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Juvenile Xanthogranuloma  [cached]
Gangopadhyay Asok Kumar
Indian Journal of Dermatology , 1999,
Abstract: A case of juvenile xanthogranuloma is presented for it′s rarity.
Juvenile Xanthogranuloma With Hydrocephalus  [cached]
Ghosh Arghyaprasun,Mandal Kakali,Samanta Asok,Barbhuiya Jayashree Nath
Indian Journal of Dermatology , 2004,
Abstract: Juvenile xanthogranuloma (JXG) is a rare, benign, self-healing tumor of unknown etiology arising from non-Langerhansa€ cell histiocytes. We report a case of 2 year old female child with few nodular lesions mainly over scalp, face, trunk and upper limbs. There was no other organ involvement. Histopathology showed presence of vacuolated histiocytes with Touton giant cells. There was concurrent hydrocephalus.
Juvenile xanthogranuloma in an adult
Nayak Surajit,Acharjya Basanti,Devi Basanti,Patra Manoj
Indian Journal of Dermatology , 2009,
Abstract: Juvenile xanthogranuloma (JXG), a rare benign histiocytic disorder, primarily seen in the first two decades of life as a solitary cutaneous lesion. Though in majority of cases lesions are confined to the skin, systemic forms can occur in rare instances. We present here a 21-year-old male patient presenting with multiple brown-to-yellowish papules and nodules over the head, neck and trunk evolving since last 2 years. A clinico/histopathologic study was done to confirm the diagnosis of JXG. We present this case, because of the unusual presentation and morphology in regards to the age and to highlight the fact that, juvenile xanthogranulomas though not so common, may occur in older age group and should always be in mind while making a diagnosis of a disease of similar morphology.
Bilateral spontaneous hyphaema in juvenile xanthogranuloma  [cached]
Vijayalakshmi P,Shetty Shashikant,Jethani Jitendra,Uma Devi T
Indian Journal of Ophthalmology , 2006,
Abstract: This report describes a rare occurrence of bilateral, spontaneous, nontraumatic hyphema in a 6 weeks old infant, associated with a small, multiple skin lesions. The diagnosis of juvenile xanthogranuloma was confirmed by histopathological examination of the cutaneous lesions. The hyphaema cleared gradually in 2 weeks time with conservative management.
Long-term results after Boston brace treatment in late-onset juvenile and adolescent idiopathic scoliosis
Johan Lange, Harald Steen, Ragnhild Gunderson, Jens Brox
Scoliosis , 2011, DOI: 10.1186/1748-7161-6-18
Abstract: 272 (78%) of 360 patients, 251 (92%) women, responded to follow-up examination at a mean of 24.7 (range 16 - 32) years after Boston brace treatment. Fifty-eight (21%) patients had late-onset juvenile and 214 had adolescent idiopathic scoliosis. All patients had clinical and radiological examination and answered a standardised questionnaire including work status, demographics, General Function Score (GFS) (100 - worst possible) and Oswestry Disability Index (ODI) (100 - worst possible), EuroQol (EQ-5D) (1 - best possible), EQ-VAS (100 - best possible), and Scoliosis Research Society - 22 (SRS - 22) (5 - best possible).The mean age at follow-up was 40.4 (31-48) years. The prebrace major curve was in average 33.2 (20 - 57)°. At weaning and at the last follow-up the corresponding values were 28.3 (1 - 58)° and 32.5 (7 - 80)°, respectively. Curve development was similar in patients with late-onset juvenile and adolescent start. The prebrace curve increased > 5° in 31% and decreased > 5° in 26%. Twenty-five patients had surgery. Those who did not attend follow-up (n = 88) had a lower mean curve at weaning: 25.4 (6-53)°. Work status was 76% full-time and 10% part-time. Eighty-seven percent had delivered a baby, 50% had pain in