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Histopatología de la Hepatitis Viral Crónica C, Pinar del Río, enero 2002-julio 2008
Cirión Martinez,Gladys R; Herrera Pérez,Miguel Angel;
Revista de Ciencias M??dicas de Pinar del R?-o , 2009,
Abstract: despite being hepatitis caused by c virus (hcv) a worldwide health problem and the most frequent cause of chronic hepatitis, liver cirrhosis and hepatocelular carcinoma, a practical score system to perform the histopathologic diagnosis does not exist. objective: to increase the competence of pathologists in the diagnosis of hcv at "abel santamaria cuadrado" university hospital from january 2002 to july 2008. design: a technological innovation was created writing a book with electronically- processed diagrams and the study of hcv-biopsies by means of a descriptive and cross-sectional design. subjects and method: universe: 236 biopsies with the diagnosis of hcv. sample: 117 biopsies having the diagnosis of chronic- hcv (the total during the period). age, sex, type of histological lesion; diagnostic correspondence, the degree of the lesion and stage of the fibrosis in respect of the age were considered. descriptive statistics was used to sum up the categorical and continuing quantitative variables and the verification of frequencies through calculation and/or association of variables x2, or. results: a system of representative histological draws for the classification of chronic viral hepatitis (ishak, 1995) was created. chronic-hcv was more frequent between ages 35-54, female sex, and moderate necro-inflammatory activityreached up to 60.6% between 35 and 44 years old. conclusion: it was confirmed that the system of draws makes possible a better standardization of the diagnosis in teams and provides a more suitable learning of the disease.
Experience with Hepatitis B viral load testing in Nigeria
AP Okwuraiwe, OB Salu, CK Onwuamah, OS Amoo, NN Odunukwe, RA Audu
African Journal of Clinical and Experimental Microbiology , 2011,
Abstract: Background: Quantification of the viral burden is an important laboratory tool in the management of hepatitis B virus (HBV)-infected patients. However, widespread use of assays is still hampered by the high cost. Treatment reduces viral load to undetectable levels. HBV infected patients tend to have high HBV DNA levels, and severe liver disease. Objectives: This study was carried out to determine the pattern of HBV viral load levels of patients assessing management in Nigeria. Method: Variables included sociodemographics like age, sex, religion, income, educational background and residence. The COBAS Amplicor automated Analyzer (PCR based) was used to assay the virus quantitatively. Results: 594 patients were tested from 2008 to 2009. Statistical analysis was done using Epi info version 2002 and test of significance by Kruskal-Wallis. Mean age of the patients was 36.8 (ranging from 9 to 69) years. HBV viral titre ranged between 4,145 and 68,011,800 DNA copies/ml. Conclusion: There was a high occurrence of viral titre in the population studied. High viral load is a risk factor for hepatocellular carcinoma. A policy earmarked to combat this virus in Nigeria is hereby solicited.
The epidemiology of viral hepatitis in Qatar  [cached]
Bener Abdulbari,Al-Kaabi Saad,Derbala Moutaz,Al-Marri Ajayeb
Saudi Journal of Kidney Diseases and Transplantation , 2009,
Abstract: Viral hepatitis is a major public health problem in many countries all over the world and especially in Middle East, Asia, East-Europe, and Africa. The aim of our study was to assess the incidence of viral hepatitis A, B and C in Qatar and compare it with other countries. This is a retrospective cohort study, which was conducted at Hamad General Hospital, State of Qatar from 2002-2006. Patients who were screened and diagnosed with viral hepatitis were included in this study. The diagnostic classification of definite viral hepatitis was made in accordance with criteria based on the International Classification of Disease tenth revision (ICD-10). A total of 527 cases of hepatitis C, 396 cases of hepatitis B, 162 cases of hepatitis A and 108 cases of unspecified were reported during the year 2006. Reported incidence rate per 10,000 populations during the year 2006 for hepatitis A was 1.9, hepatitis B 4.7, and Hepatitis C 6.3. The proportion of hepatitis B and C was significantly higher in male population than females across the years (2002-2006). Hepatitis A was more prevalent in children below 15 years (72.3%), hepatitis B in adults aged above 15 years, and hepatitis C in the population above 35 years of age. The incidence of hepatitis A has been declining in Qataris and increasing in expatriates. There was a significant relationship in gender and age group of the patients with hepatitis A, B and C. We conclude that hepatitis has become a national health issue in Qatar. The incidence rate of hepatitis in Qatar is comparable to its neighboring countries, United Arab Emirates and Saudi Arabia. There is a need for further research on hepatitis and the associated risk factors.
