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Effect of Aqueous Extract of Ruta graveolens on Spermatogenesis of Adult Rats  [PDF]
M. Bazrafkan,M. Panahi,G. Saki,A. Ahangarpour
International Journal of Pharmacology , 2010,
Abstract: In this study the effect of aqueous extract of RG on spermatogenesis of rat has been investigated. Animals were allocated into three groups as: (1) control which did not receive anything, (2) vehicle which received only normal saline (the same volume as 3rd group according to the weight) and (3) experiment which received ruta extract (300 mg kg-1 intraperitoneally once a day for 50 days). A day after last injection the animals were deeply anesthetized and dissected. The right testes were extruded and fixed for histological studies. For statistical analysis ANOVA and Tukey as a post hoc. test were used. There was a significant decrease in the number of spermatogonia (p<0.01), primary spermatocyte (p<0.05), spermatid (p<0.05) and lydig cells (p<0.01) in experimental group as compared to control and vehicle. Also there were a significant increase in thickness of tunica albugina (p<0.01) and decrease in seminiferous tubule diameter (p<0.05) in experimental group compared to control and vehicle. So, it is concluded that the aqueous extract of Ruta graveolens diminishes the reproductive system activity and might be a useful substance for birth control process.
Rutin from Ruta graveolens L
Dj. Afshar,A. Delazar
DARU : Journal of Pharmaceutical Sciences , 1994,
Abstract: Quantitative determination of rutin in Ruta Graveolens, L. which is easily cultivated in Iran, is necessary for its economic importance, diversity of specialities and their pharmacological activity in blood vessels disorders. For this purpose, the plant was cultivated in botanical garden of Tabriz University of Medical Sciences and rutin was determinated at different stages of plant growth. The extraction was done from the crude plants by ethanol, boiling water and hydroalcoholic solvents. Rutin was subsequently purified by crystalization."nStructure elucidation was confirmed by the U.V spectrum in the presence of shift-producing reagents, and TLC by using different systems, HPLC and HPTLC in the presence of standard."nSugars and their sequence of bonding to genine were known by acidic hydrolysis, sequential hydrolysis and TLC in the presence of standards. For quantitative determinations of rutin two methods were selected i.e. HPLC and colorimetery. In the colorimetrey method, cyanidin reaction was used for color producing and the absorbances of other compounds of extract were eliminated in coincidence with rutin absorption.. In the HPLC method, separation was done on CN- column with mobile phase including dioxan/phosphate bnffer (pH=2.6); 2:8. In the end the results of two methods were compared.
In vitro synergistic antibacterial activity of Salvia officinalis L. and some preservatives
Stanojevi? Dragana,?omi? Ljiljana,Stefanovi? Olgica,Soluji?-Sukdolak Slavica
Archives of Biological Sciences , 2010, DOI: 10.2298/abs1001167s
Abstract: The aim of this work was to investigate the antibacterial activity of aqueous extracts of the species Salvia officinalis L. and its synergistic action with the preservatives sodium nitrite, sodium benzoate and potassium sorbate in vitro against selected food spoiling bacteria. Synergism was assessed by the checkerboard assay method and quantitatively represented by the FIC index. Synergistic action was established for aqueous extract/sodium benzoate, aqueous extract/potassium sorbate, aqueous extract/sodium nitrite combinations. Synergism was detected in relation to: Agrobacterium tumefaciens, Bacillus subtilis and Proteus sp. Synergism was established at plant extract and preservative concentrations corresponding up to 1/8 MIC values.
Coumarins and alkaloids in shoot culture of Ruta graveolens L.
Halina Ekiert,Wanda Kisiel
Acta Societatis Botanicorum Poloniae , 1997, DOI: 10.5586/asbp.1997.039
Abstract: A shoot culture of Ruta graveolens L. (Rutaceae) was maintained in the stationary liquid phase. From the cultured shoots seven compounds were isolated and identified as psoralen, bergapten, xanthotoxin, isopimpinellin (linear furanocoumarins), rutamarin (linear dihydrofuranocoumarin), kokusaginine and skimmianine (furanoquinoline alkaloids) by spectral methods. The compounds are known as secondary metabolites of the intact plant, as well as its cell and tissue cultures.
Anti-inflammatory activity of Ruta graveolens Linn on carrageenan induced paw edema in wistar male rats
M Ratheesh, A Helen
African Journal of Biotechnology , 2007,
Abstract: Aqueous, ethanolic and methanolic extracts of Ruta graveolens were investigated for anti-inflammatory activity in carrageenan induced paw edema in wistar male rats, and compared to a positive control drug, Voveran. These extracts were given (ip) in a concentration of 20 and 50 mg/kg b.w. before carrageenan injection. Methanolic extracts of R. graveolens with a concentration of 20 mg/kg b.w. and ethanolic extract with a concentration of 50 mg/kg b.w. showed maximum (90.9%) inhibition on carrageenan induced rat paw edema. The effect was significantly (P< 0.05) higher than that of the standard drug Voveran (72.72%). Methanol extract with a concentration of 50 mg/kg b.w. produced 81.81% inhibition, which was also high as compared to the standard drug. Ethanolic extract with a dose of 20 mg/kg b.w and the two doses of aqueous extract produce less percentage of inhibition as compared to the standard drug voveran.
Comparison of antioxidant and antimicrobial activities of extracts obtained from Salvia glutinosa L. and Salvia officinalis L.
Veli?kovi? Dragan T.,Karabegovi? Ivana T.,Stoji?evi? Sa?a S.,Lazi? Miodrag L.
