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Phenylhydrazinium (6-carboxypyridine-2-carboxylato)(pyridine-2,6-dicarboxylato)cobaltate(II)–pyridine-2,6-dicarboxylic acid–water (1/1/3)  [cached]
Consuelo Yuste,Manuela Ramos Silva,Mohammad Ghadermazi,Fariba Feizi
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810048191
Abstract: The asymmetric unit of the title compound, (C6H9N2)[Co(C7H3NO4)(C7H4NO4)]·C7H5NO4·3H2O, contains one (6-carboxypyridine-2-carboxylato)(pyridine-2,6-dicarboxylato)cobaltate(II) anion, one phenylhydrazinium cation, one pyridine-2,6-dicarboxylic acid molecule and three uncoordinated water molecules, part of which are disordered. The CoII ion is coordinated by a pyridine-2,6-dicarboxylate ion and a 6-carboxypyridine-2-carboxylate ligand almost perpendicular to each other [the angle between the least-squares planes is 87.38 (4)°] and is surrounded by two O atoms and two N atoms in the equatorial plane and two O atoms in axial positions, resulting in a distorted octahedral coordination geometry. There is an extensive three-dimensional network of O—H...O and N—H...O hydrogen bonds, which link the components.
Bis(μ-pyridine-2,3-dicarboxylato)bis[aqua(3-carboxypyridine-2-carboxylato)indium(III)] tetrahydrate  [cached]
H. Eshtiagh-Hosseini,M. Mirzaei,A. Mousavinezhad,M. Necas
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536811053566
Abstract: In the binuclear centrosymmetric title compound, [In2(C7H3NO4)2(C7H4NO4)2(H2O)2]·4H2O, which contains both pyridine-2,3-dicarboxylate and 3-carboxypyridine-2-carboxylate ligands, the InIII atom is six-coordinated in a distorted octahedral geometry. One pyridine ligand is N,O-chelated while the other is N,O-chelated and at the same time bridging to the other via the second carboxyl group. In the crystal, an extensive O—H...O hydrogen-bonding network, involving the coordinated and lattice water molecules and the carboxyl groups of the ligands, together with C—H...O and π–π interactions [centroid–centroid distance = 3.793 (1) ], leads to the formation of a three-dimensional structure.
2,6-Bis(tosyloxymethyl)pyridine
Lynette Komarsamy,Muhammad D. Bala,Holger B. Friedrich,Bernard Omondi
Acta Crystallographica Section E , 2011, DOI: 10.1107/s160053681100050x
Abstract: The title compound, C21H21NO6S2, is organized around a twofold axis parallel to the crystallographic c axis and containing the N atom and a C atom of the pyridine ring. The tosyl moiety and the pyridine ring are both essentially planar [maximum deviations 0.028 (2) and 0.020 (3) , respectively]; their mean planes form a dihedral angle of 33.0 (2)°.
Synthesis and Anticancer Properties of Silver(I) Complexes Containing 2,6-Bis(substituted)pyridine Derivatives  [PDF]
Korany A. Ali,Mokhles M. Abd-Elzaher,Khaled Mahmoud
International Journal of Medicinal Chemistry , 2013, DOI: 10.1155/2013/256836
Abstract: Several new 2,6-bis(substituted)pyridine ligands and 2,6-bis(substituted)pyridine Ag(I) nitrate complexes were synthesized and characterized spectroscopically. The newly synthesized ligands include pyridine-2,6-bis(3-oxopropanenitrile) (1), pyridine-2,6-bis(2-cyano-N-phenyl-3-oxopropanethioamide) (2), and pyridine-2,6-bis((E)-2-(2-phenylhydrazono)-3-oxopropanenitrile) (3). The newly synthesized ligands and silver(I) complexes were evaluated for their in vitro anticancer activity against four human cancer cell lines including hepatocellular carcinoma (HePG2), lung adenocarcinoma (A549), colon carcinoma (HT29), and breast adenocarcinoma (MCF7). Most of the newly synthesized silver(I) complexes exhibited better activity than the ligands, and the results have been compared with doxorubicin as a reference drug. 1. Introduction Chemical and biological activity of the organic complexes is not possessed only by the metal or organic ligand but also this activity can be fine-tuned by subtle changes in the electronic and steric properties of the complexes or by variation of the oxidation state of the metal. These features provide a versatile platform for drug design that is now being exploited in several areas. For centuries, silver compounds have been known to possess interesting biological properties that show potent antibacterial properties [1–4]. Also, they were popular remedies for tetanus and rheumatism in the 19th century and for colds and gonorrhea before the advent of antibiotics in the early part of the 20th century [5]. Additionally, silver compounds used for treating mental illness, epilepsy, and nicotine addiction [6, 7]. Furthermore, silver compounds have reemerged as a viable treatment option for infections encountered in burns, open wounds, and chronic ulcers [8–11]. On the other hand, functionalized pyridine derivatives are gaining a great deal of interest in medicinal and organic synthesis, where some of pyridine derivatives are used as bactericides [12], fungicides [13], and anticancer agents [14–17]. In view of these observations and in continuation of our current interest in the synthesis of organic compounds for biological evaluations [18–25] and our interest in the chemistry of 2,6-disubstituted pyridine derivatives [26–29], we described herein a facile synthesis of novel silver complex with some of the newly synthesized 2,6-disubstituted pyridine ligands. The newly synthesized compounds were evaluated for their in vitro anticancer activity against four human cancer cell lines including hepatocellular carcinoma (HePG2), lung adenocarcinoma
Bis{2,6-bis[(2-hydroxy-5-methylphenyl)iminomethyl]pyridine} monohydrate  [cached]
Muhammet Kose,Vickie McKee
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811045399
Abstract: The title compound, 2C21H19N3O2·H2O, was synthesized by a Schiff base condensation of 2,6-diformylpyridine with 2-amino-4-methylphenol in ethanol. In the crystal, two molecules of 2,6-bis[(2-hydroxy-5-methylphenyl)iminomethyl]pyridine dimerize via hydrogen bonding to a water molecule, which lies on a twofold axis. There are also intramolecular phenol–imine hydrogen bonds. The dimers are further linked via π–π (phenyl–pyridine) [centroid–centroid distance = 3.707 (2) ] and π–π edge-to-edge [3.392 (2) ] interactions. The dihedral angles between the central ring and the two pendant rings are 11.46 (8) and 2.06 (8)° while the pendant rings make a dihedral angle of 10.14 (8)°.
