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TUBAL HYDATIDIFORM MOLE: REPORT OF A CASE
M. POUR-REZA
Acta Medica Iranica , 1974,
Abstract: A case report of the relatively rare condition of a primary hydatidiform mole in the fallopian tube is presented. Key words; Hydatidiform mole Fallopian tube.
A case of tubal hydatidiform mole  [PDF]
Ouafae Slimani, Fz Fdili Alaoui, Sofia Jayi, Hekmat Chaara, Hakima Bouguern, M. A. Malhouf, Nawal Hamas, Amal Bennani, Afaf Amarti
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.38112
Abstract:

Tubal hydatidiform mole is an uncommon condition with about 40 confirmed cases in the accessible literature. The patient usually presents with symptoms and signs of a classical ectopic pregnancy, and it is only after histological examination and DNA ploidy analysis of the conceptus that a hydatidiform mole is diagnosed. We present an unusual case of primi gravida at 6 weeks gestation that was diagnosed as having ectopic pregnancy.

Ruptured tubal hydatidiform mole  [cached]
Modupeola Omotara Samaila,Adebiyi Gbadebo Adesiyun,Calvin Bifam
Journal of the Turkish-German Gynecological Association , 2009,
Abstract: Objective: Ruptured ectopic gestation is a life threatening medical emergency especially in developing countries. However, the occurrence of hydatidiform mole in ruptured tubal pregnancy is uncommon. Material and Methods: A consecutive analysis of patients with hydatidiform mole in ruptured tubal gestation over a 9-year period in a tertiary hospital. Results: Of a total of 101 females with ectopic gestations, only five had ruptured tubal hydatidiform mole. The ages ranged from 20-37years and they all presented with acute abdominal symptoms which necessitated emergency surgical intervention. Intra-operative findings revealed ruptured/ leaking tubal gestation. The excised tissue specimens showed hydatidiform mole characterized by circumferential trophoblastic proliferation, hydropic degeneration and stromal karyorrhexis. Patients’ serial HCG levels were monitored before discharge. Conclusion: Ruptured tubal hydatidiform mole is uncommon and strict histologic criteria are important in diagnosis. Serial HCG levels must be monitored in individual patients to forestall development of malignant trophoblastic disease.
Hydatidiform Mole in University of Ilorin Teaching Hospital: An 8 Years Review
A.A.G. Jimoh,A.B. Ajayi,R. Saidu
International Journal of Tropical Medicine , 2012, DOI: 10.3923/ijtmed.2012.57.60
Abstract: This is an 8 years review of hydatidiform mole at University of Ilorin Teaching Hospital, Kwara State. The objective of this study is to determine the incidence, clinical presentation and management of hydatidiform mole in this centre. All cases of hydatidiform mole seen from January 1999 to 31st December 2006 at the University of Ilorin Teaching Hospital were identified through the records of names with the pathological diagnosis of hydatidiform mole kept in the medical records department of the hospital. The case records were then retrieved and the data analyzed. There were 72 cases of hydatidiform mole and 17,223 deliveries during the period of study. The incidence of hydatidiform mole during the study period was 1 in 239 deliveries. Pre-operative diagnosis was made in all of the cases. Bleeding per vaginam was the main presenting complaint in 63 cases (87.5%). About 71 cases (98.7%) were treated with vacuum aspiration while one of the patients had hysterectomy. Follow up clinic attendance was poor as only 22.2% were adequately followed up for 2 years. Hydatidiform mole remains a major premalignant tumor of the female genital tract. While clinical presentation, diagnosis and treatment outcomes are satisfactory, follow up of affected patients have been poor and pose serious challenges.
