oalib
Search Results: 1 - 10 of 100 matches for " "
All listed articles are free for downloading (OA Articles)
Page 1 /100
Display every page Item
La necrosis, un mecanismo regulado de muerte celular
Ramírez Agudelo,María Elena; Rojas López,Mauricio;
Iatreia , 2010,
Abstract: three types of cellular death have been defined by morphological and biochemical criteria: apoptosis, necrosis and autophagy. apoptosis is a regulated cell death, mainly mediated by caspases; autophagy induces degradation of intracellular damaged organelles through the formation of vesicles that fuse with hydrolytic vacuoles. necrosis has been traditionally defined by the rupture the cytoplasmic membrane with subsequent release of intracellular material, triggering localized inflammatory intrinsic cellular activities and the events preceding cellular collapse are critical to determine the type of tissue damage. the fact that all three types of cellular death can coexist in any organ and tissue with different availabilities of atp, suggests that necrosis can be conceived as an active event and that to some extent it may be regulated. alterations in the structure of proteins and in the activity of different proteases, lipases and nucleases, indicate that each cell may have its own arsenal to trigger the events leading to necrosis. in this article we review some of the evidences on cellular regulation during necrosis.
Mecanismos de muerte celular en las enfermedades neurodegenerativas: apoptosis o necrosis? Mechanisms of cell death in neurodegenerative diseases: apoptosis or necrosis?
Rommy von Bernhardi M
Revista Chilena de Neuro-Psiquiatría , 2004,
Abstract: Introducción. La apoptosis es un proceso esencial durante el desarrollo del sistema nervioso; el que además parece participar en el origen o la progresión de las enfermedades neurodegenerativas. Sin embargo, frente a un da o extremo, las células sufren necrosis, otro mecanismo de muerte, que también es crucial en el da o que las enfermedades y lesiones infringen al sistema nervioso. Métodos. Se revisan los mecanismos celulares y moleculares asociados a la muerte celular; los que pueden proveer herramientas para prevenir la neurodegeneración. Se discuten los mecanismos asociados a la apoptosis y necrosis en la patología del SNC. Resultados. Los mecanismos envueltos tanto en la apoptosis como en la necrosis son altamente conservados. Muchos de los factores envueltos en la protección frente al da o participan en la homeostasis del sistema nervioso y se expresan ampliamente en el sistema nervioso durante el desarrollo y en las etapas adultas; también tienen efectos neuroprotectores después del da o neuronal. Conclusiones. En contraste a los mecanismos de apoptosis, que evolucionarían específicamente para orquestarla, los mecanismos de necrosis corresponden a la desestabilización de funciones celulares normales frente a circunstancias extremas, con consecuencias devastadoras para las células. Un papel neuroprotector amplio probablemente es fundamental para muchos de los factores protectores descritos, como serían los factores de crecimiento, cuyo potencial terapéutico para los desórdenes del sistema nervioso podría ser mayor que el pensado hasta el momento, cambiando tanto la prevención como el tratamiento de muchas enfermedades del SNC. Introduction. Apoptosis is an essential process during the development of the nervous system. It also participates in the origin or progression of neurodegenerative diseases. However, under extreme conditions, cells undergo necrosis, another mechanism of cell death, which is also crucial for the damage that injury and disease inflict on the nervous system. Methods. The cellular and molecular mechanisms that regulate cell death are reviewed. They may provide new tools to prevent neurodegeneration. Mechanisms involved in apoptosis and necrosis, and their effect upon CNS pathology are discussed. Results. The mechanisms involved in apoptosis and necrosis are highly conserved. Many factors involved in the protection against damage are involved in the homeostasis of the nervous system and are widely expressed in the developing and adult nervous system and also show neuroprotective effects following neural damage. Conclusions. In c
Mecanismos de muerte celular en las enfermedades neurodegenerativas: ?apoptosis o necrosis?
von Bernhardi M,Rommy;
Revista chilena de neuro-psiquiatría , 2004, DOI: 10.4067/S0717-92272004000400005
Abstract: introduction. apoptosis is an essential process during the development of the nervous system. it also participates in the origin or progression of neurodegenerative diseases. however, under extreme conditions, cells undergo necrosis, another mechanism of cell death, which is also crucial for the damage that injury and disease inflict on the nervous system. methods. the cellular and molecular mechanisms that regulate cell death are reviewed. they may provide new tools to prevent neurodegeneration. mechanisms involved in apoptosis and necrosis, and their effect upon cns pathology are discussed. results. the mechanisms involved in apoptosis and necrosis are highly conserved. many factors involved in the protection against damage are involved in the homeostasis of the nervous system and are widely expressed in the developing and adult nervous system and also show neuroprotective effects following neural damage. conclusions. in contrast to apoptotic mechanisms, which evolved specifically to carry apoptosis, the mechanisms of necrosis correspond to the destabilization of normal cellular functions when exposed to extreme circumstances, with devastating consequences for the cell. a broad neuroprotective role is the foundation for many of the protective factors described, such as growth factors, whose therapeutical potential for nervous system disorders may be greater than currently thought, changing both prevention and treatment for several diseases of the cns.
