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Efecto de un extracto oleoso de rizoma de Zingiber officinale Roscoe (MVZ) sobre la anafilaxia pasiva cutánea y el espasmo bronquial inducido por histamina
Nú?ez Figueredo,Yanier; Tillán Capó,Juana; Carrillo Domínguez,Carmen; Olivares Guerra,Odila A; Nú?ez Gomero,Ramona;
Revista Cubana de Plantas Medicinales , 2005,
Abstract: in order to show the antiallergic properties conferred to mvz, it was studied its posible influence on the anaphylactic mediators and the bronchial spasm induced by histamine. in the test of cutaneous passive anaphylaxis there were used wistar male rats that were orally administered mvz at a dose of 6.5 ml/kg (4.8 of fatty acids/kg) during 10 days. ketotifen 3 mg/kg was used as a positive control. the intensity of anaphylaxis was determined by quantifying the amount of extravasated evans blue.the protective effect of bronchial spasm was determined in hartley male guinea pigs by inducing brochoconstriction through the intravenous administration of histamine and estimating the bronchial pressure. the dose of the product used was the same as that of the previous assay. as a result, it was found that mvz inhibited the cutaneous passive anaphylaxis in rats and the bronchoconstriction induced by 15 μg/kg of histamine by endovenous route. the outcomes suggest that the mvz may be effective in the prophylactic treatment of type 1 allergic diseases, such as bronchial asthma, which would justify its popular use in asthmatic patients.
Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe  [cached]
Naila Abdul Sattar,Fatma Hussain,Tahira Iqbal,Munir Ahmad Sheikh
Brazilian Journal of Pharmaceutical Sciences , 2012,
Abstract: Aqueous extracts of Zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 g/L. The antidiabetic effects were found to be dose-dependent. Antidiabetic potential of Zingiber officinale was mainly through inhibition of the glucose diffusion and to a limited extent by reducing the glycation. However, further studies are needed to determine in vitro effects of therapeutic potential by restraining postprandial glucose absorptions and plasma protein glycations in diabetic subjects. Extratos aquosos de rizomas Zingiber officinale foram estudados para avaliar os seus efeitos antidiabéticos em glica o de proteínas e sobre a difus o de glicose in vitro, no presente estudo. Extratos aquosos de Zingiber officinale foram examinados nas concentra es de 5, 10, 20 e 40 g extrato de planta/L. Os efeitos antidiabéticos observados eram dependentes da dose. O potencial antidiabético de Zingiber officinale se verificou, principalmente, através da inibi o da difus o de glicose e, em menor extens o, através da redu o da glica o. Estudos adicionais s o necessários para elucidar se efeitos in vitro representam potencial terapêutico, restringindo a absor o de glicose pós-prandial e a glica o de proteínas plasmáticas em indivíduos diabéticos.
Zingiber officinale Roscoe (A Medicinal Plant)
M. Akram,M. Ibrahim Shah,Khan Usmanghan,E. Mohiuddin
Pakistan Journal of Nutrition , 2011,
Abstract: Ginger has been used for centuries to support many various digestive imbalances including heartburn, indigestion, nausea, diarrhea and motion sickness. Zingiber officinale is commonly prescribed to treat nausea, but it is also used as an anti-inflammatory agent and cholesterol-lowering herb. Ginger is considered safe for supplemental use. It has anticoagulant affects also. This drug is prescribed in gout, rheumatoid arthritis and other inflammatory conditions.
Superoxide Scavenging and Tyrosinase Inhibitory Active Compound in Ginger (Zingiber officinale Roscoe)
F. Khanom,H. Kayahara,M. Hirota,K. Tadasa
Pakistan Journal of Biological Sciences , 2003,
Abstract: The superoxide-scavenger and tyrosinase inhibitory active material was extracted by methanol from ginger (Zingiber officinale Roscoe) and was partitioned into hexane, aqueous and ethyl acetate parts. The highly active hexane soluble part was subjected to fractioned by silica gel column chromatography and was obtained in eight fractions. All most all fractions gave a remarkable amount of superoxide-scavenging and tyrosinase inhibitory activities. The highest superoxide-scavenging and tyrosinase activities were found in the fraction five (58.2 and 42.7%, respectively) and its purity was confirmed by thin layer chromatography (TLC). This fraction was amounting as 274.3 mg and characterized by nuclear magnetic resonance (NMR), infrared (IR) and mass spectrometer. The compound was gingerol and its structure was confirmed as 3-decanone, 5-hydroxy-1 (4-hydroxy-3-methoxy phenyl) -3-one on the basis of spectral evidence.
