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Pharmacognostical studies on the leaves of Plectranthus amboinicus (Lour) Spreng  [cached]
Kaliappan Nirmala,Viswanathan Periyanayagam
International Journal of Green Pharmacy , 2008,
Abstract: Plectranthus amboinicus (Lour) Spreng belonging to the family Lamiaceae commonly known as Karpuravalli, Omavalli in Tamil, Patta ajavayin, Patharcur in Hindi, Country borage in English is a large succulent aromatic perennial herb. It is highly aromatic pubescent herb with distinctive smelling leaves. The plant is distributed throughout in India, cultivated in the gardens. The leaves of this plant have been used in malarial fever, hepatopathy, renal and vesical calculi, cough, chronic asthma, hiccough, bronchitis, anthelmintic, colic and convulsions. This paper deals with the micro morphological studies carried out on the leaves of Plectranthus amboinicus one of the WHO accepted parameter for identification of medicinal plants. For the better understanding of structural details Scanning Electron Microscopy (SEM) also employed.
Induction of Apoptosis in Human Colon Cancer Cells by Methanol Fraction of Leaves of Plectranthus amboinicus (Lour) Spreng
Preeja G Pillai,P. Suresh,Gitanjali Mishra
International Journal For Pharmaceutical Research Scholars , 2013,
Abstract: To evaluate the cytotoxicity and apoptosis inducing activities of the methanol extract from leaves of Plectranthus amboinicus (Lour) Spreng in an attempt to determine whether the medicinal uses are supported by pharmacological effects. Cytotoxicity was determined by sulforhodamine B assay method. Cytotoxicity and apoptosis inducing effect were evaluated in- vitro using human colon cancer cell line, COLO 205. There was statistically significant cell growth inhibition at the doses of 10, 20, 40 and 80 μg/ml methanol extract of Plectranthus amboinicus (Lour) Spreng. Similarly, Plectranthus amboinicus at the doses of 50 and 100 μg/ml induced apoptosis in COLO 205 cells. The results suggest that the methanol extract of Plectranthus amboinicus (Lour) Spreng possesses anti- proliferative and apoptosis inducing activities, supporting the folk use of this medicinal species.
Efecto de Plectranthus amboinicus (Lour.) Spreng. tabletas sobre la anafilaxia pasiva cutánea, transmisión histaminérgica y adrenérgica
Nu?ez Figueredo,Yanier; Tillán Capó,Juana; Carrillo Domínguez,Carmen; Menéndez Castillo,Rosa; León,Rafael Diego;
Revista Cubana de Plantas Medicinales , 2006,
Abstract: plectranthus amboinicus (lour.) spreng, well-known in our country as french origan, is a plant with many therapeutical properties for the treatment of different diseases, including bronchial asthma. in the present paper, the effect of plectranthus amboinicus tablets (100 mg) on the passive cutaneous anaphylaxis and on the adrenergic and histaminergic transmission was evaluated. as a final result of this paper, it was possible to confirm that these tablets inhibit the passive cutaneous anaphylaxis, potentiates the adrenergic transmission, and inhibits the effects of histamine when it interacts with h1 receptors present at the intestinal level. it was concluded that the plectranthus amboinicus tablets 100 mg could be used in the type i treatment of allergic diseases, and thus justify the popular use of this plant for bronchial asthma.
Actividad expectorante de formulaciones a partir de Plectranthus amboinicus (Lour) Spreng (orégano francés)
Barzaga Fernández,Pedro; Tillán Capó,Juana; Marrero Cofi?o,Gisela; Carrillo Domínguez,Carmen; Bellma Menéndez,Addis; Montero Alarcón,Claudia;
Revista Cubana de Plantas Medicinales , 2009,
Abstract: introduction: plectranthus amboinicus (lour) spreng is a widely used vegetable species because of its antiasthma, bronchodilating and antiflu properties. objectives: to evaluate the expectorant effect of several formulations. methods: the effects of extracts, syrups and tablets obtained from plectranthus amboinicus (lour) spreng dry leaves through the staining method using tracheobronchial secretion red phenol in mice. results: the administration of aqueous extract and of fluid extract as well as the syrups produced from the extracts resulted in significant increase of red phenol concentration in the tracheobronchial secretion of mice. both the aqueous and the hydroalcohol extracts have expectorant activity; the aqueous extract-made syrup was effective at 50 ml/kg dose, with an effective mean dose of 41,91 ml/kg; fluid extract-made syrup was effective at 50 and 37,5 ml/kg, being 34,64 ml/kg the effective mean dose and finally 100 mg tablets showed their expectorant action at doses of 34 and 68 mg/kg. in turn, the acute administration of 100mg tablets had the same expectorant effect as bromhexine and salbutamol. conclusions: these formulations showed some expectorant effect under the experimental conditions of the study.
