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A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex
Stephen P Myers, Joan O'Connor, J Helen Fitton, et al
Biologics: Targets and Therapy , 2011, DOI: http://dx.doi.org/10.2147/BTT.S12535
Abstract: combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex Original Research (4586) Total Article Views Authors: Stephen P Myers, Joan O'Connor, J Helen Fitton, et al Published Date February 2011 Volume 2011:5 Pages 45 - 60 DOI: http://dx.doi.org/10.2147/BTT.S12535 Stephen P Myers1, Joan O'Connor1, J Helen Fitton2, Lyndon Brooks3, Margaret Rolfe3, Paul Connellan4, Hans Wohlmuth4,5, Phil A Cheras1, Carol Morris4 1NatMed-Research Unit, Research Cluster for Health and Wellbeing, Southern Cross University, Lismore, NSW, Australia; 2Marinova Pty Ltd, Cambridge, TAS, Australia; 3Graduate Research College, Southern Cross University, Lismore, NSW, Australia; 4Centre for Phytochemistry and Pharmacology, Southern Cross University, Lismore, NSW, Australia; 5Medicinal Plant Herbarium, Southern Cross University, Lismore, NSW, Australia Background: Isolated fucoidans from brown marine algae have been shown to have a range of immune-modulating effects. This exploratory study aimed to determine whether a seaweed nutrient complex containing a blend of extracts from three different species of brown algae plus nutrients is safe to administer and has biological potential as an immune modulator. The study was undertaken as an open-label combined Phase I and II study. Methods: Participants (n = 10) were randomized to receive the study medication at either a 100 mg (n = 5) or 1000 mg (n = 5) dose over 4 weeks. The primary outcome measurement was in vivo changes in lymphocyte subsets. The secondary outcome measures were ex vivo changes in T-lymphocyte (CD4 and CD8) activation, phagocytosis of granulocytes and monocytes, T helper 1/T helper 2 cytokines, and serum oxygen radical absorbance capacity. Results: The preparation was found to be safe over the 4 weeks at both doses tested. There were no clinically relevant changes to blood measurements of hemopoietic, hepatic, or renal function. Immunomodulatory measurements showed no dose response between the two doses. The combined results from the two doses demonstrated a significant increase in cytotoxic T cell numbers and phagocytic capacity in monocytes, and a significant decrease in levels of the inflammatory cytokine interleukin 6. A separate analysis of the 100 mg dose (n = 5) alone showed a significant linear component over time (P < 0.05) for phagocytosis by both granulocytes and monocytes. Conclusion: The seaweed nutrient complex was safe to use when taken orally over 4 weeks. The preparation was demonstrated to have potential as an immune modulator, and this bioactivity deserves further exploration.
A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex
Stephen P Myers,Joan O'Connor,J Helen Fitton,et al
Biologics: Targets and Therapy , 2011,
Abstract: Stephen P Myers1, Joan O'Connor1, J Helen Fitton2, Lyndon Brooks3, Margaret Rolfe3, Paul Connellan4, Hans Wohlmuth4,5, Phil A Cheras1, Carol Morris41NatMed-Research Unit, Research Cluster for Health and Wellbeing, Southern Cross University, Lismore, NSW, Australia; 2Marinova Pty Ltd, Cambridge, TAS, Australia; 3Graduate Research College, Southern Cross University, Lismore, NSW, Australia; 4Centre for Phytochemistry and Pharmacology, Southern Cross University, Lismore, NSW, Australia; 5Medicinal Plant Herbarium, Southern Cross University, Lismore, NSW, AustraliaBackground: Isolated fucoidans from brown marine algae have been shown to have a range of immune-modulating effects. This exploratory study aimed to determine whether a seaweed nutrient complex containing a blend of extracts from three different species of brown algae plus nutrients is safe to administer and has biological potential as an immune modulator. The study was undertaken as an open-label combined Phase I and II study.Methods: Participants (n = 10) were randomized to receive the study medication at either a 100 mg (n = 5) or 1000 mg (n = 5) dose over 4 weeks. The primary outcome measurement was in vivo changes in lymphocyte subsets. The secondary outcome measures were ex vivo changes in T-lymphocyte (CD4 and CD8) activation, phagocytosis of granulocytes and monocytes, T helper 1/T helper 2 cytokines, and serum oxygen radical absorbance capacity.Results: The preparation was found to be safe over the 4 weeks at both doses tested. There were no clinically relevant changes to blood measurements of hemopoietic, hepatic, or renal function. Immunomodulatory measurements showed no dose response between the two doses. The combined results from the two doses demonstrated a significant increase in cytotoxic T cell numbers and phagocytic capacity in monocytes, and a significant decrease in levels of the inflammatory cytokine interleukin 6. A separate analysis of the 100 mg dose (n = 5) alone showed a significant linear component over time (P < 0.05) for phagocytosis by both granulocytes and monocytes.Conclusion: The seaweed nutrient complex was safe to use when taken orally over 4 weeks. The preparation was demonstrated to have potential as an immune modulator, and this bioactivity deserves further exploration.Keywords: seaweed, fucoidan, immune system, complementary medicine, nutraceutical
Impact of foliar application of seaweed extract on growth, yield and quality of potato (Solanum tuberosum L.)
