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Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors
Ito, Fabio Augusto;Ito, Kazuhiro;Coletta, Ricardo Della;Vargas, Pablo Agustín;Lopes, Márcio Ajudarte;
Brazilian Oral Research , 2009, DOI: 10.1590/S1806-83242009000400008
Abstract: the aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. a total of 41 pleomorphic adenomas, 30 warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. it was observed that all cases were negative for estrogen and progesterone receptors. androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. in conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. however, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.
MANAGEMENT OF PLEOMORPHIC ADENOMA OF SALIVARY GLANDS
Ayub ur Rehman
The Professional Medical Journal , 2000,
Abstract: By far the most common benign neoplasm of salivary origin is the pleomorphic adenoma. It is often poorlycapsulated and has bosselated surface hence more chances of recurrence after excision. OBJECTIVES: Tofind out the recurrence rate after superficial or total conservative parotidectomy and in case of minor salivarytumours, wide surgical excision. DESIGN OF STUDY: Prospective study. SETTING: Department of ENTAllied/DHQ Hospital Faisalabad. PERIOD: Apr 1994 to Dec 1998. MATERIAL AND METHODS: 25cases of benign salivary swellings (22 male and 3 females) were selected after confirming FNAC report tobe pleomorphic adenoma. These patients were subjected to surgical excision of the tumour by superficial/totalconservative parotidectomy or excision with healthy cuff of tissue. RESULTS: Only one patient having tumourspillage during excision has recurrence in scar incision during five years follow up. CONCLUSIONS: Itseems reasonable to advocate superficial parotidectomy for benign pleomorphic adenoma of parotid and excisionwith a wide cuff of healthy tissue in case of minor salivary gland adenoma and to avoid capsular rupture atall costs.
Pleomorphic Adenoma of Salivary Glands: an Experience at TUTH  [PDF]
U Gurung,BL Shrestha,BK Sinha,DK Baskota
Nepalese Journal of ENT Head and Neck Surgery , 2010, DOI: 10.3126/njenthns.v1i1.4729
Abstract: Keywords: pleomorphic adenoma; parotid; submandibular gland; parotidectomy; wide excision DOI: 10.3126/njenthns.v1i1.4729 Nepalese J ENT Head Neck Surg Vol.1 No.1 (2010) p.8-11
Pleomorphic Adenoma of the Upper Lip  [cached]
ülkü Kü?üK,Serdar TAN
Türk Patoloji Dergisi , 2011,
Abstract: Pleomorphic adenoma is the most common neoplasm of the salivary glands and is most commonly located in the parotis followed by the submandibular glands. Its localization in the minor salivary glands is mostly reported in the palate. Few publications report pleomorphic adenoma cases located in the lip.We present a 35-year-old male patient with a pleomorphic adenoma located in the upper lip.
Pleomorphic adenoma of the hard palate
Kaur S,Thami G,Nagarkar N
Indian Journal of Dermatology, Venereology and Leprology , 2003,
Abstract: Pleomorphic adenoma is a benign tumor of the salivary glands that has elements of both epithelial and mesenchymal tissues. The tumor most commonly arises in the parotid or submandibular glands. Infrequently, it may arise from the minor salivary glands and present as an intraoral mass over the palate or lip. We report a patient with pleomorphic adenoma over the hard palate, which resembled common intraoral diseases like condyloma acuminata, oral papilloma and squamous cell carcinoma.
Pleomorphic adenoma of the hard palate
Kaur S,Thami G,Nagarkar N
Indian Journal of Dermatology, Venereology and Leprology , 2003,
Abstract: Pleomorphic adenoma is a benign tumor of the salivary glands that has elements of both epithelial and mesenchymal tissues. The tumor most commonly arises in the parotid or submandibular glands. Infrequently, it may arise from the minor salivary glands and present as an intraoral mass over the palate or lip. We report a patient with pleomorphic adenoma over the hard palate, which resembled common intraoral diseases like condyloma acuminata, oral papilloma and squamous cell carcinoma.
Giant Pleomorphic Adenoma of the Parotid Gland  [cached]
?mdat Yüce,Sedat ?a?l?,Mala Bukar Sandabe,Ali Bayram
Erciyes Medical Journal , 2009,
Abstract: Pleomorphic adenoma is the most common among all the tumors of the salivary glands and frequently affecting the parotid gland. The vast majority of these tumors are between two and six centimeter in size but cases of giant pleomorphic adenoma have been reported. We present a case of giant pleomorphic adenoma, which was treated successfully by surgery and weigh 1.2 kilogram.
