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Neurological Manifestations, Diagnosis, and Treatment of Celiac Disease: A Comprehensive Review  [cached]
Shahriar Nikpour
Iranian Journal of Neurology , 2012,
Abstract: Celiac disease or gluten sensitivity may initially present asone or more neurological signs and/or symptoms. On the other hand, it may be associated with or complicated by neurological manifestations. Neurological presentations are rare in children but as many as 36% of adult patients present with neurological changes. With severe malnutrition after progression of celiac disease, different vitamin deficiencies may develop. Such problems can in turn overlap with previous neurological abnormalities including ataxia,epilepsy, neuropathy, dementia, and cognitive disorders. Inthis study, we aimed to review the neurological aspects of celiac disease. Early diagnosis and treatment could prevent related disability in patients with celiac disease.
Hepatic manifestations of celiac disease
Hugh James Freeman
Clinical and Experimental Gastroenterology , 2010, DOI: http://dx.doi.org/10.2147/CEG.S7556
Abstract: tic manifestations of celiac disease Review (6393) Total Article Views Authors: Hugh James Freeman Published Date May 2010 Volume 2010:3 Pages 33 - 39 DOI: http://dx.doi.org/10.2147/CEG.S7556 Hugh James Freeman Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada Abstract: Different hepatic and biliary tract disorders may occur with celiac disease. Some have been hypothesized to share genetic or immunopathogenetic factors, such as primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. Other hepatic changes in celiac disease may occur with malnutrition resulting from impaired nutrient absorption, including hepatic steatosis. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma.
Hepatic manifestations of celiac disease  [cached]
Hugh James Freeman
Clinical and Experimental Gastroenterology , 2010,
Abstract: Hugh James FreemanDepartment of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, CanadaAbstract: Different hepatic and biliary tract disorders may occur with celiac disease. Some have been hypothesized to share genetic or immunopathogenetic factors, such as primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis. Other hepatic changes in celiac disease may occur with malnutrition resulting from impaired nutrient absorption, including hepatic steatosis. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma.Keywords: celiac disease, autoimmune liver disease, primary biliary cirrhosis, fatty liver, gluten-free diet
Celiac disease presenting with extraintestinal manifestations  [PDF]
?ule Bilen,Memet Aslanyavrusu,Aylin Bolat,Fikri Ak
Journal of Clinical and Experimental Investigations , 2010,
Abstract: Celiac disease (CD) is a multiorgan involved systemic disease that most commonly affects the gut but also affects other organs. Up to 10% of patients with CD and gastrointestinal symptoms have otherwise unexplained neurological presentations. In this paper we report a case with the final diagnosis of celiac disease while being investigated for the underlying etiology of iron deficient anemia, peripheral neuropathy, and gait and speech disturbances. J Clin Exp Invest 2010; 1(3): 211-213
A Brief Review on Neurologic and Psychiatric Manifestations of Celiac Disease  [PDF]
Vagner Ramirez Basilio, Rondón Garzón Nilson, Cuervo Casallas Martha
World Journal of Neuroscience (WJNS) , 2016, DOI: 10.4236/wjns.2016.62017
Abstract: Celiac Disease (CD) is a rare autoimmune disorder with manifestations at different levels including the central nervous system. The disease develops as a consequence of intolerance to gluten on individuals with genetic susceptibility. It originates as a result of the interaction between genetic and environmental factors, on individuals predisposed, through a faulty immune system response to prolamin derived peptides. Usually the diagnosis is established based on clinical suspicion, either within a suspicious family group context or in patients with suggestive manifestations of this disease.
