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Detección de Helicobacter pylori en tejido aórtico humano mediante la amplificación del gen del 16S rDNA Detection of Helicobacter pylori in human aortic tissue through amplification of the 16S rDNA gen
María F Escobar,Darío Echeverri,Lorena Buitrago,Claudia Espitia
Revista Colombiana de Cardiología , 2005,
Abstract: Helicobacter pylori es un patógeno humano reportado de manera frecuente como responsable de afecciones gastrointestinales. En los últimos a os, se ha sugerido una asociación causal entre infecciones crónicas por varios patógenos, entre ellos Helicobacter pylori, y la génesis y/o progresión de la aterosclerosis. Aunque se han realizado varios estudios, no hay evidencia contundente de que esta asociación sea verdadera. El propósito de este estudio fue investigar la presencia de Helicobacter pylori en muestras de tejido aórtico de pacientes con diagnóstico clínico de ectasia anulo-aórtica, mediante la amplificación por técnicas de reacción en cadena de la polimerasa (PCR) de un fragmento del gen del 16S rDNA de este microorganismo. Se analizaron muestras de ADN de tejido aórtico obtenido de 20 pacientes. Se procesó un fragmento de aorta con lesión aterosclerótica aparente y otro de una región aparentemente sana en cada uno de los pacientes. No se detectaron ácidos nucleicos de Helicobacter pylori en ninguno de los especímenes analizados. Los resultados del estudio sugieren baja o nula asociación entre Helicobacter pylori y enfermedad coronaria en nuestro medio. Helicobacter pylori is a human pathogen, frequently reported as responsible of gastrointestinal affections. During the last years, a causal relationship between chronic infections by several pathogens, among them the Helicobacter pylori, and the genesis and/ or progression of atherosclerosis, has been suggested. Although several studies have been realized, there is no conclusive evidence to assert this association. The purpose of this study was to investigate the presence of Helicobacter pylori in aortic tissue samples from patients with clinical diagnosis of annulo-aortic ectasia, through PCR amplification of a gen fragment of the 16S rDNA of this microorganism. Samples of DNA aortic tissue obtained from 20 patients were analyzed. An aortic fragment with apparent atherosclerotic lesion, and another from an apparently healthy region, was examined in each patient. No Helicobacter pylori nucleic acids were detected in any of the analyzed specimens. The results of the study suggest low or null association between Helicobacter pylori and coronary disease in our environment.
Helicobacter pylori y diarrea en ni os Helicobacter pylori and diarrhea in children  [cached]
Vladimir Ruiz álvarez,Silvia María Marín Juliá,Manuel Hernández Triana
Revista Cubana de Higiene y Epidemiología , 2005,
Abstract: La infección por Helicobacter pylori (H. pylori) está ampliamente difundida en los países en desarrollo. La gastritis crónica ocasionada por la colonización gástrica con esta bacteria produce hipoclorhidria, la cual puede comprometer la barrera ácida del estómago, importante defensa del huésped contra las infecciones del intestino delgado. Con el objetivo de indagar sobre la posible asociación entre la infección por esta bacteria y la enfermedad diarreica se realizó un estudio de casos y controles, en el a o 2004, en 60 ni os menores de 3 a os de edad de Ciudad de La Habana, afectados por diarreas agudas o persistentes y malnutrición por defecto. La presencia de anticuerpos IgG contra H. pylori en suero de 30 ni os afectados por diarreas agudas o crónicas y malnutrición por defecto fue estudiada por inmunoensayo y comparada con los resultados de 30 ni os aparentemente sanos no afectados por diarreas y pareados por sexo y edad. La prevalencia de la infección fue del 64 % en ni os con diarreas y del 50 en los controles. No se encontró asociación entre la presencia de H. pylori y la enfermedad diarreica. The infection caused by Helicobacter pylori (H. pylori) is widely spread in the developing countries. Chronic gastritis produced by the gastric colonization with this bacteria provokes hypochlorhydria, which may compromise the acid barrier of the stomach, important defense of the host against the infections of the small intestine. In order to determine the possible association between the infection due to this bacteria and diarrheal disease, a case-control study was conducted in 2004 among 60 children under 3 years old from Havana City that were affected with acute or persistent diarrheas and malnutrition. The presence of IgG antibodies against H. Pylori in serum from 30 children affected with acute or chronic diarrheas and malnutrition was studied by immunoessay and compared with the results of 30 apparently sound children without diarrhea that were matched by sex and age. The prevalence of infection was 64 % in children with diarrhea and 50 % in the controls. No association was found between the presence of H. Pylori and the diarrheal disease.
