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Reasons for False-Negative and False-Positive Diagnosis in Fine Needle Aspiration Cytology of the Breast: 286 Cases with Cyto-Histopathologic Correlation  [cached]
Nilüfer Onak KANDEM?R,Sibel BEKTA?,Figen BARUT,Gamze YURDAKAN
Türk Patoloji Dergisi , 2010,
Abstract: Objective: Fine needle aspiration cytology is the first step in the diagnosing breast lesions. This study evaluated factors causing falsenegative and false-positive diagnoses when evaluating breast lesions using this technique.Material and Method: In this study, we retrospectively examined 511 breast diagnoses, based on Fine needle aspiration cytology specimens, made in the Medical School of Zonguldak Karaelmas University, Department of Pathology, between 2002 and 2009. Factors affecting the reliability of fine needle aspiration cytology were evaluated by comparing the cytological and biopsy diagnoses and using the clinical parameters in the diagnosis of breast lesions.Result: In our series, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of fine needle aspiration cytology were 77%, 99%, 95%, 93%, and 95%, respectively. The falsenegative diagnosis rate was 4% and the false-positive diagnosis rate was 1%.Conclusion: Sampling errors and erroneous interpretation of cellular monomorphism are the most important reasons for false-negative diagnosis results in the evaluation of breast lesions with fine needle aspiration cytology. Increased cellularity and reactive cell atypia in benign proliferative breast lesions are the most frequent reasons for false-positive diagnosis.
The Professional Medical Journal , 2007,
Abstract: Introduction: Lymph nodes are frequently enlarged in children in a widespectrum of diseases, some are of great concern while others are trivial from clinical or diagnostic point of view.Objectives: To evaluate the diagnostic role of fine needle aspiration cytology in lymphadenopathy in pediatric agegroup. Period: Jan 2001 to Aug 2005. Material & Methods: The material was obtained by FNA from children of theregion, stained with H & E, Papaniculau, giemsa and Z.N Stain. History, physical examination and other pertinentclinicopathological parameters were noted before the FNA procedure. The biopsy material where available wassubsequently correlated with FNA diagnosis. Results: A total number of 120 cases were included in the study. Out ofthese 64 were females and 56 were males. Out of non malignant cases the most common diagnosis in our cases wasreactive lymphadenitis. Conclusions: Fine needle aspiration cytology is a reliable easy and economic technique ofdiagnosis. It should particularly be adopted in children to avoid unnecessary step of surgery and mental trauma as fairlyaccurate cytodiagnosis is possible especially when majority of the cases of lymphadenopathy are inflammatory innature.
Shahida Niazi
The Professional Medical Journal , 2000,
Abstract: OBJECTIVES: To evaluate the diagnostic role of aspiration cytology in the preoperative management ofpatients with palpable breast lumps PATENTS & METHOD: A total of 510 Fine Needle Aspirations wereperformed on palpable breast masses. PERIOD: Jan - Dec 1999. SETTING: Department of Pathology,King Edward Medical College and Department of Pathology Allama Iqbal Medical College, Lahore.RESULTS: These included 497 (97.45%) female and 13 (2.54%) male patients. 148 aspirations (29.01%)were classified as malignant, 334 (65.49%) as benign, 11(2.15%) as suspicious and 17(3.33%) aspirates wereconsidered unsatisfactory for cytological diagnosis. 145 (29.17%) out of the total 497 female breastaspirations, and 3 (23.07%) out of 13(23.07%) male breast aspirations were classified as malignant.Fibrocystic Disease (24.54%) and Fibroadenoma (20.12%) were the most common benign female breastlesions followed by Pyogenic mastitis, tuberculous mastitis, galactocoele, traumatic fat necrosis etc. Benignmale breast lesions diagnosed by aspiration cytology included gynaecomastia, lipomas and tuberculousmastitis. CONCLUSION: FNAC is a simple sensitive & specific test for discriminating between benign& malignant lesions.
