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Antimicrobial activity of the essential oil of Sida cordifolia L.
Nunes, Xirley Pereira;Maia, Gabriela Lemos de Azevedo;Almeida, Jackson Roberto Guedes da Silva;Pereira, Fillipe de Oliveira;Lima, Edeltrudes de Oliveira;
Revista Brasileira de Farmacognosia , 2006, DOI: 10.1590/S0102-695X2006000500010
Abstract: the analysis of the antimicrobial activity of the essential oil of sida cordifolia was evaluated with four different strains of bacteria and nine fungi. the essential oil was tested "in natura" (100 %) and diluted from 32 until 2 %. the microorganisms, bacteria and fungi, were spread in agar muller-hinton and sabouraud dextrose, respectively. s. cordifolia showed inhibitory activity against the microorganisms tested with efficacy of 80 %. when tested against staphylococcus aureus, staphyllococus epidermidis, candida guilliermondii and trichosporon inkin the essential oil showed the best performance.
Toxicity assessment and analgesic activity investigation of aqueous acetone extracts of Sida acuta Burn f . and Sida cordifolia L. (Malvaceae), medicinal plants of Burkina Faso
Konaté Kiessoun,Bassolé Ima?l Henri,Hilou Adama,Aworet-Samseny Ra?ssa RR
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-120
Abstract: Background Sida acuta Burn f. and Sida cordifolia L. (Malvaceae) are traditionally used in Burkina Faso to treat several ailments, mainly pains, including abdominal infections and associated diseases. Despite the extensive use of these plants in traditional health care, literature provides little information regarding their toxicity and the pharmacology. This work was therefore designed to investigate the toxicological effects of aqueous acetone extracts of Sida acuta Burn f. and Sida cordifolia L. Furthermore, their analgesic capacity was assessed, in order to assess the efficiency of the traditional use of these two medicinal plants from Burkina Faso. Method For acute toxicity test, mice were injected different doses of each extract by intraperitoneal route and the LD50 values were determined. For the subchronic toxicity evaluation, Wistar albinos rats were treated by gavage during 28 days at different doses of aqueous acetone extracts and then haematological and biochemical parameters were determined. The analgesic effect was evaluated in mice by the acetic-acid writhing test and by the formalin test. Results For the acute toxicity test, the LD50 values of 3.2 g/kg and 3.4 g/kg respectively for S. acuta Burn f. and S. cordifolia L. were obtained. Concerning the haematological and biochemical parameters, data varied widely (increase or decrease) according to dose of extracts and weight of rats and did not show clinical correlations. The extracts have produced significant analgesic effects by the acetic acid writhing test and by the hot plate method (p <0.05) and a dose-dependent inhibition was observed. Conclusion The overall results of this study may justify the traditional uses of S. acuta and S. cordifolia .
Evaluation of the cardiovascular effects of vasicine, an alkaloid isolated from the leaves of Sida cordifolia L. (Malvaceae)
Silveira, A.L.;Gomes, M.A.S.;Silva Filho, R.N.;Santos, M.R.V.;Medeiros, I.A.;Barbosa Filho, J.M.;
Revista Brasileira de Farmacognosia , 2003, DOI: 10.1590/S0102-695X2003000400012
Abstract: the cardiovascular effects of vasicine, an alkaloid isolated from the leaves of sida cordifolia l., were evaluated in this work. in non-anaesthetized rats (n=6), vasicine (1, 2.5, 5 and 10 mg/kg; i.v., randomly) induced hypotension associated with an intense bradycardia. both responses were completely abolished after atropine (2mg/kg; i.v.) and attenuated after hexamethonium (20 mg/kg; i.v.). in isolated rat mesenteric artery rings, vasicine (0.03, 0.1, 0.3, 1, 3, 10, 30, 100 and 300 μg/ml, cumulatively) induced concentration-dependent relaxation of phenylephrine-induced tone (ic50= 3.8±0.9 μg/ml; n = 6). in conclusion, the results show that vasicine produce hypotension and bradycardia which appears to be due to the stimulation of cardiac muscarinic receptors (directly and/or indirectly), and by a decrease of the peripheral resistances.
