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TWO NEW COMPOUNDS FROM ARTEMISIA DRACUNCULUS L
RAZIEH YAZDANPARAST,HAMID REZA ALAVI,?AT ABACK BAZARGANIAN
DARU : Journal of Pharmaceutical Sciences , 2000,
Abstract: Two new compounds, 7-methoxycoumarin (I) and 7-hydroxyartemidin (II) were isolated from the ethanol/water (50:50, V/V) extract of Artemisia drucunculus L. leaves. Structures of the isolated compounds were elucidated on the basis of spectral data ('H NMR and MS). It is shown that compound I is devoid of anticoagulation activity in male Albino rabbits in contrast to the same activity observed in rabbits using the crude extract of the leaves.
ARTEMISIA DRACUNCULUS, PUNICA GRANATUM AND BERBERIS VULGARIS INHIBITORY EFFECTS ON PLATELET ADHESION AND COAGULATION FACTORS IN RATS  [PDF]
Dr. Razieh Yazdanparast et al
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Excessive platelet activity is one of the most important factors responsible for the incidence of cardiovascular diseases and, also, play important role in coagulation cascade. In this study, the comparative effects of methanol extracts of three herbs on adhesion of the activated platelets to fibrinogen coated plates and clotting factors were investigated. Artemisia dracunculus, Punica granatum and Brberis vulgaris are used as blood anti-coagulatory plants in Iranian folk medicine. Platelets were prepared and incubated with different concentration of the test samples (50-200 μg/ml) for 60 min. The treated and un-treated platelets were then activated with thrombin (0.25U/ml) and their adhesions to fibrinogen coated plates were investigated. Based on obtained data, the methanol extract of Artemisia dracunculus, Brberis vulgaris and Punica granatum at a concentration of 200 μg /ml reduced platelet adhesion to coated wells by 35%, 25% and 20%, respectively. In addition, the effects of the crude extracts of each plant on atherogenic lipoproteins were also examined. The results indicated that the LDL and cholesterol concentration were dramatically reduced by 56% and 36%, respectively, by B. vulgaris. This result provided the scientific basis for the traditional use of A.dracunculus and B. vulgaris in treatment of cardiovascular related disorders.
An Extract of Artemisia dracunculus L. Inhibits Ubiquitin-Proteasome Activity and Preserves Skeletal Muscle Mass in a Murine Model of Diabetes  [PDF]
Heather Kirk-Ballard, Zhong Q. Wang, Priyanka Acharya, Xian H. Zhang, Yongmei Yu, Gail Kilroy, David Ribnicky, William T. Cefalu, Z. Elizabeth Floyd
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057112
Abstract: Impaired insulin signaling is a key feature of type 2 diabetes and is associated with increased ubiquitin-proteasome-dependent protein degradation in skeletal muscle. An extract of Artemisia dracunculus L. (termed PMI5011) improves insulin action by increasing insulin signaling in skeletal muscle. We sought to determine if the effect of PMI5011 on insulin signaling extends to regulation of the ubiquitin-proteasome system. C2C12 myotubes and the KK-Ay murine model of type 2 diabetes were used to evaluate the effect of PMI5011 on steady-state levels of ubiquitylation, proteasome activity and expression of Atrogin-1 and MuRF-1, muscle-specific ubiquitin ligases that are upregulated with impaired insulin signaling. Our results show that PMI5011 inhibits proteasome activity and steady-state ubiquitylation levels in vitro and in vivo. The effect of PMI5011 is mediated by PI3K/Akt signaling and correlates with decreased expression of Atrogin-1 and MuRF-1. Under in vitro conditions of hormonal or fatty acid-induced insulin resistance, PMI5011 improves insulin signaling and reduces Atrogin-1 and MuRF-1 protein levels. In the KK-Ay murine model of type 2 diabetes, skeletal muscle ubiquitylation and proteasome activity is inhibited and Atrogin-1 and MuRF-1 expression is decreased by PMI5011. PMI5011-mediated changes in the ubiquitin-proteasome system in vivo correlate with increased phosphorylation of Akt and FoxO3a and increased myofiber size. The changes in Atrogin-1 and MuRF-1 expression, ubiquitin-proteasome activity and myofiber size modulated by PMI5011 in the presence of insulin resistance indicate the botanical extract PMI5011 may have therapeutic potential in the preservation of muscle mass in type 2 diabetes.
