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GROSS TOXICITIES AND HEPATOPROTECTIVE EFFECT OF ALOE VERA (L) BURM.F
Nuzhat Sultana,Rahila Najam
International Research Journal of Pharmacy , 2012,
Abstract: Traditional herbal drugs have a great demand in under developed countries due to their efficacy, low cost and lesser adverse effects, and they are considered to be “natural. Aloe vera at the dose of 500 mg body weight per oral was studied for the gross toxicities and hepatoprotective effect and observed the level of liver biochemical parameters in rabbits. Aloe vera showed highly significant (p<0.001) hepatoprotective effect by lowering the serum levels of serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvates transaminase (SGPT) and direct bilirubin. The overall experimental results suggests that Aloe vera protects the liver from oxidative stress and inhibits the excessive free radicals accumulation and possessing many hepatoprotective phytoconstituents which are biologically active such as flavonoids, alkaloids, they may be responsible for the significant hepatoprotective activity and the results justify the use of Aloe vera as a hepatoprotective agent.
Caracterización morfoanatómica comparativa entre Aloe vera (L.) Burm. F., Aloe arborescens Mill., Aloe saponaria Haw. y Aloe ciliaris Haw. (Aloeaceae)
Carpano, Stella Maris;Castro, María Teresa;Spegazzini, Etile Dolores;
Revista Brasileira de Farmacognosia , 2009, DOI: 10.1590/S0102-695X2009000200015
Abstract: aloe vera (l.) burm. f. (= aloe barbadensis miller) known as "the plant of immortality" in ancient egypt is used in phytotherapy as moisturizer, antibacterial, antifungal, antiviral and antioxidant. in argentina it grows in the form adventitious or cultivated, aloe arborescens mill., aloe saponaria haw. and aloe ciliaris haw. (aloaceae). in order to contribute to the identification of the drug plant the morphoanatomical characterization of the leaf was carried out. these species were studied with optical microscopy and scanning electron microscopy and the histochemical characteristics were studied in order to identify the active compounds. morphoanatomical characteristics of these species were determined through lineal and proportional (stomatal index) parameters.
Obtención de Antraquinona contenida en el exudado de Aloe Vera (L.) Burm. f. (Zábila) Anthraquinone obtention from Aloe Vera (L.) Burm. f. Exudate
Oswaldo Saavedra,Carlos Rondón,Máximo Gallignani,Carlos Ayala
Revista del Instituto Nacional de Higiene Rafael Rangel , 2012,
Abstract: La investigación tuvo como propósito obtener la antraquinona contenida en el exudado de Aloe vera (L.) Burm.f. (zábila) mediante el método de cristalización y su identificación mediante la técnica de espectrofotometría de radiación infrarroja. La muestra la conformaron 18 plantas de zábila, recolectadas al oeste de la ciudad Santa Ana de Coro, estado Falcón. Se utilizaron tres métodos para la obtención de antraquinona a partir del exudado de zábila. En el método A, la antraquinona se obtuvo por descenso de la temperatura; en el método B, las muestras fueron liofilizadas y luego se disminuyó la temperatura; y en el método C, la antraquinona se obtuvo mediante un modificador de matriz. Con el método A se obtuvo un rendimiento de antraquinona de 7,65 ± 4,62% p/p; con el método B 5,74 ± 3,25 % p/p y con el método C 25,93 ± 1,49% p/p. El mayor rendimiento de antraquinona se obtuvo con el método de precipitación mediante modificador de matriz. The purpose of this wok was obtain the anthraquinone from Aloe vera exudate applying method by crystallization and identifies it through spectrophotometric infrared and ultraviolet- visible techniques. The sample were 18 plants of Aloe vera, recollected at west of Coro city, Falcón state. It was used 3 methods to obtain anthraquinone from Aloe vera exudate. In the method A, anthraquinone was obtained by temperature descend; in the method B, the samples were lyophilized and temperature descends; and in the method C, anthraquinone was obtained by matrix modifier. With the method A it was obtained 7,65 ± 4,62% w/w of anthraquinone; with method B 5,74 ± 3,25 % w/w and with the method C 25,93 ± 1,49% w/w. The method with the best efficiency to obtain anthraquinone was the method C.
Determinación de macro elementos en exudado de hojas de zábila (Aloe vera (L.) Burm. f.) Macroelements determination in zabila leaves exudate (Aloe vera (L.) Burm. f.)
