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Demographic and pathologic findings of squamous cell carcinoma of skin and lip in pathology department of Razi Hospital1
Najafizadeh R,Gharibduost F,Khalvat A
Tehran University Medical Journal , 2000,
Abstract: Squamous cell carcinoma, a cancer of keratinocytes origin, mostly involves sun-exposed areas of the skin. To study the pathologic and demographic features of this disease, records of 395 patients of squamous cell carcinoma of skin and lip were reviewed. Most of the patients (83%) aged 40 years or more at the time of diagnosis. Respectively, 74.4% and 75.8% of cases with skin and lower lip carcinoma were men, but in upper lip cases frequencies of both sexes were equal. The number of patients referred from western and north-western provinces were much more than those of other provinces of the country. The most frequent histologic stage was grade I (53% and 58.8% in skin and lip carcinoma, respectively), showing that most patients visit physicians early enough, and are diagnosed in early stages of the disease.
Pathologic mitoses and pathology of mitosis in tumorigenesis  [cached]
RG Steinbeck
European Journal of Histochemistry , 2009, DOI: 10.4081/1640
Abstract: The gist of my hypothesis (.. is) a certain abnormal chromatin constitution. Each process, which brings about this chromatin constitution, would result in the origin of a malignant tumour. Certainly, I consider irregularities with mitosis as the normal mode of the origin of an incorrectly assembled nucleus. This statement by Boveri (1914) has considered earlier observations of asymmetric divisions in human cancers (Hansemann, 1890). The hypothesis is based on the understanding of mitosis as an equational bipartition of the hereditary substance (Flemming, 1879; Roux, 1883). Latest since it was known that genes are located on chromosomes (Sturtevant, 1913), their balanced transport in anaphase appeared as a condition of correct somatic proliferation. True mitoses guarantee the constancy of terminally differentiated tissues. Politzer (1934) has performed X-ray experiments to investigate abnormal karyokinesis with regard to anomalous chromatin condensation, chromosome breakage, spindle malformation, and failure in cytokinesis. On the basis of light microscopy, further significant progress in understanding the pathology of mitosis was not possible. Tumour cases with reduced chromosome numbers seduced to the idea that mitotic activity is rather under cytoplasmic than under nuclear control (Koller, 1947).
The Prevalence of Pemphigus (Razi Hospital and Department of Oral Pathology, Tehran University of Medical Sciences)
Eshghyar N,Eilanbo A
Journal of Dental Medicine , 1999,
Abstract: The aim of this retrospective statistical study was to determine the prevalcence and frequency of"nage and sex distributions of pemphigus disease. Pemphigus disease classified as autoimmune bullous"ndermatoses which is a chronic mucocutaneous disease."nThis study was performed in Razi Hospital and department of oral pathology of dental school, Tehran"nUniversity of Medical Sciences. The most frequently effected area was buccal moucosa of oral cavity. The"nmost rate of recurrence was found in oral cavity which being more common in middle age females (25-44"nyears).
Evaluation of pathologic and clinical findings of 366 outpatients and inpatients of Razi Hospital for 8.5 tears
Naraghie ZS
Tehran University Medical Journal , 1997,
Abstract: Mycosis fungoides is virtually a kind of cutaneous T cell lymphoma. The wide spectrum of clinical, and histopathologial features of MF accessitated performing an exact study on it. During a retrospective survey, clinical findings of 115 in-patients and histopathological finding of 366 ontpatients and inpatients of MF in an 8 years period were studies with special attention to the pathological Aspects: Males were affected more than females. Their ages ranges from 11-88 years. The most common symptom and sign were pruritus and scaling, respectively. The first involved areas in male were the limbs and females was the trunk. The role of environmental and occupational factors in pathogenesis deserves greater contemplation. There were four distinct histopathological pattern in the epidermis: 1) without significant changes, 2) hyperplasia, 3) poikilodermatosus and 4) pagetoid patten. Epidrmotropism with or without associated pauntrier's microabscesses and halo cells was noted in the majority of cases (233 patients). The inflammatory infiltrate with predominence of atypical lymphocytes and also fibrosis, edema and occasional grenz-zone were the prominent finding of papillary dermis. The major finding of hypodermis was septal panniculitis. In conclusion integrated correlation between clinical and wide spectrum pathologic features of M.F could be a gnide to early diagnosis and appropriate mangement.
