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A role for surgery in primary pancreatic B-cell lymphoma: a case report
Theodore Liakakos, Evangelos P Misiakos, Dimitrios Tsapralis, Irene Nikolaou, Gabriel Karatzas, Anastasios Macheras
Journal of Medical Case Reports , 2008, DOI: 10.1186/1752-1947-2-167
Abstract: We report a case of a 65-year-old man who was admitted with obstructive jaundice, vague upper abdominal pain and weight loss. Ultrasonography and computed tomography showed a mass at the head of the pancreas which was compressing the bile duct. The patient underwent pancreaticoduodenectomy. Histopathologic and immunohistochemical assessment of the pancreatic lesion established the diagnosis of a diffuse, extranodal, high-grade B-cell non-Hodgkin's lymphoma. Several doses of chemotherapy were administered postoperatively and at present the disease remains in remission.The favourable outcome for this patient and a thorough review of the literature underline the important role that operative resection may have in the management of at least the early stage of primary pancreatic lymphoma.Non-Hodgkin's lymphoma (NHL) most frequently arises from the lymphatic system, with the gastrointestinal (GI) tract representing the most commonly involved extranodal site, accounting for half of such cases. In Western series, GI lymphoma occurs principally in the stomach, followed by the small bowel and the colon [1]. Primary involvement of the pancreas in lymphoma is rare, representing a small fraction (less than 1 to 2%) of all pancreatic malignancies [2]. To distinguish primary pancreatic lymphoma (PPL) from secondary involvement of the pancreas by NHL, Behrns' diagnostic criteria include: a predominant pancreatic mass with gross involvement of only the peripancreatic lymph nodes; no hepatic or splenic involvement; no palpable superficial lymphadenopathy; no enlargement of the mediastinal lymph nodes on chest radiograph; and a normal leukocyte count [3].Current standard management for PPL has relied mainly on the use of various chemotherapeutic protocols, such as the commonly used regimen of cyclophosphamide, doxorubicin, vincristine and dexamethazone (CHOP). The role of surgery in the management of pancreatic lymphoma has been limited to obtaining diagnostic tissue samples or to byp
Primary pancreatic lymphoma – pancreatic tumours that are potentially curable without resection, a retrospective review of four cases
Peter S Grimison, Melvin T Chin, Michelle L Harrison, David Goldstein
BMC Cancer , 2006, DOI: 10.1186/1471-2407-6-117
Abstract: Four cases of primary pancreatic lymphoma were identified at Prince of Wales Hospital, Sydney, Australia. A literature review of cases of PPL reported between 1985 and 2005 was conducted, and outcomes were contrasted.All four patients presented with upper abdominal symptoms associated with weight loss. One case was diagnosed without surgery. No patients underwent pancreatectomy. All patients were treated with chemotherapy and radiotherapy, and two of four patients received rituximab. One patient died at 32 months. Three patients are disease free at 15, 25 and 64 months, one after successful retreatment. Literature review identified a further 103 patients in 11 case series. Outcomes in our series and other series of chemotherapy and radiotherapy compared favourably to surgical series.Biopsy of all pancreatic masses is essential, to exclude potentially curable conditions such as PPL, and can be performed without laparotomy. Combined multimodality treatment, utilising chemotherapy and radiotherapy, without surgical resection is advocated but a cooperative prospective study would lead to further improvement in treatment outcomes.Primary pancreatic lymphoma (PPL) is rare, comprising less than 0.5% of pancreatic tumours[1]. To distinguish PPL from secondary involvement of the pancreas by non-Hodgkin's lymphoma, Behrns' clinical and diagnostic criteria of PPL include: mass predominantly within the pancreas with grossly involved lymph nodes confined to the peripancreatic region, no palpable superficial lymphadenopathy, no hepatic or splenic involvement, no mediastinal nodal enlargement on chest radiograph, and normal white cell count [2]. Presenting symptoms are non-specific, typically including abdominal pain, weight loss, nausea and vomiting [2]; but also jaundice, acute pancreatitis, and small bowel obstruction [3]. PPL can be difficult to differentiate from pancreatic adenocarcinoma without definitive pathological diagnosis[3], and correct diagnosis is crucial given tha
Primary Non-Hodgkin Lymphoma of The Cervix
Nasim Valizadeh,Haleh Ayatollahi,Siamak Naji
International Journal of Hematology-Oncology and Stem Cell Research , 2011,
Abstract: Background: There are only a few reports that exist regarding primary non-Hodgkin lymphoma of the genital tract. In this article, one case of primary B-cell type non-Hodgkin lymphoma (NHL) of the cervix is presented. Case history: A 45 year-old woman presented bloody vaginal discharge. Upon vaginal examination, the cervix was found to be enlarged. Cervical biopsy revealed B-cell type non-Hodgkin lymphoma. The patient was treated with CHOP chemotherapy. Conclusion: Systemic chemotherapy and radiation are recommended and effective treatments for genital tract B-cell type non-Hodgkin lymphoma.
Primary non-Hodgkin′s lymphoma of the mandible  [cached]
Dinakar J,Priya Lakshmi,Reddy Samyukta
Journal of Oral and Maxillofacial Pathology , 2010,
Abstract: Primary non-Hodgkins′s lymphoma is a very uncommon lesion, accounting for 0.6% in jaws. As the lesions frequently resemble other disease such as chronic osteomyelitis, odontogenic or any secondary neoplasms, further evaluation and histopathologic examination allow early identification for appropriate treatment. The purpose of this case report is to describe a rare case of non-Hodgkin′s lymphoma of the mandible, explore the diagnosis and workup based on immunohistochemistry.
