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4-Hydroxy-4,6a,6b,9,9,12a,14b-heptamethylperhydropicen-3-one hemihydrate isolated from Adiantum incisum  [cached]
Altaf Hussain,Hamid Latif Siddiqui,Muhammad Zia-ur-Rehman,Mark R. J. Elsegood
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536807064021
Abstract: The title compound, C29H48O2·0.5H2O, is a triterpenoid isolated from the stems and rhizomes of Adiantum incisum. The basic skeleton of the molecule contains five six-membered rings, all adopting chair conformations, bearing a total of seven methyl, one hydroxyl and a keto group. There are two molecules of the triterpene and one water molecule of crystallization in the asymmetric unit. The two unique triterpenoid molecules hydrogen-bond directly via an O—H...O=C interaction, and are also bridged by the water molecule. The water also bridges to another pair of hydrogen-bonded triterpenoid molecules.
V. R. Mohan et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins. It also exhibited antioxidant activity by showing the increased activity of SOD, CAT, GPx and GRD and decreased in TBARS compared to CCl4 treated groups. Silymarin, a known hepatoprotective drug is used for comparison. The plant extracts were effective in protecting liver against injury induced by CCl4 in rats.
Hepatoprotective Activity of Livobond A Polyherbal Formulation Against CCl4 Induced Hepatotoxicity in Rats  [PDF]
Usha S. Satyapal,Vilasrao J. Kadam,Rumi Ghosh
International Journal of Pharmacology , 2008,
Abstract: In the present study, Livobond was evaluated for its hepatoprotective effects against carbon tetrachloride-induced hepatocellular injury in rats. Hepatotoxicity was induced in male Sprague-Dawley rats by intraperitoneal injection of CCl4 (1.5 mL kg-1) in olive oil (1:1). Livobond at a dose of 500 and 750 mg/kg/day and silymarin standard 50 mg/kg/day was administered orally for 7 days. The hepatoprotective effect of Livobond and standard was evaluated by the assay of biochemical parameters viz., alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), total and direct bilirubin, liver lipid peroxidation, total proteins, catalase and by histopathological studies of the liver. The toxic effects of CCl4 in Livobond treated group was controlled significantly by restoration of the levels of serum bilirubin, proteins and enzymes as compared to the CCl4 treated and silymarin treated groups. Histopathological studies further confirmed the hepatoprotective activity of Livobond. The results suggest that Livobond is able to significantly alleviate the hepatotoxicity induced by CCL4 and may be attributed to the antioxidant property of the formulation.
Hepatoprotective Effect of the Ethanolic Extract of Urtica parviflora Roxb. in CCl4 Treated Rats  [PDF]
Prasanna Kumar Kar,Lilakanta Nath,Suvakanta Dash,L. Sutharson
International Journal of Pharmacology , 2007,
Abstract: The ethanolic extract of leaves of Urtica parviflora (EEUP) was evaluated for the hepato protective effect in carbon tetrachloride (CCl4) induced hepatotoxicity in rats to prove its ethnomedicinal claim by the hill people of Sikkim. Hepatotoxicity was induced in Swiss Albino male rats of Sprague Dawley strain by subcutaneous injection of carbon tetrachloride at the dose of 1 mL kg-1 body weight. The hepatoprotective activity was evaluated by the assay of liver function biochemical parameters such as aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP), total bilirubin, serum protein and by study of histopathology of the livers. The toxic effect of carbon tetrachloride was controlled significantly by the EEUP at 250, 500 and 700 mg kg-1 p.o. (p<0.05) as compared to the CCl4 treated animals by restoration of the levels of serum bilirubin, proteins and hepato protective enzymes. Histopathological studies revealed that the centrolobular necrosis induced by CCl4 was recovered to normal state by EEUP in a dose dependent manner. The study confirms the possible hepatoprotective potentiality of the ethanolic extract of leaves of Urtica parviflora which had been collected from Sikkim. Studies are under process to isolate and characterize the bioactive component present in the plant as well as to establish the mechanism of action underlying for its hepatoprotective potentiality.
Hepatoprotective Action of Radix Paeoniae Rubra Aqueous Extract against CCl4-Induced Hepatic Damage  [PDF]
Ruidong Li,Wenyuan Guo,Zhiren Fu,Guoshan Ding,You Zou,Zhengxin Wang
Molecules , 2011, DOI: 10.3390/molecules16108684
Abstract: In the present study the capacity of Radix Paeoniae Rubra aqueous extract (RPRAE) as an antioxidant to protect against carbon tetrachloride (CCl4)-induced oxidative stress and hepatotoxicity in Wistar rats was investigated. Six groups of rats were used. Radix Paeoniae Rubra aqueous extract (100 or 200 or 300 mg/kg of bw) or bifendate (100 mg/kg of bw) were given daily by gavage to the animals on 28 consecutive days to elucidate the protective effects against CCl4-induced hepatotoxicity. The 20% CCl4/olive oil was gavage of gastric tube twice a week (on the third and seventh days of each week). The animals of normal control group were given only vehicle. The animals of CCl4-treated group were administered with CCl4 twice a week (on the third and seventh days of each week) and with vehicle on rest of the days. The test materials were found effective as hepatoprotective agents, as evidenced by plasma and liver biochemical parameters. Therefore, the results of this study show that Radix Paeoniae Rubra aqueous extract can protect the liver against CCl4-induced oxidative damage in rats, and the hepatoprotective effects might be correlated with its antioxidant and free radical scavenger effects.
