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Paracoccidioidoma medular
Betancur,Carlos Alberto; Ruiz,Carlos;
Acta Medica Colombiana , 2010,
Abstract: the case is reported of a 51-year-old patient with a three-month history of paraparesia that had rendered him unable to walk over a period of 45 days. the patient underwent surgical excision of 2 granulomas that had been shown by an mri scan. histopathological study with silver methenamine showed budding blastoconidia, typical of paraccoccidioides brasiliensis infection (acta med colomb 2010; 35: 183-184).
Carcinoma medular de tiroides: Experiencia de 20 a os Medullary thyroid carcinoma: 20 years experience  [cached]
ENRIQUE LANZARINI S,ANDRéS MARAMBIO G,JOSé AMAT V,FRANCISCO RODRíGUEZ M
Revista Chilena de Cirugía , 2010,
Abstract: Antecedentes: El carcinoma medular de tiroides (CMT) es un tumor maligno poco frecuente, originado a partir de las células C. Su tratamiento quirúrgico y resultados son controvertidos, por lo que hemos decidido estudiarlo. Objetivo: Describir clínicamente el CMT, tratamiento y resultados a largo plazo. Material y método: Se revisaron retrospectivamente las fichas clínicas de pacientes con CMT operados en nuestro hospital entre 1987 y el 2007. Se analizaron las características clínicas, tratamiento, morbilidad y seguimiento a largo plazo. Resultados: Se operaron 24 pacientes, cuya edad media fue 46,1 ± 16,6 a os. La principal forma de presentación fue aumento de volumen cervical (56,2%). Un 15% formaba parte de una NEM 2b. A todos se les realizó una tiroidectomía total, ampliada en el 50% de los casos. El 35,2% eran multifocales, el 29,4% bilaterales y el 62,5% tenía metástasis ganglionar. Cinco pacientes mantuvieron niveles de calcitonina elevados en el postoperatorio y nueve pacientes recurrieron clínicamente, en promedio, a los 4,5 a os. La enfermedad persistente se asoció significativamente con CMT hereditario (p = 0,0088) y la recurrencia clínica a tiroidectomía total no ampliada (p = 0,0196). La probabilidad de sobrevivir más de 19 a os fue 66,6% (IC 95% = 0,24 a 0,89). Conclusiones: EL CMT es un tumor raro cuyo tratamiento de elección es la cirugía. La persistencia de enfermedad se asocia con la forma hereditaria, y la recurrencia clínica con la tiroidectomía total no ampliada, lo que nos hace recomendar una tiroidectomía total asociada a vaciamiento central y disección yugular radical modificada. Background: Medullary thyroid carcinoma (MTC) is a rare malignant tumor that arise from C cells. Surgical treatment and its results are controversial, so we decided to study it. Aim: To describe clinically MTC, treatment and outcomes in the long term. Material and Method: We retrospectively reviewed medical records of patients with MTC operated in our hospital between the years 1987 and 2007. We analyzed the cli-nical characteristics, treatment, morbidity and long-term follow up. Results: There were 24 patients operated with a mean age of 46.1 ± 16.6 years. The main form of presentation was painless increased cervical volume (56.2%). In 15% this pathology was part of a MEN 2b. All of them have had a total thyroidectomy, which was extended in 50% of cases. The 35.2% were multifocal, 29.4% bilateral and 62.5% had metastatic lymph node involvement. Five patients remained higher calcitonin levéis in the postoperative period and 9 patients recurred clinically
Aplasia medular: Actualización Bone marrow aplasia: Update
Sergio Machín García,Eva Svarch,Elvira Dorticós Balea
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 1999,
Abstract: La aplasia medular, según su etiología puede ser congénita y adquirida; esta última es la más frecuente. La causa del fallo de la hematopoyesis parece ser multifactorial. Se revisan las causas de aplasia medular adquirida, sus mecanismos fisiopatológicos y se hace énfasis en los mecanismos inmunes, que desempe an un papel central en su fisiopatología. Se actualizan los criterios diagnósticos, los elementos de pronóstico desfavorable, así como las enfermedades con las que debe hacerse el diagnóstico diferencial. Las terapéuticas actuales más efectivas son los inmunosupresores y el trasplante de médula ósea, cada uno de ellos ofrece ventajas y desventajas y requiere de indicaciones precisas Bone marrow aplasia according to its etiology may be congenital or acquired. The latter is the most frequent. Haemopoietic failure seems to be caused by several factors. The causes of acquired medullary aplasia and its physiopathological mechanisms are reviewed. Emphasis is made on th immune mechanisms, which play an important role in its physiopathology. The diagnostic criteria as well as the elements of an unfavorable diagnosis and the disease that must be taken into consideration to make the differential diagnosis are analyzed in this paper. The most effective treatments at present are the immunosuppressors and bone marrow transplantation. Each has advantages and disadvantages and requires specific indications
Sporadic Medullary Microcarcinoma in a Young Patient - A Rare Case  [cached]
Vijayshankar S,Amita K,Abhishek M,Manjunath D
Online Journal of Health & Allied Sciences , 2010,
Abstract: Sporadic medullary microcarcinoma of thyroid is a rare disease detected usually in 0.15% of all thyroid malignancy. We report a case of sporadic medullary microcarcinoma (MMC) of thyroid in a 24 year old male presenting as solitary thyroid nodule. There was no family history of medullary carcinoma of thyroid. Although medullary carcinoma in a familial setting have been reported, sporadic MMC is rare especially in a young patient.
