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Granuloma reparativo de células gigantes agresivo en región mandibular
Sánchez Cabrales,Ernesto; álvarez Arredondo,Blanca; Vila Morales,Dadonim;
Revista Cubana de Estomatolog?-a , 2010,
Abstract: the giant cells reparative granulomas (gcrg) is a reactive and aggressive process appearing more frequently in anterior sector of mandible and maxilla in children and young adolescents accounting for the 1 % of tumor bone lesions. there is a considerable controversy if they are benign or reactive lesions from the point of view of its origin, from its clinical and histological features as well as therapeutical. this is the case of a patient seen in external consultation of maxillofacial surgery of the "juán manuel márquez" children and university hospital at october, 2007 in whom an extent lesion diagnosed as an aggressive gcrg provoked a facial deformity and osteolysis of mandibular body. complementary, physical and iconopathographic examinations were made as well as surgical treatment and analysis of this sample. patient has neither aesthetic alterations nor functional. there was no relapse after 30 months of follow-up. we made a review of more update literature in med line, lilac and google websites with the giant cells reparative granulomas as key words in english and spanish languages, to compare our procedures and results with other reports.
Quiste óseo aneurismático mandibular de tipo sólido Mandibular solid aneurysmal bone cyst  [cached]
Marta Salda?a Rodríguez,Maria Fe García Reija,Belén García-Montesinos Perea,Marta Mayorga Fernández
Revista Espa?ola de Cirugía Oral y Maxilofacial , 2013,
Abstract: El quiste óseo aneurismático sólido es una lesión ósea benigna muy infrecuente de la que no existe consenso en relación a su origen etiopatogénico. Presenta características clínicas, radiológicas e histológicas inespecíficas, por lo que los estudios ultraestructurales son fundamentales para su diagnóstico y clasificación. El diagnóstico diferencial es extenso e incluye múltiples lesiones óseas como el granuloma reparativo de células gigantes e incluso tumores malignos como el osteosarcoma. El tratamiento de elección es la cirugía conservadora. La recidiva se debe fundamentalmente a la extirpación incompleta. Solid aneurysmal bone cyst is a rare benign bone lesion for which no consensus exists regarding its origin. It has nonspecific clinical, radiological and histological features so ultrastructural studies are essential for diagnosis and classification. The differential diagnosis is extensive and includes a variety of bone lesions, such as giant cell reparative granuloma, and even malignant tumors like osteosarcoma. The treatment of choice is conservative surgery. Recurrence is due mainly to incomplete resection.
Ameloblastoma mandibular muy agresivo
ZAMORANO S,R; ROCHA A,L; Nú?EZ B,C; ESPíNOLA MJ,D; HAITO CH,Y; GONZáLEZ P,M;
Revista chilena de cirugía , 2008, DOI: 10.4067/S0718-40262008000400014
Abstract: we report a female consulting for a lump in the posteroinferior portion of the mouth with a foul smelling discharge. a partial jaw excisión is performed and pathology reported a follicular ameloblastoma. a post-operative cat sean showed a mass in the operated jaw angle. the patient was lost from control and returned three years later with a large mass. a radical excisión was performed. there was a tumor relapse and the patient died 11 months after the last surgery
Giant cell reparative granuloma of the base of the skull presenting as a parapharyngeal mass  [cached]
Magu S,Mathur S,Gulati S,Yadav A
Neurology India , 2003,
Abstract: Giant cell reparative granuloma is an infrequent non-tumoral lesion affecting the maxillary and mandibular bones and only rarely, the cranial bones. We report a case of giant cell reparative granuloma of the base of the skull in a 12-year-old female who presented with a parapharyngeal mass. Computerized Tomography (CT) showed the intracranial extension and destruction of surrounding bones.
Granuloma reparativo de células gigantes dos seios etmoidal e maxilar
Gaspar Sobrinho, Fernando P.;Martins, Ana C.;Queiroz, Lívia S.;Valle, Aldo C. do;Lessa, Hélio A.;
Revista Brasileira de Otorrinolaringologia , 2004, DOI: 10.1590/S0034-72992004000400019
Abstract: the giant cell reparative granuloma is a non-neoplasic and uncommon bone tumor that represents fewer than 7% of the mandibular tumors, its most frequent site. however, this tumor has been described in paranasal sinuses, temporal bones and orbit. the present article reports a patient with a maxillo-ethmoidal giant cell reparative granuloma affecting esphenoidal and frontal sinuses, clinically with unilateral severe proptosis and facial deformity, and other patient with maxillary disease associated to macromala. the clinical, tomographic, histophatological and therapeutical findings are described. in addition, a literature review with emphasis in differential diagnosis is offered, in particular with bone giant cell tumor.
