oalib
Search Results: 1 - 10 of 100 matches for " "
All listed articles are free for downloading (OA Articles)
Page 1 /100
Display every page Item
Síndrome de insulinorresistencia y Síndrome de ovarios poliquísticos: existe relación entre ambos? Insulin resistance syndrome and polycystic ovary syndrome, are they related?
Raúl Orlando Calderín Bouza,Miguel ángel Yanes Quesada,Marelis Yanes Quesada,Miguel Lugones Botell
Revista Cubana de Obstetricia y Ginecolog?-a , 2009,
Abstract: Desde que fue identificado el Síndrome de insulinorresistencia (SIR), o Síndrome X por Gerald M. Reaven en su brillante conferencia por la medalla de Banting, en New Orleans, desde entonces el síndrome ha tenido una variación de nombres y conceptos. Este síndrome se caracteriza por un estado de insulinorresistencia (IR), hiperinsulinemia e inflamación crónica y se refiere a una condición metabólica caracterizada por una disminución en la capacidad de respuesta del ser humano a concentraciones fisiológicas de la hormona insulina, además de la inflamación crónica presente. El SIR se asocia con alteraciones metabólicas como la prediabetes y la diabetes mellitus tipo 2 (DM2), dislipidemia, hipertensión arterial y riesgo para desarrollar una enfermedad cardiovascular. Una hemostasis alterada, adiposidad central, hígado graso no alcohólico (HGNA), cáncer, e hiperuricemia son componentes en la actualidad de este síndrome. También en las mujeres jóvenes de edad premenárquica, la insulinorresistencia está involucrada en la patogénesis del síndrome de ovarios poliquísticos (SOP), un trastorno caracterizado por irregularidad menstrual y exceso de andrógenos. El SIR es un trastorno muy prevalente con factores tanto genéticos como ambientales que están implicados en su patogénesis. Una ingestión excesiva de calorías, combinada con una vida sedentaria, promueve la expresión fenotípica de este síndrome en individuos con predisposición genética. Se hace énfasis en la relación entre el síndrome metabólico y el de ovarios poliquísticos, tanto desde el punto de vista clínico y fisiopatológico, como epidemiológico y preventivo. Since the insulin resistance syndrome or X syndrome was identified by Gerald M. Reaven in his brilliant lecture for Banting′s medal in New Orleans, it has comprised several names and concepts. This syndrome is characterized by insulin resistance condition (IR), hyperinsulinemia and chronic inflammation and defines a metabolic condition causing a reduction in the ability of the human being to respond to physiological concentrations of insulin hormone in addition to present chronic inflammation. The insulin resistance syndrome is associated to metabolic alterations such as pre-diabetes and diabetes mellitus type 2 (DM2), dyslipidemia, blood hypertension and risk of developing cardiovascular diseases. Also, altered hemostasis, central adiposity, non-alcoholic fat liver, cancer and hyperuricemia are elements included in this syndrome nowadays. Additionally, insulin resistance found in girls prior to menarche is involved in the pathogenesis of polycystic
El síndrome de ovarios poliquísticos y su rol potencial en la patogénesis de la hipertensión inducida por el embarazo Polycystic ovary syndrome and its potential role in the pathogenesis of pregnancy-induced hypertension  [cached]
Leyla Margarita Kuzmar-Daza,Ivonne Díaz-Yamal,Luis Ernesto Pérez-Agudelo
Revista Colombiana de Obstetricia y Ginecología , 2007,
Abstract: La hipertensión inducida por el embarazo-HIE (que incluye preeclampsia e hipertensión gestacional) es una complicación común del embarazo, cuya patogénesis se mantiene incierta. Muchas manifestaciones del síndrome de ovarios poliquísticos (SOP) se han asociado con esta patología. Estas incluyen hipertensión, hiperinsulinemia, intolerancia a la glucosa, obesidad, y anormalidades lipídicas. Otras anormalidades presentes incluyen la elevación en los niveles de leptina, factor de necrosis tumoral (FNT), activador del plasminógeno tisular (APT), inhibidor del plaminógeno tisular-1 (IPT-1) y testosterona. El documentar estos hallazgos antes del inicio de la hipertensión en el embarazo sugiere que la resistencia a la insulina o sus anormalidades asociadas, pueden tener un papel importante en la patogénesis