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Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy
Da-Cruz, Alda M;Filgueiras, Danilo V;Coutinho, Ziadir;Mayrink, Wilson;Grimaldi Jr, Gabriel;De Luca, Paula M;Mendon?a, Sergio CF;Coutinho, Sergio G;
Memórias do Instituto Oswaldo Cruz , 1999, DOI: 10.1590/S0074-02761999000400020
Abstract: an atypical case of acquired immunodeficiency syndrome-associated mucocutaneous lesions due to leishmania braziliensis is described. many vacuolated macrophages laden with amastigote forms of the parasite were found in the lesions. leishmanin skin test and serology for leishmaniasis were both negative. the patient was resistant to therapy with conventional drugs (antimonial and amphotericin b). interestingly, remission of lesions was achieved after an alternative combined therapy of antimonial associated with immunotherapy (whole promastigote antigens). peripheral blood mononuclear cells were separated and stimulated in vitro with leishmania antigens to test the lymphoproliferative responses (lpr). before the combined immunochemotherapy, the lpr to leishmanial antigens was negligible (stimulation index - si=1.4). after the first course of combined therapy it became positive (si=4.17). the antigen responding cells were predominantly t-cells (47.5%) most of them with cd8+ phenotype (33%). very low cd4+ cells (2.2%) percentages were detected. the increased t-cell responsiveness to leishmanial antigens after combined therapy was accompanied by interferon-g (ifn-g) production as observed in the cell culture supernatants. in this patient, healing of the leishmaniasis lesions was associated with the induction of a specific t-cell immune response, characterized by the production of ifn-g and the predominance of the cd8+ phenotype among the leishmania-reactive t-cells.
Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy  [cached]
Da-Cruz Alda M,Filgueiras Danilo V,Coutinho Ziadir,Mayrink Wilson
Memórias do Instituto Oswaldo Cruz , 1999,
Abstract: An atypical case of acquired immunodeficiency syndrome-associated mucocutaneous lesions due to Leishmania braziliensis is described. Many vacuolated macrophages laden with amastigote forms of the parasite were found in the lesions. Leishmanin skin test and serology for leishmaniasis were both negative. The patient was resistant to therapy with conventional drugs (antimonial and amphotericin B). Interestingly, remission of lesions was achieved after an alternative combined therapy of antimonial associated with immunotherapy (whole promastigote antigens). Peripheral blood mononuclear cells were separated and stimulated in vitro with Leishmania antigens to test the lymphoproliferative responses (LPR). Before the combined immunochemotherapy, the LPR to leishmanial antigens was negligible (stimulation index - SI=1.4). After the first course of combined therapy it became positive (SI=4.17). The antigen responding cells were predominantly T-cells (47.5%) most of them with CD8+ phenotype (33%). Very low CD4+ cells (2.2%) percentages were detected. The increased T-cell responsiveness to leishmanial antigens after combined therapy was accompanied by interferon-g (IFN-g) production as observed in the cell culture supernatants. In this patient, healing of the leishmaniasis lesions was associated with the induction of a specific T-cell immune response, characterized by the production of IFN-g and the predominance of the CD8+ phenotype among the Leishmania-reactive T-cells.
Mycotic skin lesions in an adult reindeer caused by Debaryomyces bansenii. A case report
Claes Rehbinder,Roland Mattsson
Rangifer , 1994,
Abstract: This report apparently is the first to describe candidosis in reindeer. It is imperative that reindeer kept in corrals during winter and spring for supplementary feeding, are provided clean, dry conditions and that strict hygenic measures are followed. If reindeer on the other hand are kept in dirty, wet and muddy corrals, among other things, skin lesions due to fungal infections may possibly appear rather frequently.
