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Investigations of seborrheic dermatitis. Part II. Influenceof itraconazole on the clinical condition and the level of selected cytokinesin seborrheic dermatitis
Ewa Trznadel-Grodzka,Marcin B?aszkowski,Helena Rotsztejn
Post?py Higieny i Medycyny Do?wiadczalnej , 2012,
Abstract: Introduction:The pathogenesis of seborrheic dermatitis has not been fully elucidated. A number of anascogenic yeasts of Malassezia spp. appear to be involved in the intensity of the symptoms. The purpose of the study is to evaluate the levels of selected inflammatory cytokines, IL-2, IL-4, IFN-γ and TNF-α, in the serum after treatment with itraconazole.Material/Methods:Sixty-six subjects were enrolled in the study. The control group consisted of 30 participants (23 females and 7 males) without any clinical disorders, aged 24–65 (37.41±6.08 years). Thirty-six patients with seborrheic dermatitis (16 females and 20 males), aged 19–76 (38.61±13.77), constituted the study group. The measurement of IL-2, IL-4, IFN-γ and TNF-α levels was performed by ELISA using a Human High Sensitivity kit (Diaclone, France).Results:After six-week treatment with itraconazole administered daily at a dose of 200 mg using pulse therapy, there was remission of the disease or at least substantial clinical improvement in the patients with seborrheic dermatitis. The levels of IL-2 and IFN-γ cytokines in the study group were higher than in the control group. After the treatment the level of IFN-γ secretion in the male patients with seborrheic dermatitis significantly increased. The levels of the other studied cytokines did not significantly differ.Conclusions:The treatment with itraconazole had a beneficial effect on the clinical condition of the skin of the patients. IFN-γ is a cytokine whose secretion might affect the condition of the skin in seborrheic dermatitis.
Seborrheic Dermatitis  [PDF]
Tuncer Sa?ar,Handan Sa?ar
Journal of Clinical and Analytical Medicine , 2011, DOI: 10.4328
Abstract: Seborrehic dermatitis is a common inflammatory skin condition occurring most often on the face, scalp and chest. It affects between 1-3 of adults and is more common in males. It is especially common in adolescents, young adults and people older than 50 years old. Frequently, it involves scalp, nasolabial folds, ears, eyebrows and sternum. It is characterised by symetriccal erythematous papules and plaques with greasy yellow squams. The condition has multifactorial etiology and stress, atopy, Pityrosporum ovale, central nervous system diseases and drugs are the mostly accused factors. Antiinflammatory, antimicotic and immunomodulatory drugs are used for therapy. In resistent cases, systemic steroids, isotretinoin, antimycotics and phototherapy can be tried. In this review, the literature associated with the etiology, clinical manifestations and treatment of seborrheic dermatitis is overviewed.
Seborrheic dermatitis and homeopathy  [PDF]
Lawrence Chukwudi Nwabudike
Our Dermatology Online , 2011,
Abstract: Introduction: Seborrheic dermatitis is a common, usually mild skin condition affecting both sexes. Infants as well as adults may be afflicted. It may cause discomfort when not properly treated. Seborrheic dermatitis is in the spectrum of diseases found frequently in HIV infected patients and in people with AIDS. Various treatment modalities exist, all aimed at control and not cure of the disease. Homeopathy is a system of treatment that is cheap, apparently free of side-effects, does not interact with regular medications and is widely applicable in many fields of medicine, including dermatology. Any new, but efficacious, treatment modality is always welcome in dermatology. Materials and methods: Two patients with seborrheic dermatitis of varying severity and duration were treated with homeopathy and the results documented. Results: The patients recovered fully and are still in remission years later. Conclusions: Homeopathy may be of use in the treatment of acute and chronic seborrheic dermatitis. Since it is cheap, free of side-effects and does not interfere with regular medication, it may become an attractive option in the treatment of this disorder, especially in patients with multiple pathologies.