The Electrophysiological Consequences of Artemisia dracunculus L. (Tarragon) Extract on Pentylenetetrazol-Induced Epileptiform Activity in Snail Neurons  [PDF]
Sahar Farajnia,Mahyar Janahmadi,Jafar Vatanparast,Habib Abbasipour
Cell Journal , 2011,
Abstract: Objective: Plant extracts are of considerable interest because of their antiepileptic activities.However, the mechanisms of action are not clearly defined.Materials and Methods: Here, the effects of Artemisia dracunculus L. (tarragon) leavesextract on excitability and electrophysiological characteristics of snail neurones were investigated,using an intracellular recording technique.Results: Application of tarragon extract (0.05%) resulted in complete disappearanceof paroxysmal depolarization shift (PDS) as elicited by pentylenetetrazol (PTZ), an epileptogenicdrug. It also significantly decreased the firing frequency and shifted the firingpattern from bursting in the presence of PTZ to an irregular doublet activity. Changesin excitability properties were associated with a significant increase and decrease inthe duration of action potential, and in the amplitude of after-hyperpolarization (AHP),respectively. When tarragon extract was applied alone, spontaneous activity becameirregular and was interrupted by large inhibitory postsynaptic potentials (IPSPs), whichdisappeared following application of picrotoxin (100 μM). Tarragon also caused a significantdecrease both in the amplitude of action potentials and AHP, and broadened theaction potentials. However, pretreatment with extract did not prevent the induction ofepileptiform activity by PTZ.Conclusion: The findings suggest that tarragon extract may affect membrane ion channelsand/or GABAA receptors leading to a reduction in neuronal excitability.
Essential oil of tarragon (Artemisia dracunculus) antibacterial activity on Staphylococcus aureus and Escherichia coli in culture media and Iranian white cheese
M Raeisi,H Tajik,SM Razavi roohani,M Maham
Iranian Journal of Microbiology , 2012,
Abstract: Background and Objectives: In this study, the antibacterial effect of essential oil of tarragon (Artemisia dracunculus) on Staphylococcus aureus and Escherichia coli was evaluated in culture media and Iranian white cheese.Materials and Methods: The tarragon essential oil (EO) obtained by the steam distillation method and its antibacterial activity was evaluated in 96-well microtiter plates containing brain heart infusion broth. The enumeration of S. aureus and E. coli in cheese samples were carried out on the following media: Baired parker agar for S.aureus, incubated at 37 °C for 24 h; and MacConkey sorbitol agar for E. coli, incubated at 37°C for 24 h. Iranian white cheese was produced from fresh and whole pasteurized cow milk (2.5%). Bacteria (103 cfu/mL) were inoculated to different batches. Cheese was treated with different concentrations of EO (15 and 1500 μg/mL) and separated into four parts in an equal manner. The sensory evaluation was done by a panel of four judges.Results: According to the results obtained, minimum inhibitory concentrations (MIC) for E. coli and S. aureus were 2500 and 1250 μg/mL, respectively. Also, minimum bactericidal concentration (MBC) for the mentioned microorganisms were 5000 and 2500 μg/mL, respectively. All the EO concentrations for each bacteria result in reducing bacterial count of cheese samples compared to control (P < 0.05). Also, with increasing concentration of EO in cheese samples, the bacterial count was reduced further (P < 0.05).Conclusion: Based on our findings, tarragon essential oil has antibacterial effect on two important pathogen bacteria (S. aureus and E. coli) and can be applied as a preservative in foods such as cheese.
High-Fat Diet-Induced Neuropathy of Prediabetes and Obesity: Effect of PMI-5011, an Ethanolic Extract of Artemisia dracunculus L.
Pierre Watcho,Roman Stavniichuk,David M. Ribnicky,Ilya Raskin,Irina G. Obrosova
Mediators of Inflammation , 2010, DOI: 10.1155/2010/268547
Abstract: Artemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-sfat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. C57Bl6/J mice fed high-fat diet for 16 weeks developed obesity, moderate nonfasting hyperglycemia, nerve conduction deficit, thermal and mechanical hypoalgesia, and tactile allodynia. They displayed 12/15-lipoxygenase overexpression, 12(S)-hydroxyeicosatetraenoic acid accumulation, and nitrosative stress in peripheral nerve and spinal cord. PMI-5011 (500 mgkg?1d?1, 7 weeks) normalized glycemia, alleviated nerve conduction slowing and sensory neuropathy, and reduced 12/15-lipoxygenase upregulation and nitrated protein expression in peripheral nervous system. PMI-5011, a safe and nontoxic botanical extract, may find use in treatment of neuropathic changes at the earliest stage of disease.