Topical Application of Cudrania tricuspidata Stem Extract Inhibits Atopic Dermatitis-Like Skin Lesions in an NC/Nga Mouse Model: An Experimental Animal Study  [PDF]
Yoo-Sin Park, Shin-Hee Kim, Sang-Yeon Kim, Gae-Myoung Koh, Ju-Hwan Suh, Ju-Seop Kang
Pharmacology & Pharmacy (PP) , 2016, DOI: 10.4236/pp.2016.78044
Abstract:
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by elevated immunoglobulin E (IgE), mast cell infiltration and skin lesions including pruritus, erythema and eczema. Cudrania tricuspidata extracts have been clinically administered for a long time in the East Asia including Korean and China as a home-remedy to diminish the inflammation of gastritis and hepatitis. To examine whether it works on AD or not, an AD-like animal model was experimented in this study. AD was induced by applying Dermatophagoides farinae (D. farinae) extract to the backs of 9-week old NC/Nga mice for 21 days. Following this, an ethanol extract of C. tricuspidata stems (EECT) was applied topically for 14 days to the sensitized skin, while distilled water was used as a control (EECT0 mice). Anti-AD effects of EECT were evaluated using scores for AD-like skin lesions, serum IgE levels and mast cell counts in the skin dermal layers to assess inflammation. Topically applied ethanol extract of Cudrania tricuspidata stems (EECT 7.5, 25 and 75 mg/mL) markedly reduced AD-like skin lesions after 4 days (by 30.1%, 31.4% and 38.5%, respectively) and also after 14 days (by 63.6%, 66.1% and 49.6%, respectively), while distilled water improved AD by 17.8% and 38.7%, respectively (p < 0.05). Serum IgE production was reduced in the EECT7.5, EECT25 and EECT75 groups after 4 days (by 57.6%, 65.9% and 59.3%, respectively) and after 14 days of the treatment (by 82.0%, 79.6% and 75.3%, respectively), while distilled water decreased it by 38.8% and 62.3% (p = 0.0001 and p = 0.0001, respectively). Mast cell counts increased after sensitization by D. farinae extract (p =
Dermatosis provocadas por la luz solar e influencia en la calidad de vida Skin lesions caused by sunlight and their influence on quality of life
Leopoldina Falcón Lincheta,Bettsy Martínez Cardoso
Revista Cubana de Medicina Militar , 2012,
Abstract: Introducción: en los últimos a os ha existido un incremento de lesiones dermatológicas en las zonas expuestas al sol como resultado del deterioro de la capa de ozono, lo que se ha comportado según los distintos tipos de piel, ello ha determinado que los sujetos vean afectada su calidad de vida. Objetivos: determinar las afectaciones por da o solar según fototipo cutáneo y su relación con la calidad de vida en sujetos que trabajan en el mar. Métodos: estudio descriptivo en 204 sujetos trabajadores del mar mediante el examen clínico-dermatológico y una medición de su calidad de vida a través del Cuestionario General de Calidad de Vida, el que definió la afectación o no de esta. Resultados: predominaron los fototipos IV, V y III. La mayoría de los sujetos presentaron da o solar y afectaciones de la calidad de vida. Hubo relación significativa entre el fototipo cutáneo, el da o solar, la calidad de vida y el número de lesiones actínicas. Los diagnósticos más frecuentes fueron los léntigos y fotoenvejecimiento. Las dimensiones más afectadas fueron la salud física y la salud psicológica. Conclusiones: Se encontró relación entre el fototipo cutáneo de los sujetos, da o solar y la calidad de vida. Introduction: recent years have witnessed an increase in the number of dermatological lesions on skin areas exposed to sunlight, as a result of the depletion of the ozone layer. Sun damage varies with skin type, and affects the subjects' quality of life. Objectives: determine sun-related skin damage by skin phototype and its relationship to quality of life in sea workers. Methods: Descriptive study of 204 sea workers. All underwent clinical and dermatological examination as well as measurement of their quality of life through the General Quality of Life Questionnaire. Results: most subjects had sun-related skin damage and deterioration of their quality of life. Phototypes IV, V and III were predominant, and the most common diagnoses were lentigos and photoaging. The most affected areas were physical health and psychological health. Conclusions: sea workers show damage to their physical health due to their lengthy exposure to sunlight, which in turn affects their psychological health, particularly their self-esteem and mood. The combination of these factors negatively affects their quality of life and should be taken into account in the work strategies designed by their managers.
Taenia taeniaeformis in Rat Favors Protracted Skin Lesions Caused by Sporothrix schenckii Infection: Dectin-1 and IL-17 Are Dispensable for Clearance of This Fungus  [PDF]
Xiaohui Zhang, Jing Zhang, Huaiqiu Huang, Ruzeng Xue, Xuchu Hu, Meirong Li, Yi Zhong, Liyan Yuan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052514
Abstract: We occasionally found that cestode Taenia taeniaeformis in rats favored Sporothrix schenckii infection and survival, causing protracted cutaneous lesions. In this study, we compared the pathology and cytokines profile of rats co-infected with the two pathogens and infected with S. schenckii alone to explore underlying mechanisms. In the co-infection group, there was high expression of β-glucan receptor Dectin-1 in the cutaneous lesions and no multinucleated giant cells, but in the S. schenckii infection group the opposite was observed. Cytokines profiles demonstrated an expected finding that IL-4, commonly expressed in helminth and fungus infection, is undetectable in the two infection groups. In the single fungal infection group, cytokines IFN-γ, IL-10 and IL-17 kept increasing in the first few weeks of infection to a peak which was followed by gradual decrease. This study showed that Dectin-1 and IL-17, which were believed to be the major anti-fungus mechanisms, are Th2 independent and dispensable for clearance of S. schenckii infection, suggesting that S. schenckii has a different molecular recognition pattern and evokes anti-infection mechanisms other than Dectin-1 and IL-17.