Follow up through Endoscopical – Histological Studies and Helicobacter Pylori Infections in Patients Suffering from Gastric Ulcers Seguimiento evolutivo mediante estudio endoscópico-histológico e infección por Helicobacter pylori en pacientes con úlcera gástrica  [cached]
Marcos Félix Osorio Pagola,Antonio Moré Pérez,Libán álvarez Cáceres,Juan Luis de Pasos Carrazana
MediSur , 2010,
Abstract: Background: Endoscopic follow up of gastric ulcers until healing has a great important due to the possibility of a new proliferation. The commonest chronic infection worldwide is caused by Helicobacter pylori and it is associated to gastro duodenal diseases. Objective: To determine the endoscopic-biopsic follow up and to set the frequency of infection due to Helicobacter pylori in those patients who suffer from gastric ulcers . Methods: observational, descriptive and prospective study carried out at the University Hospital “Arnaldo Milián Castro”. It included 96 gastric ulcer sufferers diagnosed endoscopically and who fulfilled with the selection criteria. Endoscopy and biopsy of the gastric mucosa was done for the histological study of the gastric ulcers and for the diagnosis of infection due to Helicobacter pylori through hematoxiline-eosine and giemsa stains respectively. Results: 89 patients (92,7 %) healed their ulcers in the first three months of follow up and 5 patients underwent a histological diagnosis of malignant ulcers (5,2 %). Surgery was done on the two patients whose ulcers did not heal. (2,1 %). 67,7 % had been infected with the bacteria. There was a greater frequency of patients infected with Helicobacter pylori, either with benign or malignant ulcus (93,8 % y 6,2 %) respectively. Conclusions: the follow up of benign ulcers was good , almost all of them healed in a three-month follow up. 5 patients suffered from malignant ulcers, being 2 of them diagnosed in their second endoscopy. More than half of the patients were infected with Helicobacter pylori. Fundamento: el seguimiento endoscópico evolutivo de la úlcera gástrica hasta su cicatrización es muy importante, debido a la posibilidad de neoproliferación. La infección crónica más frecuente en el mundo es la causada por Helicobacter pylori y se asocia a enfermedad gastroduodenal. Objetivo: determinar la evolución endoscópico-biópsica y precisar la frecuencia de infección por Helicobacter pylori en pacientes con úlcera gástrica. Métodos: estudio observacional, descriptivo y prospectivo realizado en el Hospital Universitario “Arnaldo Milián Castro” que incluyó 96 pacientes con úlcera gástrica a los que se les diagnosticó mediante endoscopia y que cumplieron con los criterios de selección. Se practicó endoscopia y biopsia de mucosa gástrica para estudio histológico de las úlceras gástricas y diagnóstico de infección por Helicobacter pylori, mediante coloración de hematoxilina-eosina y de giemsa respectivamente. Resultados: se observó que 89 pacientes (92,7 %) lograron la cicatrización de l
Alteraciones del tracto digestivo superior e infecciones por Helicobacter pylori en el paciente con trasplante renal en el Instituto Nacional de Nefrología 2002-2005
Pérez Rodríguez,Alexis; Parodis López,Yanet; Mármol Só?ora,Alexander; González-Carbajal Pascual,Miguel; Hernández Garcés,Héctor; Pérez del Prado Valdivia,Juan C.;
Revista Cubana de Medicina , 2007,
Abstract: a prospective, descriptive and observational study was conducted on all the renal transplant recipients at the institute of nephrology from 2002 to 2004. gastroduodenoscopy in addition to an urease test were performed to diagnose helicobacter pylori and associated alterations in the first month of transplantation, and then they were repeated six and 12 months afterwards. the infection prevalence rate was 34,1 per 100 patients. it was more frequent in the 40-49 years age group. the most significant infection-associated digestive disorders were erythematous gastritis and duodenal ulcer. it was demonstrated that all the treated patients managed to get over the infection and only one patient with associated digestive alteration did not suceed.
