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Sterol composition of caper (Capparis spinosa) seeds
N Tlili, N Nasri, E Saadaoui, A Khaldi, S Triki
African Journal of Biotechnology , 2010,
Abstract: Caper is a perennial shrub of the Mediterranean Basin. The most important economical species is Capparis spinosa. Sterols of C. spinosa seed oil isolated from seven Tunisian stands were identified and quantified. C. spinosa contained high levels of phytosterols (2240.4 mg/kg of total extracted lipids), of which -sitosterol, with 1390 mg/kg, was the most abundant (57.53%). Campesterol and stigmasterol accounted for 382 and 265 mg/kg, respectively (17.05 and 11.85% of the total sterols, respectively). C. spinosa seed oil also contained a high level of 5-avenasterol (6%). We detect also brassicasterol (3.39 mg/kg). Cholesterol and campestanol are detected in much lower levels. These results bring attention to the richness of C.spinosa seed oil with sterols which are the most important class of the minor components.
HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACTS OF NARINGI CRENULATA (ROXB) NICOLSON AGAINST CCl4 INDUCED HEPATOTOXICITY IN RATS
V. R. Mohan et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins. It also exhibited antioxidant activity by showing the increased activity of SOD, CAT, GPx and GRD and decreased in TBARS compared to CCl4 treated groups. Silymarin, a known hepatoprotective drug is used for comparison. The plant extracts were effective in protecting liver against injury induced by CCl4 in rats.
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF CAPPARIS SEPIARIA LEAVES  [cached]
R. Thirumalaikumaran,Uma Maheswara Reddy
International Journal of Biomedical Research , 2011, DOI: 10.7439/ijbr.v2i3.93
Abstract: The effect of the ethanolic extract of the leaves of capparis sepiaria Linn was studied against carbon tetrachloride induced hepatotoxicity in Wister rats. Significant hepatoprotective effects were obtained liver damage induced by carbon tetrachloride as evident from decreased serum levels of glutamate pyruvate transaminase (SGPT),glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (SAKP) and bilirubin (SB) in the capparis sepiaria (CS) treated groups (100,200 mg/kg), compared to the intoxicated controls. The hepatoprotective effect was further confirmed by histopathalogical studies of the liver, which showed improved architecture, absence of nuclear pycnosis, hepatocyte congestion and necrosis, when compared with the liver of the toxin group of animals. capparis sepiaria (CS) extract also showed significant free radical scavenging activity in vitro. Thus the present study provides a scientific rationale for the traditional use of this plant in the management of liver disorders.
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF CAPPARIS SEPIARIA LEAVES  [cached]
R. Thirumalaikumaran,Uma Maheswara Reddy
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v2i3.93
Abstract: The effect of the ethanolic extract of the leaves of capparis sepiaria Linn was studied against carbon tetrachloride induced hepatotoxicity in Wister rats. Significant hepatoprotective effects were obtained liver damage induced by carbon tetrachloride as evident from decreased serum levels of glutamate pyruvate transaminase (SGPT),glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (SAKP) and bilirubin (SB) in the capparis sepiaria (CS) treated groups (100,200 mg/kg), compared to the intoxicated controls. The hepatoprotective effect was further confirmed by histopathalogical studies of the liver, which showed improved architecture, absence of nuclear pycnosis, hepatocyte congestion and necrosis, when compared with the liver of the toxin group of animals. capparis sepiaria (CS) extract also showed significant free radical scavenging activity in vitro. Thus the present study provides a scientific rationale for the traditional use of this plant in the management of liver disorders.
Stachydrine and Volatile Isothiocyanates from the Unripe Fruit of Capparis spinosa L.
SULEIMAN AFSHARYPUOR AMIR AREFIAN JAZY
DARU : Journal of Pharmaceutical Sciences , 1999,
Abstract: The alkaloid stachydrine of the unripe fruit as well as other parts of Capparis spinosa var. mucronifolia was extracted by 80% methanol, purified by column chromatography and identified by 'H NMR and IR spectroscopic methods. Volatile isothiocyanates were prepared by hydro-distillation of the autolyzed plant material and studied by GC and GC/MS methods.The volatile oil of the unriupe fruit was composed mainly of methyl isothiocyanate (39.2%), isopropyl isothio-cyanate(21.4%), and sec-butyl isothiocyanate (6.4%).
Anti-inflammatory activity of bark of Xeromphis spinosa
Biswa Nath Das,Achinto Saha,Muniruddin Ahmed
Bangladesh Journal of Pharmacology , 2009,
Abstract: The bark of Xeromphis spinosa extracted by a mixture of equal proportions of petroleum ether, ethyl acetate and methanol at an oral dose of 200 and 400 mg/kg body weight exhibited significant anti-inflammatory activity when compared with control.
