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DEVELOPMENT AND VALIDATION OF DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND OFLOXACIN IN TABLET DOSAGE FORM  [PDF]
Patel Satish A,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: The present manuscript describe simple, sensitive, rapid, accurate, precise and economic dual wavelength spectrophotometric method was developed for the simultaneous determination of cefixime trihydrate (CEFI) and ofloxacin (OFLO) in combined tablet dosage form. The utility of dual wavelength data processing program is its ability to calculate unknown concentration of components of interest in a mixture containing an interfering component. The principle for dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest”. The method was based on determination of ofloxacin at 350 nm using its absorptivity value and cefixime at 264 nm after deduction of absorbance due to ofloxacin. The two drugs follow Beer-Lanbert’s law over the concentration range of 2-14 μg/ml. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.
SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND LINEZOLID IN TABLET DOSAGE FORM  [PDF]
Patel Satish A,Patel Jinalben V
International Research Journal of Pharmacy , 2013,
Abstract: The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Cefixime Trihydrate and Linezolid in bulk and tablet dosage form. The method is based on the simultaneous equations for analysis of both the drugs using 0.05 M Potassium phosphate buffer pH 7.2 as solvent. Cefixime Trihydrate has absorbance maxima at 287.20 nm and Linezolid has absorbance maxima at 250.60 nm in 0.05 M Potassium phosphate buffer pH 7.2. The linearity was obtained in the concentration range of 2-22 μg/ml and 2-18 μg/ml for Cefixime Trihydrate and Linezolid, respectively. The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 100.2 ± 0.56 and 101.23 ± 0.63 for Cefixime Trihydrate and Linezolid, respectively. The method was successfully applied to tablet dosage form. The suitability of this method for the quantitative determination of Cefixime Trihydrate and Linezolid was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of Cefixime Trihydrate and Linezolid in combination. The results of analysis have been validated statistically and by recovery studies.
Visible spectrophotometric determination of valdecoxib in tablet dosage forms  [cached]
Suganthi A,Sivakumar H,Vijayakumar S,Ravimathi P
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: A simple, accurate, rapid, and sensitive visible spectrophotometric method has been developed for the determination of valdecoxib in pure and pharmaceutical dosage forms. The method is based on the reaction of valdecoxib with potassium permanganate to form a bluish green coloured chromogen with an absorption maximum at 610 nm. Beer′s law was obeyed in the range of 5-25 mg/ml. The proposed method has been successfully applied to the analysis of the bulk drug and its dosage forms
SIMULTANEOUS ESTIMATION OF AMOXICILLIN TRIHYDRATE AND BROMHEXINE HYDROCHLORIDE IN ORAL SOLID DOSAGE FORMS BY SPECTROPHOTOMETRIC METHOD
Dhoka Madhura Vishal,Gawande Vandana Tukaram,Joshi Pranav Pramod
International Research Journal of Pharmacy , 2011,
Abstract: Two accurate, precise, rapid and economical methods were developed and validated for the estimation of Amoxicillin Trihydrate and Bromhexine Hydrochloride in Bulk and combined Pharmaceutical Dosage Form. First method is First order Derivative method, wherein wavelengths selected for quantitation were 283 nm, for Amoxicillin Trihydrate and 218.6 nm, for Bromhexine Hydrochloride. Second method is area under curve method wherein two wavelength ranges chosen were 271-274nm and 244-248nm for Amoxicillin trihydrate and Bromhexine hydrochloride respectively. In both of the methods linearity for detector response was observed in the concentration range of 100-300μg/ml for Amoxicillin Trihydrate and 2-10μg/ml for Bromhexine Hydrochloride. The proposed methods were successfully applied for the simultaneous determination of both drugs in capsule dosage form. The results of the analysis have been validated statistically and by recovery studies.
DEVELOPMENT OF NEW VISIBLE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF CINITAPRIDE IN PHARMACEUTICAL DOSAGE FORMS  [PDF]
Ch.V. Suresh,G. Vidya Sagar
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Three simple and sensitive Spectrophotometric methods have been developed for the determination of Cinitapride (CNP) in pure and pharmaceutical dosage forms. Method A is based on the formation of charge transfer complex of the drug with chloranilic acid ( max : 550 nm). Method B is based on oxidative coupling of the drug with 3-methyl-2-benzothiazolinone hydrazone ( max : 420 nm). Method C is based on oxidation followed by complex formation with 1, 10-Phenanthroline (PTL) in the presence of ferric chloride to form a colored chromogen ( max : 510 nm). These methods have been statistically evaluated and found to be precise and accurate.
VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF CEFADROXIL IN TABLET DOSAGE FORM  [PDF]
Patel Satish A,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: A simple, sensitive, accurate, precise and economical visible spectrophotometric method was developed and validated for the estimation of cefadroxil in tablets. The method is based on the reaction of cefadroxil with ninhydrin reagent in methanol giving blue color chromogen, which shows maximum absorbance at 578 nm against reagent blank. The chromogen obeyed Beer’s law in the concentration range of 5-50 μg/ml for cefadroxil. The results of the analysis have been validated statistically and by recovery studies.
SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF CEFIXIME TRIHYDRATE AND OFLOXACIN IN TABLETS  [PDF]
Patel Satish A,Patel Paresh U,Patel Natavarlal J.
International Research Journal of Pharmacy , 2011,
Abstract: The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of cefixime trihydrate and ofloxacin in combined tablet dosage form. Absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. Cefixime trihydrate and ofloxacin show an isoabsorptive point at 280.2 nm in methanol. The second wavelength used is 291.4 nm, which is the λ-max of cefixime trihydrate in methanol. The linearity was obtained in the concentration range of 2-14 μg/ml for both cefixime trihydrate and ofloxacin. The concentrations of the drugs were determined by using ratio of absorbances at isoabsorptive point and at the λ-max of cefixime trihydrate. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.
