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N′-(5-Chloro-2-hydroxybenzylidene)nicotinohydrazide  [cached]
Chong-Gui Ren
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809020819
Abstract: There are two independent Schiff base molecules in the asymmetric unit of the title compound, C13H10ClN3O2. The dihedral angles between the benzene and pyridine rings are 12.8 (2) and 1.9 (2)° in the two molecules. Intramolecular O—H...N hydrogen bonds are observed. Molecules are linked into centrosymmetric R44(26) motifs by N—H...O and N—H...N interactions.
(E)-6-Chloro-N′-(3,5-dichloro-2-hydroxybenzylidene)nicotinohydrazide  [cached]
Chun-yan Ren
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809007272
Abstract: The title Schiff base compound, C13H8Cl3N3O2, was synthesized by the condensation reaction of 3,5-dichlorosalicylaldehyde with 6-chloronicotinic acid hydrazide in 95% ethanol. The molecule is nearly planar, with a dihedral angle of 1.9 (2)° between the aromatic ring planes, and an intramolecular O—H...N hydrogen bond is observed. In the crystal, the molecules are connected by intermolecular N—H...O hydrogen bonds into infinite chains propagating in [100].
Synthesis of 2’-(5-Chloro-2-Hydroxybenzylidene) Benzenesulfanohydrazide Schiff Base and its Anti- Ulcer Activity in Ethanol-Induced Gastric Mucosal Lesions in Rats
NS Gwaram, L Musalam, HM Ali, MA Abdulla
Tropical Journal of Pharmaceutical Research , 2012,
Abstract: Purpose: To study the anti-ulcer activity of 2’-(5-Chloro-2-hydroxybenzylidene) benzenesulfanohydrazide Schiff base against ethanol-induced gastric mucosal lesions in rats. Methods: 2’-(5-Chloro-2-hydroxybenzylidene) benzenesulfano-hydrazide (Cl-BzSO-HAP) was synthesized, and structurally characterized by elemental analysis, FT-IR, 1H-NMR and C-NMR. Its preventive activity against ulcer induced by absolute ethanol in Sprague-Dawley rats were studied in vivo. Twenty four Sprague Dawley (SD) rats (12 males and 12 females) were assigned equally into 4 groups (n = 6), including negative control and positive control groups. The third group received a low oral dose of the compound (50 mg/kg) while the fourth group was administered a high oral dose (100 mg/kg). The degree of gastric lesion formation was assessed. Prior to dosing, the animals were fasted overnight. Results: Cl-BzSO-HAP showed significant preventive activity against ulcer induced by absolute ethanol. Oral administration of the compound (both low and high doses) prior to ethanol administration inhibited gastric lesion formation by 88.0 and 94.9 %, respectively, compared to 82.7 % for the positive control, cimetidine. Conclusion: Extensive gastric necrosis in rats induced by absolute ethanol was prevented by administration of Cl-BzSO-HAP resulting in reduced or total absence of lesions.
Yu-Mei Hao
Acta Crystallographica Section E , 2010, DOI: 10.1107/s160053681002180x
Abstract: The title Schiff base compound, C15H13ClN2O3, was prepared by the reaction of equimolar quantities of 5-chloro-2-hydroxybenzaldehyde with 2-methoxybenzohydrazide in a methanol solution. The dihedral angle between the two benzene rings is 20.6 (3)°. An intramolecular O—H...N hydrogen bond may influence the molecular conformation. In the crystal structure, molecules form chains along the b direction via intermolecular N—H...O hydrogen bonds which are bifurcated involving an intramolecular N—H...O hydrogen bond.
Heng-Yu Qian,Da-Ping Qu
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809033108
Abstract: In the title Schiff base compound, C14H10ClN3O4, the molecule adopts an E geometry with respect to the C=N bond and an intramolecular O—H...N hydrogen bond is present. The benzene rings form a dihedral angle of 73.4 (2)°. In the crystal, inversion dimers linked by pairs of N—H...O hydrogen bonds occur.
Zahid H. Chohan,Hazoor A. Shad,M. Nawaz Tahir,Islam Ullah Khan
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808005084
Abstract: In the molecule of the title compound, C15H15ClN2O3S, the S atom adopts a distorted tetrahedral coordination geometry with two O atoms, one N atom of the amide group and one C atom of the aromatic ring. An intramolecular O—H...N hydrogen bond results in the formation of a planar six-membered ring, which is oriented with respect to the adjacent aromatic ring at a dihedral angle of 3.38 (11)°. Thus, the two rings are nearly coplanar. In the crystal structure, intermolecular N—H...O hydrogen bonds link the molecules into centrosymmetric dimers.
M. Aslam,I. Anis,N. Afza,A. Nelofar
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811048690
Abstract: The title Schiff base compound, C20H14ClNO2, adopts an E configuration about the azomethine bond. The phenol and chlorobenzene rings form dihedral angles of 84.71 (9) and 80.70 (8)°, respectively, with the phenyl ring and are twisted by 15.32 (8)° with respect to one another. The molecular conformation is stabilized by an intramolecular O—H...N hydrogen bond, which forms an S(6) ring motif. In the crystal, molecules are linked by C—H...O hydrogen bonds, forming columns parallel to the a axis.
2-Chloro-N′-(3,5-dibromo-2-hydroxybenzylidene)benzohydrazide methanol solvate
Chun-Bao Tang
Acta Crystallographica Section E , 2008, DOI: 10.1107/s160053680801965x
Abstract: The title Schiff base compound, C14H9Br2ClN2O2·CH4O, was derived from the condensation reaction of 3,5-dibromosalicylaldehyde with 2-chlorobenzohydrazide. The dihedral angle between the two benzene rings is 48.2 (2)°. In the crystal structure, molecules are linked through O—H...O and N—H...O intermolecular hydrogen bonds, forming layers parallel to the bc plane. There is also an O—H...N intramolecular hydrogen bond.
(E)-N′-(5-Chloro-2-hydroxybenzylidene)-2,4-dihydroxybenzohydrazide methanol monosolvate  [cached]
Kun Li
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812009178
Abstract: In the title compound, C14H11ClN2O4·CH3OH, the molecule adopts an E conformation about the C=N bond. The compound is in the enamine–keto form. The two terminal benzene rings make a dihedral angle of 10.53 (9)°. Intra-molecular O—H...O and O—H...N hydrogen bonding stabilizes the molecular structure. In the crystal, O—H...O hydrogen bonds link the molecules, forming chains running along the b axis.
Zhi-hong Xu,Wei-yun Guo,Bo-wei Su,Xu-Ke Shen
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810019549
Abstract: The title compound, C35H35ClN4O3, resulted from a spirolactam ring closure of rhodamine B dye. The xanthene ring system is approximately planar [r.m.s. deviation = 0.050 (9) for the xanthene ring]. The dihedral angles formed by the spirolactam and 5-chloro-2-hydroxybenzene rings with the xanthene ring system are 87.9 (7) and 79.1 (7)°, respectively.
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