Oswaldo R Saavedra A,Carlos E Rondón
Revista del Instituto Nacional de Higiene Rafael Rangel , 2010,
Abstract: El Aloe vera (L.) Burm. f. (zábila) es una planta utilizada por sus propiedades medicinales, la parte utilizada de esta planta es su hoja, de ésta se extraen dos componentes: los cristales y el exudado. En esta investigación se estudió la concentración de macro elementos presentes en el exuda-do de hojas de zábila, a saber: sodio (Na), calcio (Ca), magnesio (Mg) y potasio (k) por espectrometría de absorción atómica en llama (FAAS). Las plantas estudiadas fueron cultivadas en la ciudad de Coro, estado Falcón. Las muestras compuestas de exudado se recolectaron en hojas ubi-cadas en las posiciones bajas, medias y superiores de las plantas. Luego se secaron por liofilización, y se mineralizaron: 0.25 g de muestra de exudado se sometieron a digestión ácida, con 1:2 HNO3 concentrado y H2O2 en plancha de calentamiento. Se utilizó material certificado NIST 1572, USA: Hojas de plantas cítricas, para evaluar la exactitud del método, no encontrándose diferencias estadísticamente significativas (p <0.05) entre los valores del material de referencia con los valores obtenidos con el método aplicado en esta investigación. El promedio de la desviación estándar relativa (RSD) fue de 1.41%, lo que certifica la precisión del método empleado. Las concentraciones de los macro elementos encontradas fueron: Na: 0.24 ± 0,03% p/p, k: 0.69 ± 0,13% p/p, Ca: 0.07 ± 0,01% p/p y Mg: 0.01 ± 0,00% p/p. El método empleado para determinar la concentración de Na, Ca, Mg y k en muestras de exudado de zábila por FAAS fue exacto, preciso y libre de interferencias. The objective of this work was to determine the metals in Aloe vera (L.) Burm. f. (zabila). Theses metals are necessary in the human organism; namely: Na, k, Ca y Mg. It was digested for 1 hour in a hot plate at 70 oC 0.25 g of lyo-philized exudate with 1:2 nitric acidic and hydrogen peroxi-de. It was no found significatives statistics differences at 95% of confidence between the standard calibration curve and the aqueous calibration curve, so no matrix effect was observed. The recovery studies was satisfactory, the mean value was 99.77 ± 2%. It was no found significatives statistics differences at 95% of confidence between the certificated values (NBS: Citrics leaves 1572) of studied metals and the values found with the applied methodology. The concentrations of these elements in the real composed samples were: Na: 0.24 ± 0,03% w/w; k: 0.69 ± 0,13% w/w; Ca: 0.07 ± 0,01% w/w; Mg: 0.01 ± 0,00% w/w. The method used to determine the determined elements was exact, pre-cise and free from interferences.
Espermidina e espermina exogena na micropropaga??o de Aloe vera (L.) Burm
Mógor,Gilda; Pace Pereira Lima,Giuseppina; Mogor,Atila;
Revista Cubana de Plantas Medicinales , 2007,
Abstract: the lateral shoots of the aloe vera l. burm have been inoculated in culture medium. the work has been divided in two phases. in the phase i different concentrations of naa and bap were added to the ms . in the phase ii, plants proceeding of the ms were inoculated in medium containing or not spermidine and/or spermine. in the phase i the best results for mass production and shooting came out with the use of ms + 8,88 m mol l -1 bap + 5,36 m mol l -1 naa and these treatments didn′t induce the rooting. plants submitted to treatments with polyamines presented emission of roots during the phase ii, suggesting possible inductor effect when used by isolated means during the rooting. no traces of oxidation were noted in the culture medium containing the polyamines. the use of spermidine in the culture-medium promoted a greater mass increasing and the most number of shoots was obtained with the use of the combination of polyamines.
