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Antioxidant properties of some medicinal Aristolochiaceae species
R Thirugnanasampandan, G Mahendran, VN Bai
African Journal of Biotechnology , 2008,
Abstract: Antioxidant properties of five Aristolochiaceae species namely Aristolochia brasiliensis Mart. and Zucc., Aristolochia bracteolata Retz., Aristolochia indica Linn., Apama siliquosa Lamk. and Aristolochia tagala Cham. were investigated. Antioxidant and 2,2-diphenyl picrylhydrazyl (DPPH) radical scavenging activities, reducing powers, and the amount of total phenolic compounds of the extracts were studied. The highest antioxidant activity was shown by A. tagala and the lowest one was A. brasiliensis. The highest DPPH radical scavenging activity was shown by A. tagala and the least one was shown by A. brasiliensis. The highest reducing power and amount of total phenolic compounds was shown by A. tagala and lowest one was A. brasiliensis.
Chemical constituents of Aristolochia giberti
Marchesini, Alessandra M.;Prado, Giovana G.;Messiano, Gisele B.;Machado, Marcos B.;Lopes, Lucia M. X.;
Journal of the Brazilian Chemical Society , 2009, DOI: 10.1590/S0103-50532009000900006
Abstract: fourteen compounds were isolated from aristolochia giberti. these included a new triterperne, (-)-onocera-8,8'-diol. in addition, 3-hydroxypropanoate, acetate, and formate were detected by nmr techniques, which suggests that they are derivatives from 2-butynedioate, which is not detected by 1h nmr. gc-ms and chemometric analyses of essential oils from stems and leaves showed great similarity between this cultivated species in brazil and that in argentina, which allowed us to confirm the species identity and to differentiate the oils according to the plant parts.
Aristolactams and Alkamides of Aristolochia gigantea  [PDF]
Juliana C. Holzbach,Lucia M. X. Lopes
Molecules , 2010, DOI: 10.3390/molecules15129462
Abstract: A new aristolactam, aristolactam 9-O-β-D-glucopyranosyl-(1→2)-β-D-glucoside, and two alkamides, N-cis- and N-trans-p-coumaroyl-3-O-methyldopamine, were isolated from stems of Aristolochia gigantea, together with the known compounds allantoin, E-nerolidol, β-sitosterol, (+)-kobusin, (+)-eudesmin, trans-N-feruloyltyramine, trans-N-coumaroyltyramine, trans-N-feruloyl-3-O-methyldopamine, aristolactam Ia-N-β-D-glucoside, aristolactam Ia 8-β-D-glucoside, aristolactam IIIa, and magnoflorine. Their structures were determined by spectroscopic analyses.
Antibacterial activity of leaf extracts of Aristolochia bracteate retz  [cached]
Manikandar R,Selvamani P,Latha S
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: Aristolochia bracteate Retz, family, Aristolochiaceae is a common annual herb widely distributed in India and widely used in indigenous system of medicine. The objective of the present study was to investigate the antibacterial activity of crude extracts of Aristolochia bracteate Retz leaves by disc diffusion method. The leaves of Aristolochia breacteate Retz were extracted with petroleum ether, chloroform and alcohol. The concentrated crude leaf extracts of Aristolochia bracteate Retz were tested against Bacillus subtilus, Lactobacillus plantarum, Escherichia coli, Staphylococcus aureus, Streptococcus faecalis and Pseudomonas aeruginosa . Alcoholic extract showed significant antibacterial activity as compared to that of other extracts.
Aristolochia indica L.: A Review  [PDF]
Abhijit Dey,Jitendra Nath De
Asian Journal of Plant Sciences , 2011,
Abstract: Aristolochia indica L. (Aristolochiaceae) has long been used in Indian subcontinent in the traditional system of medicine to treat cholera, fever, bowel troubles, ulcers, leprosy, skin diseases, menstrual problems and snakebites. The plant is also used as emmenagogue, abortifacient, antineoplastic, antiseptic, anti-inflammatory, antimicrobial, antipyretic, antifertility and antispermatogenic agent. Aristolochic acid, a major active constituent of the plant is reported to cause cancer, nephropathy, sister chromatid exchange and is a potent abortifacient. The present review deals with the different scientific studies and reports available in different aspects of this plant in the areas of Morpho-taxonomy, Phytochemistry, Pharmacology, Medicoethnobotany, Tissue culture and Chromosomal study.
