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Infección por Helicobacter pylori en pacientes con mucosa sana y con gastritis erosiva
Martínez Echavarría,María Teresa; Noa Pedroso,Guillermo;
Revista Cubana de Medicina , 2009,
Abstract: helicobacter pylori (hp) is a bacterium causing colonization and infection of gastric epithelium of man. infection allows appearance of a gastritis that may to evolve to a peptic ulcer, a gastric adenocarcinoma, or a type malt lymphoma. in other cases, infection has a silent presentation. authors studied presence of hp in patients with gastritis and in others with a healthy mucosa, seen in endoscopy consultation of "hermanos ameijeiras" surgical clinical hospital by others disorders in high digestive tract pathways. fifty patients were investigated, 30 of them had an erosive gastritis, and 20 had a healthy mucosa histology confirmed. hc was detected by amplification of a fragment of ure a gen, by means of polymerase chain reaction (pcr), in 90% of cases with erosive gastritis, and in 75 % of subjects with a healthy mucosa. the reason of odds ratio (or) was of 3 with a confidence interval (ic) of 0.52-18.9. we conclude that hp infection is so high in patients with gastritis than in those with a healthy gastric mucosa.
Gene Expression Profiling in Gastric Mucosa from Helicobacter pylori-Infected and Uninfected Patients Undergoing Chronic Superficial Gastritis  [PDF]
Ze-Min Yang, Wei-Wen Chen, Ying-Fang Wang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033030
Abstract: Helicobacter pylori infection reprograms host gene expression and influences various cellular processes, which have been investigated by cDNA microarray using in vitro culture cells and in vivo gastric biopsies from patients of the Chronic Abdominal Complaint. To further explore the effects of H. pylori infection on host gene expression, we have collected the gastric antral mucosa samples from 6 untreated patients with gastroscopic and pathologic confirmation of chronic superficial gastritis. Among them three patients were infected by H. pylori and the other three patients were not. These samples were analyzed by a microarray chip which contains 14,112 cloned cDNAs, and microarray data were analyzed via BRB ArrayTools software and Ingenuity Pathways Analysis (IPA) website. The results showed 34 genes of 38 differentially expressed genes regulated by H. pylori infection had been annotated. The annotated genes were involved in protein metabolism, inflammatory and immunological reaction, signal transduction, gene transcription, trace element metabolism, and so on. The 82% of these genes (28/34) were categorized in three molecular interaction networks involved in gene expression, cancer progress, antigen presentation and inflammatory response. The expression data of the array hybridization was confirmed by quantitative real-time PCR assays. Taken together, these data indicated that H. pylori infection could alter cellular gene expression processes, escape host defense mechanism, increase inflammatory and immune responses, activate NF-κB and Wnt/β-catenin signaling pathway, disturb metal ion homeostasis, and induce carcinogenesis. All of these might help to explain H. pylori pathogenic mechanism and the gastroduodenal pathogenesis induced by H. pylori infection.
Topography Of Helicobacter Pylori Gastritis In Different Biopsy Sites Of Gastric Mucosa Of Residents Of A High Risk Area For Gastric Adenocarcinoma
Mikaeili J,Sotoodeh M,Derakhshan M H,Yazdanbod A
Tehran University Medical Journal , 2004,
Abstract: Background: Many recent studies have examined potential risk factors of H. pylori gastritis to improve our understanding of the early events in gastric carcinogenesis. We evaluated the extent and topography of chronic gastritis in a high risk area for gastric cardia cancer and investigated the critical role of H.pylori, risk index and age in its pathogenesis. Materials and Methods: During a national population-based endoscopic survey, we enrolled 508 participants aged ≥40 from urban and rural areas of Meshkin-Shahr, Ardebil province of Iran. After informed consent, all underwent complete upper GI endoscopy. At least one mucosal biopsy was obtained from 6 standard sites: three of antrum (sites 1, 2, 3), two of corpus (sites 4, 5) and one of cardia (site 6). Severity, activity and combined inflammatory scores (CIS) of chronic gastritis and H.pylori infection status were assessed according to modified Sydney Classification of Gastritis. Statistical effects of H.pylori, age, gender, and residency place on mean gastritis severity, activity and CIS were separately calculated in each site. Results: Total of 508 participants with mean age (±SD) of 54.6(±SD) were enrolled. 234(46.1%) were male and 274(53.9%) were female. Histologically 80.5% of cases were H.pylori positive. Mean activity scores of all sites except for site 5 are significantly (P<0.01) higher in H.pylori + cases. Mean CIS of all sites was significantly (P<0.01) higher in H.pylori + patients. In 44% of infected subjects, CIS of the corpus was at least equally as severe as that in antrum. Also in 54% of H.pylori + cases, cardia’s CIS was ≥ than antral CIS. Age had a significant (P<0.01) negative relationship with CIS of antral site, but this relationship in cardia was positive and more potent. Conclusion: H.pylori is the main cause of gastritis activity in all sites of stomach; this causality is more potent in antrum and cardia. Continuous cardia inflammation in advanced age may contribute to high incidence of gastric cardia cancer in this region.
