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Relación entre hiperparatiroidismo y gamapatía monoclonal
Ca?as Dávila,Carlos Alberto;
Acta Medica Colombiana , 2007,
Abstract: a 66-year-old man with primary hyperparathyroidism (phpt) and monoclonal gammapathy associated to it of uncertain significance (mgus). a possible pathogenic relationship between hptp and mgus is analyzed. interleukin 6 could play a pivotal role.
Cirugía radioguiada para la extirpación de un quiste paratiroideo gigante con hiperparatiroidismo Radio-guided surgery for removal of a giant parathyroid cyst related to hyperthyroidism  [cached]
Edelberto Fuentes Valdés,Julio C. Escarpanter González,Adlín López Díaz,Yiovanni Alfonso Trujillo
Revista Cubana de Endocrinología , 2009,
Abstract: Entre los avances actuales del tratamiento quirúrgico del hiperparatiroidismo se encuentra la localización preoperatoria de la(s) glándula(s) hiperfuncionante(s) mediante gammagrafía preoperatoria e intraoperatoria, esta última a través de una sonda gamma especial. Por otro lado, los quistes paratiroideos son raros; pueden ser funcionantes o no. Se describe un nuevo caso de quiste paratiroideo hiperfuncionante, así como los hallazgos de la gammagrafía con 99mTc-MIBI y el uso intraoperatorio de la sonda gamma para evaluar todos los sitios probables donde pudieran existir glándulas hiperproductoras de hormona paratiroidea. Se describen aspectos de la manipulación, seguridad y administración del radiofármaco en el período preoperatorio inmediato, así como la utilización de la sonda gamma durante la intervención. Se informa la evolución durante el seguimiento. Este caso representa el tercer paciente intervenido por hiperparatiroidismo mediante cirugía radioguiada en nuestro centro, institución en la que se introdujo esta técnica en el país Among present advances of surgical treatment of hyperthyroidism is the preoperative localization of hyper-functioning glands by preoperative and intraoperative scan, this later one by a special gamma probe. By the other hand, parathyroid cysts are rare; may be of functioning type or not, as well as the findings of 99mTc-MIBI, and the intraoperative use of gamma probe to assess all the possible sites where could be hyperproductive glands of parathyroid hormone. We describe features of management, safety, and administration of radiological agent during the immediate preoperative period, as well as use of gamma probe during intervention. Evolution over follow-up is reported. This case represents the third patient operated on from hyperthyroidism by radio-guided surgery in our center, which introduced this technique in our country.
Hipertiroidismo Hyperthyroidism
Adalberto Infante Amorós,Silvia Elena Turcios Tristá
Revista Cubana de Endocrinología , 2012,
Abstract: El hipertiroidismo se presenta con un cuadro clínico característico por la hiperproducción de hormonas tiroideas por el tiroides, y obedece a múltiples causas. Su forma clínica más frecuente es el bocio tóxico difuso o enfermedad de Graves Basedow. Es un síndrome caracterizado por manifestaciones de tirotoxicosis, bocio y manifestaciones extratiroideas, entre las que se encuentra la orbitopatía, que en ocasiones sigue un curso independiente de la enfermedad tiroidea. El interrogatorio, el examen físico y la determinación de hormonas tiroideas, son suficientes para confirmar el diagnóstico. Los pilares básicos del tratamiento, además de una adecuada orientación higiénico-dietética, son: el medicamentoso, el radioyodo y la cirugía, y su indicación debe ser individualizada para evitar la toma de conductas inadecuadas e innecesarias. Hyperthyroidism has a clinical picture characterized by overproduction of thyroid hormones by the thyroid gland and is derived from a number of causes. The most frequent clinical presentation is toxic diffuse goiter or Graves Basedow's disease. It is a syndrome with thyrotoxicosis, goiter and extrathyroid manifestations such as orbitopathy that occasionally develops regardless of the thyroid disease. Questioning, physical exam and estimation of thyroid hormones are enough to confirm the diagnosis. In addition to adequate hygienic-dietary orientation, the basis pillars of the treatment are drugs, radioiodine and surgery, but indication of treatment should be personalized to avoid inadequate and unnecessary behaviors.