Hemijska Industrija , 2011, DOI: 10.2298/hemind110412034v
Abstract: Antioxidant and antimicrobial activities as well as total phenols and flavonoids contents of Salvia glutinosa L. (glutinous sage) and Salvia officinalis L. (sage) extracts were studied. Methanol and aqueous ethanol (70% v/v) were used for extraction of bioactive compounds, both in the presence and the absence of ultrasound, from herb and the spent plant material remaining after the essential oil hydrodistillation. The ratio of plant material to extracting solvent was 1:10 g/ml. Antioxidant and antimicrobial activities of the extracts were found to depend on the type of plant material and the extraction conditions. The plant materials from which essential oil had been recovered were proven to be valuable raw materials for making various herbal preparations.
Ileana C. Farcasanu,Eliza Oprea
Analele Universitatii Bucuresti : Chimie , 2006,
Abstract: The baker’s yeast Saccharomyces cerevisiae was tested for modifications in sensitivity to ethanol extracts from Salvia officinalis leaves. The extracts obtained with aqueous ethanol of various concentrations showed different antifungal effect against the yeast cells. The strongest growth inhibitory capacity was noted for the extracts obtained in 90% ethanol demonstrating that under these conditions the yeast cells were more susceptible to metabolic or structural damage.
Asian Journal of Pharmacy and Life Science , 2011,
Abstract: Salvia officinalis L. is a perennial woody shrub; mainly dried leaves used as raw material in medicine,perfumery and food industry. The aim of this study was to investigate diuretic effects of leaf extract of Salviaofficinalis L. in normal rats. Methanolic extract of Salvia officinalis L. leaves were administered toexperimental rats orally at doses of 50 and 100 mg/kg p.o., Hydrochlorothiazide (10 mg/kg) was used aspositive control in study. The diuretic effect of the extract was evaluated by measuring urine volume &excretion of sodium-potassium content. Urine volume was significantly increased by methanolic extract incomparison to control group. While the excretion of sodium was also increased by extract (100mg/kg). Themethanolic extract had the additional advantage of a potassium-conserving effect. We can conclude thatmethanolic extract of Salvia officinalis L. produced notable diuretic effect which appeared to becomparable to that produced by the reference diuretic HCTZ (Hydrochlorothiazide). The present studyprovides a quantitative basis for explaining the folkloric use of Salvia officinalis L. as a diuretic agent.
The occurrence of pests on lemon balm (Mellisa officinalis) and garden sage (Salvia officinalis)  [PDF]
Bokor Peter,Tancik Ján,Habán Miroslav,Marinkovi? Branko J.
Zbornik Matice Srpske za Prirodne Nauke , 2008, DOI: 10.2298/zmspn0815059b
Abstract: Production of medicinal plants is accompanied by many problems, out of which some are overcome. Problems in medicinal plant production, including the production of sage and lemon balm that cannot be avoided are pathogens, the presence of insects and weeds. During the summer of 2003 and 2004, the occurrence of animal pests and pathogens was investigated in the medicinal plants lemon balm (Mellisa officinalis) and garden sage (Salvia officinalis). The pathogens Alternaria alternata and Fusarium moniliforme and the insects Eupterix atropunctata and Empoasca pteridis (Homoptera, Cicadelidae) were identified as the cause of various damages to medicinal plants.
Phytochemical Composition and Antioxidant Potential of Ruta graveolens L. In Vitro Culture Lines  [PDF]
Renuka Diwan,Amit Shinde,Nutan Malpathak
Journal of Botany , 2012, DOI: 10.1155/2012/685427
Abstract: Ruta graveolens L. is a medicinal plant used in traditional systems of medicine for treatment of psoriasis, vitiligo, leucoderma, and lymphomas with well-known anti-inflammatory and anticancer properties. Therefore antioxidant potential of R. graveolens (in planta and in vitro) was investigated. As antioxidants present in plant extracts are multifunctional, their activity and mechanism depends on the composition and conditions of the test system. Therefore, the total antioxidant capacity was evaluated using assays that detect different antioxidants: free radical scavenging (DPPH and ABTS), transition metal ion reduction (phosphomolybdenum assay), reducing power, and nitric oxide reduction. Content of furanocoumarin-bergapten in the extracts showed good corelation with free radical scavenging, transition metal reduction and reducing power, while total phenolic content showed good corelation with nitric oxide reduction potential. Antioxidant activity of in vitro cultures was significantly higher compared to in vivo plant material. The present study is the first report on comprehensive study of antioxidant activity of R. graveolens and its in vitro cultures. 1. Introduction Free radicals, together with secondarily formed radicals, are known to play an important role in the pathogenesis of many chronic conditions like atherosclerosis, arthritis, diabetes, ischemia, reperfusion injuries, central nervous system injury, and cancer [1, 2]. Hence, the study of antioxidant status during a free radical challenge can be used as an index of protection against the development of these degenerative processes in experimental condition for therapeutic measures. Ruta graveolens is used in homeopathic, ayurvedic, and unani preparations [3] because this herb is so efficacious in various diseases (Ruta derived from Greek “reuo” means to set free). It has been extensively used in treatment of leucoderma, vitiligo, psoriasis, multiple sclerosis, cutaneous lymphomas, rheumatic arthritis and recently reported to possess anti-inflammatory and anticancer activity [4, 5]. Antioxidants in plants are affected by area, climatic conditions, and pest attack [6, 7]; therefore in vitro cultures are being investigated as alternate source of natural antioxidants [8]. For estimation of total antioxidant potential many authors have stressed the need to perform more than one type of antioxidant activity measurement to take into account the various mechanisms of antioxidant action [9]. With this perspective the present study investigates the total antioxidant activity evaluated using DPPH,
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