de este desorden. Más aún, el identificar que estas manifestaciones del síndrome de resistencia a la insulina pueden persistir muchos a os después de la gestación, indica que estas mujeres tendrían mayor riesgo de desarrollar enfermedades cardiovasculares en el futuro. Estas observaciones sugieren que las intervenciones dirigidas a disminuir la resistencia a la insulina podrían reducir tanto el riesgo de desarrollar hipertensión en el embarazo, como complicaciones cardiovasculares a os más tarde. Pregnancy-induced hypertension which includes both gestational hypertension and preeclampsia is a common and morbid pregnancy complication for which the pathogenesis remains unclear. Many features of polycystic ovary syndrome have been associated with this condition; these would include hypertension, hyper-insulinaemia, glucose intolerance, obesity and lipid abnormalities. Other accompanying abnormalities may include increased leptin levels, tissue necrosis factor, tissue plasminogen activator, plasminogen activator inhibitor-1 and testosterone. Documenting these alterations before the onset of hypertension in pregnancy suggests that insulin resistance or associated abnormalities may play a role in this disorder’s pathogenesis. Furthermore, recognising that insulin resistance syndrome features persist many years after pregnancy, amongst women having this condition, raises the possibility that these women may have an increased risk of future cardiovascular disease. These observations suggest that interventions to reduce insulin resistance may reduce the risk of hypertension in pregnancy and later-life cardiovascular complications.
Patrón hormonal de mujeres con diagnóstico clínico y ecográfico del síndrome de ovarios poliquísticos Hormonal pattern of women with clinical and echographic diagnosis of polycystic ovary syndrome  [cached]
Alina Acosta Cede?o,Gilda Monteagudo Pe?a,Ahmed Menocal Alayón
Revista Cubana de Endocrinología , 2004,
Abstract: El síndrome de ovarios poliquísticos (SOP) es un trastorno de etiología no bien precisada con un patrón hormonal aberrante. Se muestran los resultados de un estudio descriptivo transversal en el que se incluyeron 30 mujeres con hiperandrogenismo clínico y al menos 2 elementos ecográficos sugestivos del SOP, a quienes se les determinó testosterona (T), androstenediona (Ad), dihidroepiandrosterona (DHEA) y su sulfato (DHEAs), hormona folículo estimulante (FSH) y hormona luteinizante (LH). Se emplearon estadígrafos descriptivos y prueba de correlación de Person para el análisis de los resultados. El comportamiento de las gonadotropinas fue muy variable: la FSH estuvo disminuida en 3 casos, normal en 24 y aumentada en 3, con valores medios normales (5,45 UI/L); la LH tuvo valores inferiores al rango de la normalidad en 1 caso, normales en 10 y elevados en 19, y un valor medio elevado (12,49 UI/L); la relación LH/FSH fue mayor de 3 en 14 pacientes (46,6 %). Los valores medios de todos los andrógenos, excepto la DHEAs, estuvieron elevados; en el 46,6 % de los casos se encontró elevación de más de 1 andrógeno y en 4 casos no se demostró hiperandrogenismo bioquímico; la Ad y la DHEA fueron los andrógenos más frecuentemente elevados (50 % cada una), seguidos de la T (30,0) y la DHEAs (10,0). No se demostró correlación entre ninguna de las variables estudiadas. Se concluye que la asociación de hiperandrogenismo clínico y signos ecográficos del SOP no garantiza uniformidad en el comportamiento hormonal, por lo que se debe continuar trabajando para determinar el elemento diagnóstico que verdaderamente identifique el síndrome. The polycystic ovary syndrome (POS) is a disorder of non well defined etiology with an aberrant hormonal pattern. The results of a descriptive cross-sectional study in which 30 women with clinical hyperandrogenism and at least 2 echographic elements suggestive of POS that were determined testosterone (T), androstenedione (Ad), dihydroepiandrosterone (DHEA) and its sulfate (DHEAs), follicle stimulating hormone (FSH) and luteinizing hormone (LH), were shown. Descriptive statiscians and Person's correlation test were used to analyze the results. The behavior of gonadotropins was very variable. The FSH was diminished in 3 cases, normal in 24 and increased in 3, with normal mean values (5.45 UI/L). The LH had values under the range of normality in 1 case, normal in 10 and high in 19, and an elevated mean value (12.49 UI/L). The ratio LH/FSH was over 3 in 14 patients (46.6 %). The mean values of all the androgens, excepting DHEAs were high; in 46.6