pregnancy. The mean (SD) GFS was 7.4 (10.8), ODI 9.3 (11.0), EQ-5D 0.82 (0.2), EQ-VAS 77.6 (17.8), SRS-22: pain 4.1 (0.8), mental health 4.1 (0.6), self-image 3.7 (0.7), function 4.0 (0.6), satisfaction with treatment 3.7 (1.0). Surgical patients had significantly reduced scores for SRS-physical function and self-image, and patients with curves ≥ 45° had reduced self-image.Long-term results were satisfactory in most braced patients and similar in late-onset juvenile and idiopathic adolescent scoliosis.A recent Cochrane systematic review evaluated the efficacy of bracing in adolescent idiopathic scoliosis (AIS) [1]. The full text of 128 studies was reviewed, but only one randomized controlled trial [2] and one prospective cohort study [3] could be inc
Juvenile Xanthogranuloma Presenting as Bilateral Non-Infiltrative Extraconal Superior Orbital Tumour in a 27 Year Old Nigerian Woman: Features, Management and Outcome
Okosa Michael Chuka and Anyiam Daniel Chukwuemeka Darlinton
Clinical Medicine Insights: Case Reports , 2012, DOI: 10.4137/CCRep.S10138
Abstract: Introduction: Orbital masses in adults are often caused by systemic diseases or are associated with systemic manifestations. Juvenile xanthogranuloma as a cause is rare and unreported in Africa. We present clinical features, management, and outcomes of bilateral orbital adult onset juvenile xanthogranuloma. Case Presentation: A 27 year old Nigerian woman presented with bilateral upper-lid lumps having lasted 5 months. These increased in size for about 1 month and stopped. Lid swelling was preceded by itchy eyes, redness of conjunctiva, and occasional mild pain. There were no visual or systemic symptoms. The lumps were firm, slightly mobile, not tender, and not attached to skin but rather to deeper structures. There was restriction on up-gaze but no proptosis or diplopia. Hematological, biochemical, and X-ray investigations were normal. Prednisolone tablets 10 mg daily for two weeks were not useful. Tissue biopsy was invaluable in diagnosis of this rare condition and disclosed juvenile xanthogranuloma. Partial surgical excision was done under lidocaine infiltration. No recurrence has occurred in 40 months of follow-up. No systemic disease has manifested. Conclusion: Juvenile xanthogranuloma can present as bilateral superior orbital tumor in adults; functional and cosmetic aims were achieved by sub-total excision.
Multiple juvenile xanthogranuloma in an adult patient: a case report
Mirshams Shahshahani M,Kiavash K
Tehran University Medical Journal , 2008,
Abstract: Background: Juvenile xanthogranuloma is a benign, normolipemic, dendrocytic histiocytosis that usually affects young children. It presents clinically as single or multiple yellow-brown papulonodular lesions in the upper part of the body, especially the head and neck. In adults, xanthogranuloma is not common and usually presents as a single lesion. Multiple xanthogranuloma in adults is rare. For the most part, cutaneous lesions are self-limited and seldom necessitate treatment. Here we report an adult patient with multiple xanthogranuloma.Case: A 45-year-old woman presented with multiple papulonodular lesions around the eyes and over her breasts and back. Biopsy showed giant cells with a wreath-like arrangement of nuclei (Touton giant cell) and diagnosis of juvenile xanthogranuloma was made.Conclusion: Although juvenile xanthogranuloma is a disease of children, it can rarely occur in adults. These patients should be evaluated for involvement of other organs to prevent complications. With ocular involvement, the risk of morbidity is high, and complications can include glaucoma, retinal detachment, cataract, vascular occlusion, hyphema, and corneal blood staining.