Evaluation of Hepatotoxicity and Renal Toxicity of Methanolic Extract of Capparis Spinosa in Rats
M Heidari,M Mirshamsi,B Naghibi,M Heidari
Journal of Shahid Sadoughi University of Medical Sciences , 2010,
Abstract: Introduction: Certain herbal medicines are being marketed without standard toxicological study. Although people believe that herbal medicine don’t have toxic effects, there are some reports indicating the toxicity of herbal medicine. The aim of this investigation was to evaluate hepatic and renal toxicity of percolated extract of Capparis Spinosa that has an analgesic effect and is traditionally used for treatment of rheumatism, gout and also used for its analgesic and anti inflammatory activities. Methods: In this study, the doses of 200, 400 and 800 mg/kg of methanolic extract of C. Spinosa were administrated by oral gavages for 7 days in rats. Normal saline, 5ml/kg was given to the control group. Each group contained 6 male rats. On the 8th day, serum and urine samples were collected for liver function tests (ALT, AST, ALP) and renal function tests (BUN , Cr ,urine ALP and ALP). The livers and kidneys were isolated for histopathological studies. Results: There were no significant differences in ALTand AST levels of the control and extract treated groups, but there was a significant increase in ALP levels only at doses of 200 mg/kg (p<0.05). The histopathological studies of livers showed no evidence of hepatotoxicity at dose of 200 and 400 mg/kg. Renal function tests including BUN (Blood Urea Nitrogen) and Creatinine were significantly increased after oral administration of 400 and 800 mg/kg (p<0.05). The histopathologic studies of kidneys showed evidence of renal toxicity at doses of 400 and 800 mg/kg. Conclusion: The results suggest that methanolic extract of C. Spinosa has no liver toxicity, but it seems that it results in renal toxicity, especially in high dosage.
Hepatoprotective Effect of the Aqueous Root-Bark Extract of Ficus sycomorus (Linn) on Carbon Tetrachloride Induced Hepatotoxicity in Rats
S.H. Garba,J. Prasad,U.K. Sandabe
Journal of Biological Sciences , 2007,
Abstract: The aqueous root-bark extract of Ficus sycomorus (Linn) was tested for its chemical constituents, acute toxicity and hepatoprotective effect against Carbon tetrachloride (CCl4) induced hepatotoxicity in rats. A total of 78 adult albino rats weighing between 150-320 g were used. The animals were each weighed at the start of the experiment and divided into two segments consisting of 42 rats for the acute toxicity and 36 rats for the hepatoprotective study segments, respectively. In the acute toxicity study the aqueous extract of the root-bark of Ficus sycomorus was administered intraperitoneally (ip) in a dose range of 0.2-12 g kg-1 and the rats were observed for the physical signs of toxicity for 24 h. The hepatoprotective segment involved dosing the negative control rats intraperitonealy with carbon tetrachloride (CCl4) 3 mL kg-1 that was dissolved in corn oil to induce liver damage while the treatments groups were pretreated with 640 mg kg-1 of the extract orally an hour before CCl4 (3 mL kg-1) was administered to observe if the extract has any hepatoprotective effect against CCl4 induced hepatotoxicity At the end of each treatment period, the animals were weighed and blood was obtained from animals administered CCl4 and pre-treated with 640 mg kg-1 of the extract for biochemical analysis with the liver extracted, weighed and processed for histological assessment. Phytochemical analysis of the extract revealed the presence of saponins, flavonoids, alkaloids, tannins and reducing sugar and LD50 was calculated as 3.20 0.6031 g kg-1. Pre-treatment of the rats with the extract was able to reduce though not significantly, changes in the biochemical parameters (decrease in albumin but increase in Aspartate Transaminase (AST), Alanine-Transaminase (ALT), Alkaline Phosphatase (ALP) and bilirubin) and preserved the liver parenchymal architecture against CCl4 induced degenerative changes, fibroplasia and cirrhosis. The results of this study showed that the plant extract had hepatoprotective effect on the parenchymal architecture of the liver against CCL4 induced hepatotoxicity in rats. But further studies to observe its hepatocurative potentials would be useful and is recommended.
ECO-PHYSIOLOGY OF CAPPARIS SPINOSA L. : A PLANT SUITABLE FOR COMBATING DESERTIFICATION  [PDF]
M. S. SAKCALI,H. BAHADIR,M. OZTURK
Pakistan Journal of Botany , 2008,
Abstract: Capparis spinosa from the family Capparidaceae is widely distributed on varying habitats in Turkey. Recently, it has been recommended for the evaluation of degraded arid lands in the country. This study was thus undertaken to investigate the diurnal time course of water relations of C. spinosa L. growing on healthy and degraded sites. Water stress was analysed on the basis of stomatal conductance (gs), leaf water potential ( w) and transpiration rate. The species appeared to be a drought resistant with lower WSIS (16 MPa h), showing a negligible difference between the two sites. A high gs, with lowest WSIS value shows that despite being a water spender, C. spinosa dynamically recovers even in the warmest hours of the day and under drought conditions. The long roots and wide ecological amplitude allow it to withstand harsh environments. The species thus appears to be a suitable candidate for the protection of degraded areas.
Studies of Antioxidants and Xanthine Oxidase Inhibitory Potentials of Root and Aerial Parts of Medicinal Plant Capparis Spinosa L.
American Journal of Medicine and Medical Sciences , 2012, DOI: 10.5923/j.ajmms.20120201.06
Abstract: Capparis spinosa aerial part and root extracts were prepared using solvents of varying polarity. Results showed that ethyl acetate extract (EAE) of the aerial part contains the highest concentration of phenolic compounds and flavonoids followed by the chloroform extract (CHE) of roots. The enzymatic methods were realised by the production of uric acid and reduction of cytochrome c. Result showed that all plant extracts were effective either in inhibiting the activity of XO or Cyt C. The IC50 ranges from 0.0226 ± 0.00019 to 4.32 ± 0.15g/l. The non enzymatic methods were conducted using in vitro techniques: In DPPH test, the radical scavenging activity for the root and aerial part extracts decreased in the following order CHE> EAE> CE and EAE> CE> CHE, respectively. In general the aerial part extracts had an antioxidant activity through -carotene-linoleate model system and ferric reducing ability greater than that of root part. In conclusion, Capparis spinosa appears to be a valuable plant and could be used to treat conditions where inhibition of XOR and free-radicals scavenging action are warranted.
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