Polycystic ovary syndrome
S Maharaj, A Amod
Journal of Endocrinology, Metabolism and Diabetes of South Africa , 2009,
Abstract: The description of polycystic ovaries dates back as far as 17211 but it was Stein and Leventhal who first reported the disorder, that we now know as the polycystic ovary (or ovarian) syndrome (PCOS), in seven women with amenorrhoea, enlarged ovaries with multiple cysts and hirsutism.2 These patients were treated with ovarian wedge resection and of the seven all had return of their menstrual cycles, and two conceived. With the advent of hormonal assays in the late 1960’s and early 1970’s, the diagnostic focus expanded to include endocrine abnormalities in the hypothalamic-pituitary-gonadal (HPG) axis.3 Elevated luteinising hormone (LH) levels and hyperandrogenaemia were therefore added to the diagnostic criteria for PCOS.4 The advent of pelvic ultrasonography in the late 1970’s allowed for the non-invasive detection of polycystic ovarian morphology. However, this tool confounded matters when it was discovered that polycystic ovaries was a “common finding in normal women”,5 and that it also occurred in diverse endocrine disorders such as hypothyroidism, hyperprolactinaemia, congenital adrenal hyperplasia and hypothalamic amenorrhoea.6 The finding of polycystic ovaries in normal women has been variably referred to as polycystic ovarian disease (PCOD), polycystic ovaries (PCO) and polycystic ovarian morphology (PCOM). We prefer the to use the term PCOM in this setting as it simply describes the ultrasound appearance of the ovaries without any syndromic connotations. Despite the strong link between diabetes mellitus and PCOS, it was only in 1980 when Burghen and coworkers first described hyperinsulinaemia and insulin resistance in PCOS.7 This has subsequently been confirmed by many others. The identification of PCOS now encompasses a heterogeneous presentation but has at its core three principal features: i. Hyperandrogenism ii. Anovulation, and/or iii. Polycystic ovarian morphology (PCOM) on ultrasonography
Polycystic ovary syndrome and hirsuti
Olcay
Turk Pediatri Ar?ivi , 2011,
Abstract: Polycystic ovary syndrome is a multi-factorial heterogenous disorder characterized by chronic anovulation and hyperandrogenism. Diagnosis is based on clinical or laboratory evidence of hyperandrogenism. For diagnosis at least two of the three Rotterdam criteria (oligo/anovulation, clinical or biochemical signs of hyperandrogenism, polycystic ovaries) should be ensured. Clinical symptoms usually begin around menarche. Oligomenorrhea, amenorrhea, hirsutism, acne , alopecia can be associated with central obesity. nsulin resistance, hyperandrogenism, LH excess, and sonographic appearance of polycystic ovaries are the laboratory findings. Functional ovarian and adrenal hyperandrogenism can be demonstrated in the majority of the patients. Although pathogenesis is multifactorial, insulin resistance seems to play a central role. rrespective of obesity there is insulin resistance in 50-70% of the patients. Adolescents presenting with hirsutism, menstrual irregularities and central obesity should be evaluated for differential diagnosis of hyperandrogenism and the etiology be determined. Treatment depends on the clinical signs and the source of hyperandrogenism. In the patients with menstrual disorders and/or functional ovarian hyperandrogenism, oral contraceptives are the first line drugs. Antiandrogens are prefered in patients with hirsutism and functional hyperandrogenism. If insulin resistance is the heading symptom insulin sensitizers can be used.Hirsutism is defined as excessive terminal hair growth at androgen dependent sites and is the most frequent symptom of hyperandrogenism. Treatment consists of androgen decreasing drugs related to the etiology of androgen excess and locally epilation of the hair. In patients presenting with polycystic ovary syndrome and hirsutism, initially the etiology of hyperandrogenism should be identified and treatment planned appropriate to the reason. (Turk Arch Ped 2011; 46 Suppl: 97-102)