Carcinoma familiar del tiroides no medular (CFTNM): características de presentación en 17 casos Clinical features of 17 patients with familial non medullary thyroid carcinoma
Lorena Mosso,Soledad Velasco,Iván Salazar,Antonieta Solar
Revista médica de Chile , 2007,
Abstract: Background: Papillary thyroid carcinoma can have familial aggregation. Aim: To compare retrospectively familial non medullary thyroid carcinoma (FNMTC) with sporadic papillary thyroid carcinoma (PTC). Material and methods: Retrospective analysis of medical records of patients with thyroid carcinoma. An index case was defined as a subject with the diagnosis of differentiated thyroid carcinoma with one or more first degree relatives with the same type of cancer. Seventeen such patients were identified and were compared with 352 subjects with PTC. Results: The most common affected relatives were sisters. Patients with FNMTC were younger than those with PTC. No differences were observed in gender, single or multiple foci, thyroid capsule involvement, surgical border involvement, number of affected lymph nodes and coexistence of follicular hyperplasia. Patients with FNMTC had smaller tumors and had a nine times more common association with lymphocytic thyroiditis. Five patients with FNMTC had local recurrence during 4.8 years of follow up. Conclusions: Patients with FNMTC commonly have an associated chronic thyroiditis, are younger and have smaller tumors than patients with PTC
An Unusual Variant of Medullary Carcinoma of Thyroid – A Case Report
R. Thamil Selvi,Pammy Sinha,P.G. Konapur,P.R. Rekha
Al Ameen Journal of Medical Sciences , 2011,
Abstract: A 32 years old female presented with midline swelling of neck since 10 years, FNAC of Neck mass was done and diagnosed as Malignant Thyroid neoplasm. On histopathological Examination it was diagnosed as Medullary carcinoma of thyroid - Papillary variant and diagnosis was confirmed by Immunohistochemistry. We report this rare variant of Medullary carcinoma of thyroid
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma
Toledo, Sergio PA;Louren?o Jr, Delmar M;Santos, Marcelo Augusto;Tavares, Marcos R;Toledo, Rodrigo A;Correia-Deur, Joya Emilie de Menezes;
Clinics , 2009, DOI: 10.1590/S1807-59322009000700015
Abstract: hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. currently, calcitonin measurements are mostly useful in the evaluation of tumor size and progression, and as an index of biochemical improvement of medullary thyroid carcinomas. although measurement of calcitonin is a highly sensitive method for the detection of medullary thyroid carcinoma, it presents a low specificity for this tumor. several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. several cases of thyroid nodules associated with increased values of calcitonin are not medullary thyroid carcinomas, but rather are related to other conditions, such as hypercalcemias, hypergastrinemias, neuroendocrine tumors, renal insufficiency, papillary and follicular thyroid carcinomas, and goiter. furthermore, prolonged treatment with omeprazole (> 2-4 months), beta-blockers, glucocorticoids and potential secretagogues, have been associated with hypercalcitoninemia. an association between calcitonin levels and chronic auto-immune thyroiditis remains controversial. patients with calcitonin levels >100 pg/ml have a high risk for medullary thyroid carcinoma (~90%-100%), whereas patients with values from 10 to 100 pg/ml (normal values: <8.5 pg/ml for men, < 5.0 pg/ml for women; immunochemiluminometric assay) have a <25% risk for medullary thyroid carcinoma. in multiple endocrine neoplasia type 2 (men2), ret mutation analysis is the gold-standard for the recommendation of total preventive thyroidectomy to relatives at risk of harboring a germline ret mutation (50%). false-positive calcitonin results within men2 families have led to incorrect indications of preventive total thyroidectomy to ret mutation negative relatives. in this review, we focus on the differential diagnosis of hypercalcitoninemia, underlining its importance for the avoidance of misdiagnosis of medullary thyroid carcinoma and conseq
Carcinoma medular do rim
Salles, Paulo Guilherme de Oliveira;Miranda, Dairton;Seleiro, Arnaldo Jonas Pimentel;Castelo Branco, José Ribamar;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2006, DOI: 10.1590/S1676-24442006000200009
Abstract: we report the case of a 24-year-old patient who presented a left kidney tumor that was diagnosed as a medullary renal cell carcinoma. the following aspects of this neoplasia are discussed in this communication: frequency, pathogenesis, clinical presentation, histopathological findings, differential diagnosis and follow-up.
Doen?a cística medular do rim: relato de um caso diagnosticado por ultra-sonografia e tomografia computadorizada
Carvalho, Tarcísio Nunes;Araújo Jr., Cyrillo Rodrigues de;Fraguas Filho, Sérgio Roberto;Costa, Marlos Augusto Bittencourt;Ribeiro, Flávia Aparecida de Souza;Teixeira, Kim-Ir-Sen Santos;
Radiologia Brasileira , 2003, DOI: 10.1590/S0100-39842003000600013
Abstract: the terms medullary cystic disease, juvenile nephronophthisis or medullary cystic disease complex refer to a group of similar diseases in which the basic pathological abnormality is progressive renal tubular atrophy with secondary glomerular sclerosis and medullary cystic formation. medullary cystic disease is an important cause of renal failure in adolescent patients. imaging methods play a primary role in the diagnosis of these diseases. cysts are characteristically seen in the renal medulla and corticomedullary junction whereas kidneys may be of normal to small size. in this article we present the ultrasonography and computed tomography findings of a female adolescent patient with characteristic clinical picture of medullary cystic disease.
Kinase inhibitors for advanced medullary thyroid carcinoma
Schlumberger, Martin;Massicotte, Marie-Hélène;Nascimento, Camila L.;Chougnet, Cécile;Baudin, Eric;Leboulleux, Sophie;
Clinics , 2012, DOI: 10.6061/clinics/2012(Sup01)21
Abstract: the recent availability of molecular targeted therapies leads to a reconsideration of the treatment strategy for patients with distant metastases from medullary thyroid carcinoma. in patients with progressive disease, treatment with kinase inhibitors should be offered.
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