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Metastatic sweat gland adenocarcinoma: A clinico-pathological dilemma
Chintamani, RD Sharma, Rohini Badran, Vinay Singhal, Sunita Saxena, Anju Bansal
World Journal of Surgical Oncology , 2003, DOI: 10.1186/1477-7819-1-13
Abstract: Two cases of metastatic sweat gland adenocarcinoma (one of eccrine and the other one of apocrine origin) are being reported on account of the rarity and different outcome.Sweat gland carcinomas are rare cancers with a poor prognosis often presenting as histological surprises. Surgery in the form of wide local excision and lymph node dissection is the mainstay of treatment. Chemotherapy and/or radiotherapy has limited role.Sweat gland neoplasms (microcystic adenexal carcinoma) are rare with approximately 200 cases of eccrine sweat gland and 38 cases of apocrine gland carcinoma being reported in the world literature [1,2]. It is often not diagnosed clinically or incorrectly and is encountered as a histological surprise i.e. as an incidental finding at histology of resected specimen. A wide surgical excision is the treatment of choice with clearance of draining lymph nodes. The role of adjuvant chemotherapy and radiotherapy is not established. We report here two cases of sweat gland adenocarcinoma one each of eccrine and apocrine origin.A 45-year-old man presented to the surgical wing with swelling in the right axilla of 2 months duration. There was a past history of pulmonary tuberculosis, two years back, for which patient had taken anti tubercular treatment. On examination the thyroid, breasts, chest, abdomen, and per rectal examinations were normal. Examination of axilla revealed a tiny, indurated, non tender, pink skin nodule of about 5 mm diameter (figure 1) with multiple, firm, non tender, discrete, axillary lymph nodes measuring 1 to 4 cm.Hematological and biochemical investigations were within normal limits. Chest roentgenogram showed healed tubercular lesion in right apical area. A contrast enhanced computerized tomographic scan (CECT) of the chest and fiber optic bronchoscopy was carried out which did not reveal any significant pathology except healed fibro cavitatory lesion in the right apex. Ultrasound examination of both the breasts, and abdomen was essent
Adenocarcinoma of the Rectum with Cutaneous Metastases  [cached]
Gamal Abdul Hamid,Nohad Hanbala
Middle East Journal of Cancer , 2012,
Abstract: Cutaneous metastases of rectal carcinoma is a rare event. It occurs in fewer than 4% of all patients with rectal cancer. When present, it typically signifies a disseminated disease with a poor prognosis. Early detection and proper diagnosis of metastatic rectal cancer can significantly alter treatment and prognosis. We report a 70-year-oldmale who underwent rectal resection with permanent colostomy for rectal adenocarcinoma since seven years. The patient recently developed multiple skin nodules, mainly in his face, scalp, and upper trunk, associated with itching. Fine needle aspiration cytology from a face nodule was done which revealed metastatic adenocarcinoma associated with severe inflammation. Cutaneous metastasis of rectaladenocarcinoma is an unusual event that presents mainly in the form of skin nodules and could be the first sign of metastasis. Early diagnosis of cutaneous metastasis in these patients is important because it can alter treatment and prognosis.
Primary Cutaneous Low Grade Mucinous Adenocarcinoma of Eyelid  [cached]
Geethalakshmi U,Vijayshankar S,Abhishek MG,Indira CS
Online Journal of Health & Allied Sciences , 2010,
Abstract: Primary cutaneous mucinous adenocarcinoma is a rare adnexal neoplasm, eyelid being the most common site of presentation. Clinically it is mistaken for a benign / cystic lesion. Its morphologic similarity to metastatic deposits from breast, gastrointestinal tract (GIT) or any visceral sites adds to the diagnostic difficulty mandating the role of ancillary techniques in precise diagnosis and hence planning the management. We report a case of primary cutaneous mucinous adenocarcinoma of eyelid with emphasis on pathology along with a brief review of literature.
Extramammary Paget's disease of the penis: a case report and review of the literature
Kingsley C Ekwueme, Hani D Zakhour, Nigel J Parr
Journal of Medical Case Reports , 2009, DOI: 10.1186/1752-1947-3-4
Abstract: We describe the case of an 87-year-old Caucasian male who presented with a non-healing erythematous plaque on the shaft of the penis previously misdiagnosed as Bowen's disease. The diagnosis was made histologically on the excised specimen and was supported by immunohistochemical staining.Extramammary Paget's disease is a rare disease which can mimic various types of dermatosis. A high index of suspicion is required, combined with biopsy and immunohistochemical staining in order to make the correct diagnosis. Long-term follow-up is mandatory in these patients in order to identify and treat any subsequent recurrence or concurrent malignancy.Extamammary Paget's disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma involving primarily the epidermis but occasionally extending into the underlying dermis. It has predilection for apocrine gland-bearing areas: mostly the perineum, vulva, axilla, scrotum and penis. Isolated Paget's disease of the penis is rare and only a few cases have been reported in the literature [1].We describe a case of EMPD confined to the shaft of the penis and initially misdiagnosed on punch biopsy. We also review the literature and highlight the need for a high index of suspicion in the diagnosis of this rare neoplasm.An 87-year-old Caucasian male was referred to our centre by a dermatologist, having undergone punch biopsy of a penile lesion with the initial histology reported as showing Bowen's disease. The patient gave a 6-month history of an enlarging lesion on the shaft of his penis prior to presentation to the dermatologist, which had been treated with topical agents and antibiotics. Nevertheless, the dermatologist was clinically suspicious of an invasive lesion prompting referral for wide excision. The patient had had a similar lesion at the same location 10 years earlier which was excised by his general practitioner but no histology report could be traced. He had no other lumps anywhere in the rest of the body and no family histo
Choroidal and cutaneous metastasis from gastric adenocarcinoma  [cached]
Shoichiro Kawai,Tsutomu Nishida,Yoshito Hayashi,Hisao Ezaki
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i9.1485
Abstract: Choroidal or cutaneous metastasis of gastric cancer is rare. Gastrointestinal cancer was found in only 4% in patients with uveal metastasis. Choroidal metastasis from gastric cancer was reported in two cases in earlier literature. The frequency of gastric cancer as a primary lesion was 6% in cutaneous metastasis of men, and cutaneous metastasis occurs in 0.8% of all gastric cancers. We report a patient with gastric adenocarcinoma who presented with visual disorder in his left eye and skin pain on his head as his initial symptoms. These symptoms were diagnosed to be caused by choroidal and cutaneous metastasis of gastric adenocarcinoma. Two cycles of chemotherapy consisted of oral S-1 and intravenous cisplatin (SPIRITS regimen); this was markedly effective to reduce the primary gastric lesion and almost all the metastatic lesions.