Fine needle aspiration cytology of pilomatrixoma  [cached]
Bansal Cherry,Handa Uma,Mohan Harsh
Journal of Cytology , 2011,
Abstract: Aim : To delineate and characterize the cytomorphologic features of pilomatrixoma (PMX) helpful in correct diagnosis of the lesion on fine needle aspiration cytology (FNAC). Materials and Methods : Archival records of clinical findings, FNAC and histopathological reports of PMX cases were analyzed. Aspirate findings in 14 cases of PMX were correlated with detailed clinical data and subsequent histopathology on excisional biopsy. Different morphological findings were graded semiquantitatively from 0 to 3+. Results : The series showed female preponderance, with head and neck being the commonest site. Majority patients had a single tumor with mean size of 1.6 cm. Out of 14 biopsy proven cases of PMX, cytology findings revealed PMX in 7 cases on the basis of ghost cells, groups of basaloid cells, squamous cells in combination with multinucleated giant cells and calcium deposits in a background of debris. The main reasons for erroneous diagnosis were predominance of one component over the others and non-representative aspirated material. Conclusions : The cytological features of PMX are characteristic and allow a conclusive diagnosis provided the smears are examined keenly bearing in mind the diagnostic traps that can mislead a cytopathologist.
Fine needle aspiration cytology in leprosy
Prasad PVS,George Raj,Kaviarasan P,Viswanathan P
Indian Journal of Dermatology, Venereology and Leprology , 2008,
Abstract: Background: Laboratory diagnosis of leprosy by slit skin smear and skin biopsy is simple but both techniques have their own limitations. Slit skin smear is negative in paucibacillary cases whereas skin biopsy is an invasive technique. Fine needle aspiration cytology (FNAC) from skin lesions in leprosy with subsequent staining with May-Grunwald-Giemsa (MGG) stain has been found useful. Aim: To evaluate the possible role of cytology in classifying leprosy patients. Methods: Seventy-five untreated cases of leprosy attending the outpatient department were evaluated. Smears were taken from their skin lesions and stained using the MGG technique. Skin biopsy was also done from the lesions, which was compared with cytology smears. Results: A correlation of clinical features with FNAC was noticed in 87.5% of TT, 92.1% of BT, 81% of BL, and 66% of LL cases. Correlation of clinical with histopathological diagnoses revealed 12.5% specificity in TT leprosy, 55.3% in BT, 52.4% in BL and 50% in LL, and 100% in neuritic and histoid leprosy cases. Both correlations were found to be statistically significant by paired t test analysis. Thus, it was possible to distinguish the tuberculoid types by the presence of epithelioid cells and the lepromatous types by the presence of lymphocytes and foamy macrophages. Conclusion: FNAC may be used to categorize the patients into paucibacillary and multibacillary types, but is not a very sensitive tool to classify the patients across the Ridley-Jopling spectrum.
Fine Needle Aspiration Cytology In Tumour Diagnosis
DE Obaseki
Benin Journal of Postgraduate Medicine , 2008,
Abstract: Fine needle aspiration cytology (FNAC), a technique for obtaining cellular material for cytological examination and diagnosis using a 21- gauge or smaller needle, is performed using a 5, 10, or 20ml syringe either freehand or using special syringe holders. It allows a minimally invasive, rapid diagnosis of tissue samples but does not preserve its histological architecture.
Extrapulmonary tuberculosis: Fine needle aspiration cytology diagnosis
MOA Samaila, OP Oluwole
Nigerian Journal of Clinical Practice , 2011,
Abstract: Background: The increasing prevalence of extrapulmonary manifestation of tuberculosis with the HIV scourge is a cause for concern. Objective: To determine the role of fine needle aspiration cytology (FNAC) in the diagnosis of extrapulmonary tuberculosis. Patients and Methods: This is a consecutive 9-year analysis of patients with peripheral lymphadenopathy. All the patients had fine needle aspiration. Smears were made, fixed in 95% alcohol and stained with hematoxylin and eosin and Zeihl Neelsen stains. Results: 48 patients, 31 males and 17 females, were analyzed. The mean age was 27.9 years. Aspirates were mainly from cervical lymph nodes. Four patients were HIV 1 seropositive. Macroscopically, 23 (48%) of the aspirates were purulent and 7 (14.6%) had caseous material. Microscopy showed granular eosinophilic material (caseation), multinucleated giant cells, epithelioid cells, neutrophils and lymphocytes. Staining for acid-fast bacilli was positive in 23 (48%) cases. Conclusion: Early diagnosis of extrapulmonary tuberculosis in a resource- limited setting can be achieved with fine needle aspiration cytology technique (FNAC). This will ensure prompt treatment and thus reduce attendant morbidity and mortality.