VIRAL HEPATITIS
M. Zahoor ul Hassan Dogar
The Professional Medical Journal , 2001,
Abstract: Viral Hepatitis “An AIDS of Pakistan”, a poster exhibited on a local walk against Hepatitis, depictsthe severity of the disease. A survey published recently in a daily newspaper narrated that about10-25% of total population in Pakistan is either suffering from, or is included among carrier ofthis disease. Among them, the common prevalent types are hepatitis B & C. This article is a reviewcompilation of the various research materials published in international journals, related actually to Pakistanor Pakistani population settled elsewhere in the world.
Epidemiology of viral hepatitis in Sudan
Hatim MY Mudawi
Clinical and Experimental Gastroenterology , 2008, DOI: http://dx.doi.org/10.2147/CEG.S3887
Abstract: emiology of viral hepatitis in Sudan Review (6698) Total Article Views Authors: Hatim MY Mudawi Published Date November 2008 Volume 2008:1 Pages 9 - 13 DOI: http://dx.doi.org/10.2147/CEG.S3887 Hatim MY Mudawi Department of Internal Medicine, Faculty of Medicine, University of Khartoum, Khartoum, Sudan Abstract: Hepatitis virus infections are the most common cause of liver disease worldwide. Sudan is classified among the countries with high hepatitis B virus seroprevalence. Exposure to the virus varied from 47%–78%, with a hepatitis B surface antigen prevalence ranging from 6.8% in central Sudan to 26% in southern Sudan. Studies pointed to infection in early childhood in southern Sudan while there was a trend of increasing infection rate with increasing age in northern Sudan. Hepatitis B virus was the commonest cause of chronic liver disease and hepatocellular carcinoma and was the second commonest cause of acute liver failure in the Sudan. Studies of hepatitis C virus showed a low seroprevalence of 2.2%–4.8% and there was no association with schistosomiasis or with parenteral antischistosomal therapy. Hepatitis E virus was the commonest cause of acute hepatitis among pediatric, adult, and displaced populations. Recent introduction of screening of blood and blood products for hepatitis B virus and hepatitis C virus infections and the introduction of hepatitis B virus vaccine as part of the extended program of immunization is expected to reduce the infection rate of these viruses in the Sudan.
Association of markers of chronic viral hepatitis and blood mercury levels in US reproductive-age women from NHANES 2001–2008: a cross-sectional study
Mary C Sheehan, Thomas A Burke, Patrick N Breysse, Ana Navas-Acien, John McGready, Mary A Fox
Environmental Health , 2012, DOI: 10.1186/1476-069x-11-62
Abstract: Geometric mean (GM) TBHg levels from a representative sample of over 5,000 seafood-consuming, reproductive-age women from eight years (2001–2008) of the US NHANES survey were compared by viral hepatitis status (as determined by serological assay) using multiple linear regression. Adjustment was made for estimated MeHg intake from seafood consumption, social and demographic variables and other predictors.Women with chronic HBV had 1.52 (95% CI 1.13, 2.05, p?<?0.01) times the GM TBHg of women who had not come into contact with the virus. The positive association was strongest in those with most severe disease. A modest negative association was found with HCV markers.While study design prevents inferences on causality, the finding that MeHg biomarkers differ by hepatitis status in this population suggests viral hepatitis may alter the pace of MeHg elimination. Offspring of HBV-infected seafood-consuming women may be at higher risk of MeHg-induced developmental delays than offspring of those uninfected. Possible reasons for the unanticipated negative association with HCV are explored.Methylmercury (MeHg) is a neurotoxin widely present in the environment to which the developing fetus is acutely vulnerable [1]. The primary exposure source and pathway for this sensitive population is maternal seafood consumption [2]. Numerous countries have issued commercial seafood advisories for reproductive-age women [3] with the goal of minimizing MeHg intake and protecting offspring from the verbal, spatial and fine-motor skill delays associated with MeHg-induced developmental neurotoxicity [2].Individuals are known to differ in susceptibility to health risks from contaminants such as MeHg [4,5]. Variability has been observed in MeHg’s toxicokinetic processing as well as its neurotoxic effects in association with differences in maternal age [6], genetic polymorphisms in the glutathione (GSH) system [7], nutrient intake [8,9] and the social environment [10], among other factors. Furthe