Free radical scavenging capacity, anticandicidal effect of bioactive compounds from Sida Cordifolia L., in combination with nystatin and clotrimazole and their effect on specific immune response in rats
Ouédraogo Maurice,Konaté Kiessoun,Lepengué Alexis Nicaise,Souza Alain
Annals of Clinical Microbiology and Antimicrobials , 2012, DOI: 10.1186/1476-0711-11-33
Abstract: Background Infectious diseases caused by fungi are still a major threat to public health, despite numerous efforts by researchers. Use of ethnopharmacological knowledge is one attractive way to reduce empiricism and enhance the probability of success in new drug-finding efforts. In this work, the total alkaloid compounds (AC) from Sida cordifolia L. (Malvaceae) have been investigated for their free radical scavenging capacity, antifungal and immunostimulatory properties. Method The antifungal activity was investigated against five candida strains using the microplate dilution method and the Fractional Inhibitory Concentration Index (FICI) of compounds was evaluated. The antioxidant activity of the samples was evaluate using three separate methods, at last, the immunostimulatory effect on immunosuppressed wistar rats was performed. Results As for the antifungal activity, result varied according to microorganism. The results obtained in this antifungal activity were interesting and indicated a synergistic effect between alkaloid compounds and the antifungal references such as Nystatin and Clotrimazole. Antioxidant capacity noticed that the reduction capacity of DPPH radicals obtained the best result comparatively to the others methods of free radical scavenging. Our results showed a low immunostimulatory effect and this result could be explained by the lack of biologically active antioxidants such as polyphenol compounds lowly contained in the alkaloid compounds. Conclusion The results of this study showed that alkaloid compounds in combination with antifungal references (Nystatin and Clotrimazole) exhibited antimicrobial effects against candida strains tested. The results supported the utilization of these plants in infectious diseases particularly in treatment of candida infections.
Antistress, adoptogenic activity of Sida cordifolia roots in mice  [cached]
Sumanth Meera,Mustafa S
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: Ethanol extract of roots of Sida cordifolia was evaluated for antistress, adaptogenic activity using cold restraint stress and swim endurance in mice. Mice pretreated with extract of Sida cordifolia showed significant improvement in the swim duration and reduced the elevated WBC, blood glucose and plasma cortisone.
Serasanambati Mamatha Reddy,Challa Krishna Kumari,Chilakapati Shanmuga Reddy,Yakkanti Raja Ratna Reddy
International Research Journal of Pharmacy , 2012,
Abstract: The antimicrobial activity of Sida cordifolia leaf extracts (aqueous and methanolic) on pathogenic bacteria (Staphylococcus aureus, Enterococcus fecalis, Pseudomonas aeruginosa, and Proteus mirabilis) and fungi (Candida albicans and Cryptococcus neoformans) was tested by disc diffusion method. The aqueous extract was found to be moderately effective against bacteria and exhibited high antifungal activity at a concentration of 2mg/disc. The methanolic extract was effective on bacteria and did not show any antifungal activity. Acetone fraction did not contain any antimicrobial activity. Increasing concentrations of the extracts (aqueous and methanolic) exhibited increased zone of inhibition against the bacteria and fungi (7-20mm). Our results suggest that aqueous extracts of Sida cordifolia leaves show high antimicrobial activity and contains phytochemicals that are responsible for such an activity. Further analysis of the extracts to isolate and identify the phytochemicals from Sida cordifolia will be helpful to test the therapeutic potential and industrial applications.
Estimativa da área foliar de Sida cordifolia e Sida rhombifolia usando dimens?es lineares do limbo foliar
Bianco, S.;Carvalho, L.B.;Bianco, M.S.;
Planta Daninha , 2008, DOI: 10.1590/S0100-83582008000400012
Abstract: leaf area estimate may contribute to understand the relationship of interference between weeds and crops. the objective of this research was to obtain a mathematical equation to estimate sida cordifolia and sida rhombifolia leaf area based on linear measures of leaf blade. correlation studies were conducted between real leaf area (af) and dimensional leaf blade parameters such as leaf length (c) and maximum leaf width (l). around 200 leaf blades of each species were analyzed, collected from several agro-ecosystems at s?o paulo state university, in jaboticabal, sp, brazil. the statistical models evaluated were: linear y = a + bx; simple linear y = bx; geometric y = axb; and exponential y = abx. all the evaluated models can be used for s. cordifolia and s. rhombifolia leaf area estimation. for practical purposes, the simple linear regression model is suggested using the c*l multiplication product and taking the linear coefficient equal to zero. thus, an estimate of s. cordifolia leaf area can be obtained using the equation af = 0.7878*(c*l) with a determination coefficient of 0.9307 and s. rhombifolia leaf area by using the equation af = 0.6423*(c*l) with a determination coefficient of 0.9711.
