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3-Chloro-6-{4-[3-(4-chlorophenoxy)propyl]piperazin-1-yl}pyridazine
Hongliang Wang,Junhai Xiao,Xian Zhang,Tiemin Sun
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810005337
Abstract: In the title compound, C17H20Cl2N4O, the piperazine ring adopts a chair conformation and the dihedral angle between the pyridazine ring and the benzene ring is 36.3 (1)°. In the crystal, weak C—H...O and C—H...(N,N) interactions help to establish the packing, which also features short intermolecular Cl...Cl contacts [3.331 (2) ].
3-Chloro-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyridazine
Hakan Arslan,Semra Utku,Kenneth I. Hardcastle,Mehtap Gökçe
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810004137
Abstract: The title compound, C15H14ClF3N4, was synthesized from 3,6-dichloropyridazine and 1-[3-(trifluoromethyl)phenyl]piperazine. The piperazine ring is flanked by 3-chloropyridazine and 3-trifluoromethylphenyl rings and adopts a chair conformation, whereas the 3-chloropyridazine and 3-trifluoromethylphenyl rings are planar, with maximum deviations of 0.0069 (13) and 0.0133 (14) , respectively. The crystal structure is stabilized by weak intermolecular C—H...N hydrogen-bond interactions.
3-Chloro-6-[2-(cyclopentylidene)hydrazin-1-yl]pyridazine
Abdul Qayyum Ather,M. Nawaz Tahir,Misbahul Ain Khan,Muhammad Makshoof Athar
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811011342
Abstract: The asymmetric unit of the title compound, C9H11ClN4, contains two virtually planar molecules that differ in conformation about the bond connecting the hydrazine and pyridazine units. The 3-chloro-6-hydrazinylpyridazine and cyclopentane groups are oriented at dihedral angles of 4.5 (3) and 8.8 (4)° in the two molecules. In the crystal, the molecules form a one dimensional polymeric structure extending along the a axis via N—H...N hydrogen bonds. The crystal stucired was an inversion twin [ratio of the twin domains = 0.73 (9):0.27 (9)].
3-Chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine
Abdul Qayyum Ather,M. Nawaz Tahir,Misbahul Ain Khan,Muhammad Makshoof Athar
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810034756
Abstract: In the title compound, C9H9ClN4, the dihedral angle between the aromatic rings is 6.25 (9)°. The whole molecule is approximately planar (r.m.s. deviation = 0.070 ). In the crystal, π–π interactions between the centroids of the pyridazine rings [separation = 3.5904 (10) ] occur.
Synthesis and Preliminary Pharmacological Evaluation of 2-[4-(Aryl substituted) piperazin-1-yl]-Nphenylacetamides: Potential Antipsychotics
S Kumar, AK Wahl, R Singh
Tropical Journal of Pharmaceutical Research , 2011,
Abstract: Purpose: Arylpiperazines have been recognized as the largest and most diverse class of compounds exerting actions on the central nervous system with strong affinity for serotonin and dopamine receptors. We here report the synthesis of some novel arylpiperazines and their evaluation for possible antipsychotic properties. Methods: The target compounds 2-[4-(aryl substituted) piperazin-1-yl]-N-phenylacetamides (3a-j) were synthesized by first reacting aniline (1) in 2 N sodium hydroxide with chloroacetylchloride in dichloromethane to obtain 2-chloro-N-phenylacetamide (2) and subsequently treating with appropriate phenylpiperazine in acetonitrile in the presence of K2CO3 and KI. All the compounds were characterized by analytical and spectroscopic methods. The compounds were evaluated for antipsychotic activity using three animal models. Results: All the 10 new arylpipeazines showed variable antipsychotic activity with compound 3h being the least effective in the induction of catalepsy. Their effect may involve interaction with 5-HT2A and D2 receptors. Conclusion: A synthetic method and possible antipsychotic effect have been established for 2-[4-(Aryl substituted) piperazin-1-yl]-N-phenylacetamides.
[1-(4-Chlorophenyl)cyclopropyl](piperazin-1-yl)methanone  [PDF]
Basavaraj Padmashali,Siddapura M. Mallikarjuna,Ballekere N. Chidananda
Molbank , 2009, DOI: 10.3390/m641
Abstract: The title compound, [1-(4-chlorophenyl)cyclopropyl](piperazin-1-yl)methanone, was synthesized and characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data.
3-Chloro-6-(1H-pyrazol-1-yl)pyridazine  [cached]
Abdul Qayyum Ather,M. Nawaz Tahir,Misbahul Ain Khan,Muhammad Makshoof Athar
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810027121
Abstract: The title compound, C7H5ClN4, is almost planar (r.m.s. deviation = 0.022 ). The dihedral angle between the aromatic rings is 2.82 (5)°. The packing results in polymeric chains extending along the a axis. In the crystal, molecules are connected to each other through intermolecular C—H...N hydrogen bonds, resulting in R22(10) ring motifs.
7-Chloro-4-(piperazin-1-yl)quinoline  [cached]
Amol A. Kulkarni,Christopher L. King,Joseph M. D. Fortunak,Ray J. Butcher
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812014912
Abstract: There are two molecules in the asymmetric unit (Z′ = 2) of the title compound, C13H14ClN3, Each molecule is linked by N—H...N hydrogen bonds to another of the same type in a chain in [110]. The crystal studied was a non-merohedral twin with components 0.622 (2) and 0.378 (2).
4-(4-Pyridyl)pyridinium pentaaqua(pyridazine-4,5-dicarboxylato)praseodymate(III)
Zhen-Qin Zhang,Xiao-Dong Xue,Bi-Xia Yao,Xing Ji
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810033477
Abstract: In the title complex, (C10H9N2)[Pr(C6H2N2O4)2(H2O)5], the Pr atom is nine-coordinated by nine O atoms from two pyridazine-4,5-dicarboxylate anions and five water molecules. It is noteworthy that there is a protonated bipyridine molecule in the structure. Intermolecular O—H...O, O—H...N and N—H...N hydrogen bonds are present, resulting in a three-dimensional network.
3-Chloro-6-[(E)-2-(1-phenylethylidene)hydrazinyl]pyridazine  [cached]
Abdul Qayyum Ather,M. Nawaz Tahir,Misbahul Ain Khan,Muhammad Makshoof Athar
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810024402
Abstract: Two independent molecules are present in the asymmetric unit of the title compound, C12H11ClN4, (Z′ = 2): the dihedral angles between the phenyl and pyridizine rings are 8.35 (10) and 37.64 (6)°. In the crystal, the two molecules form inversion dimers with R22(8) ring motifs through intermolecular N—H...N hydrogen bonds. The crystal structure is stabilized by π–π interactions between the pyridazine rings of symmetry-related molecules. In one of the independent molecules, the centroid–centroid separations are 3.6927 (13) and 3.7961 (13) , whereas in the other, the separations are 3.6909 (13) and 3.9059 (13) .
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