Search Results: 1 - 10 of 100 matches for " "
All listed articles are free for downloading (OA Articles)
Page 1 /100
Display every page Item
Vitiligo: Compendium of clinico-epidemiological features
Sehgal Virendra,Srivastava Govind
Indian Journal of Dermatology, Venereology and Leprology , 2007,
Abstract: Vitiligo, an autoimmune disorder characterized by localized and / or generalized depigmentation of the skin and / or mucous membranes, is a well-recognized entity. The imperatives of its epidemiology both in rural India and in global reckoning have been highlighted frequently. Its morphology is striking and is characterized by asymptomatic ivory / chalky white macule(s) that may be frequently surrounded by a prominent pigmented border, the ′trichrome vitiligo′. However vitiligo may have morphological variations in the form of: trichrome, quadri-chrome, penta-chrome, blue and inflammatory vitiligo. Its current topographical classification into segmental, zosteriform and nonsegmental, areata, vulgaris, acrofacialis and mucosal represent its well acclaimed presentations. Its adult and childhood onset is well appreciated as also its presentation in males and females. Occasionally, it may be possible to identify triggering factors. Vitiligo may be associated with cutaneous, ocular and systemic disorders, the details of which are discussed in this article.
Childhood vitiligo  [PDF]
Pr?i? Sonja,?uran Verica D.,Polja?ki Mirjana N.
Medicinski Pregled , 2002, DOI: 10.2298/mpns0212475p
Abstract: Introduction Vitiligo is an acquired, sometimes familial skin depigmentation disorder due to selective destruction of melanocytes. Vitiligo is primarily a disease of the young; in about half of patients it occurs before the age of twenty. The aim of this study was to investigate some epidemiological and clinical characteristics of vitiligo in children, in relation to adults with vitiligo and children without vitiligo. Material and methods The research was conducted in fifty children with clinically diagnosed vitiligo (2 to 16 years of age). Children were compared with control groups of children with other skin diseases (age 2 to 16) and with adults with vitiligo. Each group comprised 30 patients. A detailed history was obtained and physical examination performed in each patient to determine the age of onset, clinical type (segmental or generalized), family history of vitiligo and other autoimmune and/or endocrine diseases, association with halo nevi, poliosis and Koebner phenomenon. Results Of the 50 children with vitiligo, 29 (58%) were girls and 21 (42%) boys. The mean age at first visit was 9 years and the mean age of onset was 7 years. Children with vitiligo had positive family history of vitiligo and autoimmune and endocrine diseases more often compared to children without vitiligo (p<0.05). Children with vitiligo had poliosis, especially in cases of segmental vitiligo, more often compared to their age group (p<0.001). Children had an increased incidence of segmental vitiligo compared to adults (p<0.05). Halo nevi were more common in children with generalized vitiligo, in comparison with children without vitiligo (p<0.01) and adults with vitiligo (p<0.05). Discussion and conclusion Our results show that segmental vitiligo and halo nevi occurred significantly more often in children than adults with vitiligo.
Steiner, Denise;Bedin, Valcinir;Moraes, Mirella Brito;Villas, Ricardo Tadeu;Steiner, Tatiana;
Anais Brasileiros de Dermatologia , 2004, DOI: 10.1590/S0365-05962004000300010
Abstract: vitiligo is a skin disease of unknown etiology that affects 1% of the population. it affects both sexes equally and the mean age at onset is between 10 and 30 years. some of the factors involved are: emotional or physical stress, mechanical trauma, chemicals such as phenol and certain diseases. autoimmune diseases, especially of thyroid origin, may be linked to vitiligo. new and emerging therapies have been proposed such as topical immunomodulators, allied to traditional therapies with psoralen and steroids. the most important factor in the therapeutic success depends on the doctor and patient relationship.
A clinical study of vitiligo  [cached]
Martis Jacintha,Bhat Ramesh,Nandakishore B,Shetty J
Indian Journal of Dermatology, Venereology and Leprology , 2002,
Abstract: A clinical study of one hundred patients having vitiligo revealed the incidence among new patients to be 1.84%. The male/female ratio was 1:1.22. Family history of vitiligo was available in 8% of our patients. The different morphological pattern consisted of vitiligo vulgaris (39 cases), focal vitiligo (27 cases), acrofacial vitiligo (18 cases), lip - tip vitiligo (7 cases), lip vitiligo (5 cases), segmental vitiligo (3 cases) and universal vitiligo (1 case). Associated diseases include atopic dermatitis (2 cases), Hansen s disease (2 cases), alopecia areata (1 case), halo naevus (1 case), chronic urticaria (1 case), lichen planus (1 case), diabetes mellitus (9 cases), hypertension (4 cases), hypothyroidism (2 cases), epilepsy (1 case) and IHD (1 case).
CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population  [cached]
Deeba Farha,Syed Rabbani,Quareen Jariya,Waheed M
Indian Journal of Dermatology , 2010,
Abstract: Background: Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is a polygenic disease and is associated with autoimmunity with an unknown etiology. Aims: One of the candidate genes which has a strong association with several autoimmune diseases is ctla0 -4 gene located in chromosome 2q33 region. We investigated the possible association between ctla0 -4 gene polymorphism in exon 1 (A49G) and vitiligo in patients from South India and compared the distribution of this polymorphism to matched control groups. Patients and Methods: The polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 175 patients and 180 normal, age/ethnicity matched individuals. Consistency of genotype frequencies with the Hardy-Weinberg equilibrium was tested using a ÷2 test. Results: There was no significant difference between the genotype (P=0.93) and allele (P=0 .615) frequencies of CTLA-4 A49G polymorphism in patients and normal healthy individuals. However there was significant association of the CTLA-4 genotype ( P=0.02) and allelic frequency ( P=0.008) between the segmental and non-segmental sub groups within vitiligo. Conclusion: Our results indicate that there is no association between CTLA-4 A49G gene polymorphism and vitiligo in southern Indian population.
A measurement of the stigma among vitiligo and psoriasis patients in India
Pichaimuthu Rajan,Ramaswamy Premkumar,Bikash Kar,Joseph Richard
Indian Journal of Dermatology, Venereology and Leprology , 2011,
Abstract: Background and Aim: The aim is to measure and to compare the level of social participation experienced by vitiligo and psoriasis patients in their domestic and social life in an Indian context. Methods: A cross-sectional comparative study with a sample of 150 cases each of psoriasis and vitiligo, a total of 300 subjects. A detailed clinical assessment of these two conditions, including the extent of lesions on the affected body parts, socioeconomic status and participation levels in social and domestic lives, was done. Results: The result showed that, 17.3% of vitiligo patients participated minimally in domestic and social life, whereas 28% of psoriasis patients had this problem (P=0.027). Extreme participation restriction was observed only among psoriasis patients (2.7%). Psoriasis patients also faced significantly more restrictions in a number of day-to-day life situations such as, less confidence in learning and applying knowledge, difficulties in meaningfully participating in major life areas like, work, education and employment, and also in community, social and civic life (all three domains P<0.0001), to vitiligo patients. Conclusion: Both psoriasis and vitiligo patients suffered moderate to severe restriction while participating in their domestic and social life. Of these two groups, psoriasis patients faced significantly more restrictions in a number of day-to-day life situations. The Indian population of this study was predominantly dark-skinned and hypo-pigmentation as seen in vitiligo is much more noticeable than psoriatic red patches. However, the results showed that the component of hypo or hyperpigmentation of the skin is not the only factor leading to participation restrictions.