Actividad de Plectranthus amboinicus (Lour) Spreng tabletas 100 mg sobre la musculatura lisa intestinal. Activity of Plectranthus amboinicus (Lous.) Spreng 100 mg tablets on the intestinal smooth musculature
Yanier Nu?ez Figueredo,Juana Tillán Capó,Carmen Carrillo Domínguez,Claudia Montero Alarcón
Revista Cubana de Plantas Medicinales , 2006,
Abstract: En el presente trabajo se evaluaron las tabletas de 100 mg de Plectranthus amboinicus (Lour.) Spreng. (orégano francés) sobre la musculatura lisa y su influencia en la transmisión colinérgica, para lo cual se utilizaron cobayos machos de la raza Hartley de 200-250 g de masa corporal, para la extracción de diferentes porciones de íleon. Como resultado se obtuvo que las tabletas 100 mg de P. amboinicus (Lour.) Spreng., a las diferentes concentraciones evaluadas, provocaron contracción inmediata de la musculatura lisa; el orégano francés mostró un marcado efecto antimuscarínico frente a las concentraciones inducidas por acetilcolina (ACh) de 10-6 a 10-3 M. La administración conjunta de P. amboinicus (Lour.) Spreng. 10 mg/mL y ACh 10-3 M no superó la contracción provocada por esta última de manera independiente y la atropina 3 x 10-12 M disminuyó las contracciones provocadas por las diferentes concentraciones de orégano francés y ACh 10-3 M, por lo que las tabletas evaluadas presentan tanto efecto agonista como antagonista de la transmisión colinérgica. In the present paper, the effects of Plectranthus amboinicus (Lour.) Spreg (French origan) 100 mg tablets on the smooth musculature, as well as their influence on the cholinergic transmission were evaluated by using male Hartley guinea pigs with 200 to 250 g of body mass for extracting different portions of ileum. It was observed that the P. amboinicus (Lour.) Spreg, 100 mg tablets at the different assessed concentrations provoked an immediate contraction of the smooth musculature. The French origan showed a marked antimuscarinic effect against Acethylcholine-induced contractions (ACh) from 10-6 to 10-3 M. The combined administration of P. amboinicus (Lour.) Spreg 10 mg/mL and ACh 10-3 M did not surpass the contraction induced by the latter in a independent way, whereas atropine 3 x 10-12 M decreased the contractions produced by different concentrations of French origan and ACh 10-3 M. That is why, the evaluated tablets present an agonist and antagonist effect of the cholinergic transmission.
