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Validación de método analítico para el control de la calidad de vitamina B12 10 000 inyección
Botet García,Martha; García Pe?a,Caridad Margarita; Troche Concepción,Yenilen; Ca?izares Arencibia,Yanara; Moreno Correoso,Bárbara;
Revista Cubana de Farmacia , 2009,
Abstract: analytical method reported by usa pharmacopeia was validated for quality control of injectable b12 vitamin (10 000 u) by uv spectrophotometry because this is a simpler and low-cost method allowing quality control of finished product. calibration curve was graphed at 60 to 140 % interval, where it was linear with a correlation coefficient similar to 0, 9999; statistical test for interception and slope was considered non-significant. there was a recovery of 99.7 % in study concentrations interval where the cochran (g) and student(t) test were not significant too. variation coefficient in repetition study was similar to 0.59 % for the 6 assayed replies, whereas in intermediate precision analysis, the fisher and student tests were not significant. analytical method was linear, precise, specific and exact in study concentrations interval.
Iron, folate and vitamins B12 & C dietary intake of an elderly institutionalized population in León, Spain Aporte de hierro, ácido fólico y vitaminas B12 y C a una población de ancianos de una residencia de León, Espa a
M. T. García-Arias,A. Villarino Rodríguez,M. C. García-Linares,A. M. Rocandio
Nutrición Hospitalaria , 2003,
Abstract: Aging is associated with increased risk of developing anaemia and micronutrient deficiencies. The purpose of this study was to evaluate the daily intake of micronutrient whose deficient in diet could cause anaemia (iron, folic acid, vitamin B12) and vitamin C to establish the prevalence of anaemia in a group of institutionalized of 124 elderly subjects residing in five nursing homes in León (Spain). A precise weighing method was used to conduct the control of food intake covering seven days. Energy, alcohol, iron, folate, vitamin B12, and vitamin C intake were obtained. Weight, and Height also were measured. Serum iron, serum ferritin, haemoglobin and hematocrit were also measured. Average daily iron intake was higher than the 10 mg recommended by the National Academy of Science although significantly higher (p < 0.05) in males (17.0 ± 7.4 mg) than in females (11.8 ± 1.5 mg). Moreover, vitamin C intake in all subjects is high (118.8 ± 43.7 mg) and higher than Spanish RDA (198%). Average intakes of folate and vitamin B12 in the present study exceeded the RDA, (103% and 144%). However, 45.83% of males and 5.97% of females showed deficiencies in vitamin B12 and 53.91% of the subjects showed deficiencies in folic acid. The average haemoglobin concentration (14.28 ± 1.33 g/dL), hematocrit percentage (43.71 ± 6.31), ferritin concentration (87.01 ± 59.74 ng/mL) and serum iron (85.36 ± 33.98 μg/dL) showed similar figures to the results obtained in other studies carried out on elderly populations. It would be necessary to adequately compose the menus given in nursing homes, decreasing energy contribution, and supplying micronutrient rich foods or fortified foods. El envejecimiento comporta un mayor riesgo de anemia y deficiencias de micronutrientes. El objetivo de este estudio consistió en evaluar el aporte diario de micronutrientes, cuya carencia dietética podría ocasionar anemia (hierro, ácido fólico, vitamina B12), así como de vitamina C para conocer la prevalencia de anemia entre un grupo de 124 ancianos que vivían en cinco residencias de León (Espa a). Se utilizó un método preciso de pesaje para controlar la ingestión de alimentos durante 7 días. Se midieron el aporte de energía, alcohol, hierro, ácido fólico, vitamina B12 y vitamina C. También se registraron el peso y la talla. Además, se analizaron el hierro sérico, la ferritina sérica, la hemoglobina y el hematócrito. El aporte diario medio de hierro resultó mayor que los 10 mg recomendados por la Academia Nacional de Ciencias, si bien la cantidad recibida por los varones (17,0 ± 7,4 mg) era significativa
Fast quantum control and light-matter interactions at the 10,000 quanta level  [PDF]
J. Alonso,F. M. Leupold,Z. U. Soler,M. Fadel,M. Marinelli,B. C. Keitch,V. Negnevitsky,J. P. Home
Physics , 2015,
Abstract: Fast control of quantum systems is essential in order to make use of quantum properties before they are degraded by decoherence. This is important for quantum-enhanced information processing, as well as for pushing quantum systems into macroscopic regimes at the boundary between quantum and classical physics. Bang-bang control attains the ultimate speed limit by making large changes to control fields on timescales much faster than the system can respond, however these methods are often challenging to implement experimentally. Here we demonstrate bang-bang control of a trapped-ion oscillator using nano-second switching of the trapping potentials. We perform controlled displacements which allow us to realize quantum states with up to 10,000 quanta of energy. We use these displaced states to verify the form of the ion-light interaction at high excitations which are far outside the usual regime of operation. These methods provide new possibilities for quantum-state manipulation and generation, alongside the potential for a significant increase in operational clock speed for ion-trap quantum information processing.
