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Evaluation of Diuretic Activity of Different Extracts of Mimosa pudica Linn.
A. Baghel,D.S. Rathore,V. Gupta
Pakistan Journal of Biological Sciences , 2013,
Abstract: In that study, Mimosa pudica linn was tested for diuretic activity using the lipschitz test. The ethanolic and aqoues extract of Mimosa pudica Linn. was studied at two dose level 100 and 200 mg kg-1 b.wt. Furosemide (20 mg kg-1 b.wt.) was used as standard drug in a 0.9% saline solution. Urine volumes were measured for all the groups up to 5 h. The ethanolic extract of Mimosa pudica linn was exhibited significant diuretic activity at doses of 100 and 200 mg kg-1 b.wt. by increasing total urine volume and ion concentration of Na+ k+ and Clˉ.
Neelmani Chauhan et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Clitoria ternatea L. (Family: Fabaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antioxidant and antiasthmatic activity of ethanol extract of Clitoria ternatea roots. The present investigation was undertaken to evaluate the histamine-induced bronchospasm of alcoholic extract of Clitorea ternatea Linn. roots in experimental animals. Bronchodilator activity of aqueous extract of C. ternatea studied on the histamine aerosol induced bronchospasm in wister rats. Treatment with alcoholic extract of clitorea ternatea (400 mg/kg, p.o) showed significant protection against histamine aerosol induced bronchospasm in wister rats. The results of the histamine- induced bronchospasm paradigms demonstrate bronchospasmolytic activity of ethanolic extract of clitorea ternatea (400 mg/kg, p.o.). Clitorea ternarea shows 47.45 % protection against histamine induced bronchoconstriction in rats. These results suggest that aqueous extract of C. tenatea has not only bronchodilating activity but also decreases bronchial hyperreactivity by decreasing the infiltration of inflammatory cells in the airway and inhibition of release of histamine like mediators from the mast cell by stabilizing it. Clitoria ternatea is diuretic and laxative, a decoction is given as a demulcent in the irritation of the bladder and urethra. It is useful in ophthalmopathy, bronchitis, asthma tubercular glands, hemicrania, burning sensation, starngury, helminthiasis, inflammation, vitiated condition of pitta vicerormegaly and fever.
Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China  [cached]
Zhang Jing,Yuan Ke,Zhou Wen-long,Zhou Jian
Pharmacognosy Magazine , 2011,
Abstract: Background: The total flavonoid (TF) and total phenolic (TP) contents of the ethanol extracts of the whole plant, stem, leaf, and seed of Mimosa pudica Linn belonging to the genus Mimosa (Family: Fabaceae alt. Leguminosae), which originates from the subtropical regions of southern China, were determined in this experiment. Materials and Methods: The antioxidant activity of the extracts and 5 flavonoid monomers of M. pudica Linn. were also evaluated by 2 assays, the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and ferric reducing/antioxidant power (FRAP) assays. In addition, correlation analysis was also made in the present study. Results: The results showed that leaf extracts contained the highest amount of TF and TP, and the content was significantly higher than that found in other parts of the plant. Moreover, the sequence of antioxidant activity of the ethanol extracts was as follows: leaf > the whole plant > seed > stem; the sequence of the 5 flavonoid monomers was as follows: 5,7,3′,4′-tetrahydroxy-6-C-[β-D-apiose-(1→4)]-β-D-glycopyranosyl flavone (1) > isorientin (2) > orientin (3) > isovitexin (4) > vitexin (5) , and the antioxidant activity of compound 1 is equivalent to the synthetic antioxidant trolox or a bit stronger than trolox, and significant correlations were found among the active ingredient contents and the results of antioxidant activity. Conclusion: The present study suggested that M. pudica Linn. could be a potential rich source of natural antioxidants.
A sensitive, rapid and validated liquid chromatography ? tandem mass spectrometry (LC-MS-MS) method for determination of Mimosine in Mimosa pudica Linn  [PDF]
Parikshit A. Champanerkar, Vikas V. Vaidya, Sunita Shailajan, Sasikumar N. Menon
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.27088
Abstract: A rapid, sensitive and accurate liquid chroma-tographic tandem mass spectrometric method is described for the determination of Mimosine in Mimosa pudica Linn. whole plant powder. Mi-mosine was extracted from the plant using 1.0% HCl in water. The chromatographic separation was achieved using a Thermo Hypurity C18 (50 x 4.6 mm) 5.0 μ column interfaced with a triple quadrapole mass spectrometer. The mobile phase consisted of a mixture of Methanol: 10 mM ammonium formate buffer whose pH was ad-justed to 3.00 ± 0.05 with formic acid (80:20, v/v) and was delivered at a flow rate of 1.0 mL min-1. Electrospray ionization (ESI) source operated in the negative ion mode was used for the quantitation. Detection was performed using an Applied Biosystems Sciex API 3200 Mass spec-trometer. The method was found to be simple, precise, accurate, fast, specific and sensitive and can be used for routine quality control analysis of Mimosine in Mimosa pudica Linn.