Muerte celular y necrosis  [cached]
Juan Antonio Barcat
Medicina (Buenos Aires) , 2009,
Abstract:
El mecanismo de muerte celular programada y su importancia en el proceso de maduración de la carne bovina
Ortega Torres,Janeth; Ariza Botero,Manuel Fernando;
Revista de Medicina Veterinaria , 2012,
Abstract: the purpose of this paper is to present the mechanism of programmed cell death and the evidence supporting its relation to the ripening of beef. the tenderness of beef is perhaps one of the most important features for consumers, because it makes meat a desirable product in global markets and influences their price and quality. these features depend on genetic, nutritional and environmental factors. although in colombia there is still no culture of traceability of meat products in supermarkets, an increase in the number of consumers in latin america is expected in the near future and they will also have the option of demanding the best meat. deciphering the biochemical and molecular factors that influence the ripening of beef is a large task that is still in its early stages. some pathways involved have been deciphered, such as the calpain-calpastatin, the proteasomal and that off cathepsins, proteins that have been recognized as a positive influence in the process of muscle fiber degradation during the ripening process. the conversion of muscle onto flesh is a process that begins once the animal has been sacrificed and, therefore, it is associated with the processes of cell death and necrosis. in recent years, many studies have focused on the importance and contribution of the programmed cell death mechanism or apoptosis on meat tenderness.
Mecanismos reguladores de la muerte celular no necrótica  [cached]
Violeida Sánchez Socarrás
Revista Cubana de Investigaciones Biom??dicas , 2001,
Abstract: Se describieron los mecanismos reguladores de la muerte celular no necrótica, los factores intrínsecos y extrínsecos en la proliferación celular, sus efectos. Se explica la diferencia entre muerte celular y procesos necróticos. También se definen la necrosis, el suicidio celular y las alteraciones de la proliferación celular, donde se relaciona la muerte celular con el cáncer, la autoinmunidad, las infecciones virales, las enfermedades neurovegetativas y los trastornos de la sangre The regulating mechanisms of non-necrotic cell death, the intrinsic and extrinsic factors in cellular proliferation and their effects are described. The difference between cell death and necrotic processes is also explained here. The necrosis, cellular suicide and the alterations of cellular proliferation, where the cell death is related to cancer, autoimmunity, viral infections, neurovegetative diseases and blood disorders, are defined
Conceptos y definiciones de la vida y la muerte celular Conceptos y definiciones de la vida y la muerte celular
Fernando Anaya Velázquez,Felipe Padilla Vaca
Acta Universitaria , 2012,
Abstract: In the present work scientific concepts and definitions about life and cell death are revised.General properties of biological life and live organisms as well as cellular death are described.Although it is known how life and death occur in cells, a convincing definition is stilllacking on what are biological life and death. Finally, the recent reported experiments onsynthetic genomics raise the importance to updating concepts and definitions of life anddeath in biology. En el presente trabajo se revisa la información científica sobre las definiciones y conceptos sobre la vida y la muerte celular. Se describen las características generales de la vida biológica y los seres vivos, así como de la muerte celular. Aunque se sabe cómo ocurre la vida y la muerte de las células aún no se tiene una definición precisa de qué es la vida y qué es la muerte biológica. Finalmente, derivado de los recientes avances en la genómica sintética, se concluye que es necesario actualizar los conceptos y definiciones sobre la vida y la muerte en la biología.
Los esfingolípidos en la muerte y proliferación celular  [cached]
N. Sterin-Speziale,F. Leocata Nieto
Química Viva , 2007,
Abstract: Los esfingolípidos tienen función crucial en la regulación de diversos procesos incluyendo el cáncer. Mientras la ceramida y la esfingosina inducen apoptosis y arresto del ciclo celular, la esfingosina 1-fosfato promueve la proliferación y supervivencia celular. El delicado equilibrio entre los niveles intracelulares de cada uno de estos esfingolípidos está controlado por las enzimas que los produces. La esfingosina cinasa es reguladora esencial de este balance ya que, produce el metabolito pro-supervivencia esfingosina 1-fosfato y reduce el contenido de los metabolitos pro-apoptóticos. El gen que codifica a la enzima es un encogen, y su RNA m está sobreexpresado en numerosos tumores y la actividad de la enzima disminuye en los tratamientos anti-cáncer. Estrategias para eliminar tumores por aumento del contenido de ceramida con bloqueo de la generación de esfingosina 1-fosfato puede tener un índice terapéutico favorable
Mecanismos reguladores de la muerte celular no necrótica
Sánchez Socarrás,Violeida;
Revista Cubana de Investigaciones Biom??dicas , 2001,
Abstract: the regulating mechanisms of non-necrotic cell death, the intrinsic and extrinsic factors in cellular proliferation and their effects are described. the difference between cell death and necrotic processes is also explained here. the necrosis, cellular suicide and the alterations of cellular proliferation, where the cell death is related to cancer, autoimmunity, viral infections, neurovegetative diseases and blood disorders, are defined
Es la muerte importante para la vida?  [cached]
Fernando Iván Flores Pérez
Veterinaria México , 2002,
Abstract: El fenómeno de muerte celular programada, o apoptosis, es actualmente uno de los más estudiados en el campo de la biomedicina; su importancia radica en que varias enfermedades, que afectan tanto al hombre como a los animales, son causadas por una alteración en este mecanismo fisiológico tan relevante, a tal grado que sin la existencia de este fenómeno fisiológico, la vida, como actualmente se conoce no sería posible. El propósito del presente trabajo es definir el fenómeno de apoptosis, describir cómo se regula y dar cuenta de algunas enfermedades causadas por su alteración, así como de las técnicas de detección.
Page 1 /100
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.