18.2, 153.67±13.8 and 133.83±10.4 recorded in the groups treated with 100, 200 and 400 mg/kg. The histopathological studies of the pancreas of diabetic animals revealed the degeneration of pancreatic Islet cells, but with the restoration of pancreatic Islet cells in the pancreas of diabetic group treated with various doses of the plant extract. The implications of the results obtained in the present study provide the scientific rationale for the use of Mucuna pruriens as anidiabetic agent.
Preliminary Studies of Effects of Vitamin C and Zinc on Some Liver Enzymes in Alloxan-induced Diabetic Wistar Rats  [cached]
E.D. Eze,F.A. Dawud,A.A. Zainab,A. Jimoh
Asian Journal of Medical Sciences , 2012,
Abstract: Oxidative stress has been implicated in the pathogenesis of diabetes mellitus through increased generation of reactive oxygen species and consequent decline in antioxidant defenses. Diabetes is known to alter the levels of liver enzymes due to production of free radicals. The free radicals may cause hepatic injury. The current study was aimed at evaluating the effects of vitamin C and Zinc on the levels of some liver enzymes in alloxan-induced diabetic Wistar rats. Diabetes was induced in animals by intraperitoneal injection of Alloxan (150 mg/kg). Diabetic rats were randomly divided into four groups (n = 5): Group I (Normal control) received distilled water, Group II (Diabetic control) received distilled water, while Group III and IV were orally administered 100 and 50 mg/kg b w of vitamin C and Zinc respectively for seven days. Blood samples collected from the animals were assayed for liver enzymes viz: serum Aspartate aminotransaminase (AST), Alanine aminotransaminase (ALT) and Alkaline phosphatase (ALP). The result showed that the activities of liver enzymes such as AST, ALT and ALP were significantly increased in the diabetic control. Oral treatment with 100 mg/kg of vitamin C and 50 mg/kg of zinc significantly decreased (p<0.05) the concentration of serum of AST and ALT, while no significant change (p>0.05) was observed on the serum levels of ALP. The results obtained from this study may suggest that vitamin C and zinc may play an important role in the prevention of hepatocellular injury that occurs in diabetes.
Anti-diabetic and antioxidant effects of virgin coconut oil in alloxan induced diabetic male Sprague Dawley rats  [PDF]
Bolanle Iranloye, Gabriel Oludare, Makinde Olubiyi
Journal of Diabetes Mellitus (JDM) , 2013, DOI: 10.4236/jdm.2013.34034
Abstract:

Oxidative stress has been discovered to be involved in the progression of diabetes mellitus. The antioxidant properties of virgin coconut oil (VCO) among other functions might have a beneficial effect in ameliorating the disease. This study was aimed to determine the glycemic and antioxidant effects of VCO in alloxan induced diabetic rats. 24 male Sprague-Dawley rats were divided into 4 groups as follows: control (C), diabetes untreated (DUT), diabetes treated with 7.5 ml/kg VCO (DT7.5) and diabetes treated with 10 ml/kg VCO (DT10). Alloxan (100 mg/kg b.w I.P) was used to induce diabetes and VCO was administered orally once daily for 4 weeks. Fasting blood glucose level was measured on Day 0 (72 hours post alloxan injection) and after 4 weeks. Glucose tolerance test was conducted on the 4th week as well as the determination of serum insulin and liver antioxidant parameters using standard biochemical methods. Values are means ± S.E.M., compared by ANOVA and Tukey’s post hoc test. The results show that VCO significantly reduced the fasting blood glucose level in DT7.5 rats (132.4 ± 6.911) and DT10 rats (131.6 ± 12.2) are compared with DUT rats (320.4 ± 22.99) and improved the oral glucose tolerance. Serum insulin was increased in DT10 rats. GSH activities significantly increased p < 0.05 in DT10 rats (0.39 ± 0.022) when compared to DUT rats (0.032 ± 0.004). CAT activities also significantly increased p < 0.05 in

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