Debashisha Panda et al
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: A complete documentation of the ethno-biological information presently existing among the diverse communities is needed at an earliest so as to restore the traditional medicinal knowledge. Research to find out scientific evidence for claims by tribal healers on Indian herbs has been intensified as being evidenced from many cited literatures. Once these local ethno medical
Rekha Rajendran
Journal of Global Pharma Technology , 2009, DOI: 10.1234/jgpt.v1i1.31
Abstract: Mimosa pudica known as chue Mue, is a prostrate shrubby plant with the compound leaves sensitive to touch, grows as weed in almost all parts of the country. In the present investigation, preliminary phytochemical analysis and antibacterial activity of different extracts (n-hexane, chloroform, ethylacetate, methanol and methanolic fractions (No. I to VIII) of the leaves of Mimosa pudica was studied. The antibacterial activity was assessed by standard dilution test using Mueller Hinton Agar medium. The zone of inhibition of the fraction (VII) was compared with that of Standard antibiotic ciprofloxacin (5μg/disc) by disc diffusion method. The findings showed potential antibacterial properties of the extracts and fractions against the organisms tested. Minimum inhibitory concentration (MIC) of the extracts and fractions was found to be 133.33 μg/ml. But fraction no.VII was found to have 33.33 μg/ml as MIC against the tested organisms. So the zone of inhibition of that fraction was comparable with that of ciprofloxacin. Preliminary phytochemical analysis may also helps to standardize this plant species from other related species. Our findings confirm that the traditional therapeutic claims for this plant, in near future surely be able to replace the conventional anti-microbial agents to which there is increased incidence of drug interactions and the study suggests that this plant is promising for development of phytomedicine for antibacterial properties.
Antitoxin activity of Mimosa pudica root extracts against Naja naja and Bangarus caerulus venoms
Subramani Meenatchisundaram, Selvin Priyagrace, Ramasamy Vijayaraghavan, Ambikapathi Velmurugan, Govindarajan Parameswari, Antonysamy Michael
Bangladesh Journal of Pharmacology , 2009,
Abstract: Aqueous extract of dried roots of Mimosa pudica was tested for inhibitory activity on lethality, phospholipase activity, edema forming activity, fibrinolytic activity and hemorrhagic activity of Naja naja and Bangarus caerulus venoms. The aqueous extract displayed a significant inhibitory effect on the lethality, phospholipase activity, edema forming activity, fibrinolytic activity and hemorrhagic activity. About 0.14 mg and 0.16 mg of M. pudica extracts were able to completely neutralize the lethal activity of 2LD50 of Naja naja and Bangarus caerulus venoms respectively. The present finding suggests that aqueous extract of M. pudica root possesses compounds, which inhibit the activity of Naja naja and Bangarus caerulus venoms.
Antiulcer activity of the Leaf ethanolic extract of Mimosa pudica in Rats
Elango.V,Carolin Oliver,Raghu, P.S
Hygeia : Journal for Drugs and Medicines , 2012,
Abstract: Plan: The present study was designed to investigate the antiulcer potential of ethanolic extract of Mimosa pudica leaves.Methodology: Antiulcer activity was evaluated by pylorus ligation, aspirin and ethanol induced ulcer models. The ethanolic extract of the leaves of Mimosa pudica was given by oral route at a dose of 100 mg/kg b.w.Outcome: Ethanolic extract of Mimosa pudica, dose dependently reduce, the total acidity, ulcer index, and an increase in pH of gastric juice in pylorus ligated ulcer model. Extract of Mimosa pudica may be useful as a natural antioxidant in the treatment of ulcer.
Tamhane Adesh S.,Mute Vaishali M.,Takawale Harshada,Awari Deorao M.
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: The present study was designed to investigate the efficacy and safety of Cassia tora Linn leaves. The anti-asthmatic activity of the extract by using different concentration of aqueous extract as 500, 1000 and1500 μg/ml was evaluated in isolated goat trachea chain, preparations by using standard drugs histamine. In the present study, histamine produced dose dependent contraction of goat tracheal chain preparation was studied. As number of papers with antiasthmatic activity are reported with use of guinea pig ileum, tracheal chain preparation but yet antiasthmatic activity was not carried out using tracheal chain hence present study was designed using tracheal chain preparation. The actual dose required to produce bronchodilation was not known so comparison was made by testing various concentration of drug extract of Cassia tora L. The modified physiological salt solution containing hydroalcoholic extract of Cassia tora (1.5 mg/ml) significantly inhibited the contractile effect of histamine thus produces significant bronchodilation. It is concluded that 1500 μg/ml of Cassia tora showed potent antiasthmatic activity due to bronchodilator activity.
Srivastava Varnika,Sharma Ashish,Alam Imran
International Research Journal of Pharmacy , 2012,
Abstract: Mimosa pudica (from Latin: Pudica”shy, shrinking” also called sensitive plant and touch me not), is a creeping annual and perennial herb.The species is native to South America and Central America. Mimosa belongs to the taxonomic group Magnoliopsida and family Mimosaseae. It has been described as”sparshaat sankochataam yaati punashcha prasruta bhavet”- a plant which folds itself when touched and spreads its leaves once again after a while. The roots, leaves and flower heads of Mimosa pudica may be used by those who practice ayurveda. The sensitive plant is commonly used for bleeding disorders like menorrhagia, dysentry with blood, mucus and piles. It is due to the specific characteristics of its leaves that mimosa is regarded as a plant of high ornamental value. Since it has an ability of fixing atmospheric nitrogen, it grows well even in nutrient deficient soils.It is mainly used in herbal preparation for gynecological disorders. Recent researches show that the extract of this plant can be used for checking child birth. Some herbal doctors recommend it for bronchitis, general weakness and impotence. All five parts of the plant (that is the panchang) - leaves, flowers, stems, roots and fruits are used as medicines in the traditional health care system.
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