Actividad antiinflamatoria de compuestos liposolubes de Zingiber officinale Roscoe frente a diferentes agentes flogísticos
Tillán Capó,Juana; Nu?ez Figueredo,Yanier; Agüero Fernández,Sara; Carrillo Domínguez,Carmen;
Revista Cubana de Plantas Medicinales , 2007,
Abstract: there is a background for use of oily extract with purified butter of zingiber officinale roscoe in treatment of allergic diseases and of airways by mexican people; also, tasks performed in our lab demonstrated a protective effect of it in case of bronchospasm provoked by hystamines, and in experimental cutaneous passive anaphylaxis. since these results anti-inflammatory assessment of such extract was made in induction models of plantar edema in rat, using different flogistic agents as dextran, histamine, serotonine, and carragenine. rats received oleic extract of zingiber officinale roscoe by oral route, at a dosis of 6,5 ml/kg of body weight, one hour before induction of plantar edema, also we assessed cyproheptadine, diphenhydramine and indomethacin as positive controls. statistical analysis showed that administration of oleic extract of zingiber officinalie roscoe produces a significant inhibition (p < 0,05) of edema development induced by dextran, histamine, serotonine, and carragenine.
Actividad antiinflamatoria de compuestos liposolubes de Zingiber officinale Roscoe frente a diferentes agentes flogísticos Anti-inflammatory activity of liposoluble compounds of Zingiber officinale Roscoe versus different inflammatory agents
Juana Tillán Capó,Yanier Nu?ez Figueredo,Sara Agüero Fernández,Carmen Carrillo Domínguez
Revista Cubana de Plantas Medicinales , 2007,
Abstract: Existen antecedentes del uso de un extracto oleoso con mantequilla purificada del Zingiber officinale Roscoe en el tratamiento de enfermedades alérgicas y de las vías respiratorias por parte de la población mexicana; también trabajos realizados en nuestro laboratorio demostraron un efecto protector del mismo ante el broncoespasmo inducido por histamina y en la anafilaxia pasiva cutánea experimental. Dado estos resultados se realizó la evaluación antiinflamatoria de dicho extracto en los modelos de inducción del edema plantar en rata, utilizando diferentes agentes flogísticos como dextrán, histamina, serotonina y carragenina. Las ratas fueron administradas por vía oral con el extracto oleoso de Zingiber officinale Roscoe a la dosis 6,5 mL/kg de peso corporal, una hora antes de la inducción del edema plantar, también se evaluó la ciproheptadina, difenhidramina e indometacina como controles positivos. El análisis estadístico demostró que la administración del extracto oleoso de Zingiber officinale Roscoe produce una inhibición significativa (p < 0,05) al desarrollo del edema inducido por dextrán, histamina, serotonina y carragenina. There is a background for use of oily extract with purified butter of Zingiber officinale Roscoe in treatment of allergic diseases and of airways by Mexican people; also, tasks performed in our lab demonstrated a protective effect of it in case of bronchospasm provoked by hystamines, and in experimental cutaneous passive anaphylaxis. Since these results anti-inflammatory assessment of such extract was made in induction models of plantar edema in rat, using different flogistic agents as Dextran, Histamine, Serotonine, and Carragenine. Rats received oleic extract of Zingiber officinale Roscoe by oral route, at a dosis of 6,5 mL/kg of body weight, one hour before induction of plantar edema, also we assessed Cyproheptadine, Diphenhydramine and Indomethacin as positive controls. Statistical analysis showed that administration of oleic extract of Zingiber officinalie Roscoe produces a significant inhibition (p < 0,05) of edema development induced by Dextran, Histamine, Serotonine, and Carragenine.