Fine Needle Aspiration Cytology of Pediatric Thyroid Nodules
Türk Patoloji Dergisi , 2010,
Abstract: Objective: The objectives were to evaluate fine needle aspiration cytology results of 39 pediatric patients, and the pathologies that cause childhood thyroid nodules, and to review the literature on the subject.Material and Method: Thyroid fine needle aspiration cytology results of 39 pediatric patients were retrospectively reviewed. Associated diseases, thyroid functions, anti-thyroid antibody levels, ultrasonographic findings and number of nodules were also evaluated.Results: The vast majority of patients with thyroid nodules were cytopathologically diagnosed as benign (97.3%). Of these patients, 64.8% (24 patients) were diagnosed as nodular goiter and 35.2% (13 patients) as lymphocytic thyroiditis. Thyroid malignancy was found in two patients; one was diagnosed as follicular neoplasm/ minimal invasive follicular carcinoma on surgical evaluation while the other was a secondary tumor (Burkitt's lymphoma). The majority of our subjects were females (66.6%): the female/male ratio was 2:1 for nodular goiter and 3.3:1 for thyroiditis. Surgical resection was performed in 5 patients (4 cases of nodular goiter, 1 suspicious for malignancy) and cytological diagnoses were confirmed by histology.Conclusion: Our study confirmed the utility of fine needle aspiration cytology in childhood thyroid disorders along with a possible higher incidence of nodular thyroiditis in childhood. Nodular autoimmune thyroiditis, focal thyroiditis and thyroid cancer in children are discussed and attention is drawn to some special subtypes of thyroid cancer and some benign lesions that can cause difficulty in interpreting fine needle aspiration cytology and frozen sections at this age.
Axillary Schwannoma: Diagnosed on Fine Needle Aspiration Cytology  [cached]
Dhiraj B Nikumbh,Hemant B Janugade,Roopali K Mali,Poonam S Madan
Online Journal of Health & Allied Sciences , 2011,
Abstract: Schwannomas affect mainly head, neck and flexor aspect of the limbs. Axillary Schwannoma is extremely uncommon, that is neurogenic tumors arising from brachial plexus are rare. We report one such rare case of a solitary axillary Schwannoma which was diagnosed on fine needle aspiration cytology (FNAC) and subsequently confirmed by histopathological examination. Clinically it was diagnosed as axillary lymphadenopathy and FNAC was advised to rule out granulomatous lymphadenitis.
Fine Needle Aspiration Cytology of Fibromatosis Colli
Türk Patoloji Dergisi , 2010,
Abstract: Fibromatosis colli, also known as sternomastoid tumor, is considered a rare benign lesion of infancy of uncertain etiology and pathogenesis. Usually a self-limiting condition, diagnosis of this lesion by less invasive techniques is important to avoid an unnecessary surgical procedure. We report a case of a one-month-old male infant who presented with a firm 3 cm swelling on the left side of the neck. Fine needle aspiration was performed and the cytological features were suggestive of fibromatosis colli. Fibromatosis colli has to be differentiated from various congenital, inflammatory and neoplastic conditions that can occur in a similar location. Fine needle aspiration cytology appears to be a cheap, rapid, less invasive and fairly accurate diagnostic aid for excluding other causes and detection of this type of lesion. Identification of these lesions is important as they are usually self-eliminating with some cases requiring conservative management and rarely surgical intervention.
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