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The child and adolescent psychiatry trials network (CAPTN): infrastructure development and lessons learned  [cached]
Shapiro Mark,Silva Susan G,Compton Scott,Chrisman Allan
Child and Adolescent Psychiatry and Mental Health , 2009, DOI: 10.1186/1753-2000-3-12
Abstract: Background In 2003, the National Institute of Mental Health funded the Child and Adolescent Psychiatry Trials Network (CAPTN) under the Advanced Center for Services and Intervention Research (ACSIR) mechanism. At the time, CAPTN was believed to be both a highly innovative undertaking and a highly speculative one. One reviewer even suggested that CAPTN was "unlikely to succeed, but would be a valuable learning experience for the field." Objective To describe valuable lessons learned in building a clinical research network in pediatric psychiatry, including innovations intended to decrease barriers to research participation. Methods The CAPTN Team has completed construction of the CAPTN network infrastructure, conducted a large, multi-center psychometric study of a novel adverse event reporting tool, and initiated a large antidepressant safety registry and linked pharmacogenomic study focused on severe adverse events. Specific challenges overcome included establishing structures for network organization and governance; recruiting over 150 active CAPTN participants and 15 child psychiatry training programs; developing and implementing procedures for site contracts, regulatory compliance, indemnification and malpractice coverage, human subjects protection training and IRB approval; and constructing an innovative electronic casa report form (eCRF) running on a web-based electronic data capture system; and, finally, establishing procedures for audit trail oversight requirements put forward by, among others, the Food and Drug Administration (FDA). Conclusion Given stable funding for network construction and maintenance, our experience demonstrates that judicious use of web-based technologies for profiling investigators, investigator training, and capturing clinical trials data, when coupled to innovative approaches to network governance, data management and site management, can reduce the costs and burden and improve the feasibility of incorporating clinical research into routine clinical practice. Having successfully achieved its initial aim of constructing a network infrastructure, CAPTN is now a capable platform for large safety registries, pharmacogenetic studies, and randomized practical clinical trials in pediatric psychiatry.
Real-Time Biosurveillance Pilot Programme in Sri Lanka: Lessons Learned  [cached]
Weerasinghe Gamachchige Chamindu Sampath
Sri Lanka Journal of Bio-Medical Informatics , 2010, DOI: doi: 10.4038/sljbmi.v1i3.1774
Abstract: The latter parts of 2007 and early months of 2008 witnessed an alarming number of deaths due to a Leptospirosis outbreak in Sri Lanka(1). An unusual number of patients presenting with symptoms of fever, headache or myalgia concentrated in particular geographic areas (North Central and North Western Province in Sri Lanka) could have signalled the epidemiologists of an abnormal event with the help of a quicker surveillance programme leading to possible implementation of optimal strategies which could possibly have minimized the early deaths and even prevented the progression of the outbreak. The present day paper-based disease surveillance and notification systems in Sri Lanka(2), confined to a set of notifiable diseases, often require 15-30 days to communicate data and for the central Epidemiology Unit to process it. This latency does not allow for timely detection of disease outbreaks and it limits the ability of the health system to effectively respond and mitigate their consequences. Therefore it negatively affects the health status of the work force and productivity of the country. The Real Time Bio-surveillance Program (RTBP) is a pilot study aiming to introduce modern technology to the Health Department of Sri Lanka to complement the existing disease surveillance and notification systems. The processes involve digitizing all clinical health records and analysing them in near real-time to detect unusual events to forewarn health workers before the diseases reach epidemic states. Similar studies have been conducted on bio terrorism surveillance in Winnipeg, Canada(3), pandemic surveillance in Morocco(4) and North Carolina Disease Event Tracking and Epidemiologic Collection Tool (NC DETECT) in North Carolina(5). The infrastructure of the project RTBP is