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Clinical Study: Lotion Containing Propolis Special Extract GH 2002 0.5% vs. Placebo as On-Top Treatment of Herpes Zoster  [PDF]
Denisa Tomanova, Simona Holcova, M. Hladíková
Health (Health) , 2017, DOI: 10.4236/health.2017.910097
Abstract: Background: The aim of the clinical trial was to establish the contribution of propolis special extract GH 2002 as constituent of a lotion for the supportive treatment of Herpes zoster. Methods: 60 patients with diagnosed Herpes zoster were either treated with a propolis containing (n = 33) or an identical, but propolis-free lotion (n = 27) for 28 days, as an add-on therapy to oral antiviral treatment with aciclovir. Study parameters were the assessment of pain on a visual analogue scale, the assessment of the formation of new vesicles, and the safety of application of the preparation. Results: Improvement of pain was significantly better and quicker in the propolis lotion group (p < 0.001 at all visits). On day 3/4, the reduction of pain versus baseline was 54% versus 20% reduction in favour of propolis lotion. On day 14 the results were 80% versus 42% pain reduction. Healing of lesions was significantly quicker with the propolis-containing lotion: at visit 3 on day 7, 21% versus none of the patients showed a closed skin with or without crusting. After 14 days, the comparison showed 57.6% versus 25.9%. At least 50% of propolis-treated patients were lesion-free on day 14, versus day 28 in the control group (p = 0.013). The formation of new vesicles was also significantly suppressed. On day 3/4 the number of newly formed vesicles was 15 versus 25, on day seven the number of new vesicles was 4 versus 14 (p < 0.001). The advantage of propolis lotion was confirmed through the global assessment of efficacy by the physician, with 75.8 versus 33.3% “good” to “excellent” ratings already on day 3/4, 90.9 vs. 44.4% on day 7, and 100 vs. 74.1% on day 28 (p < 0.001). Skin tolerability was excellent, no allergic reactions, skin irritations or other adverse events were observed. Conclusion: The observations clinically confirm antiviral and anti-inflammatory effects of propolis special extract GH 2002 and at the same time demonstrate the benefits of the topical add-on to the systemic antiviral therapy of Herpes zoster.
Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds  [PDF]
?aneta Jastrz?bska-Stojko,Rafa? Stojko,Anna Rzepecka-Stojko,Agata Kaba?a-Dzik,Jerzy Stojko
Molecules , 2013, DOI: 10.3390/molecules181114397
Abstract: Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey—products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy.
Recrudescent herpes labialis mimicking primary herpes labialis in pregnancy
Shaveta Sood,Aneet Mahendra,Sanjeev Gupta,Shalu Chandna
North American Journal of Medical Sciences , 2010,
Abstract: Context: Herpes simplex virus (HSV) infection is prevalent worldwide. Herpes labialis is caused predominantly by HSV-1, and herpes vulvo-vaginitis is caused predominantly by HSV-2. HSV-2 may result in significant morbidity and mortality for infected neonates exposed during delivery. Due to this fact, a large amount of literature exists for HSV-2 but data for HSV -1 is scanty. Case Report: We report two cases of recrudescent herpes labialis in 3rd trimester of pregnancy with extensive peri-oral lesions resembling primary herpes labialis. There was no obvious cause of immunosupression. The patients were followed up with a normal outcome of pregnancy and no fetal abnormality. Conclusions: The reasons for such extensive perioral lesions are uncertain. Immunosupression of pregnancy may be a factor in a sub group of patients.
The BALM Copula  [PDF]
Boyan Dimitrov,Nikolai Kolev
International Journal of Stochastic Analysis , 2013, DOI: 10.1155/2013/652364
Abstract: The class of probability distributions possessing the almost-lack-of-memory property appeared about 20 years ago. It reasonably took place in research and modeling, due to its suitability to represent uncertainty in periodic random environment. Multivariate version of the almost-lack-of-memory property is less known, but it is not less interesting. In this paper we give the copula of the bivariate almost-lack-of-memory (BALM) distributions and discuss some of its properties and applications. An example shows how the Marshal-Olkin distribution can be turned into BALM and what is its copula. 1. Introduction The class of probability distributions called “almost-lack-of-memory (ALM) distributions” was introduced in Chukova and Dimitrov [1] as a counterexample of a characterization problem. Dimitrov and Khalil [2] found a constructive approach considering the waiting time up to the first success for extended in time Bernoulli trials. Similar approach was used in Dimitrov and Kolev [3] in sequences of extended in time and correlated Bernoulli trials. The fact that nonhomogeneous in time Poisson processes with periodic failure rates are uniquely related to the ALM distributions was established in Chukova et al. [4]. It gave impetus to several additional statistical studies on estimations of process parameters (see, e.g., [5, 6] to name a few) of these properties. Best collection of properties of the ALM distributions and related processes can be found in Dimitrov et al. [7]. Meanwhile, Dimitrov et al. [8] extended the ALM property to bivariate case and called the obtained class BALM distributions. For the BALM distributions, a characterization via a specific hyperbolic partial differential equation of order 2 was obtained in Dimitrov et al. [9]. Roy [10] found another interpretation of bivariate lack-of-memory (LM) property and gave a characterization of class of bivariate distributions via survival functions possessing that LM property for all choices of the participating in it four nonnegative arguments. One curious part of the BALM distributions is that the two components of the 2-dimensional vector satisfy the properties characterizing the bivariate exponential distributions with independent components only in the nodes of a rectangular grid in the first quadrant. However, inside the rectangles of that grid any kind of dependence between the two components may hold. In addition, the marginal distributions have periodic failure rates. This picture makes the BALM class attractive for modeling dependences in investment portfolios, financial mathematics, risk
