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Posible relación entre el uso de isotretinoína y la presencia de globozoospermia
Pe?a,Ruth Beatriz; Cadavid,ángela; Cardona Maya,Walter;
Revista Cubana de Obstetricia y Ginecolog?-a , 2011,
Abstract: isotretinoin was tested for treatment of acne from 1982 and nowadays is used for treatment of a wide number of skin alterations. among the recommendations of the american academy of dermatology consensus conference is included the non-use of this treatment in pregnant women, however, it is not mentioned the potential risks in sexual and reproductive men health, group in which is commonly used for treatment of acne.
Successful pregnancies and a live birth after intracytoplasmic sperm injection in globozoospermia
Banker Manish,Patel Pravin,Joshi Bharat,Shah Preeti
Journal of Human Reproductive Sciences , 2009,
Abstract: Globozoospermia is a severe form of teratozoospermia characterized by round-headed acrosomeless spermatozoa. Here we present two successful pregnancies and a live birth after intracytoplasmic sperm injection.
Uso de medicamentos durante el embarazo y su posible efecto teratogénico Use of drugs during pregnancy and its possible teratogenic effect  [cached]
Noel Taboada Lugo,Roberto Lardoeyt Ferrer,Manuel S. López Cárdenas,Gretsy Arcas Ermeso
Revista Cubana de Medicina General Integral , 2004,
Abstract: Se realizó un estudio descriptivo en el área de salud Esperanza, del municipio Ranchuelo, provincia Villa Clara. Se incluyeron 82 embarazadas captadas entre los meses de octubre de 2002 y marzo de 2003. Nos propusimos describir los problemas de salud más frecuentes en las gestantes, la prescripción de medicamentos en ellas y su posible relación con la presencia de defectos congénitos en la descendencia. Las infecciones respiratorias altas y la anemia fueron los problemas de salud más frecuentes. Los medicamentos que con mayor frecuencia se prescribieron durante el embarazo fueron las tabletas prenatales, el fumarato ferroso, el ácido ascórbico, el ácido fólico y el toxoide tetánico. El mayor número de prescripciones fueron realizadas por los Médicos de Familia y el nivel de automedicación resultó bajo en las embarazadas estudiadas. No se comprobó relación alguna entre los medicamentos usados en la gestación y la aparición de defectos congénitos en la descendencia. A descriptive study was conducted at Esperanza health area, Ranchuelo muncipality, Villa Clara province. 82 pregnant women recruited between October 2002 and March 2003 were included. Our purpose was to describe the most frequent health problems in pregnant women, as well as drug prescription and its possible relation to the presence of congenital defects in the offspring. Upper respiratory infections and anemia were the commonest health problems. The most frequently prescribed drugs were prenatal pills, ferrous fumarate, ascorbic acid, folic acid and tetanus toxoid. Most of the prescriptions were made by family physicians and the selfmedication level was low in the studied pregnant women. No relation was found between the drugs used during pregnancy and the appareance of congenital defects in the descendants.
Hypoacusia in a Patient Treated by Isotretinoin
L. Rosende,M. M. Verea-Hernando,A. de Andrés,F. Pi eyro-Molina,J. Barja,S. Castro-Castro,E. Fonseca
Case Reports in Medicine , 2011, DOI: 10.1155/2011/789143
Abstract: Isotretinoin is the most effective treatment for severe acne, but there are several adverse effects associated with its use, some of them very exceptional (<1/10000). We report one case of hypoacusia and tinnitus in a 15-year-old boy treated with isotretinoin during 6 weeks, who quickly improved after isotretinoin withdrawal. Also, we comment other publications about hearing alterations in patients treated with isotretinoin and other retinoids.