Nodular gastritis and Helicobacter pylori infection in childhood
. Kostaki Maria, Fessatou Smaragdi, Karpathios Th.
Annals of Gastroenterology , 2007,
Abstract: Helicobacter pylori (HP) associated gastritis and peptic ulcer have been initially reported in adult patients. Recently, this association has also been demonstrated in children. We investigated 18 children (8-14 years old) with recurrent abdominal pain. In 7 patients gastroduodenoscopy revealed gastritis and HP was identified. Giemsa stain was more sensitive than urease testing in identifying the bacteria. In 5 of the 7, a nodular appearance of the antral mucosa was observed. The histological examination suggests lymphoid hyperplasia as the cause of the nodularity. All 7 patients became symptomless after a triple therapy with omeprazole, clarithromycin and amoxycillin for 2 weeks. We conclude that nodular gastritis is a peculiar type of gastritis in children. It is frequently found in association with HP infection. Two weeks triple therapy is an effective treatment in children with HP infection. Key words: Helicobacter pylori, nodular gastritis, peptic ulcer disease, childhood
Endoscopic features of Helicobacter pylori induced gastritis  [cached]
Khan Mohammed,Alhomsi Zuhair,Al-Momen Sami,Ahmad Mahmuda
Saudi Journal of Gastroenterology , 1999,
Abstract: It′s still controversial whether certain macroscopic endoscopic features can be used to diagnose Helicobacter pylori (HP) related gastritis. The literature dealing with this subject is confusing, because of the lack of precise terminology, no large control trials, major discrepancies in interpretations of macroscopic changes and poor correlation of the macroscopic appearance and histological finding of gastritis. We conducted a prospective study of 208 dyspeptic patients, who underwent upper gastrointestinal endoscopies from February 1997 to June 1997. Only those patients who had either normal looking gastric mucosa or macroscopic gastritis were included in the study. Endoscopically normal looking mucosa was seen in 67 patients (65.6%), erythematous gastritis in 51 (74%), mosaic appearance in 18 (88%), erosive gastritis in 14 (85%), nodular gastritis in 17 (94%), atrophic gastritis in 12 (75%), and fundal rugae hypertrophies in 5 (80%). We suggest that the antral nodularity, raised erosions, mosaic appearance and mixed findings, are the reliable indicators of the underlying HP induced gastritis. However, these endoscopic findings are very specific, though not sensitive, for HP gastritis.
Chronic gastritis and Helicobacter pylori in digestive form of Chagas' disease
Barbosa, A. J. A.;Queiroz, D. M. M.;Nogueira, A. M. M. F.;Roquette Reis, M. J. A.;Mendes, E. N.;Rocha, G. A.;Romanello, L. M. F.;Troncon, L. E. A.;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1993, DOI: 10.1590/S0036-46651993000200002
Abstract: patients with the digestive form of chagas'disease frequently present chronic gastritis. as the microorganism helicobacter pylori is now accepted as the most common cause of human chronic gastritis, the present work was undertaken to verify a possible relationship between the presence of this bacterium and inflammatory changes of antral mucosa in chagasic patients. seventeen chagasics, with megaesophagus and or megacolon were studied. fragments from two different regions of antral mucosa were obtained by endoscopy, fixed in 4% neutral formaldehyde and embedded in paraffin. the sections were stained by haematoxylin and eosin for histology analysis, and by carbolfuchsin for h. pylori identification. h. pylori was found in 16 (94.1%) chagasic patients, all of them presenting chronic gastritis. superficial gastritis was seen in 9 (52.9%) while atrophic gastritis was present in 8 (47.1%) patients. h. pylori was present on gastric mucosa of 8 (100%) patients with atrophic gastritis and of 8 (88.8%) patients with superficial gastritis. we concluded that the microorganism h. pylori should be considered a possible factor connected with the etiopathogenesis of chronic superficial and atrophic gastritis frequently observed in patients with the digestive form of chagas' disease.
Association of Helicobacter pylori infection with nodular antritis and follicular gastritis  [PDF]
Toma?evi? Ratko,Golubovi? Gradimir,Kiurski Miroslav,Stankovi? Dragana
Vojnosanitetski Pregled , 2006, DOI: 10.2298/vsp0603313t
Abstract: Introduction. Helicobacter pylori (H. pylori) infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic finding of nodular antritis and the presence of H. pylori infection and active chronic gastritis. Case report. Our patient underwent upper gastrointestinal endoscopy for dyspeptic complaints and was diagnosed as having nodular antritis, but also underwent urease test and hystopathologic examination of antral mucosa, to determine the presence and density of H. pylori infection and the presence and severity of gastritis. After a course of anti H. pylori treatment, dyspepsia improved and new biopsy specimens obtained two months and six months afterwards revealed no pathological findings. Conclusion. The case report supported the association of H. pylori infection of lymphoid follicles with nodular gastric mucosis.
