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The Effect of Phencyclidine New Derivatives on Anxiety Behaviors in Rats  [PDF]
Ramin Hajkhani,Jalal Solati,Abbas Ahmadi,Ali-Akbar Salari
Iranian Journal of Basic Medical Sciences , 2010,
Abstract: Objective(s) Anxiety is a common disorder which afflicts many people in any society and is often accompanied by physiological sensations such as tachycardia, chest pain, shortness of breath, insensitivity, etc. The purpose of present study was to evaluate the putative anxiolytic-like effects of phencyclidine (1-(1-phenylcyclohexyl) piperidine, CAS 956-90-1, PCP, I) and its methyl and methoxy hydroxyl derivatives (II, III) using elevated plus maze test of anxiety. Materials and Methods Phencyclidine as well as its methyl and methoxy hydroxyl derivatives (I, II, III) (hydrochloride, 1, 2, 5 mg/kg) were synthesized and administrated intraperitoneally (IP) on adult male Wistar rats.ResultsThe results of this study demonstrated that, intraperitoneal (IP) administration of PCP analogues (I, II, III) hydrochloride (1, 2, 5 mg/kg) increases the percentage of open arm time (OAT%) and percentage of open arm entries (OAE%).ConclusionThis study revealed that both derivatives of phencyclidine (II, III) were more effective than PCP (I) itself in modulation of anxiety behavior in rats.
The synthesis and characterization of some new diazoamino derivatives  [PDF]
ANCA MIHAELA MOCANU
Chemical Industry and Chemical Engineering Quarterly , 2010,
Abstract: The sulfonamidic moiety is much encountered in structures of bioactive compounds. In the present paper the studies on the sulfonamidated aryloxyalkylcarboxylic acids are extended by their attaching on certain substrata able to confer some special biological properties to the final products, such as anti-tumor and antioxidant actions useful in treating inflammatory processes, ulcer, convulsions and diabetes, as well as a herbicidal action. The stepwise syntheses of the sulfonamidated aryloxyalkylcarboxylic acid derivatives and their characterization by elemental analysis data and IR, 1H-NMR and UV-Vis spectral measurements are described. The newly obtained compounds could show potential pharmaceutical and herbicide properties.
A MICROWAVE SYNTHESIS AND CHARACTERIZATION OF SOME QUINOLINE DERIVATIVES AND TESTED THEIR ANTIMICROBIAL ACTIVITY  [cached]
Ajaypal Prajapati
International Journal of Pharmaceutical Research and Development , 2011,
Abstract: In the present research work there are synthesis some quinoline derivations by using microwave techniques. The synthesis of 6- methoxy acetanilide (1) by reaction of 6-methoxy aniline with acetic anhydride under microwave irradiation. This acetanilide (2) treated withPOCl3 and DMF under microwave irradiation to form 2-chloro -3- formyl-6- methoxy quinoline (3). the synthesis of 2- chloro-6-methoxy 3- substituted amine by condensing with 2-chloro -3- formyl-6- methoxy quinoline(3) and substituted aromatic amine in presence of catalytic amount of glacial acetic acid under microwave irradiation and get final products(4) which displays valuable pharmaceutical activities such as antifungal, antibacterial, anticancer and anti inflammatory activities. The structural characterization of the synthesized compound by I R. and 1HNMR spectral data reported in table No 1.The synthesized quinoline derivatives were tested their antimicrobial activity with different strain of gram-positive and gram- negative bacteria and fungi the chloro and bromo moiety derivatives of the synthesized compounds show good activity against S-aurous and B-subtilis and nitro group containing compounds showed moderate activity against gram- negative stain of micro organisms.
Synthesis, Characterization, and Photovoltaic Properties of Soluble TiOPc Derivatives  [PDF]
Young-Keun Kim,Hyo-Jin Kang,Young-Wook Jang,Su-Bin Lee,Seung-Min Lee,Ki-Suck Jung,Jin-Kook Lee,Mi-Ra Kim
International Journal of Molecular Sciences , 2008, DOI: 10.3390/ijms9122745
Abstract: We have synthesized soluble TiOPc derivatives containing alkoxy groups for use as additives in dye-sensitized solar cells (DSSCs). The DSSC devices containing these TiOPc derivatives exhibited short-circuit current densities of 8.49~10.04 mA/cm2 and power conversion efficiencies of 2.73~3.62 % under AM 1.5 illumination and 100 mW/cm2 irradiation.
Synthesis and Characterization of Novel Nano Derivatives of Graphene Oxide  [PDF]
Hawraa H. Radey, Hadi Z. Al-Sawaad, Moayed N. Khalaf
Graphene (Graphene) , 2018, DOI: 10.4236/graphene.2018.73003
Abstract: Graphene oxide has many carboxylic groups within its molecular structure, which is perfect for esterification and imidation, the derivatives graphene oxide GAP, GSO when reaction grapheme oxide with 2-amino pyridine (GAP) and 2-hydroxy-5-sulfobenzoic acid (GSO). These derivatives have been characterized by FTIR, H1 NMR, XRD and FSEM. The patterns of XRD calculated particles size using two equations and compared between them.