Antioxidant Activities, Total Phenolics and Flavonoids Content in Two Varieties of Malaysia Young Ginger (Zingiber officinale Roscoe)  [PDF]
Ali Ghasemzadeh,Hawa Z. E. Jaafar,Asmah Rahmat
Molecules , 2010, DOI: 10.3390/molecules15064324
Abstract: Ginger (Zingiber officinale Roscoe) is a well known and widely used herb, especially in Asia, which contains several interesting bioactive constituents and possesses health promoting properties. In this study, the antioxidant activities of methanol extracts from the leaves, stems and rhizomes of two Zingiber officinale varieties (Halia Bentong and Halia Bara) were assessed in an effort to compare and validate the medicinal potential of the subterranean part of the young ginger. The antioxidant activity and phenolic contents of the leaves as determined by the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and the total amounts of phenolics and flavonoids were higher than those of the rhizomes and stems. On the other hand, the ferric reducing/antioxidant potential (FRAP) activity of the rhizomes was higher than that of the leaves. At low concentration the values of the leaves’ inhibition activity in both varieties were significantly higher than or comparable to those of the young rhizomes. Halia Bara had higher antioxidant activities as well as total contents of phenolic and flavonoid in comparison with Halia Bentong. This study validated the medicinal potential of the leaves and young rhizome of Zingiber officinale (Halia Bara) and the positive relationship between total phenolics content and antioxidant activities in Zingiber officinale.
Studies on the antimicrobial effects of garlic (Allium sativum Linn), ginger (Zingiber officinale Roscoe) and lime (Citrus aurantifolia Linn)
RA Onyeagba, OC Ugbogu, CU Okeke, O Iroakasi
African Journal of Biotechnology , 2004,
Abstract: The antimicrobial effect in vitro of aqueous and ethanolic extracts of garlic (Allium sativum Linn.), ginger (Zingiber officinale Roscoe) and lime (Citrus aurantifolia Linn.) juice were assayed against Staphylococcus aureus; Bacillus spp., Escherichia coli and Salmonella spp. All the test organisms were susceptible to undiluted lime-juice. The aqueous and ethanolic extracts of garlic and ginger singly did not inhibit any of the test organisms. The highest inhibition zone of 19 mm was observed with a combination of extracts on Staphylococcus aureus. Salmonella spp were resistant to almost all the extracts except lime. Key Words: Antimicrobial, ginger, garlic, lime, concoctions. African Journal of Biotechnology Vol.3(10) 2004: 552-554
TO ESTABLISH THE ULCEROGENIC POTENTIAL IF ANY, OF GINGER-JUICE ZINGIBER OFFICINALE ROSCOE (ZINGIBERACEAE) ON IMPORTANT PARAMETERS OF GASTRIC ULCERATION  [PDF]
S.S. Prasad*, Anita Sinha, Kamlesh Patel, Chandresh Dumatar, S.K. Vajpeyee and V.H. Bhavsar
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The aim of this study was to investigate the possibility of gastric-ulceration by ginger-juice (Zingiber officinale Roscoe) in rat. (A) Albino rats (n=6-12) were administered G.J at two doses (2ml & 4 ml/rat, p.o) as single administration and chronic treatment over period of 30 days. Following this assessment was done for possible gastric lesion. Effect of treatment with G.J acutely and chronically (30 days) administered, was assessed. Parameters used during assessment were total acidity, gastric volume & pH and ulcer index ‘UI’ (acute and chronic). Acute & chronic administration of G.J (2ml & 4ml/rat, p.o) caused an increase in pH and vol. of gastric content, a decrease in total acidity and no significant change in ulcer index.
Study of Genetic Variation among Some Wild Landraces of Zingiber officinale Roscoe Correlated with Their Antioxidant Potential Status  [cached]
Subhabrata Ghosh,Swati Sen Mandi
Journal of Molecular Biology Research , 2011, DOI: 10.5539/jmbr.v1n1p77
Abstract: DNA fingerprinting based genotype characterization and assessment of genetic diversity of fifteen wild landraces of Zingiber officinale. Roscoe, collected from different parts of northern West Bengal, India, has been done using 16 random decamer primers. Out of 117 amplified products, 97 bands showed polymorphism (82.90%) and an average of 7.5 bands was amplified per primer. The genetic similarity coefficients among accessions ranged from 0.673 to 0.912 with an average of 0.792. Cluster analysis based on Jaccard’s similarity coefficient using UPGMA grouped the landraces into three clusters: cluster I consisting of 5 landraces, Cluster II consisting of 6 landraces, and cluster III of 4 landraces; Antioxidant potential status of these genotypes exhibit variation that shows grouping comparable with the RAPD based dendogram (reflecting genetic relatedness) of the landraces.
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