Constituintes voláteis de Mentha pulegium L. e Plectranthus amboinicus (Lour.) Spreng
Oliveira, R.A;Sá, I.C.G;Duarte, L.P;Oliveira, F.F;
Revista Brasileira de Plantas Medicinais , 2011, DOI: 10.1590/S1516-05722011000200007
Abstract: this work investigated the chemical composition of the essential oils of two medicinal plants grown in ilhéus municipality, bahia state, brazil: plectranthus amboinicus (lour.) spreng (mexican mint) and mentha pulegium l. (pennyroyal). the essential oils were extracted from fresh leaves by hydrodistillation and analyzed by gc-fid and gc-ms, in the spring and in the winter. in both seasons, p. amboinicus yielded 0.10% oil and had thymol as major component. m. pulegium yielded 0.20% and 0.09% oil in the spring and winter, respectively. the major components were pulegone and trans-caryophyllene, whereas borneol, menthol and piperitone were identified at small quantities. higher menthol and isomenthol levels were detected in the winter. in addition, neoisomenthyl, menthyl and isomenthyl acetates were only observed in the winter. this work contributes to the knowledge of plant species grown in southern bahia
Variability in growth, nutrition and phytochemical constituents of Plectranthus amboinicus (Lour) Spreng. as influenced by indigenous arbuscular mycorrhizal fungi
Sevanan Rajeshkumar
Maejo International Journal of Science and Technology , 2008,
Abstract: A study was conducted under greenhouse nursery condition on the efficacy of seven indigenous arbuscular mycorrhizal (AM) fungi in the improvement of growth, biomass, nutrition and phytochemical constituents, namely total phenols, ortho dihydroxy phenols, flavonoids, alkaloids, tannins and saponins, in the roots and leaves of Plectranthus amboinicus (Lour) Spreng. Seedlings were raised in polythene bags containing soil inoculated with isolates of seven different indigenous AM fungi, viz. Acaulospora bireticulata, A. scrobiculata, Gigaspora margarita, Glomus aggregatum, G. mosseae, G. geosporum, and Scutellospora heterogama. P. amboinicus seedlings raised in the presence of AM fungi generally showed an increase in plant growth, nutritional status and phytochemical constituents over those grown in the absence of AM fungi. The extent of growth, biomass, nutritional status and phytochemical constituents enhanced by AM fungi varied with the species of AM fungi inhabiting the roots and leaves of P. amboinicus seedlings. Considering the various plant growth parameters, nutritional status of the plant, total phenols, ortho dihydroxy phenols, alkaloids , flavonoids , tannins, and saponins in the roots and leaves, it was observed that Gigaspora margarita is the best AM symbiont for P. amboinicus used in this experiment.
Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo
Yung-Jia Chiu,Tai-Hung Huang,Chuan-Sung Chiu,Tsung-Chun Lu,Ya-Wen Chen,Wen-Huang Peng,Chiu-Yuan Chen
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/508137
Abstract: Plectranthus amboinicus (Lour.) Spreng. is a native Labiatae plant of Taiwan. The plants are commonly used in Chinese folk medicine for the treatment of cough, fever, sore throats, mumps, and mosquito bite. The aim of this study was to investigate the analgesic and antiinflammatory properties of the aqueous extract from Plectranthus amboinicus (PA) in vivo and in vitro. PA inhibited pain induced by acetic acid and formalin, and inflammation induced by carrageenan. The anti-inflammatory effect of PA was related to modulating antioxidant enzymes' activities in the liver and decreasing the Malondialdehyde (MDA) level and the production of tumor necrosis factor alpha (TNF-α), and cyclooxygenase2 (COX-2) in edema-paw tissue in mice. In vitro studies show that PA inhibited the proinflammatory mediators in RAW 264.7 cells stimulated with lipopolysaccharide (LPS). PA blocked the degradation of IκB-α and nuclear translocation of NF-κB p65 subunit. Finally, the amount of carvacrol in the aqueous extract of PA was 1.88 mg/g extract. Our findings suggest that PA has analgesic and anti-inflammatory activities. These effects were mediated by inhibiting the proinflammatory mediators through blocking NF-κB activation. Meanwhile, the effects observed in this study provide evidence for folkloric uses of Plectranthus amboinicus (Lour.) Spreng. in relieving pain and inflammation.
Efecto de Plectranthus amboinicus (Lour.) Spreng. tabletas sobre la anafilaxia pasiva cutánea, transmisión histaminérgica y adrenérgica Effect of Plectranthus amboinicus (Lour.) Spreng tablets on the passive cutaneous anaphylaxis, histaminergic and adrenergic transmission.