Alteraciones del tracto digestivo superior e infecciones por Helicobacter pylori en el paciente con trasplante renal en el Instituto Nacional de Nefrología 2002-2005 Upper digestive tract disorders and Helicobacter pylori infection in the renal transplant patient at the National Institute of Nephrology 2002-2005  [cached]
Alexis Pérez Rodríguez,Yanet Parodis López,Alexander Mármol Só?ora,Miguel González-Carbajal Pascual
Revista Cubana de Medicina , 2007,
Abstract: Se realizó un estudio observacional, descriptivo, prospectivo con todos los pacientes que habían recibido un trasplante renal en el Instituto de Nefrología desde el 2002 hasta el 2004. Se les realizó gastroduodenoscopia con prueba de ureasa para diagnóstico de Helicobacter pylori y alteraciones asociadas en el primer mes del trasplante y se repitió el estudio a los 6 meses y al a o. Se encontró una prevalencia de la infección de 34,1 por cada 100 pacientes. Se halló con mayor frecuencia entre los 40 y 49 a os de edad. Se encontraron como alteraciones digestivas asociadas a la infección de forma significativa: la gastritis eritematosa y la úlcera duodenal. Se comprobó que todos los pacientes tratados lograron curar la infección y solo uno con alteración digestiva asociada no resolvió con el tratamiento. A prospective, descriptive and observational study was conducted on all the renal transplant recipients at the Institute of Nephrology from 2002 to 2004. Gastroduodenoscopy in addition to an urease test were performed to diagnose Helicobacter pylori and associated alterations in the first month of transplantation, and then they were repeated six and 12 months afterwards. The infection prevalence rate was 34,1 per 100 patients. It was more frequent in the 40-49 years age group. The most significant infection-associated digestive disorders were erythematous gastritis and duodenal ulcer. It was demonstrated that all the treated patients managed to get over the infection and only one patient with associated digestive alteration did not suceed.
Chronic Helicobacter Pylori Infections and Carotid Intima- Media Thickness: Is There a Link
Engin Altintas,Enver Ucbilek,Oguz Ulu,Orhan Sezgin,Caner Uzer,Canten Tataroglu,Handan Camdeviren
The Cardiology , 2011,
Abstract: Chronic infections are related with cardiovascular diseases. The thickness of carotid intima-media is an indicator of atherosclerosis. Helicobacter pylori induced chronic active gastritis is resulted with atrophic gastritis. This study was done to studied the thickness of carotid intima-media in patients with atrophic gastritis and without it. One hundred and twenty three patients who were performed esophagogastroduodenoscopy for various reasons. Biopsy samples have been taken from antrum and corpus for histologic evaluation and rapid urease test. Helicobacter pylori was accepted as positive in patients in whom both histologic evaluation and rapid urease test result had been positive. Histopathologic evaluation has been performed according to to the Sydney classification. Helicobacter pylori positive casess were diveded into two groups as atrophic gastritis and non-atrophic gastritis. In 92 of 123 patients, helicobacter pylori positive non-atrophic gastritis and in 31 of them, helicobacter pylori positive atrophic gastritis was observed. In both groups. The mean age was 46 years. There were not differences between the two groups according to age, sex, body mass index, blood lipids, ferritin, platelet count, fibrinogen, vitamin B-12, C-reactive protein and the thickness of carotid intima media. The thickness of carotid intima media was not found as related with the chronic helicobacter pylori infection.
Chronic Helicobacter Pylori Infections and Carotid Intima- Media Thickness: Is There a Link
Engin Altintas,Enver Ucbilek,Oguz Ulu,Orhan Sezgin
The Cardiology , 2005,
Abstract: Chronic infections are related with cardiovascular diseases. The thickness of carotid intima-media is an indicator of atherosclerosis. Helicobacter pylori induced chronic active gastritis is resulted with atrophic gastritis. This study was done to studied the thickness of carotid intima-media in patients with atrophic gastritis and without it. One hundred and twenty three patients who were performed esophagogastroduodenoscopy for various reasons. Biopsy samples have been taken from antrum and corpus for histologic evaluation and rapid urease test. Helicobacter pylori was accepted as positive in patients in whom both histologic evaluation and rapid urease test result had been positive. Histopathologic evaluation has been performed according to to the Sydney classification. Helicobacter pylori positive casess were diveded into two groups as atrophic gastritis and non-atrophic gastritis. In 92 of 123 patients, helicobacter pylori positive non-atrophic gastritis and in 31 of them, helicobacter pylori positive atrophic gastritis was observed. In both groups. The mean age was 46 years. There were not differences between the two groups according to age, sex, body mass index, blood lipids, ferritin, platelet count, fibrinogen, vitamin B-12, C-reactive protein and the thickness of carotid intima media. The thickness of carotid intima media was not found as related with the chronic helicobacter pylori infection.
