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A Practical Approach to Managing Patients with HCV Infection
Huang Richard H.,Hu Ke-Qin
International Journal of Medical Sciences , 2006,
Abstract: Hepatitis C virus (HCV) infection is a major worldwide public health concern. It is a common cause of chronic liver disease and hepatocellular carcinoma. HCV antibody and HCV RNA testing are available diagnostic studies that offer high degree of accuracy. Current standard therapy includes a combination of pegylated interferon and ribavirin. Response rate is approximately 40% for genotype 1 and 80% for genotypes 2 and 3, respectively. Successful treatment can stop the progression of chronic liver disease, reduce the need for liver transplantation, and possibly decrease the risk for Hepatocellular carcinoma (HCC). Evaluating for potential treatment candidacy is an important initial step in the management of chronic HCV infection as not all individuals may need or qualify for the treatment. Understanding the natural history, the different diagnostic modalities, the current therapeutic options and, the treatment response and adverse effect profiles can help the practitioners better manage chronic HCV infection.
Managing HCV infection in pediatric age group: Suggested recommendations  [cached]
Danish Fazal,Koul Salman,Subhani Fazal,Rabbani Ahmed
Saudi Journal of Gastroenterology , 2010,
Abstract: Hepatitis C virus (HCV) infection in children is different from the adult infection in many ways, like natural course of the disease; duration, therapeutic response and side effects profile of the drug therapy; and prognosis. Special considerations include consideration on what could be the appropriate time to investigate a suspected child, when to institute drug therapy and how to prevent vertical transmission. Although over the past one decade many landmark studies have greatly increased our insight on this subject, yet we are far from developing a consensus statement. In this article, a concise yet comprehensive review of HCV infection in children - diagnosis and treatment - is given, followed by suggested recommendations at the end. It is hoped that these recommendations will help develop local guidelines on this subject.
Study of Various HCV Genotypes in Patients Managing by Referral Clinic in Yazd Province
M Molaabedin,M Pedarzadeh
Journal of Shahid Sadoughi University of Medical Sciences , 2012,
Abstract: Introduction: Determining virus genotype is a major factor for initiation of treatment because various kinds of genotypes need different antiviral drugs. Distribution of hepatitis C genotype in the word is variable in each country or even in each province. So we need to determine distribution pattern of hepatitis C genotype in our region. This study was performed in referral clinic of Yazd province. Methods: This was a descriptive study conducted between 2007 and 2010 on patients who were observed by Yazd referral clinic (the clinic for evaluating and management of patients with high risk behaviors). Ninety two patients who had positive RIBA test for hepatitis C infection were randomly selected and entered the study. Genotyping was performed using RT-PCR method. The primer was "universal primer HCV". Prevalence of various genotypes was analyzed according to gender, addiction and co- existence of HCV-HIV infection. Personal information and laboratory results were analyzed using SPSS. Results: The most common genotype in our study was genotype 3a (65% of cases), followed by 1a (35%). Globally 83% of patients were IV drug addict. Genotype distribution in these patients was similar to others. Fifteen patients had co-infection of HCV-HIV, and 47% of them were contaminated by genotype 1a and 53% with 3a. We could not find any patient contaminated with genotypes 2 or 4. No other genotypes except 1 & 3 or mixed genotype infection could be determined in our patients. Twenty three percent of patients had negative PCR despite positive RIBA test. This indicates that self improvement from acute hepatitis C infection in IV drug addict patients is similar to other people. Conclusion: According to the results of our study, about 2/3 of patients were infected by genotype 3a. This kind of chronic hepatitis C shows a better response to treatment comparing genotype 1a (or 1b) with shorter duration and lower cost drugs. But despite higher incidence of genotype 3a, we can not start chronic hepatitis C therapy without knowing virus genotype. Determination of genotype is mandatory for the initiation of specific antiviral treatment.
Managing the Organizational Culture: A Technological Issue
Ludmila N. Aksenovskaja,Takhir U. Bazarov
Psychology in Russia : State of Art , 2011,
Abstract: Organizational culture presents an interest for research and practice of social psychology. This article is intended to discuss the problem of managing the organizational structure on two levels that contain most topical problems: general methodological level and technological level. Organizational culture is a system with its distinct features that consists of units and sub-systems with their specific features. An organizational-culture system comprises several levels: leader's personality level (as well as the personality level in general), level of executive team (as well as of a small group in general), level of organization in general (level of a large group).