Primary Thyroid Non-Hodgkin’s Lymphoma  [PDF]
Madiha Mahfoudhi, Khaled Khammassi, Imen Gorsane, Mounira El Euch, Sami Turki, Mamia Ben Salah, Taieb Ben Abdallah
Open Journal of Pathology (OJPathology) , 2015, DOI: 10.4236/ojpathology.2015.54015
Abstract: Primary non-Hodgkin’s lymphoma of the thyroid gland was rarely described. We report the case of a 44-year-old man admitted for an anterior neck swelling, hoarseness and dyspnea. The chest radiograph showed a trachea deviation. He had no clinical, biological or radiological sign of other lymphoma locations. Ultrasound examination of the neck revealed a bilateral heterogeneous thyroid lesion. Cytology revealed lymphoid cells having high nuclear-cytoplasmic ratio with multiple and irregular nucleoli. An urgent thyroid surgery consisting of total thyroidectomy had been performed since the presence of compressive signs due to the tumor. The histopathological examination of a biopsy from the thyroid tissue confirmed a high-grade non-Hodgkin’s lymphoma. Then, L-thyroxin substitution therapy, chemotherapy and radiotherapy were initiated. A prolonged remission was noted.
Primary Non-Hodgkins lymphoma of the parotid gland
Dispenza, Francesco;Cicero, Giuseppe;Mortellaro, Gianluca;Marchese, Donatella;Kulamarva, Gautham;Dispenza, Carlo;
Brazilian Journal of Otorhinolaryngology , 2011, DOI: 10.1590/S1808-86942011000500017
Abstract: primary malignant lymphomas in the salivary glands are relatively rare. clinical presentation is not characteristic and the disease is often overlooked resulting in diagnosis and treatment delays. aim: to stress the importance of the diagnostic process and combined management, we present a series of eight patients with malignant lymphoma of the parotid who were diagnosed only after surgery and managed with radiation and chemotherapy. methods: retrospective series of patients with primary malignant lymphoma of the parotid gland managed with radiotherapy and diagnostic surgical partial resection. results: after treatment completion we achieved a loco-regional control rate of 87.5%. toxicity was charted according to the common toxicity criteria and it was seen in six patients (75%). six patients are still alive without evidence of recurrent disease in their last follow-up. conclusion: our study confirms that primary early stage non-hodgkin lymphoma of the parotid gland is a disease with an excellent prognosis and a good local control rate, with minimal morbidity.
Primary Pancreatic Lymphoma in a Patient with Maturity Onset Diabetes of the Young type 3  [cached]
Valentina Bozzoli,Maria Chiara Tisi,Luigi Pianese,Stefano Tumini
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Primary pancreatic lymphoma (PPL) is an extremely rare disease which occurs in pancreas, accounts for less than 1% of extra-nodal malignant lymphomas and 0,5% of cases of pancreatic masses. We report the case of PPL in a 15 year-old boy suffering from Maturity onset Diabetes of the young type 3 (MODY3) diagnosed at the age of 1 year
Primary non-Hodgkin’s lymphoma of the breast: a case report
Mangal Pandure, Ravindra Karle, Suryakant Dongre, Bharti Baviskar
Internet Journal of Medical Update - EJOURNAL , 2013,
Abstract: ABSTRACT: The breast is rarely a primary site for extranodal lymphoma. Majority of primary Non-Hodgkin’s lymphoma of breast occurring in younger age group are bilateral and those in older age group are unilateral. They are of B cell phenotype. We report a rare case of Primary Non-Hodgkin’s lymphoma of Breast-B cell phenotype diagnosed on fine needle aspiration cytology and confirmed by histopathological examination and immunohistochemical markers.
Primary non-Hodgkin’s lymphoma of the breast: a case report  [PDF]
Mangal Pandure,Ravindra Karle,Suryakant Dongre,Bharti Baviskar
Internet Journal of Medical Update - EJOURNAL , 2013,
Abstract: The breast is rarely a primary site for extranodal lymphoma. Majority of primary Non-Hodgkin’s lymphoma of breast occurring in younger age group are bilateral and those in older age group are unilateral. They are of B cell phenotype. We report a rare case of Primary Non-Hodgkin’s lymphoma of Breast-B cell phenotype diagnosed on fine needle aspiration cytology and confirmed by histopathological examination and immunohistochemical markers.
Primary Extradural Non-Hodgkin's Lymphoma  [PDF]
Rakesh Kapoor, Vinay Kumar, S.C. Sharma
JK Science : Journal of Medical Education & Research , 2006,
Abstract: A 28 years old male presented to our institute with 3 months history of paraparesis with decreased sensationover left foot and loss of bladder and bowel control .The diagnostic work up revealed an extradural massat spinal level L3 L4.Had laminectomy and the tumour was sub totally resected. Histological examinationrevealed non hodgkin's lymphoma. The patient was worked up for disease anywhere else and was confirmedto have primary extra-dural non-hodgkin's lympoma(PENHL). Patient was treated with corticosteroides,adjuvant radiotherapy and chemotherapy. The residual tumour completely disappeared and patient isliving normal healthy life and is walking without support after 9 years of follow-up.
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