Mola hidatiforme parcial Partial hydatidiform mole
Lázaro López Ba?os,José Adalberto Oliva Rodríguez,José Pérez Trujillo,Estela Paula Hernández Pérez
Revista Cubana de Obstetricia y Ginecolog?-a , 2012,
Abstract: Introducción: el término enfermedad trofoblástica gestacional es una anormal proliferación del trofoblasto, que desde el punto de vista histológico se clasifica en mola hidatiforme, mola invasora, coriocarcinoma y tumor del sitio de implantación del trofoblasto. Objetivo: describir las características clínicas y ultrasonográficas de una mola hidatiforme parcial o mola embrionada. Paciente: se presenta un caso de 24 sem de gestación con el diagnóstico ultrasonográfico de mola hidatidiforme parcial. Resultados: se realizó cariotipo fetal y determinación de niveles de gonadotropina coriónica en suero materno. Se hallaron defectos congénitos en el feto, por lo que se ofreció asesoramiento genético a la pareja, que optó por la interrupción de la gestación. Conclusiones: el diagnóstico prenatal fue confirmado por la anatomía patológica. Introduction: the term gestational trophoblastic disease is an abnormal proliferation of the trophoblast, which is histologically classified as hydatidiform mole, invasive mole, choriocarcinoma, and tumor trophoblast implantation site. Objective: to describe the clinical and ultrasonographic partial hydatidiform mole or mole embrionada. Patient: we report a 24- week - prenancy case with ultrasonographic diagnosis of partial hydatidiform mole. Results: fetal karyotype was performed and levels of chorionic gonadotropin in maternal serum were determined. We found congenital defects in the fetus, so genetic counseling was offered to the parents, who chose ending this pregnancy. Conclusions: the prenatal diagnosis was confirmed by pathology.
Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole  [PDF]
Naoki Matsumoto,Marie Osada,Kou Kaneko,Ken Ohara,Daito Noguchi,Haruhiko Udagawa,Nagazumi Suzuki,Chieko Matsumoto,Sachio Takahashi
Case Reports in Obstetrics and Gynecology , 2013, DOI: 10.1155/2013/267268
Abstract: Pemphigoid gestationis (PG) is a rare, perinatal, autoimmune, and blistering dermatosis. Only few cases of PG involving hydatidiform moles have been reported. Complete hydatidiform moles are usually evacuated by dilatation and curettage. We report a patient with a massive complete hydatidiform mole that underwent spontaneous expulsion; she subsequently developed PG. A 19-year-old unmarried nulligravid woman was referred to our hospital following excessive vaginal bleeding after an uncertain amenorrheal period. The patient presented with preshock vital signs, severe anemia, and a positive urine pregnancy test. Imaging examinations revealed a massive intrauterine mass (19?×?15?×?10?cm), suggesting a complete hydatidiform mole. She was hospitalized and treated with blood transfusion. Sixteen hours after hospitalization, the massive molar mass underwent spontaneous expulsion and bleeding ceased. Three days after the expulsion, she developed pruritic skin lesions including papules, erythemas, and bullae, which spread over her entire body. Skin biopsy revealed PG and subepidermal blister formation and linear complement C3 deposition along the basement membrane zone, and the serum anti-BP180 antibody level was found to be high on measurement. She was effectively treated with 50?mg/day of oral prednisolone. Her skin lesions disappeared, leaving pigmentation. 1. Introduction Recently, in Japan, almost all pregnancies, irrespective of normal or abnormal, are examined during the early gestational weeks. When a hydatidiform mole in the uterus is suspected following an imaging examination, such as ultrasonography, it is usually evacuated by dilatation and curettage (D&C) for histopathological diagnosis and treatment. However, massive moles are occasionally difficult to remove by D&C. Pemphigoid gestationis (PG), which has previously been called “herpes gestationis,” is a rare, autoimmune, self-limiting, and blistering dermatosis associated with pregnancy [1]. Its incidence is considered to be 1 in 50,000 to 60,000 pregnancies [2]. Hydatidiform moles occur in about 1 in 1,200 to 1,500 pregnancies [3, 4]. Therefore, PG in hydatidiform mole patients is considered extremely rare. We report a patient who presented with a massive complete hydatidiform mole that underwent spontaneous expulsion; she subsequently developed PG. We report a summary of our patient from obstetrical and gynecological aspects. 2. Case Presentation The patient was a 19-year-old unmarried nulligravid Japanese woman with no relevant past history. Her sexual partner was a 40-year-old Japanese man. On
Successful Primary Treatment of a Hydatidiform Mole with Methotrexate and EMA/CO
M. De Vos,M. Leunen,C. Fontaine,Ph. De Sutter
Case Reports in Medicine , 2009, DOI: 10.1155/2009/454161
Abstract: Background. The preferred treatment method of most hydatidiform moles is suction aspiration. In rare circumstances uterine abnormalities may preclude surgical treatment. Case. We report a case of complete molar pregnancy successfully treated with methotrexate followed by EMA/CO. A 38-year-old woman with a complete hydatidiform mole and multiple uterine fibroids underwent a failed attempt at suction aspiration. Following treatment with methotrexate, a nonmetastatic persistent trophoblastic tumour developed. Six cycles of EMA/CO led to complete remission. Conclusion. We propose that primary treatment of molar pregnancies with chemotherapy is a useful treatment option in cases where uterine abnormalities interfere with suction aspiration.