Quality of life in patients with vitiligo
Davinder Parsad, Sunil Dogra, Amrinder Kanwar
Health and Quality of Life Outcomes , 2003, DOI: 10.1186/1477-7525-1-58
Abstract: Last decade has witnessed an increasing interest in psychological effects of various skin diseases and quality of life in patients suffering from these diseases. A healthy normal skin is essential for a person's physical and mental well being. It is an important aspect of their sexual attractiveness, a sense of well being and a sense of self confidence. The skin is the largest and most visible organ of the human body. Hence any blemish on the skin visibly affects the onlooker and thus the person affected profoundly.Vitiligo is an acquired depigmentation disorder of great concern affecting 1–4% of the world population [1-5]. Since ancient times patients with vitiligo suffered the same mental abuses as lepers. In actual fact vitiligo was referred as Sweta Kustha meaning "White leprosy". Vitiligo is disfiguring in all races but particularly more so in dark skinned people because of strong contrast [6].In India and perhaps elsewhere also men, women and children with vitiligo face severe psychological and social problems. It is more acute in the case of young women and children. The first prime minister of India, Pt Jawaharlal Nehru ranked vitiligo as one of three major medical problems of India the other two being leprosy and malaria. In India vitiligo commonly known as leucoderma [7] is unfortunately associated with some religious beliefs. In some Indian religious texts where reincarnation is believed, it is said that a person who did "Guru Droh" in his previous life suffers from vitiligo in this life. Thus people suffering from vitiligo in India have more social problems than in other countries. This is seriously felt among young unmarried women. This is so because of arranged marriages. Thus an young woman with vitiligo has little chance of getting married. A married women developing vitiligo after marriage shall have marital problems perhaps ending in divorce.Vitiligo is thus an important skin disease having major impact on the quality of life of patients suffering
Psoriasis lineal y vitiligo segmentario, manifestación sobrepuesta de dos enfermedades frecuentes Lineal psoriasis and segmental vitiligo overlapped. Presentation of two frequent conditions  [cached]
MC Valbuena,LA Pati?o
Revista Argentina de Dermatología , 2013,
Abstract: La asociación de psoriasis y vitiligo es un evento bien documentado, con una incidencia del 3%, según diferentes series de casos, aunque no hallamos trabajos de superposición de ambas enfermedades siguiendo las líneas de Blaschko, en la literatura revisada por nosotros. Presentamos el caso de una mujer de 47 a os de edad con lesiones de vitiligo en rostro y en abdomen, desde la infancia, que se distribuyeron sobre las líneas de Blaschko; después de 30 a os aparecieron placas eritematoescamosas sobre las manchas acrómicas del abdomen, que clínica e histopatológicamente correspondieron a psoriasis y mejoraron parcialmente con fototerapia UVB de banda estrecha. La psoriasis y el vitiligo son entidades multifactoriales, poligénicas, que pueden exhibir patrones de mosaicismo cutáneo. Se han planteado algunas teorías para explicar este fenómeno, pero todavía no son conocidos todos los factores que influyen en este tipo de presentación. The association of psoriasis and vitiligo is a well documented event, with an incidence of 3% according to different case series, but reports of an overlap of both diseases following Blaschko lines were not found in the reviewed literature. We present the case of a 47 years old woman with vitiligo lesions in the face and abdomen, starting since childhood, distributed over the Blaschko lines; thirty years later erythematous and squamous plaques appeared over the achromic macules of the abdominal region which were clinically and histopathologically compatible with psoriasis and improved partially with narrow band UVB phototherapy. Psoriasis and vitíligo are multifactorial and polygenic skin disorders that can show patterns of cutaneous mosaicism. Some theories have tried to explain this phenomenon, but the factors that influence this presentation are still unclear.
Some new powdery mildews from Northern India  [cached]
Indian Phytopathology , 2012,
Abstract: Three new powdery mildews viz. Cystotheca quercina sp. nov., Oidium brassicae sp. nov. and Oidiopsis solani sp. nov. are reported on Quercus incana Roxb., Brassica napus L. var. glauca (Roxb.) Schulz. and Peganum harmala L., respectively for the science from northern India.
Some modifications in transplantation of autologus non -cultured melanocytes-keratinocytes suspension in treatment of segmental and focal vitiligo (Egyptian Experience in Alexandria University)  [cached]
Nagat Sobhy,Ali Atia,Mahmoud Elramly
Our Dermatology Online , 2013,
Abstract: Introduction: Transplantation of Autologous non-cultured melanocytes suspension is a simple yet effective cell-based therapy for vitiligo.Materials and Methods: 20 patients with stable vitiligo were subjected to epidermal cell suspension transplantation using Osslon’s method with some new modifications.Result: The repigmentation at 7 of the test sites (35.0%) was excellent. It was good for more than half of the test sites (55.0%). Fair repigmentation was encountered among only 2 (10.0%) of the tested sites. None of the tested sites showed poor repigmentation. On the other hand, none of the control sites showed excellent or even good repigmentation. However, repigmentation was fair for nearly 10% and it was poor for 90% of the control sites.Conclusion: Autologus non cultured basal -enriched epidermal cell suspension transplantation is an effective, simple and safe method for treatment of stable vitiligo.
Page 1 /100
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.