The impact of demographic factors on the possibility of cleft lip and palate occurrence  [PDF]
Radoji?i? Julija,Tani? Tatjana
Stomatolo?ki Glasnik Srbije , 2007, DOI: 10.2298/sgs0701034r
Abstract: Introduction: Lip and palate clefts (cheilognathopal atoschisis) are very severe congenital anomalies. Aim: To examine the impact of demographic factors in the first pregnancy trimester on the occurrence of lip and palate cleft. Subjects and Methods: Children born in the period between March 1999 to December 2003, as well as their parents were included in the study. The study group consisted of 96 children with cleft lip and palate treated at the Gynecology - Obstetrics clinics of the Clinical Center in Nis (Neonatology ward), VMA (Military Medical Academy) Belgrade (Institute for plastic surgery), Mother and Child Institute - Novi Beograd and University children's Clinic, Belgrade. The control group comprised 142 healthy children. The examination was carried out using two questionnaires. One was for mothers and consisted of 41 questions related to the first pregnancy trimester. The other questionnaire was filled in by fathers and had 16 questions also related to the period of the first trimester of their wives' pregnancies. Results: The results showed that unilateral lip and palate cleft occurred in the same percentage in boys and girls (53.1%). Isolated palate cleft was more frequently found in boys, and unilateral lip cleft in girls. Statistically higher possibility for lip and palate cleft was found in the third child. The age of mothers in the time of conception does not represent risk factor for the cleft occurrence. Mothers who gave birth to children with clefts were younger (26.4 years old) than mothers in control group (28.4 years old). Conclusion: There is a need for constant education of women on risk factors that they can be exposed to during pregnancy. .
One stage reconstruction of large lower lip carcinoma, with local flaps  [PDF]
Mergime Prekazi Loxha, Fellanza Gjinolli, Osman Sejfija, Aida Rexhepi, Zana Agani
Open Journal of Stomatology (OJST) , 2013, DOI: 10.4236/ojst.2013.37058
Abstract:

Squamous cell carcinoma (SCC) of the lower lip is a frequently diagnosed malignant pathology in the maxillofacial region. It is a slow-growing cancer, and can be diagnosed and treated easily and effectively; however, early treatment is important because its mortality rate is 10%-30%. Reconstruction for a large lower lip defect is surgically challenging, especially reconstruction with local flaps. Here, we present a 52-year-old male with a large T3 SCC, which started 13 years before this treatment and involved nearly all of his lower lip, oral commissure and upper lip. It was reconstructed by local flaps with good aesthetic and functional results. The lip was reconstructed with a combination of a Karapandzic flap on one side and a contralateral Webster cheek advancement, using a functional neck dissection on the tumor side and supraomohyoid neck dissection contralaterally. Histopathology results of the neck were negative for metastasis. We were satisfied with the aesthetic and functional results of the neck.

Pathologic Pattern of Invasive Bladder Carcinoma: Impact of Bilharziasis
I Khalaf, E El-Mallah, I Elsotouhi, H Abu-Zeid, A Elmeligy
African Journal of Urology , 2008,
Abstract: Objective: To describe the pathologic pattern of invasive bladder carcinoma in cystectomy specimens in relation to bilharziasis. Patients and Methods: Between April 2002 and October 2006, 148 consecutive patients with invasive bladder cancer were subjected to radical cystectomy and orthotopic sigmoid bladder substitution at Al-Azhar Urology Department, Cairo, Egypt. A retrospective computerized data- base analysis of the pathologic features of the cystectomy specimens was done focusing on the impact of bilharziasis on the pathology of bladder carcinoma. The tumor cell type, stage, grade and gross features in addition to lymph node involvement were particularly noted. Results: Bilharzial bladder pathology (lesions or ova) was present in 105 (70.9%) of 148 cystectomy specimens. Tumor histology included transitional cell carcinoma (TCC) in 84 (56.7%), squamous cell carcinoma (SCC) in 51 (34.5%), adenocarcinoma in 9 (6.1%) and anaplastic tumor in 4 (2.7%) of these specimens. Most tumors associated with bilharziasis were bulky and appeared fungating or ulcerative. The pathologic tumor stage was pT2 in 23%, pT3 in 70.9% and pT4a involving the prostate or seminal vesicles in 6.1%. None of these pT4a tumors were SCC. The tumor grade was described as low grade in 72 (48.6%) and high grade in 76 (51.4%) specimens. Regional lymph node involvement was detected in 31 (20.9%) specimens irrespective of bilharzial infestation. Conclusion: Invasive bladder carcinoma associated with bilharzial pathology is mainly stage pT3, low-grade SCC and commonly appears as an ulcerative, bulky, fungating or verrucous mass. On the other hand, bladder carcinoma not associated with bilharziasis is mainly high-grade TCC and commonly appears as nodular or fungating lesions. Positive surgical margin and lymph node involvement are unrelated to bilharzial infestation. Africain Journal of Urology Vol. 14 (2) 2008: pp. 90-97