Hepatitis viral aguda
Hernández Garcés,Héctor Rubén; Espinosa álvarez,René F.;
Revista Cubana de Medicina General Integral , 1998,
Abstract: a bibliographical review of acute viral hepatitis was made taking into account those aspects connected with its etiology. some epidemiological markers, the most important clinical forms, and the complementary examinations with special emphasis on the viral markers and the positive diagnosis were also considered
Angiogenesis in chronic viral hepatitis
Micha? Kukla,Andrzej Gabriel,Marek Waluga,Rafa? Bu?dak
Polish Gastroenterology , 2009,
Abstract: It is unresolved whether angiogenesis is merely a homeostatic mechanism aimed at ensuring an adequate oxygen supply or one that exerts an additional pathogenic role leading to liver tissue damage.The development of fibrosis and the accumulation of inflammatory cells which occur in viral hepatitis may increase the resistance of liver tissue to blood flow and oxygen supply. Under these circumstances, an angiogenesis switch occurs leading to an increase in proangiogenic factors which contribute to vascular remodeling and the formation of new vessels. On the other hand, the process of chronic liver wound healing typical of fibrogenic chronic liver diseases is characterized by an over-expression of the same proangiogenic growth factors. The exact role of the virus in the pathogenesis of angiogenesis is also unclear. This review describes the pathogenesis of new blood vessel formation in chronic viral hepatitis and its potential role in disease progression. It also points to angiogenesis as a pos-sible new therapeutic target. Moreover, it summarizes recent findings concerning the pathogenic role, intrahepatic expression, and variations in the circulating levels of proangiogenic factors in patients with chronic viral hepatitis.
Ribavirin in acute viral hepatitis.  [cached]
Tilve G,Patel K,Mogre V
Journal of Postgraduate Medicine , 1991,
Abstract: Sixty-four patients suffering from acute viral hepatitis (excluding those suffering from hepatitis B) were selected for the double blind clinical trial. They were randomly allocated to either ribavirin therapy (200 mg four times a day) or placebo. Four patients were lost to follow up and therefore final analysis was carried out on 60 patients (thirty had received ribavirin and the rest placebo). Patients receiving ribavirin showed significant rapid improvement, with the disappearance of annoying symptoms (e.g., nausea, vomiting, etc) and return of good appetite; moreover, the abnormal blood parameters showed significant rapid changes towards normal values in ribavirin treated patients as compared to those observed in placebo group. Ribavirin was well tolerated and there were no side effects. Since acute viral hepatitis is endemic with outbreaks of epidemics in many areas at various times and as yet there is no effective anti-viral drug available with the physicians in India, ribavirin is indeed a most welcome drug for its therapy.
Hepatitis viral aguda
Héctor Rubén Hernández Garcés,René F. Espinosa álvarez
Revista Cubana de Medicina General Integral , 1998,
Abstract: Se realizó una revisión bibliográfica de las hepatitis virales agudas sobre aspectos vinculados a su etiología. Se tuvieron en cuenta además algunos datos epidemiológicos, las formas clínicas más importantes, los exámenes complementarios con especial énfasis en los marcadores virales y el diagnóstico positivo A bibliographical review of acute viral hepatitis was made taking into account those aspects connected with its etiology. Some epidemiological markers, the most important clinical forms, and the complementary examinations with special emphasis on the viral markers and the positive diagnosis were also considered
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