Toxicity of Essential Oils Isolated from Achillea millefolium L., Artemisia dracunculus L. and Heracleum persicum Desf. Against Adults of Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae) in Islamic Republic of Iran  [PDF]
Asgar Ebadollahi,Shabnam Ashouri
Ecologia Balkanica , 2011,
Abstract: The environmental problems caused by overuse of synthetic insecticide have been the matter of concern in recent years. Essential oils from aromatic plants are recognized as proper alternatives to conventional insecticides. Therefore, this study was conducted to determine the Fumigant toxicity of essential oils from Achillea millefolium, Artemisia dracunculus and Heracleum persicum against adults of Plodia interpunctella under laboratory conditions and mortality was determined after 12, 24, 36 and 48 h from beginning of exposure. The essential oils were extracted from seeds of H. persicum and aerial parts from 1.5 cm of top of A. millefolium, A. dracunculus by hydrodistillation method using a Clevenger apparatus. All essential oil were highly effective against P. interpunctella and the mortality values reached 100% when the adults were exposed to 50, 65 and 80 μl/ l concentrations of A. dracunculus, A. millefolium and H. persicum essential oil, respectively. The LC50 (lethal concentration to kill 50% of the population) values of essential oils from A. dracunculus, A. millefolium and H. persicum were 22.24, 34.80 and 36.96 μl/ l after 24 h fumigation, respectively. On the other hand, A. dracunculus oil was more effective than the other essential oils against P. interpunctella adults. The LC50 values decreased with increasing of exposure times. In all cases, considerable differences in the mortality of insect to essential oils were observed with different concentrations and exposure times. These results suggest that the essential oils of A. millefolium, A. dracunculus and H. persicum have merit further studies as potential fumigants for the management of P. interpunctella or probably other stored-product insects.
Atividade antibacteriana e a preditividade do condimento Artemisia dracunculus Linn. (Asteraceae), variedade inodora - estrag?o -, frente à Salmonella sp
Carvalho, Heloisa Helena;Wiest, José Maria;Greco, Dalton Palmeira;
Ciência e Tecnologia de Alimentos , 2006, DOI: 10.1590/S0101-20612006000100013
Abstract: it was evaluated antibacterial activity of watery extract of the condiment tarragon - artemisia dracunculus linn., var. inodora -, against the salmonella enteritidis (atcc 11076), through the system of multiple pipes and the job of bacterial inhibitors, it was determined intensity of inhibition/inativation (iinib/iinab), observing expressive inhibition, as well as absence of inativation on this salmonela. in presence of the organic substance, represented by skimmed barren milk, these attributes if had repeated, even so with lesser intensity of inhnibition. later, it was evaluated preditividade of one official technique of isolation of this bacterium, using an experimental solution of milk and bhi broth (brain heart infusion), contaminated with 104 cfu/ ml of salmonela in study. it was verified absence of isolation of this bacterium in aliquots of 25 ml, after periods of 24, 48 and 72 hours of incubation at 36oc, compromising the preditive validity of the negative results (pvr-) of the test. one suggests that, in the inquiries epidemiologists of alimentary toxinfectives studies, information could be increased about vegetal condimentary, among others, pertinent to the increasing complexity of the system of feeding and nutrition.
Phyllochron and differential growth between plants of French tarragon (Artemisia dracunculus L.) with different source of propagation  [cached]
Fernández Lizarazo John Cristhian,Mosquera Vásquez Teresa,Chaves Bernardo,Sarmiento Felipe
Agronomía Colombiana , 2011,
Abstract: French tarragon is included within the brochure of herbs that Colombia is offering to export. Although renewal is recommended every three or four years, in Colombia there are crops more than eight years of age and with low yield because its traditional vegetative propagation is difficult, therefore it is necessary to establish alternative propagation methods to improve its yield. In order to analyze the phyllochron and growth between French tarragon plants with different origin of propagation (micropropagation and traditional propagation), parameters to simulate field behavior from a model was estimated. From cardinal temperatures, a quadratic function of tarragon’s phyllocron, whose rate was higher in plants from micropropagation during establishment, was determined. The general meristematic activity in plants of in vitro treatment shown to be greater than plants of field treatment, as well as leaf area index (LAI), fraction of intercepted light (FLINT) extinction coefficient (K) and radiation use efficiency (RUE), which involved differences in the architecture of plants in both treatments. Distribution of biomass to leaves and stems was similar in both treatments. This is the first study using a deterministic model to analyze the effect of micropropagation in field tarragon’s growth.
Efficient in vitro micropropagation and regeneration of Artemisia vulgaris L.  [PDF]
Sujatha Govindaraj,Ranjitha Kumari Bollipo Diana
Crop Breeding and Applied Biotechnology , 2007,
Abstract: This paper describes efficient propagation of Artemisia vulgaris using shoot tip explants isolated from 35 daysold in vitro grown seedlings. Optimum proliferation was obtained on Murashige and Skoog s salts and B5 vitamins supplementedwith 3% sucrose, 4.44 μM BA, and 0.7% agar. Shoot proliferation was maximal (99.8%) with 14-23 shoots per explant after6 weeks of culture. Shoots with a minimum length of 1.5 cm were transferred to shoot elongation medium supplemented with0.44 μM BA and 1.44 μM GA3. The successfully elongated shoots with a height of 7.2-12.1 cm were transferred to rootingmedium augmented with 8.56 μM IAA. Rooted plantlets were transferred to plastic cups containing autoclaved garden soil,farmyard soil and sand (2:1:1) for hardening. Plantlets were initially maintained under culture room conditions (5 weeks),followed by normal laboratory conditions (4 weeks) and finally transferred to a Botanical Evaluation Garden and maintainedthere.
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