Muhammad Wasim Haider, Chaudhary Muhammad Ayyub, Muhammad Aslam Pervez, Habat Ullah Asad, Abdul Manan, Syed Ali Raza and Irfan Ashraf
Soil & Environment , 2012,
Abstract: A field trial was carried out in 2010 to investigate the effect of foliar application of seaweed extract “Primo” as an organic biostimulant on potato cv. ‘Sante’. Foliar application of seaweed extract was carried out at different growth stages of the crop (i.e. 30 days; 45 days; 60 days; 30 and 45 days; 30 and 60 days; 45 and 60 days; 30, 45 and 60 days after sowing). Control plants were sprayed with water without seaweed extract. A significant improvement in growth, yield and tuber quality of potato was observed where treatment was applied. The highest tuber yield was recorded with applications of seaweed extract at 30 + 60 days interval after planting. The treatment also improved nitrogen, total soluble solids and protein contents of the potato tubers. The results of the study concluded a positive response of potato plant growth and yield to the foliar application of seaweed extract.
DEVELOPMENTAL CHANGES IN THE GERMINATION, GROWTH AND CHLOROPHYLLASE ACTIVITY OF VIGNA MUNGO L. USING SEAWEED EXTRACT OF ULVA RETICULATA FORSSKAL.  [PDF]
Ganapathy Selvam G.,Balamurugan M.,Thinakaran T.,Sivakumar K
International Research Journal of Pharmacy , 2013,
Abstract: The effect of seaweed extract prepared from Ulva reticulata on seed germination, seedling growth and chlorophyllase activity of Vigna mungo L. was studied. 100% germination was recorded in the seeds treated with lower concentration of seaweed extract. The V. mungo seeds soaked with lower concentrations of the seaweed extracts showed higher rates of germination, while the higher concentrations of the extracts inhibited the germination.
Noninvasive ventilation: has Pandora’s box been opened?
Ari Manuel, Richard EK Russell, Quentin Jones
International Journal of Chronic Obstructive Pulmonary Disease , 2010, DOI: http://dx.doi.org/10.2147/COPD.S9343
Abstract: Noninvasive ventilation: has Pandora’s box been opened? Other (4506) Total Article Views Authors: Ari Manuel, Richard EK Russell, Quentin Jones Published Date February 2010 Volume 2010:5 Pages 55 - 56 DOI: http://dx.doi.org/10.2147/COPD.S9343 Ari Manuel1, Richard EK Russell2, Quentin Jones3 1Department of Respiratory Medicine, High Wycombe Hospital, Bucks, UK; 2Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK; 3Specialist Registrar, Department of Respiratory Medicine, Churchill Hospital, Oxford Exacerbations of COPD are the largest single cause of hospital admission with respiratory disease, and are frequently associated with impaired gas exchange and mortality rates of up to 14%. Acute hypercapnic respiratory failure leads to admissions to intensive care units with a mortality rate of 59% at one year. Noninvasive ventilation (NIV) is a well established and validated therapy for acidotic hypercapnia respiratory failure in COPD, a leading cause of global mortality and morbidity. The use of NIV in patients with acute type II or chronic respiratory failure has increased over the past 10 years. Post to: Cannotea Citeulike Del.icio.us Facebook LinkedIn Twitter Readers of this article also read: Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis Beyond the black box: drug- and device-associated hypersensitivity events Fibrinogen and rhegmatogenous retinal detachment: a pilot prospective study On the antiatherogenic effects of vitamin E: the search for the Holy Grail Valsartan addition to amlodipine is more effective than losartan addition in hypertensive patients inadequately controlled by amlodipine Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy Analysis of in situ and ex vivo αV 3 integrin expression during experimental carotid atherogenesis Evolving role of platelet function testing in coronary artery interventions Advances in dental veneers: materials, applications, and techniques
Response of Channa striatus Extract Against Monosodium Iodoacetate Induced Osteoarthritis in Rats
F.J. Al-Saffar,S. Ganabadi,S. Fakuraz
Journal of Animal and Veterinary Advances , 2012, DOI: 10.3923/javaa.2011.460.469