Clinical and Laboratory Features and Extraintestinal Manifestations of Celiac Disease in Adults
Mete Ak?n,Y?ld?ran Songür,G?khan Aksakal
Journal of Clinical and Analytical Medicine , 2012, DOI: 10.4328
Abstract: Aim: Celiac disease an autoimmune disorder resulting from an immune response to the gluten in genetically predisposed patients. Although, diarrhea is the most common finding at presentation in adults, disease may present with extraintestinal manifestations such as anemia, osteoporosis, elevated transaminase levels and growth retardation. In this article, symptoms, extraintestinal manifestations and coexistence with other autoimmune disorders of adult patients with celiac disease were evaluated. Material and Method: 22 patients whose followed with the diagnosis of celiac disease in Suleyman Demirel University Department of Gastroenterology, between January 2007 and Semptember 2010, were evaluated retrospectively. Symptoms, extraintestinal manifestations and coexistence with other autoimmune disorders of patients at presentation were investigated. Results: 13 (59%) of all cases were female and 9 (41%) were male. Mean age at presentation was 38,5 years. Most common complaints were diarrhea and weakness . Tissue transglutaminase and/or antiendomysium antibody were positive, and diagnosis was confirmed by histopathologic examination in all patients. Iron deficiency, vitamine B12 deficiency and folic acid deficiency were detected in 17 (77%), 8 (36%) and 6 (27%) patients, respectively. There were elevated transaminase levels in 8 (36%) patients. Osteoporosis was detected in 4 female and 1 male patients. Sensorimotor polineuropathy was detected in 2 patients. There was growth retardation in 2 patients. Autoimmune hypothyroidism and Type 1 diabetes mellitus were detected in 2 and 1 patients, respectively. Coexistence with Crohn%u2019s disease was detected in a patient. Discussion: Celiac disease may present with extraintestinal manifestations in adults. It should be remembered, especially in patients with iron deficiency and mild to moderate transaminase elevations with unexplained etiology. It should be considered in patients with chronic diarrhea and, complications such as anemia, osteoporosis and growth retardation, must be prevented.
NEUROLOGICAL AND OTHER MANIFESTATIONS OF WILSON DISEASE; 1998-2005  [cached]
A. Fallah
Iranian Journal of Child Neurology , 2009,
Abstract: bjectiveWilson disease (WD) is an inherited copper metabolism dysfunction disease characterized by cirrhosis and CNS findings. Wilson disease is important because it is fatal if not recognized and treated. Our Goal of study is to investigate the clinical signs and symptoms, lab results and other relevant matters in our patients in order to obtain a better understanding of this potentially lethal disease in our country.Materials & MethodsWe have evaluated 21 cases of children with Wilson disease who were referred to Loghman and Imam Hussein Hospital between years 1998-2005. The mean age of our patients was 9 years.ResultsThe presenting symptom was ascites and extremity edema in 6(28.5%) patients, behavioral changes or neurological signs in 5 (24%) simultaneous Ascites and icter in 9(43%) patients and in one patient the presenting manifestation was hemolytic anemia(4.8%). One of our patients died because of fulminant hepatitis in the course of admission(4.8%).Conclusionwe showed in this study that Wilson disease can be presented by a manifold symptoms in children and adolescence .Having a good concept of these symptoms and high clinical suspicious are required to diagnose this potentially lethal disease at the proper time in order to decrease the potential adverse effects of the disease especially the neuropsychiatric damages significantly.
Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy
Marzia Caproni,Veronica Bonciolini,Antonietta D'Errico,Emiliano Antiga,Paolo Fabbri
Gastroenterology Research and Practice , 2012, DOI: 10.1155/2012/952753
Abstract: Cutaneous manifestations of intestinal diseases are increasingly reported both in the adult and in the children, and this association cannot longer be considered a simple random. Besides the well-known association between celiac disease (CD) and dermatitis herpetiformis (DH), considered as the cutaneous manifestation of gluten-dependent enteropathy, is more frequently reported also the association with other mucocutaneous diseases. Among these there are both autoimmune, allergic, and inflammatory diseases, but also a more heterogeneous group called miscellaneous. The knowledge about pathogenic, epidemiological, clinical, and diagnostic aspects of CD is increasing in recent years as well as those about DH, but some aspects still remain to be defined, in particular the possible pathogenetic mechanisms involved in the association between both CD and DH and CD and other immunological skin diseases. The aim of this paper is to describe the skin diseases frequently associated with CD, distinguishing them from those which have a relationship probably just coincidental.