EXPRESSION OF MATRIX METALLOPROTEINASE MMP-2 AND ITS TISSUE INHIBITOR TIMP-2 IN INTRAORAL PLEOMORPHIC ADENOMA AND ADENOID CYSTIC CARCINOMA
Natheer Hashim AL-Rawi,Muthanna Al-Samarai,Sausan Al-Kawas,Ahlam H. Majeed
Journal of International Dental and Medical Research , 2011,
Abstract: Matrix metalloproteinases (MMPs) are proteolytic enzymes that are capable of degrading different substrates within extracellular matrix (ECM), and are believed to be crucial for tumor invasion and metastasis. Tissue inhibitors of MMP (TIMPs) can inhibit the action of MMPs The aim of this study was to analyze protein expression of MMP-2 and TIMP-2 in intraoral pleomorphic adenoma (PLA) and adenoid cystic carcinoma (ACC). A total of 35 formalin-fixed paraffin-embedded specimens comprising 19 PLA and 16 ACC were utilized in this study. A standard immunohistochemical technique was used to determine the expression levels of MMP-2 and TIMP-2 proteins. Sections were assessed semi quantitatively .Staining was scored as 0 (< 1% positive tumor staining), 1+ (< 25% positive tumor cells), 2+ (20-50% positive tumor cells) and 3+ (> 50% positive tumor cells). For statistical analysis, tumors were divided into two groups, low expressors ( 0-1+) and high expressors (2-3+). PLA showed higher TIMP-2 expression than ACC (p<0.05). No significant difference was observed between PLA and ACC regarding MMP-2 expression. MMP-2 and TIMP-2 expressed mainly in the cytoplasm of epithelial/ myoepithelial components of PLA and neoplastic epithelial cells of ACC. Myoepithelial cells may be the primary source of gelatinases in PLA and the down regulation of TIMP-2 expression in ACC might be responsible for metastasis and recurrence. The ratio value of MMP-2/TIMP-2 is valuable parameter to demonstrate the ECM degradation/ deposition imbalance.
Pleomorphic adenoma of the nasal septum: a case report
Polycarp Gana, Liam Masterson
Journal of Medical Case Reports , 2008, DOI: 10.1186/1752-1947-2-349
Abstract: We present the case of a 61-year-old man who presented with a 2-year history of left nasal obstruction, occasional epistaxis and facial pain. Radiological examination demonstrated well pneumatised paranasal sinuses and a soft tissue mass in the anterior aspect of the left nasal cavity. In this patient, an intranasal approach was used to achieve a wide local resection.Pleomorphic adenomas are rare tumours of the nasal cavity and have been shown to be misdiagnosed in over half of cases leading to more aggressive treatment than is necessary. If unilateral nasal obstruction is the main presenting complaint, we suggest consideration of this diagnosis. In view of the potential for tumour recurrence, long-term follow-up and careful examination of the nose with an endoscope are necessary.Salivary gland tumours constitute about 3% [1] of all neoplasms. The majority of these tumours are benign and about 70% are pleomorphic adenomas. A small minority (8%) are located in the oral cavity, neck and nasal cavity. We present a rare case of pleomorphic adenoma of the nasal septum.Several benign lesions of the septum such as leiomyoma, osteochondroma and transitional cell papilloma have been reported in literature. The other differential diagnoses may include malignant tumours such as melanoma, adenoid cystic carcinoma and squamous cell carcinoma. The majority of these tumours arise from the mucosa of the bony and cartilaginous septum.Nasoseptal swell body is a discrete area of erectile tissue in the submucosa over the anterior nasal septum. In some individuals, it can present as a suspicious lesion. It does not have a significant relevance when considering the differential diagnosis in this patient given the enormous size of the septal mass. However, in smaller septal swellings, it could be given consideration.A 61-year-old man presented with a 2-year history of left nasal obstruction, occasional epistaxis and facial pain. There was no history of visual defect, atopy or previous tra
Pleomorphic adenoma of minor salivary gland: rare tumor in tongue base
R. Fuente Ca?ibano,P. Blanco Pérez
Revista de la Sociedad Otorrinolaringológica de Castilla y León, Cantabria y La Rioja , 2010,
Abstract: Pleomorphic adenoma (PA) is the neoplasm most common salivary gland. Mainly affects themajor salivary glands, and is much less commonly found in minor salivary glands, the mostfrequent being the palate and upper lip. Although pleomorphic adenoma is abenign neoplasm, usually the capsule is incomplete and tends to recur after incompletesurgical resection.
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