Linfoma renal primario en paciente con gammapatía monoclonal IgM
Rodríguez Faba,O.; Fernández Gómez,J.M.; Martín Benito,J.L.; Parra Muntaner,L.; Gutiérrez Palacios,A.M.; García Rodríguez,J.; Jalón Monzón,A.; Regadera Sejas,J.;
Actas Urológicas Espa?olas , 2004, DOI: 10.4321/S0210-48062004000500011
Abstract: reports on primary renal lymphoma are scarce in the urological literature, the most part of them are secondary on a lymphomatous infiltration of the kidneys. we report the case of a 77 year old man with an incidental mass on the kidney. after radiological studies (ct), we practise nephrectomy with a pathological result of a non-hodking b primary lymphoma. the patient present a igm monoclonal gammapathy who need complementary treatment with chemotherapy. a literature review on currently recommended diagnostic and treatment practices in presented.
Atrial Fibrillation and Hyperthyroidism  [cached]
Jayaprasad N,Johnson Francis
Indian Pacing and Electrophysiology Journal , 2005,
Abstract: Atrial fibrillation occurs in 10 – 15% of patients with hyperthyroidism. Low serum thyrotropin concentration is an independent risk factor for atrial fibrillation. Thyroid hormone contributes to arrythmogenic activity by altering the electrophysiological characteristics of atrial myocytes by shortening the action potential duration, enhancing automaticity and triggered activity in the pulmonary vein cardio myocytes. Hyperthyroidism results in excess mortality from increased incidence of circulatory diseases and dysrhythmias. Incidence of cerebral embolism is more in hyperthyroid patients with atrial fibrillation, especially in the elderly and anti-coagulation is indicated in them. Treatment of hyperthyroidism results in conversion to sinus rhythm in up to two-third of patients. Beta-blockers reduce left ventricular hypertrophy and atrial and ventricular arrhythmias in patients with hyperthyroidism. Treatment of sub clinical hyperthyroidism is controversial. Optimizing dose of thyroxine treatment in those with replacement therapy and beta-blockers is useful in exogenous subclinical hyperthyroidism.
Congenital hyperthyroidism: autopsy report
Lima, Marcus Aurelho de;Oliveira, Lília Beatriz;Paim, Neiva;Borges, Maria de Fátima;
Revista do Hospital das Clínicas , 1999, DOI: 10.1590/S0041-87811999000300007
Abstract: we report the autopsy of a stillborn fetus with congenital hyperthyroidism born to a mother with untreated graves' disease, whose cause of death was congestive heart failure. the major findings concerned the skull, thyroid, heart, and placenta. the cranial sutures were closed, with overlapping skull bones. the thyroid was increased in volume and had intense blood congestion. histological examination showed hyperactive follicles. the heart was enlarged and softened, with dilated cavities and hemorrhagic suffusions in the epicardium. the placenta had infarctions that involved at least 20% of its surface, and the vessels of the umbilical cord were fully exposed due to a decrease in wharton 's jelly. hyperthyroidism was confirmed by the maternal clinical data, the fetal findings of exophthalmia, craniosynostosis, and goiter with signs of follicular hyperactivity. craniosynostosis is caused by the anabolic action of thyroid hormones in bone formation during the initial stages of development. the delayed initiation of treatment in the present case contributed to the severity of fetal hyperthyroidism and consequent fetal death.