Disseminated American muco-cutaneous leishmaniasis caused by Leishmania brasiliensis brasiliensis in a patient with AIDS: a case report
Machado, Elizabeth S.;Braga, Maria da Providencia;Da-Cruz, Alda Maria;Coutinho, Sérgio G.;Vieira, Alba Regina M.;Rutowitsch, Marcio S.;Cuzzi-Maya, Tulia;Grimaldi Junior, Gabriel;Menezes, Jacquelie A.;
Memórias do Instituto Oswaldo Cruz , 1992, DOI: 10.1590/S0074-02761992000400005
Abstract: the authors report a case of culture-proven disseminated american muco-cutaneous leishmaniasis caused by leishmania brasiliensis brasiliensis in an hiv positive patient. lesions began in the oropharynx and nasal mucosa eventually spreading to much of the skin surface. the response to a short course of glucantime therapy was good.
Granulomatous lesions of the skin  [PDF]
K Gautam,RR Pai,S Bhat
Journal of Pathology of Nepal , 2011, DOI: 10.3126/jpn.v1i2.5397
Abstract: Background: Granulomatous skin lesions often present as a diagnostic challenge to dermatopathologists due to various modes of presentation and identical histological picture produced by several causes. The aim of the study was to study different granulomatous skin lesions and to determine the relative frequency, the level of clinicopathologic concordance and to compare our results with those of other workers. Materials and Methods : A retrospective analysis of skin biopsies received over a period of two years from January 2007 to December 2008; was performed, and cases of granulomatous dermatitis reported on histopathological examination were reviewed along with special stains. Results: Out of a total of 1590 skin biopsies 106 (6.67%) cases were found to have a granulomatous reaction. It was common in males (63.21%) with most occurring in the fourth to fifth decades. Majority of cases (79 cases, 74.5%) were categorized as infectious granulomatous lesions with predominance of leprosy (63 cases, 79.7%) followed by tuberculosis (6 cases, 7.6%). An overall clinicopathologic concordance was seen in 97% of cases of leprosy. Conclusion: In this study leprosy is the most common cause of granulomatous skin lesions. It can be concluded that histopathology plays an important role in classification of leprosy, and in diagnosis and management of a variety of granulomatous skin diseases. Special stains play a supportive role in infectious granulomas. Keywords: Granulomatous skin lesion; Leprosy; Skin biopsy DOI: http://dx.doi.org/10.3126/jpn.v1i2.5397 JPN 2011; 1(2): 81-86
Immunopathology of skin lesions
Khan Nazoora,Maheshwari Veena,Trivedi Indu,Kalam Abul
Indian Journal of Dermatology, Venereology and Leprology , 2001,
Abstract: A study was conducted on 130 patients suffering from skin lesions which included psoriasis, lichen planus, DLE, pemphigus, vitiligo and alopecia areata. Forty age-and-sex-matched healthy individuals served as control. Serum IgG, IgM, and circulating immune complexes (CIC) were estimated. Significant increase in serum IgG (1937.2 ± 1030.43 mg%) and IgM (232.12 ± 136.98 mg%) was observed in all the skin lesions when compared with controls except in lichen planus where they were significantly lowered, values being 580.61± 77.35 mg% and 66.88 ± 6.59mg% respectively. CIC levels were significantly raised (P<0.00 1) in various skin lesions (40.49±23.29) when compared with controls (17.68± 3.21), but no significance was observed in lichen planus( 17.72 ± 4.28). Serum IgG, IgM and CIC were statistically significantly altered depending on the extent of the lesion and lowered significantly to almost normal values following treatment, thereby confirming the role of immunity in the pathogenesis of these skin disorders.
Development of Cutaneous Leishmaniasis after Leishmania Skin Test
Paulo R. Machado,Augusto M. Carvalho,Gustavo U. Machado,Marina L. Dantas,Sérgio Arruda
Case Reports in Medicine , 2011, DOI: 10.1155/2011/631079
Abstract: Thirty-year-old female with a previous history of a cutaneous ulcer suspicious of leishmaniasis 20 years ago presented with a new complaint of a depressed papular lesion 8×7 mm in the right lower extremity. The lesion was of 10-day duration. Because early cutaneous leishmaniasis (CL) lesions may have a non-ulcerated appearance, a Leishmania skin test (LST) was performed on the forearm with a strong positive result (38×32 mm). After 8 days, the lesion in the leg, which was diagnosed as folliculitis, completely healed. However, a typical CL ulcer (26×24 mm) developed at the LST site. Histopathology of the new lesion did not identifiy parasites, but the findings were consistent with a diagnosis of CL. Further analysis identified amastigotes by immunohistochemical stain. Mononuclear cells harvested from the patient were stimulated with Leishmania antigen and showed high levels of production of both tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ): 2,943 pg/mL and 2,313 pg/mL, respectively. After 40 days of treatment with antimony and pentoxifylline, the ulcer resolved. The development of CL at the LST site suggests a strong Th1 immune response, and it is an in vivo documentation of the role of the host immune response in the pathology of CL. It teaches us that LST should be cautiously, if at all, used in patients with self-healing CL ulcers.
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