Efecto del extracto acuoso de Aloe vera (L.) N. L. Burm. sobre indicadores lipídicos de suero de conejo
Tillán Capó,Juana; Fernández Nieves,Marjorie; Menéndez Castillo,Rosa; Carrillo Domínguez,Carmen; Pérez González,Dariel;
Revista Cubana de Plantas Medicinales , 2008,
Abstract: introduction: the research works conducted with water extract and gel from aloe vera (l.) n. l. burm., administered to mice in a triton-induced acute hyperlipidemia pattern, showed a protective effect against the increase of lipids. objetives: to study the effect of administration of water extract from a. vera at repeated doses on the lipid indicators of rabbit serum. methods: male new zealand rabbits were treated with water extracts from aloe vera at doses of 17 and 34 mg/kg of bodyweight, on the basis of whole solids for 6 weeks. an untreated control group was included. body weight, total cholesterol, hdl-cholesterol, ldl cholesterol and triglycerides were determined at the beginning and at the end of the experimental period. results: it was found that cholesterol, ldl cholesterol and triglycerides significantly decreased in serum of animals treated with 34 mg/kg dose of the water extract at the end of the experiment, however, the hdl-cholesterol did not show any variation. conclusions: the administration of water extract from aloe vera to a rabbit for 6 weeks significantly reduced serum lipids.
Efecto del extracto acuoso de Aloe vera (L.) N. L. Burm. sobre indicadores lipídicos de suero de conejo Effect of the water extract from Aloe vera (L.) N. L. Burm. on rabbit serum lipids
Juana Tillán Capó,Marjorie Fernández Nieves,Rosa Menéndez Castillo,Carmen Carrillo Domínguez
Revista Cubana de Plantas Medicinales , 2008,
Abstract: INTRODUCCIóN: trabajos realizados con extracto acuoso y gel hojas de Aloe vera (L.) N. L. Burm., administrados a ratones en un modelo de hiperlipidemia aguda inducida con tritón, demostraron un efecto protector al incremento de los lípidos. OBJETIVOS: estudiar el efecto de la administración a dosis repetida de extracto acuoso de A. vera sobre los indicadores lipídicos de suero de conejo. MéTODOS: conejos machos Nueva Zelandia fueron tratados con extractos acuosos de A. vera a las dosis de 17 y 34 mg/kg de peso corporal, sobre la base de sólidos totales durante 6 semanas, también se incluyó un grupo control sin tratamiento, el peso corporal, colesterol total, HDL-colesterol, LDL colesterol y triglicéridos fueron determinados al inicio y al final del período del experimento. RESULTADOS: se encontró una disminución significativa del colesterol, LDL colesterol y triglicéridos en suero de los animales tratados con la dosis de 34 mg/kg de extracto acuoso al final del experimento, pero el HDL-colesterol no mostró variaciones. CONCLUSIóN: la administración de extracto acuoso de A. vera a conejo durante 6 semanas causó una disminución significativa de los lípidos en suero. INTRODUCTION: the research works conducted with water extract and gel from Aloe vera (L.) N. L. Burm., administered to mice in a triton-induced acute hyperlipidemia pattern, showed a protective effect against the increase of lipids. OBJETIVES: to study the effect of administration of water extract from A. vera at repeated doses on the lipid indicators of rabbit serum. METHODS: male New Zealand rabbits were treated with water extracts from Aloe vera at doses of 17 and 34 mg/kg of bodyweight, on the basis of whole solids for 6 weeks. An untreated control group was included. Body weight, total cholesterol, HDL-cholesterol, LDL cholesterol and triglycerides were determined at the beginning and at the end of the experimental period. RESULTS: it was found that cholesterol, LDL cholesterol and triglycerides significantly decreased in serum of animals treated with 34 mg/kg dose of the water extract at the end of the experiment, however, the HDL-cholesterol did not show any variation. CONCLUSIONS: the administration of water extract from Aloe vera to a rabbit for 6 weeks significantly reduced serum lipids.
Efectos alelopáticos de Aloe vera (L.) N. L Burm. sobre otras especies de plantas medicinales en condiciones de laboratorio
Hechevarría Sosa,Isabel; Rodríguez González,Horacio; Mederos Mederos,Dagoberto;
Revista Cubana de Plantas Medicinales , 2003,
Abstract: allelopathic effects of aloe vera (l) n.l burm on other species of medicinal plants under laboratory conditions the allelopathic association among 7 species of cuban medicinal plants and aloe vera l.n. burm was studied under laboratory conditions. the interest was centered on the influence of residues of aloe and an aqueous extract of a gel 20 % of the same plant on the growth of medicinal species. the studied species were: calendula officinalis l., plantago lanceolata l., plantago major l., matricaria recutita l., ocimum gratissimum l., ocimum basilicum l. and ocimum tenuiflorum l seven experiments were made, one per species. every experiment was repeated 4 times and in all cases the length of the epicotyl and of the hypocotyl measured in cm and the corresponding dry mass measured in grams, obtained from the seeds of the associated plants and not from aloe, were compared. a simple variance analysis was carried out and the means of the indicators were compared with turkey's test, with a significance of 1 %. four species, calendula officinalis l., plantago lanceolata l., matricaria recutita l. and ocimum tenuiflorum l., had a limited growth in the epicotyl and hypocotyl, or in one of these two elements when they were associated with a. vera. in the epicotyl of p. lanceolata l. and in the hypocotyl of c. officinalis l., the greatest accumulations of dry mass were observed with the lowest growths. it is recommended to take into account the results obtained for field studies with the analyzed species.
