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2-({[4-(1,3-Benzothiazol-2-yl)phenyl]amino}methyl)phenol  [cached]
Kim Potgieter,Thomas Gerber,Eric Hosten,Richard Betz
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536811051580
Abstract: In the title compound, C20H16N2OS, the aniline substituent essentially coplanar with the benzothiazole moiety (with an r.m.s. deviation of all fitted non-H atoms of 0.0612 ). The phenol group is almost perpendicular to the benzothiazolylaniline group, with an interplanar angle of 88.36 (2)°. In the crystal, molecules aggregate as centrosymmetric dimers by pairs of O—H...N hydrogen bonds. C—H...O contacts and N—H...π(arene) interactions also occur.
Modification, Biological Evaluation and 3D QSAR Studies of Novel 2-(1,3-Diaryl- 4,5-Dihydro-1H-Pyrazol-5-yl)Phenol Derivatives as Inhibitors of B-Raf Kinase  [PDF]
Yu-Shun Yang, Fei Zhang, Dan-Jie Tang, Yong-Hua Yang, Hai-Liang Zhu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095702
Abstract: A series of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-yl)phenol derivatives (C1–C24) have been synthesized. The B-Raf inhibitory activity and anti-proliferation activity of these compounds have been tested. Compound C6 displayed the most potent biological activity against B-RafV600E (IC50 = 0.15 μM) and WM266.4 human melanoma cell line (GI50 = 1.75 μM), being comparable with the positive control (Vemurafenib and Erlotinib) and more potent than our previous best compounds. The docking simulation was performed to analyze the probable binding models and poses while the QSAR model was built to check the previous work as well as to introduce new directions. This work aimed at seeking more potent inhibitors as well as discussing some previous findings. As a result, the introduction of ortho-hydroxyl group on 4,5-dihydro-1H-pyrazole skeleton did reinforce the anti-tumor activity while enlarging the group on N-1 of pyrazoline was also helpful.
New acylides: synthesis of 3-O-[γ-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives  [cached]
Deepa Pandey,Wahajul Haq,Seturam B Katti
Beilstein Journal of Organic Chemistry , 2008, DOI: 10.3762/bjoc.4.14
Abstract: In search of new erythromycin derivatives 3-O-[γ-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives have been synthesized. The 3-hydroxy group was derivatised to a primary amine and subsequently the thiazolidinone nucleus was generated at the amino functionality through DCC mediated one-pot three-component reaction in good yields.
Synthesis and Fungicidal Activity of 2-Imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones and Their 5-Arylidene Derivatives  [PDF]
Hui-Ling Liu,Zongcheng Lieberzeit,Thorleif Anthonsen
Molecules , 2000, DOI: 10.3390/50901055
Abstract: Five derivatives of 2-imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones and a series of their 5-arylidene derivatives have been synthesized and tested for antifungal activity against seven agricultural fungi. 2-Imino-3-(2,4-dichloro-5-fluorophenylthiazol-2-yl)-4-thiazolidi-none and 2-imino-3-(2,4-dichlorophenylthiazol-2-yl)-4-thiazolidione, both of them new compounds, exhibited higher fungicidal effects than the other compounds prepared.
4-{[4-(Hydroxymethyl)piperidin-1-yl]methyl}phenol  [cached]
M. C. R. Simões,I. M. R. Landre,M. S. Moreira,C. Viegas Jr.
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812028838
Abstract: In the title compound, C13H19NO2, the piperidine ring has a chair conformation with the exocyclic N—C bond in an equatorial position. In the crystal, molecules are linked head-to-tail by phenol O—H...O hydrogen bonds to hydroxymethylene O-atom acceptors, forming chains which extend along [100]. These chains form two-dimensional networks lying parallel to (101) through cyclic hydrogen-bonding associations [graph set R44(30)], involving hydroxy O—H donors and piperidine N-atom acceptors.
Tris{4-[(1,3-diphenyl-1H-pyrazol-4-yl)methylene]-41-aminobiphenyl}amine  [PDF]
Sandhya P. Veettil,Karickal R. Haridas
Molbank , 2010, DOI: 10.3390/M677
Abstract: Tris{4-[(1,3-diphenyl-1 H-pyrazol-4-yl)methylene]-4 1-aminobiphenyl}amine was synthesized from N-(4-bromophenyl)- N-[(1,3-diphenyl-1 H-pyrazol-4-yl)methylene]amine and tris(4-bromophenyl)amine based on Ullmann coupling reaction. The synthesized compound was characterized by NMR, IR, MS and elemental analysis.