Synthesis, Characterization and Cytotoxicity of New Rotundic Acid Derivatives  [PDF]
Yu-Fang He,Min-Lun Nan,Jia-Ming Sun,Zhao-Jie Meng,Fa-Gui Yue,Quan-Cheng Zhao,Xiao-Hong Yang,Hui Wang
Molecules , 2012, DOI: 10.3390/molecules17021278
Abstract: Rotundic acid (RA, 1), a natural compound, exhibits potent tumor cell growth inhibiting properties. To date there are no reports on derivatives of RA. Furthermore, the 28-COOH position of RA might make it unstable and induced serious gastrointestinal side effects when it was applied in vivo. Therefore, in order to explore and make use of this compound, eight new amino acid derivatives of RA at the 28-COOH position were synthesized and evaluated for their cytotoxicities in vitro on three tumor cell lines including A375, HepG2 and NCI-H446. As a result, a few of these new amino acid derivatives showed stronger cytotoxicity. Compound 5a was found to have the best inhibition activity on the three tested human tumor cell lines with IC50 values of less than 10 μM compared with RA treatment. Meanwhile, the cytotoxicity of compound 6b was significantly higher than that of RA on the A375 cell line and almost the same as RA on the HepG2 and NCI-H446 cell lines. Hence, compounds 5a and 6b may serve as potential lead compounds for the development of new anti-tumor drugs.
Effects of Methyl and Methoxy Derivatives of Phencyclidine on Food and Water Intake  [PDF]
J. Solati,A. Ahmadi,A.A. Salari
International Journal of Pharmacology , 2010,
Abstract: The present study examined whether administration of PCP and its methyl and methoxy derivatives affect food and water intake under deprivation. Animals were deprived for 24 h before tested for food and water intake. The PCP and its derivatives were injected intraperitoneally and treated groups measured 1-12 h for food and 30-180 min for water intake post-injection. The results showed that, both of derivatives, can increase food and water intake in comparison to the PCP and saline groups. Methyl and methoxy derivatives of phencyclidine may affect central systems that are involved in feeding behavior.
Synthesis and Characterization of Some N-Heterocyclic Carbohydrate Derivatives  [PDF]
M. A. Martins Alho,N. B. D’Accorso
Molecules , 2000, DOI: 10.3390/50300381
Abstract: The nucleophilic bimolecular substitution on 1,2:3,4-di-O-isopropylidene-α-Dgalactopyranose with NH2-heterocyclic derivatives allows us to obtain some new compounds with potential biological activities. The characterization of them as well as a discussion of their reactivities toward sulfur analogues are present.
Synthesis, Characterization, and Biological Evaluation of Some New Functionalized Terphenyl Derivatives  [PDF]
Seranthimata Samshuddin,Badiadka Narayana,Balladka Kunhanna Sarojini,Divya N. Shetty,Nalilu Suchetha Kumari
International Journal of Medicinal Chemistry , 2012, DOI: 10.1155/2012/530392
Abstract: New functionalized terphenyl derivatives incorporating various heterocyclic rings are prepared by using 4,4′′-difluoro-5′-hydroxy-1,1′:3′,1′′-terphenyl-4′-carbohydrazide as a key intermediate derived from 4,4′-difluoro chalcone, a versatile synthone. All the derivatives are characterized by 1H NMR, IR, and mass spectral data. All the synthesized products are screened for their in vitro antimicrobial and antioxidant properties. The majority of the tested compounds exhibited significant antioxidant activity and some of them showed good antimicrobial activity. 1. Introduction Terphenyl is a common structural motif found in various natural products, largely isolated from microbes and mushrooms [1]. In recent years, it has been reported that some terphenyls exhibit considerable biological activities, for example, potent anticoagulants, immunosuppressants, antithrombotic, neuroprotective, specific 5-lipoxygenase inhibitory, and cytotoxic activities [2]. Because of their promising biological activities and important properties, terphenyls have been produced increasing research interest. Therefore, synthesis of terphenyl derivatives has been a fascinating area in organic field [3]. Recently we have reported a new and simple method for the preparation of ester derivative of terphenyl starting from 4,4′-difluoro chalcone [4]. The esters can be easily converted into the corresponding carbohydrazide by the reaction with hydrazine hydrate. Hydrazides and related compounds have been described as useful precursors for the assembly of various heterocyclic rings. A large number of hydrazides are reported to be of biological interest [5, 6], while oxadiazole derivatives and thiosemicarbazides have been reported to possess antibacterial [7, 8], antifungal [9, 10], and other biological activities. Furthermore, a number of substituted thiazolines and thiazolidinones are found to exhibit appreciable antimicrobial activities [11–15]. In the course of investigation, we have found that 4,4′′-difluoro-5′-hydroxy-1,1′:3′,1′′-terphenyl-4′-carbohydrazide is an excellent building block for the synthesis of numerous heterocyclic systems. In view of the pharmacological importance of terphenyls and in continuation of our work on synthesis of various derivatives of 4,4′-difluoro chalcone [16–23], it was decided to prepare new functionalized terphenyl derivatives by using 4,4′′-difluoro-5′-hydroxy-1,1′:3′,1′′-terphenyl-4′-carbohydrazide as the key intermediate and to study their biological activities. 2. Chemistry A novel terphenyl derivative, ethyl
Synthesis, Characterization, Antimicrobial and Antifungal Screening of Some Novel Benzene Sulfonamide Derivatives
Rathod C.P.,Dhawale S.C.,Pekamwar S.S.,Kadam.N.R.
International Journal For Pharmaceutical Research Scholars , 2012,
Abstract: The present work reports the possible utility of the synthesis of some novel 4-(2-amino-3-cyano-4-(substituted-aryl)-5- oxo-5,6,7,8-tetrahydroquinolin-1(4H)-yl)benzene sulfonamide (1a–1u) starting with 4-(3-oxo-cyclohex- 1-enylamino)benzenesulfonamide and 4-(cyclohexenylamino) benzenesulfonamide in the synthesis of some novel 4-(quinolin-1-yl) benzenesulfonamide derivatives. The structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral data. Some of the newly synthesized compounds were evaluated for their in vitro antibacterial and antifungal activity.
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