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Linfoma del manto vs. Leucemia linfática crónica atípica: Utilización de inmunohistoquímica, citometría de flujo y biología molecular para su correcta tipificación
Gómez Pescie,Mariana; Denninghoff,Valeria; García,Alejandro; Rescia,Carla; Avagnina,Alejandra; Elsner,Boris;
Medicina (Buenos Aires) , 2005,
Abstract: the differential diagnosis of certain b cd5+ lymphoproliferative processes, such as mantle cell lymphoma (mcl) and atypical chronic lymphocytic leukemia (acll), is difficult. the aim of this study was to correlate morphological findings, cyclin d1 (cd1) detection by immunohistochemistry (ihc) and immunophenotype by flow cytometry (fc) with the results obtained by molecular biology in this type of neoplasias. we analyzed 20 samples classified as b cd5+ lymphoproliferative processes by fc. pcr was used for t(11;14) bcl-1/igh determination. histopathological and ihc studies for cd1 were done in 14 cases. twelve cases were diagnosed as mcl, with positive cd1 in 5 (5/9), five as acll and three as b lymphoproliferative process. pcr revealed t(11;14) in 6/12 mcl and negative results in the other groups (0/8). molecular biology evidenced translocation in 4/5 mcl positive for cd1 with ihc. the presence of translocation could be demonstrated by ihc and pcr in 7/12 mcl: 4 with both techniques, 2 with pcr alone, and 1 with ihc alone. these findings show a significant association between cd1 by ihc and bcl-1/igh gene detection by pcr, which implies that both techniques are complementary for mcl typing.
The Influence of Manto and Maupassant on Social Life  [PDF]
Aqeela Shaheen,Riaz Qadeer
Pakistan Journal of Commerce and Social Sciences , 2012,
Abstract: Literature is expression and interpretation of life. The Realism of life is exhibited in the literary masterpieces of the writers who understand life and possess enough courage to express it in their creative writings. This is quite befitting for French writer Guy DeMaupassant and Urdu writer Saadat Hassan Manto. They, through their world famous short stories, put a great impact on world literature. Their special field is Realism. They painted life as it appeared to them. They were blamed for vulgarity and resultantly suffered for that matter. The researchers and critics have acknowledged their love for humanity and their superiority as writers and as trend setters.
Manto de invisibilidad en microondas  [cached]
E. Septién,V. Aboites
Revista mexicana de física , 2012,
Abstract: Se presentan resultados experimentales de un manto de invisibilidad operando en el rango de las microondas a una frecuencia de 10.525 GHz. El análisis teórico esta basado en un análisis por mapeo conforme. Los resultados experimentales se obtuvieron a partir de la construcción de un metamaterial con anillos resonantes en cobre. Se encuentra buen acuerdo entre el planteamiento teórico y los resultados experimentales.
Multicanonical Methods vs. Molecular Dynamics vs. Monte Carlo: Comparison for Lennard-Jones Glasses  [PDF]
Kamal K. Bhattacharya,James P. Sethna
Physics , 1997, DOI: 10.1103/PhysRevE.57.2553
Abstract: We applied a multicanonical algorithm (entropic sampling) to a two-dimensional and a three-dimensional Lennard-Jones system with quasicrystalline and glassy ground states. Focusing on the ability of the algorithm to locate low lying energy states, we compared the results of the multicanonical simulations with standard Monte Carlo simulated annealing and molecular dynamics methods. We find slight benefits to using entropic sampling in small systems (less than 80 particles), which disappear with larger systems. This is disappointing as the multicanonical methods are designed to surmount energy barriers to relaxation. We analyze this failure theoretically, and show (1) the multicanonical method is reduced in the thermodynamic limit (large systems) to an effective Monte Carlo simulated annealing with a random temperature vs. time, and (2) the multicanonical method gets trapped by unphysical entropy barriers in the same metastable states whose energy barriers trap the traditional quenches. The performance of Monte Carlo and molecular dynamics quenches were remarkably similar.