Assessment of Agreement between Clinical Diagnosis and Pathologic Report in the Soft Tissue Lesions of the Patients Referring to Pathology Department of Dental School, Tehran and Shahid Beheshti University of Medical Sciences During 2005-2008
A Musavi,A Bagheri,Z Hamzeheil,M Soruri
Journal of Shahid Sadoughi University of Medical Sciences , 2013,
Abstract: Introduction: Agreement between clinical and pathologic diagnoses plays an important role in an appropriate treatment plan and it may also prevent serious side effects and problems in patients. This study was conducted to assess the agreement between clinical diagnoses and pathologic reports in soft tissue lesions of patients referring to pathology department of dental school, Tehran and shahid Beheshti university of medical sciences during 2005-2008. Methods: In this retrospective and descriptive study, 300 soft tissue lesions of patients referring to pathology department were selected by census sampling method and then were analyzed. The lesions were classified according to the criteria proposed by reference pathology textbooks and the data records regarding the patients age, gender and clinical and pathologic diagnoses were noted. Concordance between two diagnoses was determined by descriptive statistics. Results: In this study, pathologic findings were golden standard (definitive diagnoses). The results showed the concordance between two clinical and pathologic diagnoses were more than 0/7 except POF and pemphigus. Conclusion: The results showed that the surgeons of oral and maxillofacial surgery in dental departments of Tehran and shahid Beheshti university of medical science provided acceptable diagnoses regarding pathologic lesions during 2005-2008. However, even the slight differences between two diagnoses necessitate all patients to be evaluated clinically and paraclinically in order to propose an accurate scientific diagnosis and prevent the harmful outcomes of the disease. Furthermore most efforts must be done to make more agreements between clinical and pathological diagnoses.
A 10-year study of specimens submitted to oral pathology laboratory analysis: lesion occurrence and demographic features
Mendez, Marina;Carrard, Vinicius Coelho;Haas, Alex Nogueira;Lauxen, Isabel da Silva;Barbachan, Jo?o Jorge Diniz;Rados, Pantelis Varvaki;Sant'Ana Filho, Manoel;
Brazilian Oral Research , 2012, DOI: 10.1590/S1806-83242012000300009
Abstract: the purpose of the present paper was to describe the range of lesions histologically diagnosed in an oral pathology laboratory in southern brazil. a retrospective study of 8,168 specimen analyses recorded between 1995 and 2004 was conducted. the records were retrieved from the oral pathology laboratory, school of dentistry, federal university of rio grande do sul, rs, brazil. a total of 6,831 valid cases (83.63%) were examined. of these, inflammatory lesions were the most common occurrences (n = 4,320; 63.24%). benign and malignant tumors accounted for 7.66% (n = 523) and 1.9% (n = 130) of the occurrences, respectively. significant associations were observed between nonneoplastic proliferative disorders and benign mesenchymal tumors in females, and between squamous cell carcinoma and leukoplakia in males. most diagnoses were benign in nature and had an inflammatory etiology. the association of some demographic characteristics with the occurrence of lesions suggests that these characteristics should be considered in performing differential diagnoses.
Razi’s Concept of an Afterlife  [PDF]
Muhammad Wazir, Lei Wang, Xuan Wu
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.76011
Abstract: The major aspect of this paper aimed on analytical classification of Razi’s metaphysical doctrine of human existence after death. Death is an undeniable fact and merely it’s a movement from one world to another. Razi’s concept of life after death is a belief in the continued existence of the soul and a transformed physical existence of a new life. Analytical study in this paper born historical evidence and facts which developed a bent of mind in observing the research problem. Evidently, belief in afterlife was found in golden age of Islam and in classical Greek historic figures. Research findings have shown that belief in afterlife of many religions connects Razi’s concept of individual maintenance in afterlife. Death is the beginning of life and human existence is identified again after death. There are aspects in similar between golden age of Islamic philosophy and Greek historic figures in individual life after death, while sharing similar aspects in individual life after death, Razi’s understanding of life after death is evidently classified on human existence.
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