Cytokines and Chemokines in Irritant Contact Dermatitis  [PDF]
Haur Yueh Lee,Marco Stieger,Nikhil Yawalkar,Masato Kakeda
Mediators of Inflammation , 2013, DOI: 10.1155/2013/916497
Abstract: Irritant contact dermatitis is a result of activated innate immune response to various external stimuli and consists of complex interplay which involves skin barrier disruption, cellular changes, and release of proinflammatory mediators. In this review, we will focus on key cytokines and chemokines involved in the pathogenesis of irritant contact dermatitis and also contrast the differences between allergic contact dermatitis and irritant contact dermatitis. 1. Introduction Irritant contact dermatitis (ICD) is an inflammatory response of the skin to various external stimuli. It arises as a result of activated innate immunity to direct injury of the skin without prior sensitization [1–3]. ICD is a complex reaction modulated by both intrinsic and extrinsic factors [2–4]. Intrinsic factors which influence the susceptibility to ICD include genetic predisposition, for example, atopic diathesis, age, sex, and body region. Extrinsic factors include the inherent nature of the irritants, exposure volume, concentration, duration, repetition, and the presence of further environmental and mechanical factors. ICD has a spectrum of clinical features which can be divided into several different categories depending on the irritant and its exposure pattern. Ten clinical subtypes have been proposed [2]. The influence of irritants on various cytokines/chemokines has not been well delineated so far, although it is plausible that different environmental insults and the subsequent variation in cytokines/chemokines expression could result in distinct clinical phenotypes. In this review, we discuss the pathophysiological mechanisms involved in ICD with a focus on key cytokines and chemokines as well as their cellular source in the skin. Furthermore, we highlight the key differences between ICD and allergic contact dermatitis (ACD). 2. Pathophysiology of Irritant Contact Dermatitis Previously thought of as an immunologic inert process, at present there is increasing evidence showing that ICD is a complex, interlinked process involving perturbations in the skin barrier integrity, cellular changes, and release of various proinflammatory mediators [5, 6]. 2.1. Irritants and Skin Barrier Integrity Integrity of the epidermal barrier function plays an important role in the interaction and the response of the human skin to irritants [7]. Patients with atopic dermatitis are known to have an epidermal barrier dysfunction and have an augmented response to various exogenous irritants [8]. In particular, atopic dermatitis and filaggrin null alleles are associated with an increased
Seborrheic dermatitis eye lid involment (seborrheic blepharitis) in children not a rare clinical observation
Anca Chiriac,Anca E Chiriac,Alina Murgu,Liliana Foia
Our Dermatology Online , 2012,
Abstract: We present a typical case of seborrheic dermatitis, with no cutaneous manifestations, rarely reported in children, frequently misdiagnosed (especially by ophthalmologists), simply confirmed by microscopic examination of scales and with wonderful therapeutic results with antifungal agents (topical and/or systemic treatments).
Identification of Malassezia species associated with seborrheic dermatitis using PCR-RFLP
Mahnaz Mahmoudi Rad,Akram Miramin Mohammadi,Parviz Tousi,Amirhoushang Ehsani
Dermatology and Cosmetic , 2011,
Abstract: "nBackground and Aim: Malassezia is a lipophilic and dimorphic fungus which has different species. Some of them can be found as natural flora on the skin and in some conditions may cause seborrheic dermatitis. The aim of this study was to identify Malassezia species associated with seborrheic dermatitis in Iranian patients, using PCR-RFLP."n"nMethods: In this study out of 79 patients with seborrheic dermatitis, isolates of 70 patients were positive for Malassezia species using PCR-RFLP. The Internal Transcribed Spacer 2 (ITS2) region was amplified by PCR employing the ITS3 and ITS4 primers and The restriction endonucleases AluI, BanI and MspAI were selected for producing distinct RFLP patterns."n"nResults: M. globosa (48.6%), M. furfur (40.0%), M. slooffiae (8.6%) and M. sympodialis (2.8%), were the microorganisms responsible for the infection among participants. M. pachydermatis, M. japonica, M. dermatis, M. restricta, M. obtuse, M. nana and M. yamatoensis were not isolated from any samples."n"nConclusion: Our findings suggest that the most common Malassezia species associated with seborrheic dermatitis was M. globosa, followed by M. furfur.
Comparison of the Distributions of Seborrheic Dermatitis, Herpes Zoster and Pityriasis Rosea According to Seasons  [PDF]
Tuncer Sa?ar,Handan Sa?ar
Turkderm , 2010,
Abstract: Background and Design: The common characteristic of seborrheic dermatitis, herpes zoster and pityriasis rosea is the increase in their incidence in the low weather temperature periods. The aim of this study was to determine the relationships of seborrheic dermatitis, herpes zoster and pityriasis rosea with the months and sessions during the year. Material and Method: Twenty thousends three hundreds ninety seven patients referred to our dermatology policlinic between December 2006 and December 2009 with 1801 patients being diagnosed as seborrheic dermatitis, herpes zoster or pityriasis rosea were retrospectively analysed from the automation record system. The patients were grouped according to demographic data and diagnosis. Results: A statistically significant relationship was found between the diseases and the seasons in which they were frequently seen (p<0.001). It was found that 32.5% of seborrheic dermatitis was seen in autumn season, 29.8% of herpes zoster was seen in autumn season, 31.0% of pityriasis rosea was seen in winter season, and 29.1% of all dermatological diseases was seen in winter season. A statistically significant relationship was found between the diseases and the months in which they were frequently seen (p<0.001). It was detected that 12.3% of seborrheic dermatitis was seen in November, 11.5% of herpes zoster was seen in September, 10.7% of pityriasis rosea was seen in January, and 8.21% of all dermatological diseases was seen in February. Conclusion: Our study results show parallelism with literature knowledge. Seborrheic dermatitis, herpes zoster and pityriasis rosea were seen in most high ratios in autumn and winter seasons. We suggest that the decrease in the environment temperature causes a depression in cellular immune resistance, and this leads to the emergence or relapses of diseases in patients prone to diseases.