Efectos alelopáticos de Aloe vera (L.) N. L Burm. sobre otras especies de plantas medicinales en condiciones de laboratorio
Isabel Hechevarría Sosa,Horacio Rodríguez González,Dagoberto Mederos Mederos
Revista Cubana de Plantas Medicinales , 2003,
Abstract: Se estudió la asociación alelopática entre 7 especies de plantas medicinales cubanas y Aloe vera (L.)N.L. Burm en condiciones de laboratorio. El interés se centró en la influencia de residuos de Aloe y un extracto acuoso de un gel al 20% de la misma planta sobre el crecimiento de las especies medicinales. Las especies estudiadas fueron: Calendula officinalis L., Plantago lanceolata L., Plantago major L., Matricaria recutita L., Ocimum gratissimum L., Ocimum basilicum L. y Ocimum tenuiflorum L. Se realizaron 7 experimentos, uno por cada especie. Cada experimento se repitió 4 veces y en todos los casos se comparó la longitud del epicótilo e hipocótilo medidos en centímetros y la masa seca correspondiente, medida en gramos, que se obtuvieron de las semillas de las plantas asociadas y no con el Aloe. Se realizó un análisis de varianza simple y las medias de los indicadores se compararon con la prueba de Turkey con un nivel de significación de 1%.Calendula officinalis L., Plantago lanceolata L., Matricaria recutita L. y Ocimum tenuiflorum L., tuvieron limitado su crecimiento en el epicótilo e hipocótilo o en uno de estos dos elementos cuando se asoció con A. vera. En el epicótilo de P. lanceolata L. y el hipocótilo de C. officinalis L., las mayores acumulaciones de masa seca ocurrieron con los menores crecimientos. Se recomienda tener en cuenta los resultados obtenidos para experimentos de campo con las especies estudiadas. Allelopathic effects of Aloe vera (L) N.L Burm on other species of medicinal plants under laboratory conditions The allelopathic association among 7 species of Cuban medicinal plants and Aloe vera L.N. Burm was studied under laboratory conditions. The interest was centered on the influence of residues of Aloe and an aqueous extract of a gel 20 % of the same plant on the growth of medicinal species. The studied species were: Calendula officinalis L., Plantago lanceolata L., Plantago major L., Matricaria recutita L., Ocimum gratissimum L., Ocimum basilicum L. and Ocimum tenuiflorum L Seven experiments were made, one per species. Every experiment was repeated 4 times and in all cases the length of the epicotyl and of the hypocotyl measured in cm and the corresponding dry mass measured in grams, obtained from the seeds of the associated plants and not from Aloe, were compared. A simple variance analysis was carried out and the means of the indicators were compared with Turkey's test, with a significance of 1 %. Four species, Calendula officinalis L., Plantago lanceolata L., Matricaria recutita L. and Ocimum tenuiflorum L., had a limited growt
ALTERATIONS IN NEUROBEHAVIORAL AND BRAIN NEUROTRANSMITTERS BY ALOE VERA (L.) BURM.F AND VITAMIN E  [PDF]
Nuzhat Sultana,Rahila Najam
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: The purpose of the study was to detect the concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT)), and their metabolites (3, 4-hydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in mice brain after the long-term administration of Aloe vera (leaf gel) and vitamin E. Control group was treated with 0.9% saline and treated groups were administered Aloe vera leaf gel (500 mg/70kg) and vitamin E (400 IU/70 kg) orally according to the body weight of mice for 30 days daily. After the administration of drug, all groups of animals were killed by decapitation and samples of brain were removed and analyzed after homogenization. Significant changes and alterations in brain biogenic amines can be suggested that the drugs may have potential and use for the treatment of psychotropic diseases and anxiety.
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