Citocinas, gastritis crónica y Helicobacter Pylori
Pi?ol Jiménez,Felipe; Paniagua Estévez,Manuel;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: the helicobacter pylori is a curve, gram-negative bacteria that lives exclusively in the gastric mucosa. since its discovery and characterization it has been involved in the physiopathology of gastroduodenal diseases, including gastritis, peptic ulcer, gastric carcinoma and malt lymphoma. this has given rise to numerous hypotheses that try to explain the different events that occur in the inflammatory process of the stomach on its arrival, characterized by a marked infiltration of inflammatory cells (neutrophils, monocytes, lymphocytes and others) that once activated release locally various chemical mediators, which are responsible for the tissue damage. cytokines outstand as important mediators of such a process. an updated review of the different biological functions of cytokines in the tissue damage of the gastric mucosa is made
Neuropéptidos y Helicobacter pylori en la gastritis crónica
Pi?ol Jiménez,Felipe; Paniagua Estévez,Manuel;
Revista Cubana de Medicina , 2006,
Abstract: nowadays, the helicobacter pylori infection of the gastric mucosa is closely related to the gastric pathologies (acute gastritis, chronic gastritis, ulcer, cancer and gastric lymphoma), which obey to different physiopathological mechanisms that according to their intensity and persistence appear in the individuals infected by this microorganism. among the proposed mechanisms that are altered during the infection we find the neuroimmune mechanisms of the stomach that loss their regulating and defending action of the mucosa and aggravate the damage initiated by the bacterium that is clinically traduced as ulcerous-like dyspeptic syndrome of gastritis. an updated review of the failures and presence of the neuroimmune substance taking part in the inflammatory process was made. it will allow clinicians, gastroenterologists and general physcians not only to search therapeutics capable to regulate the neuroimmune system before, during and after the infection to attain an adequate histic regeneration, but to improve the functional capacity of the stomach and to prevent the torpid evolution of the disease, at worst, once the helicobacter pylori infection is diagnosed.
Neuropéptidos y Helicobacter pylori en la gastritis crónica Neuropeptides and Helicobacter pylori in chronic gastritis  [cached]
Felipe Pi?ol Jiménez,Manuel Paniagua Estévez
Revista Cubana de Medicina , 2006,
Abstract: Actualmente, la infección por Helicobacter pylori de la mucosa gástrica está muy relacionada con las patologías gástricas (gastritis aguda, crónica, úlcera, cáncer y linfoma gástrico) las cuales obedecen a diversos mecanismos fisiopatológicos que según su intensidad y persistencia aparecen en los individuos infestados por dicho microorganismo. Dentro de los mecanismos propuestos que se encuentran alterados durante la infección están los mecanismos neuroinmunes del estómago, que pierden su acción reguladora y defensora de la mucosa, y agravan el da o iniciado por la bacteria, clínicamente traducido como síndrome dispéptico de tipo ulceroso de la gastritis. Se presentó una revisión actualizada de los fallos y presencia de las sustancias neuroinmunes que participan durante el proceso inflamatorio lo que facilitará a clínicos, gastroenterólogos y médicos generales, no solo buscar terapéuticas adecuadas para erradicar la bacteria, sino también dirigir sus acciones hacia la búsqueda de terapéuticas capaces de regular el sistema neuroinmune antes, durante y después de la infección, para lograr una regeneración hística adecuada, mejorar la capacidad funcional del estómago e impedir la evolución tórpida de la enfermedad, en el peor de los casos, una vez diagnosticada la infección por Helicobacter pylori. Nowadays, the Helicobacter pylori infection of the gastric mucosa is closely related to the gastric pathologies (acute gastritis, chronic gastritis, ulcer, cancer and gastric lymphoma), which obey to different physiopathological mechanisms that according to their intensity and persistence appear in the individuals infected by this microorganism. Among the proposed mechanisms that are altered during the infection we find the neuroimmune mechanisms of the stomach that loss their regulating and defending action of the mucosa and aggravate the damage initiated by the bacterium that is clinically traduced as ulcerous-like dyspeptic syndrome of gastritis. An updated review of the failures and presence of the neuroimmune substance taking part in the inflammatory process was made. It will allow clinicians, gastroenterologists and general physcians not only to search therapeutics capable to regulate the neuroimmune system before, during and after the infection to attain an adequate histic regeneration, but to improve the functional capacity of the stomach and to prevent the torpid evolution of the disease, at worst, once the Helicobacter pylori infection is diagnosed.
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