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Early Structural and Functional Defects in Synapses and Myelinated Axons in Stratum Lacunosum Moleculare in Two Preclinical Models for Tauopathy  [PDF]
Hervé Maurin, Seon-Ah Chong, Igor Kraev, Heather Davies, Anna Kremer, Claire Marie Seymour, Benoit Lechat, Tomasz Jaworski, Peter Borghgraef, Herman Devijver, Geert Callewaert, Michael G. Stewart, Fred Van Leuven
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0087605
Abstract: The stratum lacunosum moleculare (SLM) is the connection hub between entorhinal cortex and hippocampus, two brain regions that are most vulnerable in Alzheimer’s disease. We recently identified a specific synaptic deficit of Nectin-3 in transgenic models for tauopathy. Here we defined cognitive impairment and electrophysiological problems in the SLM of Tau.P301L mice, which corroborated the structural defects in synapses and dendritic spines. Reduced diffusion of DiI from the ERC to the hippocampus indicated defective myelinated axonal pathways. Ultrastructurally, myelinated axons in the temporoammonic pathway (TA) that connects ERC to CA1 were damaged in Tau.P301L mice at young age. Unexpectedly, the myelin defects were even more severe in bigenic biGT mice that co-express GSK3β with Tau.P301L in neurons. Combined, our data demonstrate that neuronal expression of protein Tau profoundly affected the functional and structural organization of the entorhinal-hippocampal complex, in particular synapses and myelinated axons in the SLM. White matter pathology deserves further attention in patients suffering from tauopathy and Alzheimer’s disease.
Tauopathy Differentially Affects Cell Adhesion Molecules in Mouse Brain: Early Down-Regulation of Nectin-3 in Stratum Lacunosum Moleculare  [PDF]
Hervé Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Mathias V. Schmidt, Sebastian Kuegler, Fred Van Leuven
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063589
Abstract: Cell adhesion molecules are important structural substrates, required for synaptic plasticity and synaptogenesis. CAMs differ widely in their expression throughout different brain regions and their specific structural and functional roles in the brain remain to be elucidated. Here, we investigated selected cell adhesion molecules for alterations in expression levels and neuronal localization in validated mouse models for Alzheimer's disease that mimic the age-related progression of amyloid accumulation and tauopathy. Among the cell adhesion molecules analyzed, Nectin-3 expression was affected most and specifically in all mouse models with tauopathy. In particular was Nectin-3 depleted from the specific region of the hippocampus, known as the stratum lacunosum and moleculare, in mice that express wild-type or mutant human protein Tau, either chronically or sub-acutely. Tauopathy progresses from the entorhinal cortex to the hippocampus by unknown mechanisms that could involve transport by the myelinated axons of the temporoammonic and perforant pathways. The decreased expression of Nectin-3 in the stratum lacunosum moleculare is an early marker of impaired transport, and eventual synaptic problems, caused by beginning tauopathy.
Dan Tudor LAZ?R,Adrian Mihai INCEU
Revista Transilvan? de ?tiin?e Administrative , 2004,
Abstract: Performance budgeting is the same as program budgeting, except that one additional component–performance–is included to tie expenditures for each program to specific goals established for that program. For example, the amount budgeted for street sweeping would be tied to an expected level of performance, such as sweeping “X” number miles of streets during the fiscal year. Performance budgeting provides spending data that can be examine at the end of the fiscal year to identify the amount of service that each city department has actually produced. Additionally, by knowing the exact cost of each service, well can determine its relative usefulness compared to the other spending priorities. The negative aspect of performance budgeting is that it is difficult to develop measurable performance goals for simple programs, such as street sweeping. It is hard to set measurable goals for emergency medical services and other less-quantitative programs. Also, data collection can be difficult.
Doru Botezat
Revista de Economie Sociala , 2013,
Abstract: Acest articol porne te de la o analiz sistematic a literaturii specialitate pe subiectul integr rii serviciilor de s n tate i a re elelor, ncercand s ofere explica ii relevante pentru n elegerea sistemului de organizare a serviciilor n re ea. Pentru nceput, articolul pune n lumin dinamica institu ional i spa ial , care conduce la configura iile de tip re ea. Apoi, sunt analizate procesele i m surile care pot servi ca instrumente de planificare aflate la ndemana politicilor, conturandu‐se catevaprincipii de guvernare a re elelor din domeniul s n t ii. n final, articolul prezint cateva modele de configurare a re elelor de s n tate consemnate de literatura de specialitate i pune n discu ie corela ia dintre evolu ia natural spre aceste noi forme de organizare a gestiunii i noile principii ale economiei sociale ca evolu ie sistemic a organiz rii statului. Metodologic, articolul a rezultat din c utarea,selectarea, evaluarea i rezumarea unor lucr ri axate pe economia sitemelor de s n tate i politici n domeniul s n t ii.
Pop Ciprian-Marcel,Dabija Dan-Cristian
Annals of the University of Oradea : Economic Science , 2012,
Abstract: n cre … terea satisfac … £iei … i a gradului de mul … £umire al clientului fa … £ ’ de any retail store, un rol semnificativ l joac ’ … i ambian … £a sau in-store-management. De aceasta apar … £in totalitatea deciziilor privind modalit ’ … £ile n care se poate structura magazinul, se aranjeaz ’ gondolele … i rafturile, se recurge la jocul de lumini … i umbre, la mirosuri specifice sau chiar la varierea temperaturii n cadrul unor departamente. Pentru consumator ambian … £a nseamn ’ ns ’ … i existen … £a unei atmosphere pl ’cute la cump ’r ’turi, transmiterea unui spirit de aventur ’, a unor sentimente positive care s ’ l determine pe client s ’ revin ’ n magazine, s ’- … i m ’reasc ’ achizi … £iile … i de ce nu, s ’ recomande unitatea … i altora. Prezentul studiu ncearc ’ s ’ eviden … £ieze c ’ile prin care any retailer reu … e … te s ’ ac … £ioneze asupra consumatorului prin intermediul unor instrumente ale in-store-management n vederea contur ’rii unei imagini favorabile n psihicul acestuia. Cercetarea derulat ’ pe aproape 1.800 de clien … £i din comer … £ul alimentar … i nealimentar din Rom ¢nia reliefeaz ’ prin interpret ’ri pertinente implica … £iile manageriale … i c ’ile de ac … £iune care le revin ntreprinderilor apar … £in ¢nd unor different retail formats = diferite formate comerciale n vederea ac … £ion ’rii adecvate asupra clien … £ilor.