Reparative osteogenesis at hyperhomocysteinemia (experimental study)  [PDF]
Bezsmertnyi Yu.O.
Морфолог?я , 2013,
Abstract: On the model of fracture of the femur studied peculiarities of reparative osteogenesis at hyperhomocysteinemia and demonstrated the possibility of its correction drugs with hypohomocysteinemia effect. It is established, that hyperhomo-cysteinemia induces dysregulation of reparative osteogenesis with the formation of large areas of necrosis and degeneration at the fracture site. Metabolic correction of hyperhomocysteinemia preparations with hypohomocystinemic action (decamevitum, glutarginum) optimizes for reparative regeneration of the fracture.
Mandible giant-cell reparative granuloma Granuloma reparativo de células gigantes de mandíbula  [cached]
Michelle Manzini,Christian Deon,Liliam Dalla Corte,Luciana Boff de Abreu
Brazilian Journal of Otorhinolaryngology , 2009, DOI: 10.1590/s1808-86942009000400021
Abstract:
Granuloma reparativo de células gigantes em mandíbula Giant cell reparative granuloma in the mandible  [cached]
Scheila Maria Gambeta Sass,Marlene Corrêa Pinto,Yasser Jebahi,Lilian Bortolon
Brazilian Journal of Otorhinolaryngology , 2010, DOI: 10.1590/s1808-86942010000200022
Abstract:
Granuloma central de células gigantes Giant cells central granuloma
Ayelén María Portelles Massó,José María Heredia Pérez
Revista Cubana de Estomatolog?-a , 2011,
Abstract: El granuloma reparativo central de células gigantes es una lesión proliferativa no neoplásica de etiología desconocida. Se presenta un paciente masculino de 40 a os de edad, portador de prótesis parcial superior. Fue remitido al Servicio de Cirugía Maxilofacial del Hospital "V. I. Lenin" por presentar aumento de volumen en reborde alveolar superior, de color rojo grisáceo y que provocaba expansión de corticales óseas. Una vez analizados los exámenes clínicos, radiográficos e histopatológicos se diagnosticó un granuloma reparativo central de células gigantes Se realizó exéresis quirúrgica de la lesión y extracción de dientes adyacentes con una evolución satisfactoria sin se ales de recidivas luego de tres a os del tratamiento. El granuloma reparativo central de células gigantes se presentó como respuesta a un trauma. La correcta interpretación de los datos clínicos, radiográficos e histopatológicos nos permitió llegar al correcto diagnóstico y plan de tratamiento. Giant-cell central reparative granuloma is non neoplastic proliferative lesion of unknown etiology. We report a 40 years old male patient who was admitted at the Maxillofacial Service of the "V. I. Lenin" Hospital. The patient had partial upper prosthesis and was complaining of red-grey volume increase lesion in upper alveolar ridge which led to the expansion of cortical bone. Having analyzed clinical, radiographic and histopathological findings the case was concluded as a giant-cell central reparative granuloma. Surgical exeresis and adjunct tooth extraction were done. After three years of treatment, satisfactory follow up without recurrence is reported.
Pathogenesis of Cancer: Cancer Reparative Trap  [PDF]
Oleg V. Bukhtoyarov, Denis M. Samarin
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.65043
Abstract:

Cancer is one of the leading causes of death in the world while the long-term prognosis is still unfavorable, despite the enormous efforts in the search for effective anti-cancer drugs. We think that the obstacle for creating of effective anti-cancer drugs could be existing idea that the basis of cancer is caused by the damage of the genetic apparatus of the cell. In this paper, we present the pathogenesis of cancer which is based on the formation of the special sustainable pathophysiological state of the organism what we call the state of “cancer reparative trap”. The essence of this pathophysiological state of the organism is in the reparative orientation of the immune system of cancer patients, when constant tissue repair is accompanied by systemic suppression of the anti-tumor immunity. Specifically, during the long-term exposure to carcinogens (exogenous and/or endogenous), the continuous tissue damage occurs which induces permanent stimulation of cell proliferation (imbalanced Th1 < Th2 lymphocytes, M1 < M2 macrophages, inflammation, angiogenesis, etc.) in order to repair the tissues damaged. At the same time, tissue repair is necessarily accompanied by the suppression of anti-tumor immunity (increase in T-regulatory cells, imbalanced Th1 < Th2 lymphocytes, M1 < M2 macrophages et al.), which creates the necessary conditions for the survival of the malignantly transformed cells, formed by the action of carcinogens. The determining role of the imbalance in the autonomous nervous system (simpathetic/hypersympathetic dominance) in the development, maintenance and generalization of the cancer process has been shown. The explanation of a number of phenomena has been presented: the cell resistance to chemotherapy, and the phenomenon of cancer cell dormancy. The promising approaches for the cancer management in clinical practice have been proposed.

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