Controlling the sense of molecular rotation: classical vs quantum analysis  [PDF]
Yuri Khodorkovsky,Kenta Kitano,Hirokazu Hasegawa,Yasuhiro Ohshima,Ilya Sh. Averbukh
Physics , 2010, DOI: 10.1103/PhysRevA.83.023423
Abstract: Recently, it was predicted theoretically and verified experimentally that a pair of delayed and cross-polarized short laser pulses can create molecular ensembles with a well defined sense of rotation (clockwise or counterclockwise). Here we provide a comparative study of the classical and quantum aspects of the underlying mechanism for linear molecules and for symmetric tops, like benzene molecules, that were used for the first experimental demonstration of the effect. Very good quantitative agreement is found between the classical description of the process and the rigorous quantum mechanical analysis at the relevant experimental conditions. Both approaches predict the same optimal values for the delay between pulses and the angle between them, and deliver the same magnitude of the induced oriented angular momentum of the molecular ensemble. As expected, quantum and classical analysis substantially deviate when the delay between pulses is comparable with the period of quantum rotational revivals. However, time-averaged characteristics of the excited molecular ensemble are equally good described by the these two approaches. This is illustrated by calculating the anisotropic time-averaged angular distribution of the double-pulse excited molecules, which reflects persistent confinement of the molecular axes to the rotation plane defined by two polarization vectors of the pulses.
Vibrational vs. electronic coherences in 2D spectrum of molecular systems  [PDF]
Vytautas Butkus,Donatas Zigmantas,Leonas Valkunas,Darius Abramavicius
Physics , 2012, DOI: 10.1016/j.cplett.2012.07.014
Abstract: The two-dimensional spectroscopy has recently revealed oscillatory behavior of excitation dynamics in molecular systems. However, in the majority of cases it is strongly debated if excitonic or vibrational wavepackets, or evidences of quantum transport have been observed. In this letter, the method for distinguishing between vibrational and excitonic wavepacket motion is presented, based on the phase and amplitude relationships of oscillations of distinct peaks, which has been revealed using fundamental analysis of two-dimensional spectrum of two representative systems.
Molecular Cloud Evolution III. Accretion vs. stellar feedback  [PDF]
Enrique Vazquez-Semadeni,Pedro Colin,Gilberto C. Gomez,Alan Watson
Physics , 2010, DOI: 10.1088/0004-637X/715/2/1302
Abstract: We numerically investigate the effect of feedback from the ionizing radiation heating from massive stars on the evolution of giant molecular clouds (GMCs) and their star formation efficiency (SFE). We find that the star-forming regions within the GMCs are invariably formed by gravitational contraction. After an initial period of contraction, the collapsing clouds begin forming stars, whose feedback evaporates part of the clouds' mass, opposing the continuing accretion from the infalling gas. The competition of accretion against dense gas consumption by star formation (SF) and evaporation by the feedback, regulates the clouds' mass and energy balance, as well as their SFE. We find that, in the presence of feedback, the clouds attain levels of the SFE that are consistent at all times with observational determinations for regions of comparable SF rates (SFRs). However, we observe that the dense gas mass is larger in general in the presence of feedback, while the total (dense gas + stars) is nearly insensitive to the presence of feedback, suggesting that the total mass is determined by the accretion, while the feedback inhibits mainly the conversion of dense gas to stars. The factor by which the SFE is reduced upon the inclusion of feedback is a decreasing function of the cloud's mass, for clouds of size ~ 10 pc. This naturally explains the larger observed SFEs of massive-star forming regions. We also find that the clouds may attain a pseudo-virialized state, with a value of the virial mass very similar to the actual cloud mass. However, this state differs from true virialization in that the clouds are the center of a large-scale collapse, continuously accreting mass, rather than being equilibrium entities.