Isotretinoin and psychopathology: a review
Vassilis P Kontaxakis, Demetris Skourides, Panayotis Ferentinos, Beata J Havaki-Kontaxaki, George N Papadimitriou
Annals of General Psychiatry , 2009, DOI: 10.1186/1744-859x-8-2
Abstract: Retinoids represent a family of compounds that includes vitamin A, its derivatives and synthetic molecules that are chemically related to vitamin A. Isotretinoin (13-cis retinoic acid) is a synthetic oral retinoid that is used against severe, recalcitrant, nodulocystic acne, not responding to other therapies. It was introduced into the market as Accutane, by Hoffman-La Roche, in 1982, mainly in an attempt to improve biological activity and minimise the side effects of vitamin A compounds that were used as an effective acne treatment prior to the development of isotretinoin. It is also used for a number of other dermatological diseases such as psoriasis, ichthyasis, dermatological lesions in systemic lupus erythematosus, in the prevention of various types of skin cancer, or even as adjunctive therapy of acute promyelocytic leukemia. The side effect profile of isotretinoin includes skeletal system symptoms (arthralgia, osteoporosis), haematological (pancytopenia), ocular (corneal opacities conjunctivitis, optic neuritis, cataract) and dermatological symptoms (mild acne flare, rash, skin peeling, alopecia, photosensitivity) as well as hyperlipidemia [1-3]. Isotretinoin is also considered highly teratogenic and is classified as US Food and Drug Administration (FDA) Pregnancy category X [3]. Its use is therefore contraindicated during pregnancy. In the USA, the FDA has recently introduced the iPledge programme in an attempt to minimise the risk of pregnancy in female patients receiving isotretinoin.Early after its release on the market, isotretinoin use was linked with psychiatric side effects such as depression, suicidal ideation and psychosis. The first report of psychiatric side effects came in 1982 by Meyskens, who had been using isotretinoin for patients with advanced cancer. He reported that 25% of his patients developed depressive symptomatology and suicidality [4]. In 1983, Hazen et al. reported depression in 6 of 110 patients treated for acne or a keratising dis
Posible presencia de un gen R1 en germoplasma de Solanum tuberosum Grupo Phureja  [cached]
Ballesteros Diana carolina,Gomez gustavo,Delgado Maria Cecilia,Alvarez Maria Fernanda
Agronomía Colombiana , 2010,
Abstract: Phytophthora infestans causa la gota, que es la enfermedad en la papa de mayor importancia económica a nivel mundial. La obtención de cultivares resistentes al patógeno es una estrategia necesaria para su control, por lo cual la identificación de genes de resistencia a P. infestans (Rpi) es fundamental para apoyar los programas de mejoramiento. La introgresión de Rpi desde especies silvestres o nativas dentro de cultivares es una vía para desarrollar cultivares con resistencia. S. phureja tiene notables características culinarias y nutricionales, e igualmente ha sido identificada como una fuente de resistencia a la gota, lo cual la sitúa en una posición de interés desde el punto de vista de recurso genético con fines de mejoramiento. Se caracterizaron genotípicamente 88 accesiones de S. phureja con marcadores moleculares tipo SCAR, el gen R1 de resistencia a P. infestans, el gen candidato StAOS2 y un marcador tipo CAPS ligados a loci para resistencia a P. infestans en Solanum tuberosum. Se presentó polimorfismo en los marcadores Prp1 y R1. La amplificación del marcador R1 mostró el alelo de 1.400 pb, característico del gen R1 en 17 accesiones de la colección de S. phureja, lo cual sugiere que estas accesiones posiblemente podrían tener un gen homólogo al gen R1 identificado en S. demissum.
Primer registro de un posible híbrido homoploide y de un tetraploide en el género Chaetanthera Ruiz & Pav. (Asteraceae) en Chile First report of a possible homoploid hybrid and a tetraploid in the genus Chaetanthera Ruiz & Pav. (Asteraceae) in Chile
CARLOS BAEZA PERRY,EDUARDO RUIZ,JAIME ESPEJO
Gayana. Botanica , 2012,
Abstract: En este trabajo se reportan cariotipos detallados de C. elegans Phil., C. x serrata Ruiz & Pav. y C. chilensis (Willd.) DC. Además, se registra por primera vez la presencia de un posible híbrido homoploide entre C. chilensis y C. elegans.y de un tetraploide en Chaetanthera elegans. Detailed karyotypes of C. elegans Phil., C. x serrata Ruiz & Pav. and C. chilensis (Willd.) DC. are given. In addition, the result of the present contribution are the first report of a possible homoploid hybrid between C. chilensis and C. elegans, and a tetraploid in Chaetanthera elegans.
Trombosis de seno venoso cerebral y posible asociación con anticuerpos antinucleares: Reporte de dos casos y revisión de la literatura Thrombosis of cerebral venous sinuses and possible association with antinuclear antibodies: A report of two cases and a review of the pertinent literature  [cached]
Hernán Cortés Y,Mauricio Herrera M,Mario Rebolledo A
Revista Colombiana de Obstetricia y Ginecología , 2008,
Abstract: Se presentan dos pacientes posparto, con antecedente de preeclampsia, que consultaron por cefalea y síntomas neurológicos, en quienes se diagnosticó trombosis de los senos venosos cerebrales, con una posible asociación a presencia de anticuerpos antinucleares. Se hace una revisión de la literatura de la trombosis de los senos venosos durante el posparto con énfasis en el diagnóstico y las recomendaciones del tratamiento con anticoagulantes. Se recomienda la terapia anticoagulante por tres a seis meses. En ambas pacientes descritas se presentó un aumento de los títulos de anticuerpos antinucleares, por lo que surge la hipótesis de una posible asociación causal. Two postpartum patients, having a history of preeclampsia, were presented. They had consulted because of cephalalgia and neurological symptoms being presented; the diagnosis was thrombosis of the cerebral venous sinuses, possibly associated with the presence of antinuclear antibodies. The literature regarding thrombosis concerning venous sinuses during the postpartum period was reviewed, placing special emphasis on diagnosis and instructions for treatment with anticoagulants. Three to six months’ anticoagulant treatment is recommended. Both patients presented increased antinuclear antibody titres, suggesting posible causal association.