2,6-Bis[1-(2-methylphenylimino)ethyl]pyridine
Rui-Qing Fan,Xiao-Dong Ding,Guang-Peng Zhou,Yu-Lin Yang
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809020522
Abstract: The molecule of the title compound, C23H23N3, which was synthesized by the condensation reaction between 2,6-diacetylpyridine and 2-dimethylaniline, adopts an E configuration about both C=N imine bonds. The dihedral angles formed by the benzene rings with the pyridine ring are 89.68 (5) and 53.62 (6)°.
3,5-Diamino-4H-1,2,4-triazol-1-ium (6-carboxypyridine-2-carboxylato)(pyridine-2,6-dicarboxylato)cuprate(II) trihydrate  [cached]
S. Yousuf,A. S. Johnson,S. A. Kazmi,O. E. Offiong
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811011147
Abstract: In the complex anion of the title compound, (C2H6N5)[Cu(C7H4NO4)(C7H3NO4)]·3H2O, the CuII atom is coordinated by tridentate 6-carboxypyridine-2-carboxylate and pyridine-2,6-dicarboxylate ligands and is surrounded by four O atoms in the equatorial plane and two N atoms in axial positions in a distorted octahedral geometry. In the crystal, the components are linked into a three dimensional network by O—H...O, N—H...O, N—H...N and C—H...O hydrogen bonds and a π–π interaction with a centroid–centroid distance of 3.6080 (8) .
2,6-Bis[1-(2,6-diethylphenylimino)ethyl]pyridine
Yu-lin Yang,Rui-qing Fan,Wen-hui Li
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808036842
Abstract: The title compound, C29H35N3, is the product of the condensation reaction between 2,6-diacetylpyridine and 2,6-diethylaniline. In the molecule, the pyridyl ring is coplanar with the imino functional groups [torsion angles in the range 177.1 (2)–179.9 (2)°. The two 2,6-diethyl-substituted benzene rings are approximately perpendicular to the ethylidenepyridine central core, the dihedral angles being 88.7 (1) and 88.4 (1)°, respectively.
Dichlorido{2-[(2,6-dimethylphenyl)iminomethyl]pyridine-κ2N,N′}zinc  [cached]
Xue-hong Liu,Li-min Zhao,Feng-shou Liu
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812006204
Abstract: In the asymmetric unit of the title compound, [ZnCl2(C14H14N2)], the central ZnII ion is four-coordinated in a distorted tetrahedral environment by two N atoms of the ligand 2-[(2,6-dimethylphenyl)iminomethyl]pyridine and two chloride anions. In the crystal, adjacent molecules are connected through C—H...Cl hydrogen bonds between a C—H group of the ligand and a Cl anion, leading to a chain-like structure along the b direction.
Aqua[2,6-bis(2-pyridylamino)pyridine]sulfatonickel(II) monohydrate  [cached]
Lu Lu,Jun Wang,Bin Xie,Li-Ke Zou
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808035101
Abstract: The Ni atom in the title complex, [Ni(SO4)(C15H13N5)(H2O)]·H2O, has a distorted trigonal-bipyramidal coordination formed by the tridentate 2,6-bis(2-pyridylamino)pyridine (tpdaH2) ligand, one sulfate and one coordinated water molecule. The tpdaH2 ligand is three-coordinated, with the N atom of the central pyridine ring in the equatorial position [Ni—N = 1.9961 (14) ] and the N atoms of the peripheral pyridine rings in the axial positions [Ni—N = 1.9668 (15) and 1.9895 (15) ]. The remaining equatorial positions are occupied by the O atoms of the sulfate ligand and the water molecule. The H atoms of both NH groups of the tpdaH2 ligand are involved in hydrogen bonds with the O atoms of the uncoordinated water molecule and the sulfate group which link the complex molecules, forming an infinite three-dimensional network.
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