Abstract: The main aim of this study was to evaluate oral administration of Channa striatus extract on monosodium iodoacetate induced knee osteoarthritis changes in rat. About 40 rats were randomly assigned to four groups. Rats in the 1st and 2nd groups were treated with the extract in a same dose but with two different courses of therapy. Rats in the 3rd group were treated with celecoxib as a positive control where as the 4th group was treated with normal saline as a negative control. Evaluation of osteoarthritis changes was assessed with the aid of radiology, histopathology score and immunohistochemistry to explore immunoreactivity in the synovium. Assay of prostaglandins in the serum had been implemented to explore their role in osteoarthritis events and regulation. Gross and microscopic results revealed curative effects of the extract on the osteoarthritis accompanied with improved immunoreactivity of the synovium. Data showed significant hormonal changes in different treated groups, indicating their role in osteoarthritis. In conclusion, the extract showed inhibitory effect on joint degradation and its earlier therapeutic application reflects importance of earlier treatment on the disease progression. Immunoreactivity as well as serum prostaglandins concentrations could be used as good markers to evaluate osteoarthritis events in the affected joints.
A natural seaweed derived mineral supplement (Aquamin F) for knee osteoarthritis: A randomised, placebo controlled pilot study
Joy L Frestedt, Michael A Kuskowski, John L Zenk
Nutrition Journal , 2009, DOI: 10.1186/1475-2891-8-7
Abstract: This small, double blind, placebo controlled pilot study investigated the impact of treatment with a natural multi-mineral supplement from seaweed (Aquamin) on 6 minute walking distance (6 MWD), range of motion (ROM), and pain and joint mobility measured by the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index in subjects with moderate to severe OA of the knee during gradual withdrawal of non-steroidal anti-inflammatory drugs (NSAIDs) that were being used daily for pain management. Subjects (n = 29) with moderate to severe OA of the knee were randomised to receive either Aquamin (2400 mg/d) or Placebo for up to 12 weeks.Of the 29 subjects initially randomized, only 22 subjects proceeded to treatment due to 7 subjects not meeting study selection criteria at baseline. Fourteen subjects completed the study and an ITT analysis (n = 22) of the data showed no significant differences in WOMAC scores however, the data did reveal significant improvements in passive and active extension ROM (0.83° ± 1.54 vs. -1.54° ± 2.43; difference, 5.2° ± 2.2, p = 0.028) and 6 MWD (150 ± 48 ft vs. 12.5 ± 31.5 ft; difference, 136 ± 57 ft, p = 0.03) in the Aquamin group compared to the placebo group; respectively, following a 50% reduction in NSAID use. The treatments were well tolerated and the adverse event profiles were not significantly different between the groups.This small preliminary study suggests Aquamin may increase range of motion and walking distances in subjects with OA of the knee and may allow partial withdrawal of NSAIDs over 12 weeks of treatment. Additional research is needed to confirm these preliminary observations.NCT00755482Osteoarthritis (OA), also called degenerative joint disease, is a slow destructive process of the joint. Although the exact biochemical cause of OA remains unknown, the process usually begins when the joint structures are abnormal or the stress placed on the joint surfaces is unusually high. Much of the disease progression is du
Anti-inflammatory activity of the apolar extract from the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
Rozas, E.;Freitas, J. C.;
Journal of Venomous Animals and Toxins including Tropical Diseases , 2007, DOI: 10.1590/S1678-91992007000200011
Abstract: the red seaweed galaxaura marginata (ellis & solander) lamouroux, well known by the antibacterial activity of its polar extract and the cytotoxic activity of its oxygenated desmosterol, showed anti-inflammatory action in its apolar fraction. topical anti-inflammatory activity was observed in samples collected at s?o sebasti?o channel, northern littoral of s?o paulo state, brazil. the apolar extract and its fractions obtained through thin-layer chromatography (tlc) reduced the topical inflammation produced by croton oil in mouse ear. such data indicated that the apolar extract from the marine red alga g. marginata displayed anti-inflammatory activity (since 1mg/ear extract reduced 95±0.5% inflammation), which could be the result of the synergic activity of the four fractions present in the apolar extract.