Visible spectrophotometric determination of sumatriptan succinate in tablet dosage forms using folin reagent  [PDF]
Buridi Kalyana Ramu,K. Raghubabu
International Journal of Pharmacy and Biomedical Sciences , 2010,
Abstract: A simple, sensitive and cost effective visible spectrophotometric method has been developed for the determination of sumatriptan succinate from bulk and tablet dosage forms. The method is based on the formation of brown colored chromogen by the drug with Folin reagent with an absorption maximum of 455.6 nm. The Beer’s law was obeyed in the concentration range of 16 – 48 μg/mL. The proposed method was successfully applied for the estimation of sumatriptan succinate in commercially available tablets and the results were statistically compared with those obtained by the reference method and validated by recovery studies.
Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms  [PDF]
Pankaj Soni,Deepak Sinha,Rajmani Patel
Journal of Spectroscopy , 2013, DOI: 10.1155/2013/783457
Abstract: The paper describes a new and simple approach for spectrophotometric determination of tricyclic antidepressant drug amitriptyline. Enhancement of the colour intensity of the Fe(III)-SCN? complex on addition of the drug amitriptyline forms the basis of the proposed method. The value of molar absorptivity of the Fe(III)-SCN? amitriptyline ion pair complex in terms of the drug lies in the range of (2.82–3.36) × 103?L·mol?1·cm?1 at the absorption maximum 460?nm. The detection limit of the method was 0.3?μg·mL?1. The slope, intercept, and correlation coefficients for the present method were found to be 0.008, 0.002, and +0.998, respectively. The effect of analytical variables on the determination of the drug and the composition of the complex are discussed in the paper. The method is applicable in the determination of amitriptyline in pharmaceutical preparations. 1. Introduction Amitriptyline [3-(10,11-dihydro-5H-dibenzol[a,d]cyclohept-5-ylidene) propyldimethylamine] constitutes an important class among the neurotherapeutics belonging to first generation of antidepressant drug [1, 2]. Recent studies show proinflammatory cytokine process takes place during clinical depression, mania, and bipolar disorder, and it is possible that symptoms of these conditions are attenuated by the pharmacological effect of antidepressants on the immune system [3–8]. Amitriptyline has a carboxylic structure with an exocyclic double bond at C-5 which is substituted with an N, N-dimethyl-1-propanamino side chain (Figure 1). Figure 1: Amitriptyline. Amitriptyline hydrochloride [AMIYTP]Cl represents a large group of compounds used in treatment of various mental diseases. The chemical structure of this compound is based on the condensed aromatic three-ring system which includes substituents in positions 2 and 10. The difference in chemical structure causes the different pharmaceutical activity of drug. The value of angle of these molecules is important; the more nearly planar the greater the neuroleptic activity. It is believed that drug amitriptyline acts by blocking the receptors of neurotransmitters, noradrenalin, in the synopsis in the central nervous system, which results in an increase of concentration of both molecules with a subsequent enhancement of their antidepressant potency. However, this drug suffers from several drawbacks, such as antiarrhythmic, anticholinergic, cardiovascular, and hyperthermia side effect, which may be reduced if the drugs are suitably vectored to the organism. Various analytical methods have been reported for determination of amitriptyline including
Application of Certain π-Acceptors for the Spectrophotometric Determination of Alendronate Sodium in Pharmaceutical Bulk and Dosage Forms  [PDF]
Asad Raza,Muhammad Zia-ul-Haq
International Journal of Analytical Chemistry , 2011, DOI: 10.1155/2011/680902
Abstract: Two simple, fast, and accurate spectrophotometric methods for the determination of alendronate sodium are described. The methods are based on charge-transfer complex formation of the drug with two π-electron acceptors 7,7,7,8-tetracyanoquinodimethane (TCNQ) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in acetonitrile and methanol medium. The methods are followed spectrophotometrically by measuring the maximum absorbance at 840?nm and 465?nm, respectively. Under the optimized experimental conditions, the calibration curves showed a linear relationship over the concentration ranges of 2–10?μg?mL?1 and 2–12?μg?mL?1, respectively. The optimal reactions conditions values such as the reagent concentration, heating time, and stability of reaction product were determined. No significant difference was obtained between the results of newly proposed methods and the B.P. Titrimetric procedures. The charge transfer approach using TCNQ and DDQ procedures described in this paper is simple, fast, accurate, precise, and extraction-free. 1. Introduction Alendronate sodium is sodium trihydrogen (4-amino-1-hydroxybutylidene) biphosphonate trihydrate. It belongs to the bisphosphonate group and is used for the treatment of Paget’s disease of bone and osteoporosis, it diminishes bone resporption and thus reduces bone turnover [1, 2]. A survey of literature revealed that there are very few methods available for the determination of alendronate sodium. These methods include spectrophotometric [3–6], chromatographic [7–13], capillary electrophoresis [14], inductively coupled plasma [15], and voltammetric [16]. These previously reported spectrophotometric methods in the literature suffer from disadvantages like extraction, long time for the reaction to complete, narrow range of determination, and lack of sensitivity. Spectrophotometric techniques continue to be the most preferred methods for routine analytical work due to their simplicity and reasonable sensitivity with significant economical advantages. On the other hand, it is well known that p-benzoquinones such as 7,7,7,8-tetracyanoquinodimethane (TCNQ) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as π-electron acceptors often form highly colored electron-donor-acceptor (EDA) or charge transfer (CT) complexes with various donors which provides the possibility of determination of drugs by spectrophotometric methods [17, 18]. In order to develop new simple, fast, and extraction-free spectrophotometric methods for the determination of alendronate sodium in pure and pharmaceutical dosage forms, we investigated
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