Physical vs. Observational Properties of Clouds in Turbulent Molecular Cloud Models  [PDF]
Javier Ballesteros-Paredes,Mordecai-M. Mac Low
Physics , 2001, DOI: 10.1086/339624
Abstract: We examine how well the physical properties of clumps in turbulent molecular clouds can be determined by measurements of observed clump structures. We compare simulated observations of three-dimensional numerical models of isothermal, magnetized, supersonic turbulence to the actual physical structure of the models. We determine how changing the parameters of turbulence changes the structure of the simulations. Stronger driving produces greater density fluctuations, and longer wavelength driving produces larger structures. Magnetic fields have a less pronounced effect on structure, and one that is not monotonic with field strength. Aligned structures are seen only with low-density tracers, and when the intensity of the field is large. Comparing different regions with the same tracers (or the same region with different tracers) can give information about physical conditions: different density tracers can help determine the size of the density fluctuations and thus the strength of the driving. Nevertheless, velocity superposition of multiple physical clumps can fully obscure the physical properties of those clumps, and short wavelength driving worsens this effect. Regarding Larson's relationships, we confirm previous claims that the mean density-size relationship is an artifact of the observations; and the velocity dispersion-size relationship, is consistent with observations. Regarding the mass spectra, we show that, when we look for clumps with high enough resolution, they converge to a log-normal function, rather than the power-law obtained in the literature.
Manto's 'Evidence' To 'Bruised’Women Sexuality During Partition
Raju Jayasing Patole
Indian Streams Research Journal , 2012,
Abstract: The second group of stories depicts women as victims of Partition violence, sexual violation, abduction and their treatment 'enemy territory'. Stories like 'Anjam Bekhair'('A Girl from Delhi'), 'Sharifan' ('Bitter Harvest'), 'Khol Do' ('The Return') and 'Khuda ki Kasam' ('The Dutiful Daughter') illustrate the point it is women at the receiving end always during any kind of violence upheaval. It is they who lose much more than the patriarchs of the society. 'Khol Do' and 'Khuda ki Kasam' are more powerful as they depict the horror and psychological trauma experienced by women during Partition. Women bore the pathos of communal strife in the wake of the Partition of the country and became victims of gruesome communal incidents. The suffer doubly – first they become the victims of rape, then they are done to death or abducted. Manto's narration of this subject is unparalleled and regarded as masterpieces of their genre.
Rates of clinically apparent heparin-induced thrombocytopenia for unfractionated heparin vs. low molecular weight heparin in non-surgical patients are low and similar
Charles FS Locke, John Dooley, Jonathan Gerber
Thrombosis Journal , 2005, DOI: 10.1186/1477-9560-3-4
Abstract: Heparin-induced thrombocytopenia (HIT) is recognized as a rare, but potentially devastating complication of heparin therapy because of its association with arterial and venous thrombosis [1]. HIT is mediated by antibodies which recognize an antigen formed by the binding of platelet factor 4 to heparin [2]. The now widespread use of low-molecular-weight heparins for a variety of indications previously reserved exclusively for unfractionated heparin has generated interest in comparing the relative rates of HIT between the two classes of heparin.In 1995 Warkentin examined rates of HIT in patients undergoing elective hip arthroplasty who had been randomized to receive either unfractionated heparin (UFH) or low molecular weight heparin (LMWH) for thromboprophylaxis [3]. Warkentin reported that HIT occurred in 9 of 332 patients who received UFH and in none of 333 patients who received LMWH (2.7 percent vs. 0 percent). In addition, development of heparin-dependent IgG antibodies and thrombotic events associated with thrombocytopenia were more common in patients treated with UFH than in those treated with LMWH.Recently, using different criteria for HIT (an absolute drop in platelet count of 50% or greater vs. platelet count less than 150,000 cells /ml), Warkentin reanalyzed these same data and found the difference in the observed rate of HIT was even more pronounced, 8 times greater (4.8% vs. 0.6%) in UFH compared to LMWH for prophylaxis of venous thromboembolism (VTE) in patients undergoing elective hip arthroplasty [4].Warkentin's results are supported by a recent study by Walenga et al which carefully evaluated sera from three clinical studies [5]. Walenga found that LMWH was less likely to generate H-PF4 antibodies than UFH and less likely to result in clinical HIT. Walenga also noted that LMWH were more likely to generate IgA and IgM antibodies rather than IgG antibodies, which are associated with clinical HIT. However, the sera reviewed by Walenga all were from orthop
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