Introduction to the Issue  [cached]
Mark van 't Hooft
Journal of the Research Center for Educational Technology , 2009,
Abstract: Editorial
Introduction to the Issue  [cached]
Mark van 't Hooft
Journal of the Research Center for Educational Technology , 2012,
Abstract: Editorial
From the EDUCON2011 Conference Chair  [cached]
A. Y. Al-Zoubi
International Journal of Online Engineering (iJOE) , 2011, DOI: 10.3991/ijoe.v7is1.1780
Abstract: Guest Editorial
Managing HIV/HCV - related risk at private places among Belgrade injecting drug users
?iki? Bojan
Glasnik Etnografskog Instituta SANU , 2006, DOI: 10.2298/gei0654189z
Abstract: Some of the results acquired by qualitative research conducted among Belgrade injecting drug users are presented: primary aim of the research was to establish relation between HIV/HCV prevalence and socio-cultural aspects of HIV/HCV vulnerability in population issued. Understanding the way of how HIV/HCV-related risk is managed among these people in their day-to-day injecting routines is crucial tool in operating social epidemiological prevention programs. Vital part of this understanding concerns the physical risk environments, i.e., places where injection occurs. The distinctive feature of Belgrade study among the similar ones is that this happens frequently at various private places, which is depicted and discussed.
Guest Editorial  [cached]
Hsiao-Chun Wu,Tho Le-Ngoc,Jitendra K. Tugnait,Shih Yu Chang
Journal of Communications , 2010, DOI: 10.4304/jcm.5.6.445-446
Abstract: Originally, when the guest editorial board was contacted by Associate Editor-in-Chief Dr. Haohong Wang of Journal of Communications, we planned to call for the papers contributed to “Blind Signal Processing for Communications”. After collecting the submitted papers, the guest editorial board adjusted the originally focused theme to “Efficient and Robust Signal Processing Schemes for Wireless Receivers” because very few submitted papers were actually dedicated to the former topic while there were quite a few excellent papers addressing the latter thrust area. Perhaps, it seems slightly quixotic to change the course after we saddle up and run a distance. However, for the benefit of the readership, the guest editorial board tried to collect the quality papers to present in this special issue, which turned out to be in a different theme from what we foresaw. The five papers collected in this special issue are “Radio Resource Allocation for Heterogeneous Services in Relay Enhanced OFDMA Systems”, “A Low-Complexity Optimum Multiuser Receiver for DS-CDMA Wireless Systems”, “Research on Adaptive Waveform Selection Algorithm in Cognitive Radar”, “Grid-based Mobile Target Tracking Mechanism in Wireless Sensor Networks”, and “Analysis of Performance Degradation using Convex Optimization for a Mismatched Receiver”. They address the crucial problems and provide the corresponding innovative approaches and analyses for many kinds of wireless systems such as wireless local-area networks, wireless metropolitan-area networks, radars, sensor networks, etc. The important problems involving resource allocation, waveform adaptation, optimization and searching algorithms are tackled therein. In general, wireless receivers often endure the difficulties caused by the interference, hardware/software complexities, time-varying or dynamic environments, etc. The popular and key approach is to use the advanced signal processing schemes or subsystems as the solution. In this special issue, the authors with outstanding expertise in code-division multiple-access (CDMA), orthogonal frequency-division multiplexing (OFDM), radar, sensor network systems and communication theories share their state-of-the-art knowledge and innovative methods in these areas. The highlights of this special issue are given as follows. A priority based resource allocation algorithm for heterogeneous services in the relay enhanced OFDMA downlink systems is proposed to maximize the system throughput while satisfying the quality-of-service (QoS) requirements. A novel approach for reducing the asymptotic computation
Paola Mancino,Katia Falasca,Claudio Ucciferri,Eligio Pizzigallo
Mediterranean Journal of Hematology and Infectious Diseases , 2010, DOI: 10.4084/mjhid.2011.
Abstract: Haematological abnormalities are common during combination antiviral therapy for chronic hepatitis C. Although dose reduction or discontinuation can easily treat these side effects, they can adversely affect the efficacy of combination antiviral therapy reducing the likelihood of a sustained viral response (SVR). To avoid potentially diminishing a patient’s chance of response, many physicians have begun using growth factors off-label to manage anaemia and neutropenia in hepatitis C. Haematopoietic growth factors are generally well tolerated and they may be useful for managing haematological side effects of anti-HCV therapy improving patients’ quality of life. To date, the role and benefit of these agents during anti-HCV therapy and their positive impact on SVR have not conclusively determined in the published studies. However, the possibility of a benefit to individual outpatients remains, and an individualized approach is recommended. This review explores the incidence, clinical significance, and management of anaemia, neutropenia and thrombocytopenia associated with combination therapy for HCV infection.
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