Plasma total homocysteine in Brazilian overweight and non-overweight adolescents: a case-control study Homocisteína plasmática total en adolescentes brasile os con y sin sobrepeso: un estudio de casos-control  [cached]
R. S. Brasileiro,M. A. M. S. Escriv?o,J. A. A. C. Taddei,V. D'Almeida
Nutrición Hospitalaria , 2005,
Abstract: Objective: To test the hypothesis that overweight adolescents have higher plasma total homocysteine (tHcy) levels than non-overweight adolescents and to explore the association between plasma tHcy levels with folate, vitamin B12 and some risk factors for CVD in both groups. Methods: A case-control study conductec with 239 adolescentes aged 15-19 years in the city of S o Paulo, Brazil; 86 overweight and 153 non-overweight frequency matched by age, gender, pubertal and socioeconomic status. tHcy, folate, vitamin B12, lipid profile, glucose, insulin and insulin resistance were measured. Results: No significant differences were found in tHcy, folate and vitamin B12 levels between overweight and non-overweight groups. The geometric means of tHcy were elevated in both groups (overweight: 11.8 μmol/L; non-overweight: 11.6 μmol/L) higher for boys than for girls (P ≤ 0.001). Folate deficiency was identified in 68.6% of total studied population. Triacylglycerol, LDL cholesterol, insulin resistance were higher and HDL cholesterol was lower in overweight that non-overweight adolescents. In the multiple linear regression model, in overweight group, tHcy was independently associated with age (P = 0.041), sex (P = 0.004) and folate (P = 0.022) and in non-overweight group, with age (P = 0.049), sex (P < 0.001), folate (P = 0.018) and vitamin B12 (P = 0.030). Conclusions: Obesity was not a determinant factor of tHcy levels. Age, sex and folate were independent determinants of plasma tHcy levels. The high prevalence of folate deficiency may have been responsible for the elevated tHcy levels in these adolescents, increasing the risk for future development of CVD. Objetivo: Probar la hipótesis de que los adolescentes con sobrepeso tienen mayores concentraciones plasmáticas de homocisteína total (tHcy) que los adolescentes sin sobrepeso, y explorar la asociación entre las concentraciones plasmáticas de tHcy con folato, vitamina B12 y algunos factores de riesgo de ECV en ambos grupos. Métodos: Estudio de casos-control realizado en 239 adolescentes de edades entre los 15-19 a os, de la ciudad de Sao Paulo, Brasil; 86 tenían sobrepeso y 153 no, emparejados por edad, sexo, estado puberal y socioeconómico. Se midieron tHcy, folato, vitamina B12, perfil lipídico, glucosa, insulina y resistencia a insulina. Resultados: no se hallaron diferencias significativas en las concentraciones de tHcy, folato ni vitamina B12 entre los grupos con y sin sobrepeso. Las medias geométricas de tHcy estaban elevadas en ambos grupos (sobrepeso: 11,8 μmol/l; sin sobrepeso: 11,6 μmol/l), y fueron mayor
Diferencias en el metabolismo lipídico, niveles de homocisteína, folato y vitamina B12 entre gestaciones gemelares y únicas
Marcos Cuerva G,María del Mar Gil M,Sara Iacoponi,María De La Calle F
Revista Chilena de Obstetricia y Ginecología , 2011,
Abstract: Antecedentes: Se están usando diferentes tipos de suplementación nutricional durante la gestación, sin embargo, existen escasez de estudios que se centren en los resultados metabólicos de los mismos. Objetivos: Comprobar si mediante la suplementación se logra el control del impacto de los múltiples cambios metabólicos que conlleva una gestación múltiple, usando análisis comunes. Método: Comparamos tres diferentes grupos de pacientes entre la semana gestacional 25 y 27. Un grupo de 46 gestaciones únicas, un grupo de 38 gestaciones gemelares espontáneas y otro grupo de 32 gestaciones gemelares tras técnicas de reproducción asistida. Comparamos niveles de colesterol LDL, HDL, triglicéridos, folato sérico, vitamina B12, homocisteína, hemoglobina, creatinina y plaquetas. Resultados: Los niveles de triglicéridos fueron más altos en ambos grupos de gemelares (p<0,001) y los niveles de colesterol fueron similares en los tres grupos. Las concentraciones de folato sérico fueron mayores en las gestaciones gemelares (p<0,001). El resto de parámetros estudiados fueron similares en los tres grupos. Conclusión: La suplementación siguiendo las recomendaciones de la ACOG y la SEGO es efectiva en el control de colesterol LDL, HDL, folato sérico, vitamina B12, homocisteína, hemoglobina, creatinina y plaquetas. Sólo los niveles de triglicéridos no se relacionan con la suplementación y pueden estar relacionados con mayor incidencia de colestasis y preeclampsia en gestaciones múltiples. Background: Different ways of nutritional supplementation are being advised by physicians during pregnancy, but there is a lack of literature focused on its metabolical results. Aims: Check if the control of the impact that the multiple metabolic