Lower Extremity Cutaneous Lesions as the Initial Presentation of Metastatic Adenocarcinoma of the Colon
Dhyan Rajan,Mitanshu Shah,Pooja Raghavan,Shanza Mujeeb,Sadat Rashid,Aieska Desouza,Paul Mustacchia
Case Reports in Medicine , 2012, DOI: 10.1155/2012/989104
Abstract: Cutaneous metastases from colorectal cancers are rare and are usually present on the abdominal wall or previous surgical incision sites. Remote cutaneous lesions have been reported, however, often occur in the setting of widespread metastatic disease including other visceral secondaries. We present a case of lower extremity cutaneous metastases as the first sign of metastatic disease in a patient with adenocarcinoma of the colon. This case illustrates that new skin lesions may be the initial presentation of metastatic disease in a patient with a history of cancer.
Cutaneous metastatic adenocarcinoma  [cached]
Joshi Arun,Sah Shatrughan
Indian Journal of Dermatology, Venereology and Leprology , 2001,
Abstract: A 5.5-year-old male presented with asymptomatic nodules and plaques on his scalp and pubic region of 2 months′ duration. He was having productive cough, haemoptysis, chest pain, anorexia and weight loss and receiving antitubercular treatment for these symptoms for last 3 months. Clinical diagnosis of cutaneous metastatic disease was made. Chest x-ray revealed multiple coin shaped shadows on both sides with pleural effusion. Routine investigations were normal except for anemia and hyperuricemia. Biopsy of skin nodules showed features of metastatic adenocarcinoma. Features and significance of cutaneous metastases are discussed.
Gastric Adenocarcinoma Deposits Presenting as Multiple Cutaneous Nodules: A Case Report with Review of Literature
Türk Patoloji Dergisi , 2012,
Abstract: Metastases to the skin from internal tumors are uncommon, yet they may be the first presentation of such malignancies. They usually arise from the breast, lung and large bowel. Cutaneous metastases from gastric adenocarcinoma are extremely rare. We report a case of gastric adenocarcinoma that at presentation had multiple clinically benign looking skin nodules. Fine needle aspiration cytology of the cutaneous nodule revealed metastatic deposits. The current literature on cutaneous metastases of gastric carcinoma is reviewed in this case report.
Adenocarcinoma con diferenciacion apocrina de la glandula lagrimal Adenocarcinoma with apocrine differentiation of the lacrimal gland  [cached]
M. Lozano,F. Gonzalez
Archivos de la Sociedad Espa?ola de Oftalmología , 2007,
Abstract: Caso clínico: Se presenta el caso de un varón de 74 a os con una tumoración orbitaria localizada en la fosa lagrimal izquierda. La exploración oftalmológica mostró hipotropía, exoftalmos y ptosis palpebral del ojo izquierdo. Discusión: La tumoración se extirpó mediante una orbitotomía lateral y el resultado anatomopatológico fue de adenocarcinoma de la glándula lagrimal con diferenciación apocrina. Case report: A 74-year-old male presented with an orbital tumor located in the left lacrimal fossa. Ocular examination showed hypotropia, exophthalmos and palpebral ptosis. Discussion: Removal of the tumor was performed by a lateral orbitotomy. The histopathologic study showed a tumor consistent with an adenocarcinoma of the lacrimal gland with apocrine differentiation.
Cutaneous metastases of signet-ring cell colorectal adenocarcinoma
Rodrigues, André Petter;Pereira, Gustavo Becker;Schlindwein, Rafael Felix;Cruz, José Vinícius;Furquim, Lucas Cogo;
Journal of Coloproctology (Rio de Janeiro) , 2012, DOI: 10.1590/S2237-93632012000300014
Abstract: colorectal cancer is a common malignancy in our clinical practice and it often evolves to a metastatic stage. cutaneous dissemination, however, is a rare form of presentation of this disease. this study reports the case of a 38-year-old female patient that, even after neoadjuvant chemotherapy, presented cutaneous metastases of signet-ring cell colorectal adenocarcinoma. the malignancy proved to be extremely aggressive, without response to clinical therapy nor allowing surgical management, leading the patient to death about six months after the diagnosis.
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