Contractul administrativ in activitatea administratiei publice  [PDF]
Ioan LAZ?R
Revista Transilvan? de ?tiin?e Administrative , 2010,
Abstract: Aderarea Romaniei la Uniunuea European la 1 ianuarie 2007 a determinat schimbari majore in legislatia cu privire la contractele de concesiune si la parteneriatele publice-private. In acest context, au fost emise o serie de noi prevederi legislative cum ar fi Ordonanta de Urgenta a Guvernului nr. 34/2006 privind atribuirea contractelor de achizitie publica, a contractelor de concesiune de lucrari publice si a contractelor de concesiune de servicii, si Ordonanta de Urgenta nr. 54/2006 privind regimul contractelor de concesiune de bunuri proprietate publica. De asemenea, Leaga 544/2004 a litigiilor administrative include contractele incheiate de autoritati publice, contractele care urmaresc valorificarea bunurilor publice, executarea de lucrari in interes public, servicii publice si achizitii publice; prin legi speciale, alte categorii de contracte ale administratiei publice pot constitui subiecte juridice pentru litigii administrative. In mod sigur, legislatia si prevederile legislative actuale demonstreaza importanta contractelor administrative - percepute ca un aspect inseparabil de parteneriatele publice-private - ca fiind niste instrumente prin care vietile indivizilor si a intregii comunitati sunt influentate in mod pozitiv, fara a afecta bugetele publice in mod negativ.
Ki inev or Linkuva? Rumors and threats against Jews in Lithuania in 1903
Klaus Richter
Revista Romana de Studii Baltice si Nordice , 2011,
Abstract: :Over Easter 1903, a large-scale anti-Jewish riot in Ki inev, capital of the Russian governorate of Bessarabia, left dozens of Jews dead and hundreds injured, thus leading to a massive wave of emigration. A product of social discontent and anti-Semitic agitation, the riots of Ki inev became notoriously famous as the onset of a wave of pogroms of hitherto unprecedented brutality, which only subsided after the end of the Russian Revolution of 1905/06. This article analyzes the incidents by emphasizing cultural transfers between Ki inev and Lithuania, using the histoire croisée approach in order to provide for the different ethnic, social and political backgrounds and motivations of the actors. It also compares the disturbances in the rural north of Lithuania and in the Bessarabian industrial city of Ki inev in order to contextualize anti-Jewish violence in Lithuania on the larger scale of the Russian pogroms. When Lithuanian Jews were sometimes threatened to be killed “as in Ki inev” and at other times to be treated “as in Linkuva”, the significance of analyzing cultural transfer while keeping the regional context in mind becomes apparent.Rezumat: n perioada Pa telui anului 1903, o revolt antievreiasc la scar larg izbucnit la Chi in u, capitala guberniei ruse ti Basarabia, l sa n urma sa zeci de evrei mor i i sute de r ni i, ceea ce a condus la un val masiv de emigrare. Rezultat al nemul umirilor sociale i al agita iilor antisemite, revolta de la Chi in u a devenit foarte cunoscut ca marcand debutul unui val de pogromuri, de o brutalitate f r precedent pan n acel moment, care s-a diminuat abia dup ncheierea Revolu iei Ruse din 1905-1906. Articolul de fa abordeaz incidentele prin studierea transferurilor culturale dintre Chi in u i Lituania, utilizand metodele histoire croisée n scopul de a oferi explica ii pentru diferen ele ce apar n ceea ce prive te mediile etnice, sociale i politice i motiva iile actorilor. Acesta compar , de asemenea, tulbur rile din partea rural de nord a Lituaniei i din ora ul industrial basarabean Chi in u, n scopul de a contextualiza violen a anti-evreiasc din Lituania la scara mai larg a pogromurilor ruse ti. Atunci cand evreii lituanieni au fost, uneori, amenin a i c vor fi uci i ca la Chi in u” i n alte momente c vor trata i ca n Linkuva”, semnifica ia analizei transferurilor culturale, p strand n acela i timp n minte contextul regional, devine evident .
Andrei Marga, Religia in era globalizarii/ Religion in the Era of Globalization  [cached]
Sandu Frunza
Journal for the Study of Religions and Ideologies , 2004,
Abstract: Andrei Marga, Religia in era globalizarii Editura Fundatiei pentru Studii Europene, Cluj- Napoca, 2003.
Daniel Barbu, Politica pentru barbari (Politics for Barbarians)  [cached]
Marius Jucan
Journal for the Study of Religions and Ideologies , 2006,
Abstract: Daniel Barbu, Politica pentru barbari (Politics for Barbarians) Nemira, Bucharest 2005, 242 pages
Alina Branda, Repere n antropologia cultural / Orientations in Cultural Anthropology  [cached]
Ana Elena Ilinca
Journal for the Study of Religions and Ideologies , 2003,
Abstract: Alina Branda, Repere n antropologia cultural Ed. Fundatiei pentru Studii Europene, Cluj-Napoca, 2002, 272p.
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