Reproductive Wastage in Recurrent Partial Hydatidiform Mole: A Clinical Dilemma.  [cached]
Shakuntala PN,Ashmita D,Shubha R Rao,Usha R
Online Journal of Health & Allied Sciences , 2013,
Abstract: Recurrent partial Hydatidiform mole is an extremely rare clinical entity which represent a part of the gestational trophoblatic neoplasia spectrum. Since the first case was reported by Honore. LM in 1987 about eight cases of recurrent partial moles have been reported in the English medical literature. Present two cases are the 9th and 10th case with recurrent partial moles to be described. We have discussed the aetiology, environmental factors, dietary habits , clinicopathologic features, the clinical dielemmas faced by us while counselling, follow up and pregnancy outcome in women presenting with two and three recurrent partial moles respectively. We have also reviewed the literature.
Hydatidiform mole resulting from sexual violence
Jefferson Drezett, Flavia Kurobe, Cecília Nobumoto, Daniela Pedroso, Marcia Blake, Vitor E Valenti, Luiz Carlos M Vanderlei, Fernando Adami, Franciele M Vanderlei, Sandra de Araujo Moraes, Maria Auxiliadora F Vertamatti, Alberto OA Reis, Carlos de Mello Monteiro, Renata C Rossi, Luiz de Abreu
International Archives of Medicine , 2012, DOI: 10.1186/1755-7682-5-8
Abstract: Description of two cases of HM among 1146 patients with pregnancy resulting from sexual violence treated at Hospital Pérola Byington, S?o Paulo, from July 1994 to August 2011.The cases affected young, white, unmarried, low educated and low parity women. Sexual violence was perpetrated by known offenders unrelated to the victims, under death threat. Ultrasound and CT of the pelvis showed bulky uterus compatible with HM without myometrial invasion. One case was associated with theca lutein cysts. The two cases were diagnosed in the second trimester of pregnancy and evolved with hyperthyroidism. There was no hypertension, disease recurrence, metastasis or sexually transmitted infection.The incidence of HM was 1:573 pregnancies resulting from rape, within the range estimated for Latin American countries. Trophoblastic material can be preserved to identify the violence perpetrator, considering only the paternal HM chromosomes. History of sexual violence should be investigated in cases of HM in the first half of adolescence and women in a vulnerable condition.Gestational impairments are important factors to be investigated [1,2], since it affects children development [3-5]. The hydatidiform mole (HM) is a variant of gestational trophoblastic disease, a generic term that brings together different conditions of proliferation of trophoblastic epithelium, with abnormal functioning tissue producing human chorionic gonadotropin (hCG) [6]. The gestational trophoblastic disease includes forms of HM, invasive mole, gestacional choriocarcinoma and placental site trophoblastic tumor, according to anatomoclinical criteria [7].The choriocarcinoma is the most severe form of the disease with potential for invasion and metastasis, affecting every 20,000 pregnancies [8]. The etiology of HM is unknown. Studies associate it with nutritional deficiencies, environmental conditions, herbicides, parity, smoking, extremes of maternal age, intrauterine device, inbreeding, viral infections, oral h
Dizygotic Twin Pregnancy With a Complete Hydatidiform Mole and a Coexisting Viable Fetus
Ashraf Moini,Firouzeh Ahmadi,Bita Eslami,Fatemeh Zafarani
Iranian Journal of Radiology , 2011,
Abstract: Coexistence of a viable fetus with a hydatidiform mole is a rare condition and the diagnosis is very important because of the risk of developing severe complications in pregnancy. The management of these pregnancies is optional, although accurate and great care is required to find early signs of maternal or fetal complications.Hereby we report a case of dizygotic twin pregnancy with a complete mole and coexisting fetus that resulted in a live neonate.
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