ES POSIBLE MEJORAR LA CALIDAD NUTRICIONAL DE LOS ACEITES COMESTIBLES? IS IT POSSIBLE TO IMPROVE THE NUTRITIONAL QUALITY OF EDIBLE OILS?
Alfonso Valenzuela B.,Julio Sanhueza C.,Susana Nieto K.
Revista Chilena de Nutricíon , 2002,
Abstract: Los aceites comestibles constituyen un componente importante en nuestra alimentación y la variedad y el consumo de estos depende de la disponibilidad de cada país y región. La composición de los aceites no es estándar ya que varía considerablemente en el aporte de ácidos grasos saturados, monoinsaturados y poliinsaturados, y particularmente en el aporte de ácidos grasos omega-6 y omega-3. La nutrición en el mundo occidental se caracteriza por una elevada ingesta de ácidos grasos omega-6 y un bajo consumo de ácidos grasos omega-3, debido al origen mayoritariamente vegetal de los aceites que se producen y a la creciente tendencia a consumir aceites puros y refinados, ya que tienen una mejor imagen comercial. De esta forma, la relación omega-6:omega-3, es muy diferente a la que se recomienda. Es posible preparar aceites con relaciones omega-6:omega-3 muy cercanas a las recomendadas, simplemente desarrollando productos que contengan mezclas de aceites cuya composición final en ácidos grasos omega-6 y omega-3 puede ser mejorada. Del mismo modo, es posible conservar, o al menos retener, el contenido de tocoferoles, carotenoides, fitosteroles y de flavonoides los que se sustraen durante los procesos de refinación de los aceites. Estos compuestos, que corresponden a la fracción denominada insaponificable , también aportan importantes beneficios para la salud. Se propone que es posible desarrollar aceites nutricionalmente mas adecuados que los ya disponibles, con una mínima inversión y con un gran impacto para la salud nutricional Edible oils are important components of human foods and their variety and consumption depends on the availability in each country or region. Fatty acid composition of edible oils does not obey to a standard pattern because this composition is modified by the amount of saturated, monounsaturated, and polyunsaturated fatty acids, and particularly with the amount of omega-6 and omega-3 fatty acids. Western nutrition is characterized by the high ingestion of omega-6 fatty acids, and the low consumption of omega-3 fatty acids. This consumption pattern result from the wide availability of vegetable oils, and by the increasing consumption of pure and refined oils due to the commercial perception associated with these products. As a result of these practices, the omega-6: omega-3 consumption ratio is now very far from the nutritionally recommended ratio. Today it is possible to prepare oil blends with omega-6: omega-3 ratios very close to the recommended ratio for these fatty acids by simply mixing oils with different omega-6 and omega-3 comp
The effect of isotretinoin on triglycerides and liver aminotransferases
Vieira, Andreia Salezze;Beijamini, Vanessa;Melchiors, Ana Carolina;
Anais Brasileiros de Dermatologia , 2012, DOI: 10.1590/S0365-05962012000300005
Abstract: background: isotretinoin has been used to treat the most severe cases of acne; however, it may provoke adverse events in mucocutaneous and hepatic tissues, lead to alterations in lipid levels and cause teratogenicity. objective: the objective of this study was to evaluate the profile of changes in alanine aminotransferase (alt), aspartate aminotransferase (ast) and triglyceride levels in patients who had been treated with oral isotretinoin dispensed by the s?o mateus/es pharmacy for special drugs. methods: a retrospective, observational, longitudinal study was conducted by carrying out a secondary analysis of each patient's data. results: of the 130 patients who received isotretinoin between january and december 2009, only 70 were actually treated for 3 months or more and handed in the results of their laboratory tests. of these 70 patients, 39 (55.7%) were female. the mean age of the women (23.9 years) was higher than the mean age of the men (20.1 years). there was a statistically significant increase in the levels of triglycerides (87.01 ± 48.25 versus 105.32 ± 48.76 mg/dl), ast (20.44 ± 6.26 versus 24.38 ± 11.92 u/l) and alt (18.24 ± 8.31 versus 23.34 ± 20.03 u/l) performed prior to and 3 months or more after oral isotretinoin treatment. after treatment with oral isotretinoin, triglyceride levels had increased beyond the normal range in 11% of the patients, while 8.6% had elevated ast levels and 7.3% had increased alt levels. conclusion: the results in this population show that the use of oral isotretinoin for the treatment of acne may result in altered triglyceride, ast and alt levels. these findings are in accordance with data published previously in the scientific literature, confirming the need to monitor these patients.
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