Helicobacter Pylori Infections in Chronic Obstructive Pulmonary Disease  [cached]
Ali Tabaru,Metin Gorguner,Metin Akgun,Mehmet Meral
Eurasian Journal of Medicine , 2012,
Abstract: Objective: We aimed to investigate the prevalence of Helicobacter pylori (H. pylori) in patients with chronic obstructive pulmonary disease (COPD) using the C-14 urea-breath test (C14UBT) and to determine whether there is an association between H. pylori infection and the severity of COPD. This is the first report in the literature of the use of C14UBT to investigate the prevalence of H. pylori in patients with COPD.Materials and Methods: Fifty subjects with COPD (38 males and 12 females, aged 61±10 years) and 20 control subjects (10 males and 10 females, aged 55±11 years) were evaluated. C14UBT was used to determine H. pylori infection. Results: The prevalences of H. pylori infection in subjects with COPD and in controls were 72% and 65%, respectively (p=0.56). Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) values were significantly higher in the H. pylori-infected subjects with COPD than in the uninfected subjects (p=0.008 and p=0.006, respectively). Conclusion: The presence of H. pylori infection in COPD patients affects pulmonary functions, but the effects of H. pylori infection on the respiratory system and COPD are not clear.
Treatment of Helicobacter pylori infections: Mitigating factors and prospective natural remedies
CE Manyi-Loh, AM Clarke, NF Mkwetshana, RN Ndip
African Journal of Biotechnology , 2010,
Abstract: Helicobacter pylori is a Gram-negative, microaerophilic spiral or motile rod that infects about half the world’s population with a very high prevalence in the developing world. It is an important aetiological factor in the development of gastritis, peptic ulcer disease, gastric atrophy and B cell mucosa associated lymphoid tissue (MALT) lymphoma. H. pylori infection is responsible for a significant cause of morbidity and mortality imposing a major burden on health care systems world wide. The high prevalence of infection in the developing countries has been attributed to poor socioeconomic status and sanitation as well as an increased trend of antibiotic resistance. Antimicrobial chemotherapy (two antibiotics and a proton pump inhibitor) employed for the treatment of H. pylori infections has emerged as the most important means to resolve these infections. However, antimicrobial therapy is fraught with a number of inherent limitations such as resistance, cost of treatment, unavailability of drugs in rural areas and undesirable side effects necessitating the need to search for alternative approaches from natural sources including vegetables, honey and probiotics amongst others. These could form the basis of novel low cost, efficient, large-scale and alternative/complementary solutions with minimal side effects to decrease or eradicate H. pylori infections in the future.
Infección por Helicobacter pylori y diabetes en adultos cubanos Helicobacter pylori infection and diabetes in Cuban adults  [cached]
Vladimir Ruiz-álvarez,Yanik Rodríguez Enriquez,Manuel Hernández-Triana
Revista Cubana de Investigaciones Biom??dicas , 2006,
Abstract: Se determinó la seroprevalencia de anticuerpos IgG contra Helicobacter pylori determinados por inmunoensayo en un estudio de casos y controles que incluyó a 59 pacientes con diabetes mellitus y 19 individuos sanos de Ciudad Habana, incorporados como grupo control. Los pacientes fueron divididos en 3 grupos de acuerdo con: reciente captación, tratamiento solo con dieta o con dieta más hipoglicemiantes orales. La seroprevalencia de anticuerpos anti-H. pylori en los grupos de pacientes diabéticos fue de 90, 94, y 77 % respectivamente, en relación con el valor de 58 % del grupo control. La infección por H. pylori estuvo altamente asociada con la diabetes mellitus en los pacientes de reciente captación o en los tratados solo con dieta (p= 0,003, p= 0,01). The seroprevalence of IgG antibodies against Helicobacter pylori detected by immunoassay was determined in a case-control study that included 59 patients with diabetes mellitus and 19 healthy individuals from Havana City that were incorporated as a control group. Patients were divided into 3 groups according to recent recruitment, treatment only with diet, or with diet plus hypoglycemic agents. The seroprevalence of anti- Helicobacter pylori antibodies in the groups of diabetic patients was 90, 94 and 77 %, respectively, in relation to the value of 58 % of the control group. Helicobacter pylori infection was markedly associated with diabetes mellitus in recently recruited patients with diabetes mellitus, or in those treated with diet only (p= 0.03, p= 0.01).
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