MANAGEMENT OF RECURRENT HERPES LABIALIS IN IMMUNOSUPPRESSED PATIENT – A CASE REPOR
Joslei Carlos Boh,Lucimari Teixeira,Cassiano Lima Chaiben,Adriano Kuczynski
Journal of International Dental and Medical Research , 2011,
Abstract: The clinical manifestations of herpes simplex virus (HSV-1 and -2) are found in both immunocompetent patients and in those immunocompromised. However, the typical lesions observed among immunosuppressed patients usually become more severe, long-lasting and require different interventions in individuals whose immune systems can not limit the infection. Secondary or recurrent HSV-1 infection occurs through the reactivation of the virus, although many patients may present only asymptomatic infection in saliva. The hallmark of the recurrent herpes labialis is characterized by burning sensation, itching, tingling or localized heat followed by the appearance of a rash before the onset of the bullous and vesicular lesions. The majority of cases are treated by antiretroviral drugs. For this reason, clinicians need to be aware of atypical cases which suggest a clinical immunosuppression that have not yet diagnosed. The aim of this article is to report a case of recurrent herpes labialis of an immunosuppressed patient.
Recurrent post-herpetic erythema multiforme, herpes labialis and secondary vitiligo in siblings  [cached]
Mittal R,Walia R,Gupta Seema,Kaur Jastinder
Indian Journal of Dermatology, Venereology and Leprology , 1996,
Abstract: Presence of recurrent herpes labialis with resultant secondary vitiligo associated with recurrent erythema multiforme further leading to depigmentation of skin in relation to target shaped maculopapular lesions in two real sisters was observed as a unique phenomenon which probably has not been reported earlier.
Antiinflammatory constituents of teramnus labialis  [cached]
Sridhar C,Krishnaraju A,Subbaraju G
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: Bioassay-guided fractionation, based on antiinflammatory activity of the methanolic extractives of Teramnus labialis led to the isolation and characterization of vitexin, bergenin, daidzin and 3-O-methyl-D- chiro -inositol as active constituents. Vitexin exhibited a dose-dependent inhibitory activity on 5-lipoxygenase enzyme. The isolated constituents were also screened for their antioxidant activity by nitroblue tetrazolium (NBT) riboflavin photo reduction method. Vitexin exhibited moderate antioxidant activity. This is the first reported occurrence of vitexin, bergenin, daidzin and 3-O-methyl-D- chiro -inositol in T. labialis.
Fluconazole induced herpes labialis-like lesions in an adult male  [PDF]
Nisha Afonso,Pawan Rane,Amit Dang,Padmanabh V. Rataboli
Australasian Medical Journal , 2009,
Abstract: Fluconazole is a bistriazole commonly prescribed for thetreatment of various fungal infections caused by yeasts and dermatophytes. However, there have been several reports of rare Adverse Drug Reactions (ADRs) like Fixed Dose Eruption (FDE), Toxic Epidermal Necrolysis and Stevens Johnson Syndrome following oral administration of fluconazole. We report a rare case of fluconazole induced oral mucosal lesions, mimicking herpes labialis, in a 34 year old male patient receiving oral fluconazole for the treatment of allergic fungal sinusitis.
Epidermodysplasia verruciformis with Hansen′s disease, herpes simplex labialis and multiple eccrine hidradenoma  [cached]
Padmavathy L,Rao L,Ethirajan N,Krishnaswamy B
Indian Journal of Dermatology , 2009,
Abstract: Epidermodysplasia verruciformis (EV) - a rare, lifelong heritable disease due to a unique susceptibility to human papilloma virus. The disseminated verrucous lesions or pityriasis versicolor like lesions persist from early childhood and can transform into a cutaneous malignancy in a fourth of patients. The association of EV with multiple eccrine hidradenoma, herpes simplex labialis and Hansen′s disease is a very rare occurrence and is reported in a 25-year-old woman.
Antimicrobial and antioxidant activity of lemon balm Kombucha
Veli?anski Aleksandra S.,Cvetkovi? Dragoljub D.,Markov Sini?a L.,Tumbas Vesna T.
Acta Periodica Technologica , 2007, DOI: 10.2298/apt0738165v
Abstract: Kombucha is a beverage traditionally produced by metabolic activity of yeasts and acetic acid bacteria. The antimicrobial activity of lemon balm kombucha as well as of particular control samples was determined by agar-well diffusion method. Antioxidant activity on stable 1,1-diphenyl-2-picrylhydrazyl radicals of lemon balm kombucha and lemon balm tea was determined by electron spin resonance spectroscopy. Acetic acid, Kombucha samples and heat-denaturated kombucha showed significant antimicrobial activity against bacteria. However, there was no activity against yeasts and moulds. Kombucha showed higher antioxidant activity than tea sample for all applied sample volumes.
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