Thermal and Photoresponsive Studies of Starch Modified with 2-(5-(4-Dimethylamino-benzylidine)-4-oxo-2-thioxo-thiazolidin-3-yl)acetic Acid  [PDF]
Ambily Chandran,Sunny Kuriakose,Tessymol Mathew
International Journal of Carbohydrate Chemistry , 2012, DOI: 10.1155/2012/356563
Abstract: The present study describes the synthesis of a chromophoric system 2-(5-(4-dimethylamino-benzylidin)-4-oxo-2-thioxo-thiazolidin-3-yl)acetic acid and its incorporation into starch through esterification of the hydroxyl group by the free carboxyl function of the chromophoric system by DCC coupling. The products were characterized by UV-visible, fluorescence, FT-IR, and NMR spectroscopic methods. The newly developed system was subjected to photoresponsive studies such as light absorption, light stabilization and fluorescence emission. The free chromophoric system and the coupled product were also subjected to thermal analysis. The results show that modification enhances the light absorption and light fastening properties of the chromophoric system. Thermal stability of the polymeric system greatly enhances on attaching the chromophoric system. In view of these results the newly developed system is proposed as a nature friendly, green, and photoactive product which could find application in dyes, inks, paints, and so forth. 1. Introduction Starch is an inexpensive commodity that has been used for food and many nonfood purposes for centuries. Starch, one of the main polysaccharides in the world, has been paid much attention because of its biodegradability and abundance as a renewable resource. It has been widely used as a raw material for biodegradable plastics. The chemical modification of starch is of interest because the modification would not change the fundamental skeleton of starch, would keep the original physicochemical and biochemical properties, and finally would bring new or improved properties. Chemically, starch is composed of two different molecules, amylose and amylopectin. In amylose, the glucose molecules are linked in a “linear” fashion; however, the tetrahedral chemistry of carbon (and the bond angles that result from this chemistry) gives amylose an overall spiral shape. Amylopectin, on the other hand, has a linear arrangement of glucose molecules which includes, at regular intervals, a different kind of linkage between two adjacent glucoses. This different linkage results in the formation of a branched structure and an overall treelike shape for this molecule. Starch consists of amylose and amylopectin, which are polymers of glucose, linear and branched, respectively. Each glucose unit potentially has three reactive hydroxyl groups that are the basis of all derivatizations. Native starches in its derivative forms open a wide scope in pharmaceutical-, food-, and nonfood based industries. Starch modification is generally achieved through
2-{5-(1,3-Benzodioxol-5-yl)-1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4,5-dihydro-1H-pyrazol-3-yl}pyrazine  [PDF]
Balapragalathan Thappali Jothikrishnan,Sriram Narasimhan,Suban Syed Shafi
Molbank , 2010, DOI: 10.3390/M668
Abstract: A simple method for the synthesis of a pyrazolyl thiazole derivative containing a piperonal moiety was developed. Thus, 2-{5-(1,3-benzodioxol-5-yl)-1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4,5-dihydro-1 H-pyrazol-3-yl}pyrazine was synthesized using microwave irradiation and characterized by NMR, IR and LCMS data.
1,3,5-Tris{[N-(1,3-diphenyl-1H-pyrazol-4-yl)methylene]-4-aminophenyl}benzene  [PDF]
Sandhya P. Veettil,Karickal R. Haridas
Molbank , 2009, DOI: 10.3390/m624
Abstract: 1,3,5-Tris{[N-(1,3-diphenyl-1H-pyrazol-4-yl)methylene]-4-aminophenyl}-benzene was synthesised from N-(4-bromophenyl)-N-[(1,3-diphenyl-1H-pyrazol-4-yl)-methylene]amine and 1,3,5-tribromobenzene by an Ullman coupling reaction. The synthesized compound was charecterised by NMR, IR, MS and elemental analysis.
(2R)-2-(1,3-Dioxoisoindolin-2-yl)-4-(methylsulfanyl)butanoic acid
Abdul Rauf Raza,M. Nawaz Tahir,Aisha Saddiqa,Muhammad Danish
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809028992
Abstract: The title compound, C13H13NO4S, the 1,3-dioxoisoindolin-2-yl unit is planar (r.m.s. deviation 0.0192 ) and is oriented at a dihedral angle of 79.14 (18)° to the carboxylate group. An intramolecular C—H...O hydrogen bond leads to the formation of a planar (r.m.s. deviation 0.0419 )R(5) ring motif. In the crystal, molecules are connected through O—H...O and C—H...O hydrogen bonds with R22(9) ring motifs into chains extending along the b axis.
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