THYROID PATHOLOGY IN POLYCYSTIC OVARY SYNDROME  [PDF]
Gabriela Dum?chi?ǎ-?argu,Voichi?a Mogo?,Florentina Pricop
Jurnalul de Chirurgie , 2010,
Abstract: The polycystic ovary syndrome (PCOS) is defined by a chronic anovulation, clinical and/or biochemical evidence of hyperandrogenism, in the presence of polycystic ovaries and the absence of the other causes. The aim of the study is to estimate the prevalence of thyroid pathology in women with polycystic ovary syndrome. Methods: This study is a retrospective one and was made from January 2003 to December 2009 in the Endocrinology Clinic of “Saint Spiridon” Hospital and included a number of 483 women with polycystic ovary syndrome. The study includes: anamnesis dates, clinical exams, hormonal determinations, and echographic examinations of the thyroid and ovaries. Results From this group, were taken in evidence for thyroid malfunctions 179 women: 74 autoimune thyroiditis, 88 goiters, 8 congenital mixedems, 6 Basedow diseases, 1 thyroid neoplasm, 1 toxic adenoma and 1 struma ovarii. Women with polycystic ovary syndrome have a high prevalence of thyroid pathology (37,6%). This raises the possibility that female hormones might play a pathogenic role in such diseases. Conclusions: Evaluation of the thyroid gland with a blood test for thyroid stimulating hormone (TSH), antithyroglobulin and antithyroid peroxidase antibody plus an echographic examination, should be a part of the investigation of polycystic ovary syndrome. Likewise, PCOS should be evaluated in patient with under-active thyroid gland.
STATINS IN POLYCYSTIC OVARY SYNDROME
P. S. Patel*, T. D. Goswami, A. D. Sharma and B. S. Arora
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. PCOS varies from a mild menstrual disorder to severe disturbance of reproductive and metabolic functions. Statins, 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors with intrinsic antioxidant properties, exert profound and broad-reaching effects on various types of tissues. By blocking an early step of the mevalonate pathway, statins inhibit proliferation of several cell types including vascular smooth muscles, hepatocytes, and several neoplastic cell lines. The pleiotropic effects of statins may be due to inhibition of cholesterol synthesis. Some common treatments lifestyle changes, insulin-sensitizing agents.
Síndrome de ovarios poliquísticos, una mirada desde la ginecología infantojuvenil y el riesgo vascular Polycystic ovary syndrome, a look from the infantile-juvenile Gynecology and the vascular risk  [cached]
Ernesto Canciano Chirino,Reina M López Silvero,Yamilé álvarez Delgado,Orlando Río Ponciano
Revista Cubana de Obstetricia y Ginecolog?-a , 2011,
Abstract: INTRODUCCIóN: El síndrome de ovario poliquístico (SOP) constituye un dilema diagnóstico, con manifestaciones clínicometabólicas de alto riesgo. OBJETIVO: caracterizar variables de riesgo vascular en adolescentes con SOP, desde Enero 2007- Agosto 2010 asistidas en una consulta de Ginecología Infantojuvenil del Policlínico "Felipe Rodríguez Ramos", San Antonio de los Ba os. MéTODOS: Se realizó un estudio casos/control desde enero 2007- agosto 2010 en el Policlínico "Felipe Rodríguez Ramos", San Antonio de los Ba os, con 2 grupos de 60 adolescentes muestreados aleatoriamente: A (con SOP), B (negativo), se definió: edad de la menarquia, cifras de tensión arterial según circunferencia abdominal (CA), relación índice masa corporal (IMC) índice FSH/LH (realizado entre 3ro. y 5to. día del ciclo si menstruaba), niveles de glicemia, utilidad del ultrasonido transvaginal sobre el abdominal. RESULTADOS: La media global fue de 13,2 a os para la menarquia, existió en el Grupo A tendencia a la izquierda según modelo Gaussiano. Tenían aumentada su CA, 42 de las pacientes con SOP, un 54,7 % de ellas hipertensas, hubo correlación entre variables de -0,78. En el grupo A un 81,6 % tuvo aumentado el IMC, igualmente las de menor índice de hormona folículo estimulante / hormona luteinizante (FSH/LH) (55 %), con coeficiente de Spearman cercano a -1. Solo 37 pacientes del total presentaron cifras de glicemia