changes related to multiple pregnancies have on the mother's homeostasis is achieved with the supplementation, through common used blood tests. Method: We compare three different groups of patients between the 25 and 27th week of gestation. One group of 46 single pregnancies, a second group of 38 spontaneous twin pregnancies and another group of 32 twin pregnancies after assisted reproduction techniques. We compare the levels of LDL, HDL-cholesterol, triglycerides, serum folic acid, Vit B12, homocysteine, haemoglobine, creatinine and platelets. Results: The levels of triglycerides were higher in both groups of twin pregnancies (p<0.001), but the levels of cholesterol remain similar. Folic acid concentrations were higher in the groups of twin pregnancies (p<0.001). The rest of levels studied were similar in the 3 groups. Conclusion: The supplementatio
Niveles de vitamina B12 en pacientes colombianos con gastritis crónica atrófica Levels of vitamin B12 in colombian patients with chronic atrophic gastritis  [cached]
Julián David Martínez Marín,Sandra Consuelo Henao Riveros,Mario Humberto Rey Tovar
Revista Colombiana de Gastroenterologia , 2010,
Abstract: Se presenta un grupo de 75 pacientes adultos colombianos, con diagnóstico de gastritis crónica atrófica de acuerdo a los criterios de Sydney, de los cuales el 28% presentó deficiencia de vitamina B12 y al 9% se le diagnóstico anemia perniciosa. Las cifras de hemoglobina, volumen corpuscular medio no se correlacionaron con el déficit de vitamina B12. No se encontró una asociación estadística del déficit de la vitamina B12 con el género, edad mayor de 60 a os de los pacientes o con la presencia del Helicobacter pylori (H. pylori). La edad promedio de los pacientes con déficit de vitamina B12 o con anemia perniciosa es menor a la que tradicionalmente se reporta para estas enfermedades We present a group of 75 Colombian adults who were diagnosed with chronic atrophic gastritis in accordance with the Sydney criteria. 28% of the group had vitamin B12 deficiencies: 9% were diagnosed with Pernicious anemia. Hemoglobin and mean corpuscular volume were not correlated with vitamin B12 deficiency. We found no statistical association of vitamin B12 deficiency with gender, patients over 60 years of age, or the presence of Helicobacter pylori (H. pylori). The average age of patients with vitamin B12 deficiency or pernicious anemia is less than that traditionally reported for these diseases
Deficiencia de Vitamina B12, Implicaciones Clínicas: Revisión Bibliografica Actualizada
Eva Nadorfy de López
Acta Odontológica Venezolana , 2000,
Abstract: La deficiencia de vitamina B12 está asociada con anemia perniciosa (A.P). En cierto número de estos pacientes se ha reportado gastritis crónica atrófica (G.C.A) y riesgo de carcinoma gástrico. Vitamin B12 deficiency is associated with pernicious anemia.Chronic atrophic gastritis and elevated risk of cancer of the stomach, have been reported for patients with pernicious anemia.
Deficiencia de vitamina B12: tratamiento oral o parenteral Vitamin B12 deficiency: Oral or parenteral treatment  [cached]
Mariela Forrellat Barrios,Porfirio Hernández Ramírez
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2009,
Abstract: El tratamiento tradicional de la deficiencia de vitamina B12 ha sido la administración de cobalamina en inyecciones intramusculares periódicas siguiendo diferentes esquemas, en dependencia de la severidad del déficit y el cuadro clínico instalado. A pesar de que desde los a os 50 y 60 del pasado siglo se planteó que la terapia con vitamina B12 por vía oral es tan eficaz como las inyecciones en el tratamiento de esta deficiencia, en la práctica este parece ser un hecho poco aceptado. Las investigaciones encaminadas a evaluar esta alternativa y el por qué aún su uso no ha sido del todo extendido, sugieren que el cambio de los pacientes a tratamiento oral con vitamina B12 implica ahorros sustanciales en términos de costos financieros, tiempo aportado por médicos y personal de salud e inconvenientes y molestias a los pacientes, los que por lo general, aceptan bien el cambio de terapia. Traditional treatment of Vitamin B12 deficiency has been the Cobalamin administration via periodic intramuscular injections following different rules depending from deficit severity and clinical picture present. Despite that from 50s and 60s of past century, it was established that oral B12 therapy is as effective as injections ones in treatment of this type of deficiency, in practice it looks like a not very accepted fact. Researches aimed to assess this alternative, and why still its use has not been completely understood, suggest that the change to a Vitamin B12 treatment implicates significant savings in terms of financial costs, time of physicians and health staff, and the drawbacks and annoyances for patients, whom in general, accept well the change of therapy.
