oalib
匹配条件: “” ,找到相关结果约100条。
列表显示的所有文章,均可免费获取
第1页/共100条
每页显示
Determining the role of external beam radiotherapy in unresectable intrahepatic cholangiocarcinoma: a retrospective analysis of 84 patients
Yi-Xing Chen, Zhao-Chong Zeng, Zhao-You Tang, Jia Fan, Jian Zhou, Wei Jiang, Meng-Su Zeng, Yun-Shan Tan
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-492
Abstract: We identified 84 patients with ICC from December 1998 through December 2008 for retrospective analysis. Thirty-five of 84 patients received EBRT therapy five times a week (median dose, 50 Gy; dose range, 30-60 Gy, in fractions of 1.8-2.0 Gy daily; EBRT group); the remaining 49 patients comprised the non-EBRT group. Tumor response, jaundice relief, and survival rates were compared by Kaplan-Meier analysis. Patient records were reviewed and compared using Cox proportional hazard analysis to determine factors that affect survival time in ICC.After EBRT, complete response (CR) and partial response (PR) of primary tumors were observed in 8.6% and 28.5% of patients, respectively, and CR and PR of lymph node metastases were observed in 20% and 40% of patients. In 19 patients with jaundice, complete and partial relief was observed in 36.8% and 31.6% of patients, respectively. Median survival times were 5.1 months for the non-EBRT group and 9.5 months for the EBRT group (P = 0.003). One-and two-year survival rates for EBRT versus non-EBRT group were 38.5% versus 16.4%, and 9.6% versus 4.9%, respectively. Multivariate analysis revealed that clinical symptoms, larger tumor size, no EBRT, multiple nodules and synchronous lymph node metastases were associated with poorer prognosis.EBRT as palliative care appears to improve prognosis and relieve the symptom of jaundice in patients with unresectable ICC.Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary liver cancer. A recent study from the United States reported a 9% annual increase and an overall tenfold increase in ICC-related mortality since 1973 [1].Lack of symptoms until late in the disease typically results in advanced ICC at the time of diagnosis, and cure rates are low for patients with advanced stage disease, even with aggressive therapy. Overall resectability rates were 54.6% in a series from Japan [2] and 62% in a series from United States [3]; 1-and 3-year cumulative survival rates in the
Congenital dilatation of the large and segmental intrahepatic bile ducts (Caroli's disease) in two Golden retriever littermates : clinical communication  [cached]
R.D. Last,J.M. Hill,M. Roach,T. Kaldenberg
Journal of the South African Veterinary Association , 2012, DOI: 10.4102/jsava.v77i4.379
Abstract: Two, sibling, male Golden retriever puppies, 13 weeks of age, were presented with congenital biliary cysts of the liver involving both hepatic and segmental bile ducts, as well as bilateral polycystic kidney disease. Ultrasonography of the livers of both pups demonstrated segmental cystic lesions that were contiguous with the bile ducts. Histopathology revealed cystic ectatic bile duct hyperplasia and dysplasia with variable portal fibrosis in the liver, while in the kidneys there were radially arranged, cylindrically dilated cysts of the collecting ducts, which extended through the medulla and cortex. This pathology was compatible with that of congenital dilatation of the large and segmental bile ducts (Caroli's disease) described in humans, dogs and rats. In humans Caroli's disease has an autosomal recessive inheritance pattern, while in rats activation of the MEK5/ERK cascade initiates the biliary dysgenesis of Caroli's disease in this species. However, the exact mode of inheritance and pathogenesis of Caroli's disease in dogs is as yet unknown. Previous reports on congenital hepatic cystic diseases of the dog have described Caroli's disease like lesions in various breeds, but these are believed to be the 1st reported cases in the Golden retriever breed.