alteradas, predominando la prediabetes (22,5 %) significativo en A con alto riesgo relativo. La sensibilidad del ultrasonido transvaginal fue superior en ambos grupos, mayor en el A (0,55). CONCLUSIONES: Prehipertensas con distribución central de la grasa y mal control endocrino-metabólico, temprano debutan las adolescentes con SOP, potencializando el riesgo más allá de un buen diagnóstico ultrasonográfico. INTRODUCTION: The polycystic ovary syndrome (POS) is a diagnosis dilemma with clinical-metabolic manifestations of high risk. OBJECTIVE: To characterize the vascular risk variables in adolescents with POS from January, 2007 to August, 2020 treated in an infantile-juvenile Gynecology consultation of "Felipe Rodríguez Ramos" Polyclinic of San Antonio de los Ba os municipality. METHODS: A case-control study was conducted from January, 2007 to August, 2010 in the above mentioned polyclinic with two groups of 6- adolescent each random sampled: A (with POS), B (negative), defining: age at menarche, figures of blood pressure according to abdominal circumference (AC), body mass index (BMI), FSH/LH (carried out the third and the fifth day of menstrual cycle if there was menstruati
Polycystic Ovary Syndrome (PCOS) and Fertility  [PDF]
Guilherme Barbosa, Larissa Bianca Paiva Cunha de Sá, Denise Rosso Tenório Wanderley Rocha, Alberto Krayyem Arbex
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2016, DOI: 10.4236/ojemd.2016.61008
Abstract: The polycystic ovary syndrome (PCOS) is defined as a combination of hyperandrogenism (hirsutism and acne) and anovulation (oligomenorrhea, infertility, and dysfunctional uterine bleeding), with or without the presence of polycystic ovaries on ultrasound. It represents the main endocrine disorder in the reproductive age, affecting 6% - 15% of women in menacme. It is the most common cause of infertility due to anovulation, and the main source of female infertility. When in the presence of a menstrual disorder, the diagnosis of PCOS is reached in 30% - 40% of patients with primary or secondary amenorrhoea and in 80% of patients with oligomenorrhea. PCOS should be diagnosed and treated early in adolescence due to reproductive, metabolic and oncological complications which may be associated with it. Treatment options include drugs, diet and lifestyle improvement.
Obesity and hormonal status of patients with polycystic ovary syndrome  [PDF]
Radulovi? Aleksandar,Bogavac Mirjana,Pjevi? Mirko,An?eli? Luka
Medicinski Pregled , 2003, DOI: 10.2298/mpns0310476r
Abstract: Introduction Polycystic ovary syndrome is commonly associated with hyperandrogenism and anovulation. The aim of this study was to investigate the impact of obesity on hormonal status in patients with polycystic ovary syndrome. Material and methods The study was performed at the Ward of Obstetrics and Gynecology of the General Hospital in Subotica. A retrospective investigation comprised 39 patients with polycystic ovary syndrome . All patients were in the fertile age-range: 18-38 years. Following ultrasonographic examination and anamnestic data, patients underwent hormonal analyses of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, prolactin and insulin obtained from the pooled serum sample. Results Values of testosterone and insulin in the group of obese patients with polycystic ovary syndrome were significantly higher than in normal weight patients. Patients with normal body weight index had significantly increased levels of LH in regard to those with increased body weight index. Values of FSH, prolactin and LH/FSH ratio were not significantly different in both groups of polycystic ovary syndrome patients. Increased values of insulin were recorded in 43% of obese and 18.2% of normal weight patients. Conclusion Analysis of investigated results confirmed that obese patients with polycystic ovary syndrome and insulin resistance have been a special clinical entity, whereas an open question remains whether obesity is directly connected with polycystic ovary syndrome or it is only an additional factor interfering with metabolic and hormonal status of genetically predisposed and phenotypically indoctrinated women with polycystic ovary syndrome.
Page 1 /100
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.