Antioxidant and Antibacterial Properties of Methanolic Extract of Green Seaweed Chaetomorpha linum From Gulf of Mannar: Southeast Coast of India
Palanisamy Senthilkumar,Sellappa Sudha
Jundishapur Journal of Microbiology , 2012,
Abstract: Background: Plants are an essential and integral part of complementary and alternative medicine due to their ability to generate secondary metabolites that are used to restore health and treat many diseases.Objectives: The aim of the present study was to determine the antioxidant and antibacterial activities of the green seaweed Chaetomorpha linum.Materials and Methods: The antioxidant and antimicrobial activities of C. linum from the Mandapam coastal region of the Gulf of Mannar, on the southeast coast of India, were examined based on the free radical-scavenging activity of the 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH), ferrous reducing antioxidant property (FRAP), and total phenolic content in the methanolic extract. The antibacterial properties of the methanolic extract of C. linum were tested against pathogenic bacterial strains, including Staphylococcus aureus, Bacillus cereus, Escherichia coli, Proteus mirabilis, Klebseilla pneumoniae, and Salmonella typhimurium, by cup-plate agar diffusion method.Results: The DPPH scavenging activity was equivalent to an IC 50 value of 9.8 μg/mL ascorbic acid. The total phenolic content was 672.3 mg/g gallic acid equivalent, and the IC 50 value by FRAP assay was 8.2 μg/mL. The C. linum extract showed significant activity against the majority of bacteria, comparable with standard antibiotics.Conclusions: C. linum has potential as a natural antioxidant and a natural source of antimicrobials against many microbes.
Anti-inflammatory and antinociceptive activities of methanolic extract from red seaweed Dichotomaria obtusata  [cached]
Neivys García Delgado,Ana Iris Frías Vázquez,Hiran Cabrera Sánchez,Roberto Menéndez Soto del Valle
Brazilian Journal of Pharmaceutical Sciences , 2013,
Abstract: The aim of the present work was to investigate the anti-inflammatory and antinociceptive effects of methanolic extract from D. obtusata using classic models in mice (croton oil-induced ear edema and acetic acid-induced writhing) and a phospholipase A2 activity test. Qualitative analysis of the chemical composition of seaweed was also determined by extraction with solvents of increasing polarity and precipitation and color tests. Results of qualitative chemical study showed the presence of lactonic and phenolic compounds, reduced carbohydrates, other sugars, flavonoids, fatty compounds, triterpenes and steroids. The extract inhibited mouse ear edema in a dose-dependent manner with an efficacy higher than 90% and a mean effective dose of 4.87μg/ear, while intraperitoneal administration presented a moderate activity. The extract did not inhibit phospholipase A2 activity. In the writhing test, the intraperitoneal administration of the extract showed a strong antinociceptive activity (80.2%), while the oral route showed a lower efficacy. In conclusion, this study demonstrated the anti-inflammatory and antinociceptive effects of methanol extract of D. obtusata in experimental models, suggesting its therapeutic potential in the treatment of peripheral painful and/or inflammatory pathologies. O objetivo do presente trabalho foi investigar os efeitos antiinflamatórios e antinociceptivos de um extrato metanólico de D. obtusata, utilizando modelos clássicos em ratos (teste do edema de orelha induzido por óleo de cróton e teste de contor es induzidas por ácido acético) e um teste de atividade de fosfolipase A2. A análise qualitativa da composi o química das algas foi também determinada através de extra o com solventes de polaridade crescente e testes de precipita o e cor. Os resultados do estudo de química qualitativa mostraram a presen a de compostos lact nicos e fenólicos, hidratos de carbono reduzidos e outros a úcares, flavonoides, compostos graxos, triterpenos e esteroides. O extrato inibiu o edema de orelha dos ratos de um modo dependente da dose com eficácia superior a 90% e dose média efetiva de 4.87μg/orelha, enquanto a administra o intraperitoneal apresentou atividade moderada. O extrato n o inibiu a atividade da fosfolipase A2. No teste de contor o, a administra o intraperitoneal do extrato mostrou forte atividade antinociceptiva (80,2%), enquanto a administra o oral mostrou menor eficácia. Em conclus o, este estudo demonstrou os efeitos antiinflamatórios e antinociceptivos do extrato metanólico de D. obtusata em modelos experimentais, sugerindo
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