Yanier Nu?ez Figueredo,Juana Tillán Capó,Carmen Carrillo Domínguez,Rosa Menéndez Castillo
Revista Cubana de Plantas Medicinales , 2006,
Abstract: Plectranthus amboinicus (Lour.) Spreng., más conocido en nuestro país como orégano francés, es una planta a la que se le confieren una gran cantidad de propiedades terapéuticas para el tratamiento de diferentes enfermedades dentro de las que se encuentra el asma bronquial. En el presente trabajo se realizó la evaluación de las tabletas 100 mg de Plectranthus amboinicus sobre la anafilaxia pasiva cutánea y la transmisión adrenérgica e histaminérgica. Como resultado final de este trabajo pudimos comprobar que Plectranthus amboinicus tabletas de 100 mg inhibe la anafilaxia pasiva cutánea, potencia la transmisión adrenérgica e inhibe los efectos de la histamina cuando esta interactúa con los receptores H1 presentes a nivel intestinal. Podemos concluir que las tabletas de 100 mg de Plectranthus amboinicus podrían emplearse en el tratamiento de enfermedades alérgicas tipo I y con esto justificar el uso popular de la planta en el asma bronquial. Plectranthus amboinicus (Lour.) Spreng, well-known in our country as French origan, is a plant with many therapeutical properties for the treatment of different diseases, including bronchial asthma. In the present paper, the effect of Plectranthus amboinicus tablets (100 mg) on the passive cutaneous anaphylaxis and on the adrenergic and histaminergic transmission was evaluated. As a final result of this paper, it was possible to confirm that these tablets inhibit the passive cutaneous anaphylaxis, potentiates the adrenergic transmission, and inhibits the effects of histamine when it interacts with H1 receptors present at the intestinal level. It was concluded that the Plectranthus amboinicus tablets 100 mg could be used in the type I treatment of allergic diseases, and thus justify the popular use of this plant for bronchial asthma.
Actividad expectorante de formulaciones a partir de Plectranthus amboinicus (Lour) Spreng (orégano francés) Expectorant activity of formulations from Plectrantus amboinicus (Lour) Spreng (French oregano)
Pedro Barzaga Fernández,Juana Tillán Capó,Gisela Marrero Cofi?o,Carmen Carrillo Domínguez
Revista Cubana de Plantas Medicinales , 2009,
Abstract: INTRODUCCIóN: Plectranthus amboinicus (Lour) Spreng, es una especie vegetal de amplio uso popular por sus propiedades antiasmáticas, broncodilatadoras y anticatarrales. OBJETIVO: evaluar el efecto expectorante de varias formulaciones. MéTODOS: se ensayaron los efectos de extractos, jarabes y tabletas obtenidas a partir de partes aéreas secas de Plectranthus amboinicus (Lour) Spreng mediante el método de coloración con rojo fenol de la secreción traqueobronquial en ratones. RESULTADOS: la administración de extracto acuoso y extracto fluido, así como de los jarabes obtenidos de los extractos, produjeron incrementos significativos de la concentración de rojo fenol en la secreción traqueobronquial de ratón. Tanto el extracto acuoso como el hidroalcohólico presentan actividad expectorante; el jarabe preparado con extracto acuoso fue efectivo a dosis de 50 mL/kg, con una dosis efectiva media de 41,91 mL/kg; el jarabe preparado con extracto fluido fue efectivo a dosis de 50 y 37,5 mL/kg, con dosis efectiva media de 34,64 mL/kg; y las tabletas de 100 mg ejercieron efecto expectorante a las dosis de 34 y 68 mg/kg. A su vez la administración aguda de tabletas de 100 mg ejerció un efecto expectorante, similar al de la bromhexina y el salbutamol. CONCLUSIONES: las formulaciones mostraron efecto expectorante en las condiciones experimentales del estudio. INTRODUCTION: Plectranthus amboinicus (Lour) Spreng is a widely used vegetable species because of its antiasthma, bronchodilating and antiflu properties. OBJECTIVES: to evaluate the expectorant effect of several formulations. METHODS: the effects of extracts, syrups and tablets obtained from Plectranthus amboinicus (Lour) Spreng dry leaves through the staining method using tracheobronchial secretion red phenol in mice. RESULTS: the administration of aqueous extract and of fluid extract as well as the syrups produced from the extracts resulted in significant increase of red phenol concentration in the tracheobronchial secretion of mice. Both the aqueous and the hydroalcohol extracts have expectorant activity; the aqueous extract-made syrup was effective at 50 mL/kg dose, with an effective mean dose of 41,91 ml/kg; fluid extract-made syrup was effective at 50 and 37,5 mL/kg, being 34,64 mL/kg the effective mean dose and finally 100 mg tablets showed their expectorant action at doses of 34 and 68 mg/kg. In turn, the acute administration of 100mg tablets had the same expectorant effect as bromhexine and salbutamol. CONCLUSIONS: these formulations showed some expectorant effect under the experimental conditions of the st
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