Arterio-biliary fistula as rare complication of chemoradiation therapy for intrahepatic cholangiocarcinoma  [cached]
Koichi Hayano,Fumihiko Miura,Hodaka Amano,Naoyuki Toyota
World Journal of Radiology , 2010,
Abstract: Significant hemobilia due to arterio-biliary fistula is a very rare complication of chemoradiation therapy (CRT) for unresectable intrahepatic cholangiocarcinoma (ICC). Here we report a case of arterio-biliary fistula after CRT for unresectable ICC demonstrated by angiographic examinations. This fistula was successfully treated by endovascular embolization. Hemobilia is a rare complication, but arterio-biliary fistula should be considered after CRT of ICC.
Intrahepatic Transposition of Bile Ducts  [PDF]
Jasmin Deli?,Admedina Savkovi?,Eldar Isakovi?,Sergije Markovi?,Alma Bajtarevic,Amir Denjali?
ISRN Surgery , 2012, DOI: 10.5402/2012/283527
Abstract: Objective. To describe the intrahepatic bile duct transposition (anatomical variation occurring in intrahepatic ducts) and to determine the frequency of this variation. Material and Methods. The researches were performed randomly on 100 livers of adults, both sexes. Main research methods were anatomical macrodissection. As a criterion for determination of variations in some parts of bile tree, we used the classification of Segmentatio hepatis according to Couinaud (1957) according to Terminologia Anatomica, Thieme Stuugart: Federative Committee on Anatomical Terminology, 1988. Results. Intrahepatic transposition of bile ducts was found in two cases (2%), out of total examined cases (100): right-left transposition (right segmental bile duct, originating from the segment VIII, joins the left liver duct-ductus hepaticus sinister) and left-right intrahepatic transposition (left segmental bile duct originating from the segment IV ends in right liver duct-ductus hepaticus dexter). Conclusion. Safety and success in liver transplantation to great extent depends on knowledge of anatomy and some common embryological anomalies in bile tree. Variations in bile tree were found in 24–43% of cases, out of which 1–22% are the variations of intrahepatic bile ducts. Therefore, good knowledge on ductal anatomy enables good planning, safe performance of therapeutic and operative procedures, and decreases the risk of intraoperative and postoperative complications. 1. Introduction Biliary drainage has long been called Achilles heel liver transplantion, and biliary complications compromise the succese of liver transplantation [1]. A precise understanding of general anatomic principles and common variations is the key to safe living donor liver transplantation [2]. This procedure requires not only a precise understanding of liver anatomy but also the means of assessing them. One of the most important challenges is that of managing the biliary duct during liver lobe resection and reimplantation. Olos biliary anatomy variants are associated with an increased risk of postoperative complications, including biliary leaks and strictures, in both the donor and recipient [3, 4]. One cause of complications is unrecognized anomalous biliary anatomy (24%–57% of individuals have variant biliary patterns) [5–8]. Although anomalous anatomy is not always a contraindication for liver donation, knowledge of variant anatomy is critical to ensuring the safety of donors and aids selection of suitable candidates [9, 10]. The authors as Varotti et al., Heloury et al., Soares et al., and Cheng et
INTRAHEPATIC CHOLELITHIASIS
M. MEHDI HAFIZI
Acta Medica Iranica , 1987,
Abstract: A case o f Intrahepatic stone and its t r eat ment i s present e d . The t ype s o f i ntrahepatic s tones , t h e etiological f act o r , t he ways of di agno s is and t reatment a re b eing discussed. The disease is common in far Eastern c ountri es a nd Asian Are a, with c lonorchi s s i nens is inf estation, but s peci ally in Iran when the s tones i s a lone in Intrahepatic ducts without extrahepatic duc t stone,as this case repor t , i s very rare.
Segmental Neurofibromatosis  [cached]
Yesudian Devakar,Krishnan S. G. S,Jayaraman M,Janaki V. R
Indian Journal of Dermatology , 1997,
Abstract: Segmental neurofibromatosis is a rare variant of neurofibromatosis in which the lesions are confined to one segment or dermatome of the body. They resemble classical neurofibromas in their morphology, histopathology and electron microscopy. However, systemic associations are usually absent. We report one such case with these classical features.