Celiac Disease  [PDF]
Nikolaos Fotos,Hero Brokalaki
To Vima tou Asklipiou , 2008,
Abstract: Celiac disease is a small intestine disease caused by the immunological response to gluten, a component of wheat, rye and barley. The worldwide prevalence of celiac disease ranges between 0.2% and 2.2 %. The clinical features of celiac disease includes diarrhea, steatorrhea, flatulence, abdominal pain and weight loss. The asymptomatic type of celiac disease is characterized by soft or normally shaped stool, weakness, lassitude and moderate weight loss. In children, celiac disease usually arises between the first and the third year of age, with diarrhea, flatulence and low weight. The malabsorption in small intestine causes many extaintestinal manifestations, such us anemia, bone abnormalities, hemorrhage and neuropathy. Celiac disease is diagnosed by histological examination of tissue samples taken by duodenum due gastroscopy and by the detection of certain antibodies in blood (anti-GL-IgG, anti-GL-IgA, ΕΜΑ-IgA και anti-tTg-IgA). The only therapeutic approach to celiac disease is a gluten-free diet and, if it is necessary, the administration of iron, folic acid, calcium and vitamins (K, B12). The prognosis of celiac disease is excellent, if there is an early diagnosis and the patient keeps for life a gluten free diet.
A Case of Multiple Sclerosis and Celiac Disease  [PDF]
H. Z. Batur-Caglayan,C. Irkec,I. Yildirim-Capraz,N. Atalay-Akyurek,S. Dumlu
Case Reports in Neurological Medicine , 2013, DOI: 10.1155/2013/576921
Abstract: Objectives. Multiple sclerosis (MS) is an inflammatory autoimmune disorder of the central nervous system (CNS). Since a correlation between gluten intake and incidence of MS had been reported, the relationship of antigliadin antibodies and MS was debated. Case Report. We report the case of a 45-year-old female MS patient who is under interferon treatment. After seven years of monitoring, during her routine gastroenterological assessment, she was diagnosed with celiac disease. Conclusion. Beside the neurological manifestations that have been demonstrated in about 10% of celiac disease (CD) patients, white-matter abnormalities in brain MRI are uncommon and controversial. But in the literature, MS seems to be associated with CD as in our patient. We suggest that MS patients with gastroenterological complaints should undergo an assessment for CD. 1. Objectives Multiple sclerosis (MS) is an inflammatory autoimmune disorder of the central nervous system (CNS). MS, resembling other autoimmune disorders, has a multifactorial etiology, including environmental, immunological, and genetic factors. MS is sometimes difficult to be differentiated from CNS involvement in systemic autoimmune diseases [1]. Celiac disease is an immune-mediated intestinal disorder with gluten sensitivity which is characterized with villous atrophy and crypt hyperplasia. Celiac disease is well known to be associated with many neurological diseases like cerebellar ataxia, peripheral neuropathy, epilepsy, dementia, and depression. Earlier reports mainly have documented the involvement of the nervous system as a complication of prediagnosed CD. As gluten sensitivity with or without intestinal involvement shows concurrence with neurological manifestations like white-matter lesions, MS has been studied for the association with gluten sensitivity [2–5]. We describe an MS patient who is diagnosed with CD after seven years of followup. 2. Case Report Seven years ago, at the age of 38, a female patient was consulted to our clinic with right leg weakness and paresthesias in her arms and legs. Neurological examination showed right hemiparesis (4/5) and right hemihypoesthesia. Past history was unremarkable except that she had irritable bowel syndrome and iron deficiency anaemia. Routine laboratory investigations revealed haemoglobin of 12,4?g/dL with MCV of 80,8 and serum ferritin 6,36?ng/mL (normal values 7–270?ng/mL) confirming a mild iron deficiency. Detailed biochemical and immunological profiles were normal. Vitamin B12, folate, ANA, anti-dsDNA antibodies, ANCA, ASMA, AMA, and anticardiolipin and
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