Relación entre los Niveles de ácido Fólico, Vitamina B12 y Homocisteína Materna y los Defectos de Tubo Neural y Labio Hendido Relation Between Levls of Folic acid, Vitamin B12 and Maternal Homocysteine with Neural Tube Defects and Cleft Lip
D. V. Chávez-Corral,M. R Velazco-Campos,L. H Sanin,M Levario-Carrillo
International Journal of Morphology , 2008,
Abstract: El objetivo del trabajo fue determinar la asociación entre los niveles de ácido fólico, vitamina B (Vit B12) y homocisteína (Hci) maternos, con defectos del tubo neural (DTN) y labio hendido (LH) con y sin paladar hendido (c/s PH). Se realizó un estudio tipo casos y controles. Casos, con diagnóstico de DTN y LH c/s PH (n=36) y cuatro controles hospitalarios por caso (n=141). Se incluyeron recién nacidos (RN) y lactantes hasta 12 meses de edad. Las variables de pareamiento fueron: edad del RN o lactante, etniay hospital. Un 23% de etnia Tarahumara y 77% mestizos. Se determinó ácido fólico intraeritrocitario (AFI), plasmático (AFP) y Vit B12 por radioinmunoensayo, la Hci por inmunoensayo de fluorescencia polarizada. Se consideró deficiencia si el AFI fue <160 ng/mL, AFP <3.5 ng/ mL y la Vit B12 <200 pg/mL e hiperhomocisteinemia, si Hci >15 |J.mol/L. El análisis estadístico se realizó a través de regresión logística condicionada. Se identificó deficiencia de AFI en el 22% de las mujeres cuyos recién nacidos o lactantes presentaron algún tipo de defecto congénito y en el 12% de los controles. La relación entre AFI y DTN, LH c/s PH ajustada por edad materna, exposición a plaguicidas y zona de residencia fue RM 2,96 (IC 95% 0,92-9,46). No se encontraron diferencias en los niveles de Hci ni de Vit B12. Conclusiones: Nuestros resultados sugieren que RN cuyas madres cursan con una deficiencia de AFI tienen mayor riesgo de presentar DTN y LH c/s PH. Objective: To determine the association between maternal folate deficieney, neural tube defeets (NTDs), and cleft lip, with and without cleft palate (CL/P). Material and methods: A case/control study was conducted. The cases included subjeets with diagnoses of NTD and CL/P (n=36) and four hospital controls per case (n=141); the study included newborns (NBs) and nursing babies upto 12monthsof age. The parameter variables were the foliowing: the age of the NB or nursing baby, the ethnic group, and the hospital of origin. The Tarahumara ethnic group made up 23% of the cases, while 77% were mestizos. The red cell folate (RCF), the plasma folie acid (PFA), and the vitamin B12 levéis were determined by radioimmunoassay and the homocysteine levéis by polarized fluorescence immunoassay. A deficieney was considered to be present if the RCF were <160 ng/mL, the PFA <3.5 ng/mL and the vitamin B <200 pg/ mL; hyperhomocysteinemia was defined as HC >15 |J,mol/L. The statistical analysis was carried out through of conditional logistic regression. Results: An RCF deficieney was identified in 22% of the women whose newborn or nursing
Vitamina B12: metabolismo y aspectos clínicos de su deficiencia Vitamin B12: metabolism and clinical aspects of its deficiency  [cached]
Mariela Forrellat Barrios,Irma Gómis Hernández,Hortensia Gautier du Défaix Gómez
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 1999,
Abstract: Se hace una revisión sobre el metabolismo de la vitamina B12, su estructura química, fuentes dietéticas y requerimientos en los diferentes grupos de edades, así como su absorción y distribución en el organismo. Se explica además la función metabólica de las cobalaminas y su papel en la etiología de las anemias megaloblásticas, así como las causas de deficiencia de esta vitamina y su tratamiento A review is made on the metabolism of vitamin B12, its chemical structure, dietetic spurces and requirements in the different age groups, as well as on its absorption and distribution in the body. The metabolic function of cobalamins, their role in the etiology of megaloblastic anemias, the causes of the deficiency of this vitamin and its treatment are also explained in this paper
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