Segment-oriented liver resections based on posterior intrahepatic glissonian approach  [PDF]
Doklesti? Krstina,?uki? Vladimir,Bumba?irevi? Vesna,Jovanovi? Bojan
Acta Chirurgica Iugoslavica , 2012, DOI: 10.2298/aci1203041d
Abstract: Background: Segment-oriented liver resections can be performed effective by posterior intrahepatic approach. A significance of such resection is that they are oncologically radical as well as parenchyma- sparing. Methodology: Segmental liver resections were performed in 102 patients with liver tumors. Suprahilar control of the appropriate glissonean pedicle was achieved by the posterior intrahepatic approach. Liver parenchyma was transsected by ultrasonic dissector, under intermittent vascular occlusion (IVO). Pedicle was divided at the end of resection using "endo-GIA" vascular stapler. Results: The overall transection time was 30,14+12,56 min. The amount of blood loss was 285,59+129,92 ml. The postoperative complication rate was 25,49%. R0 resection had 94 (92,16%) patients. There was no liver failure or perioperative death. Conclusions: Posterior intrahepatic approach for segmental resection is safe, can expedite the liver transection and reduce intraoperative hemorrhage. This approach provides adequate tumor clearance with preservation of normal parenchyma, as well as the vasculature or the biliary drainage of the contralateral liver.
Aberrant Confluence of Intrahepatic Biliary Ducts - A Case Report  [PDF]
Dragica Jurkovikj,Kostadina Korneti-Pekevska
Macedonian Journal of Medical Sciences , 2013,
Abstract: Aim: Besides the most frequent-modal type of confluent patterns intrahepatic biliary ducts, there are cases with aberrant type of confluence. The aim of this report is to present a case with aberrant confluence of intrahepatic biliary ducts.Material and Methods: Injection-corrosive method was used to obtain acrylic cast from biliary and portal systems of one human liver. Biliary ducts were followed parallel to the adjoint portal ramification from the initial part of segmental ductules.Results: Nine portal segments of the liver were established. Segmental biliary ducts and their confluence subsequently from IV to I order, were also seen. The right hepatic duct was absent. The posterior and anterior right sectorial ducts joined consecutively the opposite left hepatic duct in front of the portal bifurcation. As to the segmental ducts 2nd segment duct inflow the left hepatic duct, then 3rd segment duct had merging pattern of double medial sector duct as well as three segmental ducts 5th, 6th and 7th had inflow pattern in posterior sector duct. This specimen with aberrant confluence of intrahepatic ducts has been selected to point out the “close” relationship of found aberrant bile ducts in the liver region.Conclusion: The knowledge of the aberrant anatomy of biliary ducts emphasizes the importance in clinical practice of basic information for portobiliary topography.
Segmental Vitiligo In Northern India  [cached]
Handa Sanjeev,Rai Ranju,Kaur Inderjeet
Indian Journal of Dermatology , 2000,
Abstract: Vitiligo is an acquired, progressive pigmentary disorder of the skin and hair, which is clinically divided into segmental and non-segmental types. Segmental vitiligo is said to have an early and rapid onset and is associated with a better prognosis as disease activity ceases early compared to the non-segmental type. We have analysed the clinical features of 100 patients of segmental vitiligo seen by use at our pigmentary clinic. The findings in our series are at variance from those reported earlier. Our cases of segmental vitiligo formed a lower proportion of the total vitiligo cases, showed an earlier age of onset, multiplicity of lesions. Progressive nature and comparatively lower incidence of poliosis.
Intrahepatic cholestasis of pregnancy  [cached]
Victoria Geenes, Catherine Williamson
World Journal of Gastroenterology , 2009,
Abstract: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICP.
第1页/共100条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.