Nephrotoxicity study of Aristolochia fangchi in rats by metabonomics  [cached]
Qi LIANG,Ming XIE
Zhong Xi Yi Jie He Xue Bao , 2009,
Abstract: Objective: To study the changes of metabolites in rat urine after treatment of Aristolochia fangchi decoction by metabonomic method. Methods: Sixty-four male SD rats were divided into Aristolochia fangchi group and normal control group. Rats in the Aristolochia fangchi group were orally administered with 8.1 g/(kg·d) of Aristolochia fangchi and the normal control group was administered with equal volume of distilled water for 4 weeks. Twenty-four hour urine was collected at different time points (before, after 2- and 4-week administration and 2 weeks after administration) and their 1H nuclear magnetic resonance (NMR) spectra were acquired and subjected to data process, including principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) or orthogonal signal correction (OSC). The contents of blood urea nitrogen (BUN) and serum creatinine (SCr) and histopathological changes of the renal tissues were also detected. Results: The content of BUN of the Aristolochia fangchi group was markedly higher than that of the normal control group after 2-week administration (P<0.05), and cellular edema in tubular endothelial cells, structure damage of glomeruli and inflammatory cell infiltration were found in the kidney. Along with the lasting of administration to 4-week, the renal injury in the Aristolochia fangchi group became more serious, and the contents of BUN and SCr were all significantly higher as compared with the normal control group (P<0.05). Two weeks after administration, the content of BUN in the Aristolochia fangchi group was still higher than that in the normal control group (P<0.05), and the pathological changes in renal tissues were not different from those on the 4th week. The urine of the Aristolochia fangchi group could be readily discriminated from the normal control group at every time point based on PCA. During the whole administration period, compared with the normal control group, the concentration of urinary taurine was increased time-dependently, while the citrate was decreased in the Aristolochia fangchi group. The concentration of hippurate was increased at the 2nd week and the 6th week (2 weeks after drug withdrawal) but decreased at the 4th week; the concentration of creatinine/creatine was increased at the 4th week but decreased at the 6th week; the concentration of 2-oxo-glutarate was decreased and the concentration of trimethylamine oxide was increased at the 4th and 6th week.Conclusion: High-dose Aristolochia fangchi can induce renal lesion and its seriousness is correspondent to the lasting of administr
Aristolochia occidentalis (Aristolochiaceae), una especie nueva de la subseccion Pentandrae de Colima y Jalisco, México  [cached]
Francisco J. Santana Michel,Sebastián Lemus Juárez
Acta botánica mexicana , 1996,
Abstract: Se describe Aristolochia occidentalis sp. nov. procedente de la región limítrofe entre los estados de Colima y Jalisco. La especie pertenece a la subsección Pentandrae Duchartre y está relacionada con Aristolochia pringlei Rose y Aristolochia bracteosa Duchartre.
Alkamides and phenethyl derivatives from Aristolochia gehrtii
Navickiene, Hosana M. D.;Lopes, Lucia M. X.;
Journal of the Brazilian Chemical Society , 2001, DOI: 10.1590/S0103-50532001000400004
Abstract: from the stems of aristolochia gehrtii, the cis-n-feruloyl-3-o-methyldopamine and a hemiacetal derivative of 5-hydroxymethylfurfural were isolated, together with twenty-two known compounds. these compounds include five lignans, three terpenes, six alkaloids (five alkamides), two benzoic acid derivatives, and six phenethyl derivatives. the structures of the isolated compounds were determined by means of spectroscopic methods and comparison with literature data.
Nitro derivatives and other constituents of Aristolochia melastoma
Nogueira, Cláudio R.;Lopes, Lucia M. X.;
Química Nova , 2012, DOI: 10.1590/S0100-40422012000400024
Abstract: a phytochemical study of aristolochia melastoma manso has led to the isolation and identification of 20 known compounds, including aristolochic acids, sodium aristolochates, lignan, flavonoids, and nitro phenylethyl derivatives. their structures were established by spectroscopic analysis. the presence of thalictricoside and secoisolariciresinol dimethyl ether diacetate is reported for the first time in the aristolochiaceae family. in addition, the presence of nitro compounds in this species is significant.
Alkamides and phenethyl derivatives from Aristolochia gehrtii  [cached]
Navickiene Hosana M. D.,Lopes Lucia M. X.
Journal of the Brazilian Chemical Society , 2001,
Abstract: From the stems of Aristolochia gehrtii, the cis-N-feruloyl-3-O-methyldopamine and a hemiacetal derivative of 5-hydroxymethylfurfural were isolated, together with twenty-two known compounds. These compounds include five lignans, three terpenes, six alkaloids (five alkamides), two benzoic acid derivatives, and six phenethyl derivatives. The structures of the isolated compounds were determined by means of spectroscopic methods and comparison with literature data.
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