Effect of the aqueous extract of Sida cordifolia on liver regeneration after partial hepatectomy
Silva, Renata Lemos;Melo, Gustavo Barreto de;Melo, Valdinaldo Arag?o de;Antoniolli, ?ngelo Roberto;Michellone, Paulo Roberto Teixeira;Zucoloto, Sérgio;Picinato, Maria Aparecida Neves Cardoso;Franco, Clarice Fleury Fina;Mota, Gustavo de Assis;Castro e Silva, Orlando de;
Acta Cirurgica Brasileira , 2006, DOI: 10.1590/S0102-86502006000700009
Abstract: purpose: the use of medicinal plants for the treatment of human diseases has increased worldwide. many of them are used by oral administration and, after absorption, may affect many organs. therefore, this study aimed at assessing the effects of the aqueous extract of sida cordifolia leaves, popularly known in brazil as "malva-branca", on liver regeneration. methods: twenty rats were divided into four groups: control, sida100, sida200 and sida400 groups. all animals were submitted to oral administration of distilled water, 100, 200 and 400 mg/kg of the aqueous extract of sida cordifolia, respectively. immediately after this, they underwent 67% partial hepatectomy. twenty four hours later, their livers were removed. hepatic regeneration was assessed by immunohistochemical staining for proliferating cell nuclear antigen (pcna) using the pc-10 monoclonal antibody. results: sida100 and sida200 groups disclosed higher liver regeneration indices than control group (p<0.001 and p<0.05, respectively). conclusion: the aqueous extract of sida cordifolia stimulates liver regeneration after 67% partial hepatectomy in rats.
Pharmacognostic Studies on Indian Madder (Rubia cordifolia L.)  [PDF]
Devi Priya M,E.A. Siril
Journal of Pharmacognosy and Phytochemistry , 2013,
Abstract: ‘Indian Madder’ (Rubia cordifolia L.) has wide range of pharmacological properties. In the present study, an attempt was made to identify the pharmacognostic features of various parts of R. cordifolia to differentiate it from adulterants. The organoleptic characters, proximate analysis, physio-chemical behavior of powders were recorded. The stomatal index, palisade ratio and ash value were shown to be characteristic under standard conditions. Opticalactivity of various R. cordifolia extracts under visible and UV light (254 nm and 366 nm) were recorded. Phytochemical studies revealed the presence of anthraquinone and other metabolites in different plant parts. Powder analysis showed trace red colour in root powder under most of the standard test conditions. Phytochemical and pharmacognostic records evolved in the present study can be used for framing standard parameters for the proper identification of raw materials of R. cordifolia.
Analgesic and Anti-inflammatory Principle from Sida cordifolia Linn  [PDF]
Ranajit Kumar Sutradhar,AKM Matior Rahman,Mesbahuddin Ahmad,Sitesh Chandra Bachar
Journal of Biological Sciences , 2006,
Abstract: A new flavonol glycoside, 3`-(3``,7``-dimethyl- 2``,6``-octadiene)-8-C- -D-glucosyl-kaempferol 3-O- -D-glucoside[1], isolated from Sida cordifolia Linn. was investigated for analgesic and anti-inflammatory activities in animal models. In the acetic acid induced writhing model, the drug at a dose of 25 and 50 mg kg-1 body weight showed statistically significant (p<0.0001) inhibition of writhing response of 25.12 and 52.30%, respectively. The drug also produced significant increase in the tail flick latency in a dose depended manner (r = 0.92) which were also statistically significant (p<0.0001). In carrageenan induced rat paw edema the compound produced 16.15 and 28.52% inhibition of paw edema at doses of 25 and 50 mg kg-1 body weight at the 3rd h of study.
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