Quality of Life, Anxiety and Depression Levels in Patients with Seborrheic Dermatitis  [PDF]
Mustafa Aksoy,Evrim ?zkorumak,Sevgi Bahad?r,Sava? Yayl?
Turkderm , 2012,
Abstract: Background and Design: Seborrheic dermatitis is a common disease characterized by the presence of erythematous plaques with oily-yellow desquamation. Due to its chronic course with remission and exacerbation periods, seborrheic dermatitis can give rise to impaired quality of life and increased levels of anxiety and depression. The purpose of this study was to evaluate the levels of anxiety and depression and quality of life in patients with seborrheic dermatitis. Material and Method: This study was conducted with 50 consecutive patients admitted to our clinic, who have been diagnosed with seborrheic dermatitis without any other systemic or psychiatric illnesses (patient group), and 50 healthy subjects with similar sociodemographic characteristics (control group). Dermatological Life Quality Index (DLQI) was administered to patient group; the Beck Depression Inventory (BDI) and the Beck Anxiety Inventory (BAI) were administered to both patient and the control groups. Results: In one half (%50) of the patients, quality of life was found to be slightly affected or not affected at all, in the other half (%50), the quality of life was affected reasonably or greatly. Anxiety and depression levels were higher in seborrheic dermatitis patients with distortion in quality of life. Also, there was a positive correlation between the levels of anxiety and depression. Conclusion: This study showed that the quality of life was affected by the seborrheic dermatitis negatively, and anxiety and depression levels were higher as much as the impairment of quality of life. According to these results, identifying the psychological symptoms of illness and dealing with these symptoms are important for both in increasing quality of life of patients and getting a well response to the treatment.
The efficacy of 1% metronidazole gel in facial seborrheic dermatitis: A double blind study  [cached]
Siadat Amir,Iraji Fariba,Shahmoradi Zabiholahe,Enshaieh Shahla
Indian Journal of Dermatology, Venereology and Leprology , 2006,
Abstract: Background: Seborrheic dermatitis is a common, chronic inflammatory disease of the skin, characterized by erythematous plaques that are covered with yellow, greasy, scales and may or may not be associated with itching. Although a few studies have suggested use of topical metronidazole for the treatment of seborrheic dermatitis, there is no general consensus about it. Aims: To evaluate the efficacy of 1% metronidazole gel and its vehicle alone, in the treatment of seborrheic dermatitis. Methods: This was a double-blind, prospective, clinical trial. Fifty six patients with seborrheic dermatitis were randomly allocated to either apply 1% metronidazole gel or placebo to their facial lesions, twice daily for 8 weeks. All the patients were evaluated and scored every 2 weeks for 8 weeks. The results were analyzed statistically. Results: A total of 56 patients entered this study and 53 patients completed the treatment course. There was no significant difference in terms of demographic data and lesions severity score. There were statistically significant differences in the reduction of mean severity scores between the 2 groups at the second, fourth, sixth and eighth weeks of treatment ( p < 0.05). Metronidazole gel significantly decreased mean of seborrheic dermatitis severity score from the 2nd visit ( p < 0.001). Conclusion: Metronidazole gel is an effective treatment for facial seborrheic dermatitis.
The pathogenesis of atopic dermatitis
Yavuz Ye?ilova,Bilal Sula,Engin Yavuz
Journal of Clinical and Experimental Investigations , 2010,
Abstract: Atopic dermatitis (AD) is a very common and recurrent chronic an inflammatory skin diseases. Atopic dermatitis is a health problem for especially industrialized countries. However in recent years AD has been more common in our country. Multiple factors play role in the pathogenesis of AD. Although the etiology is not clear, it may be related to immunologically deviated T cell functions with precipitating factors in genetically predisposed people. In present article, we reviewed actual literature on the etiopathogenesis of AD.
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