Syed Aamir,Tippeswamy B S,Kulkarni V H,Hegde Karunakar
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The present study has been designed to evaluate the hepatoprotective and in-vivo antioxidant activity of ethanolic extract of the whole plant of Euphorbia thymifolia (EEET) against carbon tetrachloride (CCl4) - induced hepatotoxicity in experimental rats. The levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), uric acid, total protein and total bilirubin were determined. Antioxidant status in liver was determined by measuring the activity of malondialdehyde (MDA), glutathione (GSH) and catalase (CAT). Total wet weight and histopathological study of isolated liver specimen was also carried out. The oral pre-treatment with EEET (100, 200 mg/kg) showed significant hepatoprotection against CCl4 induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, GSH, CAT and protein in a dose dependent manner, which was confirmed by the histopathological examinations. Data also showed that EEET possessed strong antioxidant activity, which may probably leads to the promising hepatoprotective activities of Euphorbia thymifolia whole plant extract.
Thangakrishnakumari S,Nishanthini A,Muthukumarasamy S,Mohan V.R.
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: The aim of the study was to investigate the hepatoprotective activity of ethanol extract of whole plant of Canscora perfoliata in CCl4 induced hepatotoxic rats. Administration of hepatotoxins (CCl4) showed significant elevation of serum SGOT, SGPT, ALP, bilirubin, conjugated, unconjugated bilirubin and lipid peroxidation. Treatment with Canscora perfoliata (150 and 300mg/kg) significantly reduced the above mentioned parameters. The plant extract also enhanced the antioxidant activity. The ethanol extract of Canscora perfoliata have significant effect on the CCl4 induced hepatotoxicity animal models.
Hepatoprotective and antioxidant effect of Carissa spinarum root extract against CCl4 and paracetamol-induced hepatic damage in rats  [cached]
Karunakar Hegde, Arun B. Joshi
Bangladesh Journal of Pharmacology , 2010,
Abstract: Ethanolic extract of the roots of C. spinarum was evaluated for hepato-protective and antioxidant activities in rats. Oral pre-treatment with ethanolic extract (100, 200 and 400 mg/kg) showed significant hepatoprotective activity against CCl4 and paracetamol-induced hepatotoxicity by decreasing the activities of bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, glutathione, super oxide dismutase, catalase and protein in a dose dependent manner, which was confirmed by the decrease in liver wet weight and histopathological examination. The extract possessed strong antioxidant activity. This suggests that the hepatoprotective activity of C. spinarum is possibly attributed to its free radical scavenging properties.
Hepatoprotective Activity of Capparis spinosa Root Bark Against CCl4 Induced Hepatic Damage in Mice
Nasrin Aghel,Iran Rashidi,Amir Mombeini
Iranian Journal of Pharmaceutical Research , 2007,
Abstract: Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Capparis spinosa (Capparidaceae) to treat hepatic diseases. Protective action of C. spinosa ethanolic root bark extract was evaluated in this study in an animal model of hepatotoxicity, which was induced by carbon tetrachloride.Healthy male mice (30-35 g body weight, 6-8 week old) were divided into 7 groups. Group 1 was normal control group; Group 2, the hepatotoxic group was given CCl4; Group 3 was administered olive oil (vehicle); Groups 4-6 received different doses of ethanolic root bark extract (100, 200 & 400 mg/kg) with CCl4; Group 7 was administered overdose of the extract (800 mg/kg). The parameters studied were alanine transaminase and aspartate transaminase activities and duration of sleep. The hepatoprotective activity was also supported by histopathological studies of liver tissue.Results of the biochemical studies of blood samples of CCl4 treated animals showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by CCl4. Whereas blood samples from the animals treated with ethanolic root bark extracts showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells. The results revealed that ethanolic root bark extract of C. spinosa could afford significant dose-dependent protection against CCl4 induced hepatocellular injury.
International Journal of Pharmaceutical Research and Development , 2011,
Abstract: In Indian traditional system of medicine, herbal remedies are prescribed for the treatment of various diseases including liver diseases. The present study was aimed to investigate the hapatoprotective activity of the Ethanolic Extract of Spermacoce hispida.Linn (SHE) against carbon tetra chloride (CCl4) inducd hepatotoxicity in rats. Liver functions were assessed by the determination of SGOT, SGPT, ALP and bilirubin. Histopathological studies were carried out.The serum biochemical analysis results suggest that the use of Ethanolic extract of Spermacoce hispida.Linn exhibited significant protective effect from hepatic damage in CCl4 induced hepatotoxicity model. Histopathological studies revealed that concurrent administration of the extract with CCl4 exhibited protective effect on the liver, which further evidenced its hepatoprotective activity.
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