Congenital hyperthyroidism: autopsy report  [cached]
Lima Marcus Aurelho de,Oliveira Lília Beatriz,Paim Neiva,Borges Maria de Fátima
Revista do Hospital das Clínicas , 1999,
Abstract: We report the autopsy of a stillborn fetus with congenital hyperthyroidism born to a mother with untreated Graves' disease, whose cause of death was congestive heart failure. The major findings concerned the skull, thyroid, heart, and placenta. The cranial sutures were closed, with overlapping skull bones. The thyroid was increased in volume and had intense blood congestion. Histological examination showed hyperactive follicles. The heart was enlarged and softened, with dilated cavities and hemorrhagic suffusions in the epicardium. The placenta had infarctions that involved at least 20% of its surface, and the vessels of the umbilical cord were fully exposed due to a decrease in Wharton 's jelly. Hyperthyroidism was confirmed by the maternal clinical data, the fetal findings of exophthalmia, craniosynostosis, and goiter with signs of follicular hyperactivity. Craniosynostosis is caused by the anabolic action of thyroid hormones in bone formation during the initial stages of development. The delayed initiation of treatment in the present case contributed to the severity of fetal hyperthyroidism and consequent fetal death.
Radioiodine therapy for hyperthyroidism  [cached]
Pezhman Fard-Esfahani,Davood Beiki,Babak Fallahi,Armaghan Fard-Esfahani
Iranian Journal of Nuclear Medicine , 2011,
Abstract: Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. The method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. Iodine-131 (I-131) acts by the destructive effect of short-range beta radiation on thyroid cells. Indications for radioiodine therapy include toxic nodules (in which I-131 is the first choice of treatment), recurrent hyperthyroidism after antithyroid treatment or surgery, intolerance to antithyroid therapy due to side-effects and patient preference. Due to difficulties in previous methods for dose determination, fixed dose method of I-131 is now considered the best practical method for radioiodine therapy in primary hyperthyroidism. Absolute contraindications for radioiodine treatment are pregnancy and lactation. In pediatric patients, radioiodine therapy can be used, but is mainly considered in recurrent toxic goiter and when antithyroid medication is ineffective. There is no clear evidence indicative of carcinogenic or teratogenic effect of this agent.
Oxidative Stress in Hypo and Hyperthyroidism
Suchetha Kumari N.1*, Sandhya2 and K.M.Damodara Gowda 3
Al Ameen Journal of Medical Sciences , 2011,
Abstract: Thyroid hormones from the thyroid gland are necessary for the normal development of body organs. It was demonstrated that NO participates in the regulation of thyroid function. NO brings about oxidation reactions which will produce free radicals, and can start chain reactions that damage cells. This leads to the production of ROS. These oxidants can damage cells by starting chemical chain reactions such as lipid peroxidation, or the oxidizing DNA or proteins. The oxidation status was assessed by measuring the level of nitric oxide, total antioxidants and the antioxidant enzyme, Super Oxide Dismutase (SOD) in the blood. All the data were analyzed by one-way ANOVA followed by paired t-test. The level of significance was considered at P> 0.05.Serum nitric oxide and total antioxidants were decreased significantly in hyperthyroidism and almost no change in hypothyroidism when compared to the normal levels. Further, erythrocyte super oxide dismutase (SOD) was significantly high in patients with hyperthyroidism and it is almost same in hypothyroidism and normal controls. The result indicates that the thyroid hormone has a pro-oxidant effect and increases the oxygen free radical production and hence the resultant decrease in antioxidant state in case of hyperthyroidism when compared to the normal and hypothyroidism.
ERITEMA NODOSO Y SINDROME FEBRIL PROLONGADO ASOCIADOS A HIPERPARATIROIDISMO SECUNDARIO  [cached]
Enz P,Musso C,Luque K,Kowalczuk A
Electronic Journal of Biomedicine , 2005,
Abstract: El hiperparatiroidismo secundario es uno de los principales disturbios causados por la insuficiencia renal crónica, y la paratohormona es considerada una de las toxinas del sindrome urémico. El sindrome febril prolongado secundario a hiperparatiroidismo primario ya ha sido descripto en la literatura, aunque no lo ha sido aun el inducido por hiperparatiroidismo secundario. En el presente reporte se presenta un caso de eritema nodoso y sindrome febril prolongado asociado a hiperparatiroidismo secundario y que resolvió luego de efectuada una paratiroidectomía subtotal.
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