Lingual juvenile xanthogranuloma in a woman: a case report
Alessandro Villa, Umberto Mariani, Francesco Villa
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-30
Abstract: We present a rare case of oral juvenile xanthogranuloma in a 49-year-old Caucasian woman. The histopathologic diagnosis of the lingual neoformation was histiocitary proliferation with the presence of giant cells, Touton type, compatible with juvenile xanthogranuloma.To establish an accurate diagnosis, microscopic evaluation and immunohistochemical staining are necessary. Dentists, dermatologists and general practitioners may be the first to recognize this rare condition during the inspection of the oral cavity.Juvenile xanthogranuloma is an uncommon non-Langerhans cell histiocytosis that usually occurs during infancy and early childhood. This lesion was first reported by Adamson in 1905 [1], who used the term congenital xanthoma multiplex. This pathological condition has subsequently been reported under various names such as nevoxanthoendothelioma, juvenile xanthoma or xanthoma tuberosum [2]. Its modern name was introduced by Senear [3] in 1936 and popularized by Helwig and Hackney in 1952 [4].The pathogenesis is unknown, although the disease is believed to be a reactive rather than a neoplastic process. It is caused by the proliferation of plasmacytoid monocytes in response to an unknown etiologic agent, possibly either physical or infectious [5].Juvenile xanthogranuloma is a benign and self-healing disorder which is characterized by the presence of single or multiple raised cutaneous nodules, yellow-brown to reddish in color and usually measuring from a few millimeters to a few centimeters in diameter. Sometimes superficial telangiectasias and an erythematous border may also occur [6]. The most involved cutaneous regions are the neck, head and upper trunk, followed by the extremities.Juvenile xanthogranuloma is not limited to cutaneous sites, however. The eye is the most common extracutaneous site, with other affected organs including the lung, kidney, pericardium, colon, central nervous system, liver, spleen, eye/orbit, bone, kidneys, adrenal glands, testis and o
Periocular xanthogranuloma: A forgotten entity?  [cached]
Charalampos Papagoras,George Kitsos,Paraskevi V Voulgari,et al
Clinical Ophthalmology , 2010,
Abstract: Charalampos Papagoras1, George Kitsos2, Paraskevi V Voulgari1, Anastasia K Zikou3, Maria I Argyropoulou3, Aikaterini Zioga4, Alexandros A Drosos11Rheumatology Clinic, Department of Internal Medicine; 2Department of Ophthalmology; 3Department of Clinical Imaging and Radiology, 4Department of Pathology, Medical School, University of Ioannina, Ioannina, GreeceAbstract: Periocular xanthogranulomatous diseases are a rare group of disorders which are characterized by a predilection to affect the orbit and ocular adnexa and special histopathological features, in particular infiltrates comprising non-Langerhans-derived foamy histiocytes and Touton giant cells. The differential diagnosis is difficult and occasionally definite diagnosis cannot be established even after clinical and histopathological findings are taken together. We describe a case of a middle-aged man who presented with a 10-year history of voluminous eyelid swelling with concomitant late-onset atopic manifestations, namely bronchial asthma and allergic rhinitis with nasal polyps. After thorough clinical and laboratory investigation, including a biopsy of the eyelid, we classified the patient’s disease to a rare entity that has been relatively recently described: periocular xanthogranuloma associated with adult-onset asthma. In a review of the literature, no prospective trials concerning the treatment of this disease were found. The literature mainly contained case reports and case series in which corticosteroids and chemotherapy with alkylating agents have been reported to be beneficial. We treated our patient with a combination of oral corticosteroids and cyclophosphamide pulses and we observed substantial regression of the eyelid masses together with a normalization of systemic immunologic abnormalities.Keywords: periocular xanthogranuloma, adult-onset asthma, non-Langerhans histiocytoses, cyclophosphamide, methylprednisolone
Late Onset Poststroke Seizures  [cached]
Ba?ak Karakurum G?KSEL,Mehmet KARATA?,Meliha TAN,,Tülin YILDIRIM
Journal of Neurological Sciences , 2005,
Abstract: The most common cause of seizures is cerebrovascular disease in elderly population. Late onset seizures are not investigated as well as early onset seizures in patients with stroke. There is no common consensus about clinical, electrophysiological and radiological features of these seizures. In this study, 55 patients with late onset seizure who had stroke history were investigated. The 49 % of patients were women, the mean ages of patients were 63.9±9.2 years. The mean of duration between stroke and the first seizure was 30.4±36.8 months and the mean of following time was 14±13 months. The 89% of patients ischemic stroke and 11% of patients had hemorrhagic stroke. The lesion localizations were cortical in 17 (30.9%) patients, subcortical in 8 (14.5%) and cortico-subcortical in 29 (52.7%). As a result 84 % patients’ lesions were cortical localization. There were partial seizure in 39 (%70.9) patients, generalized tonic-clonic seizure in 16 (29.1%) patients. 43 (78%) patients had no seizure during antiepileptic therapy. 7 (12.7%) patients had seizure after beginning antiepileptic drug due to stopping drug, low blood level of drug and ineffectiveness of drug. 5 (9%) patients had not been given drug because of first seizure and no seizure during follow-up. In conclusion, the late onset poststroke seizures seem frequently in ischemic stroke, the reccurence rate was high and partial type seizures were more common than generalized and cortical localization was seen frequently. On the other hand, this condition has good prognosis.
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