composed of an interconnected network between health care workers via mHealthSurvey mobile phone application, T-Cube web interface (TCWI) and Sahana Messaging/Alerting Module. Health records from health facilities, namely demographic information, symptoms, suspected and diagnosed diseases are collected through the mHealthSurvey, a mobile phone application(6), that feed in to the TCWI(7), a browser based software tool that detects adverse events; health officials are notified of the adverse events using the Sahana Alerting module that transports via Short Message Service (SMS), Email, and Web(10). Evaluation of the RTBP involves a replication study and parallel cohort study. This pilot study indicates the need for more robust mobile application for data collection with complete ontology, semantics and v
Crowdfunding Astronomy Outreach Projects: Lessons Learned from the UNAWE Crowdfunding Campaign  [PDF]
Abi J. Ashton,Pedro Russo,Thilina Heenatigala
Physics , 2014,
Abstract: In recent years, crowdfunding has become a popular method of funding new technology or entertainment products, or artistic projects. The idea is that people or projects ask for many small donations from individuals who support the proposed work, rather than a large amount from a single source. Crowdfunding is usually done via an online portal or platform which handles the financial transactions involved. The Universe Awareness (UNAWE) programme decided to undertake a Kickstarter crowdfunding campaign centring on the resource Universe in a Box2. In this article we present the lessons learned and best practices from that campaign.
Software Carpentry: Lessons Learned  [PDF]
Greg Wilson
Physics , 2013,
Abstract: Over the last 15 years, Software Carpentry has evolved from a week-long training course at the US national laboratories into a worldwide volunteer effort to raise standards in scientific computing. This article explains what we have learned along the way the challenges we now face, and our plans for the future.
Organizational Learning Through the Collection of "Lessons Learned"  [PDF]
Joseph V. Vandeville
Informing Science The International Journal of an Emerging Transdiscipline , 2000,
Abstract: This paper provides an approach for organizational learning through the collection of "Lessons Learned." The approach focuses on organizations in the Information Technology area, but is applicable to any organization having defined processes and a mechanism for process improvement. This approach ties the lessons learned program to the process infrastructure used by the organization to collect lessons that can be acted upon by the company's process improvement program
Lessons learned across a decade of knowledge modeling  [PDF]
Robert Hoffman,Jameson Beach
Journal for Educators, Teachers and Trainers , 2013,
Abstract: I review lessons learned in the creation of knowledge models composed of Concept Maps. The models were developed in studies of expertise in a variety of domains including weather forecasting, clinical oncology, and terrain analysis. Lessons learned pertain to a number of methodological issues, such as the measurement of the effectiveness of knowledge elicitation methods, issues in organizing, resourcing and navigating large sets of Concept Maps, and issues in comparing computer performance to that of humans.
Lessons learned from the TMT site testing campaign  [PDF]
T. Travouillon,S. G. Els,R. L. Riddle,M. Sch?ck,A. W. Skidmore
Physics , 2011,
Abstract: After a site testing campaign spanning 5 sites over a period of 5 years, the site selection for the Thirty Meter Telescope (TMT) culminated with the choice of Mauna Kea 13N in Hawaii. During the campaign, a lot practical lessons were learned by our team and these lessons can be shared with current and future site testing campaign done for other observatories. These lessons apply to the preselection of the site, the ground work and operations of the campaign as well as the analysis of the data. We present of selection of such lessons in this paper preceded by a short summary of the TMT site testing activities.
Successes, Challenges and Lessons Learned in Accelerating Introduction of Rotavirus Immunisation in Zambia  [PDF]
Roma Chilengi, Cheryl Rudd, Carolyn Bolton, Bradford Guffey, Penelope Kalesha Masumbu, Jeffrey Stringer
World Journal of Vaccines (WJV) , 2015, DOI: 10.4236/wjv.2015.51006
Abstract: Introduction: Under five mortality in Zambia is unacceptably high and diarrhoea is the third leading contributor. The Programme for Awareness and Elimination of Diarrhoea (PAED) sought to support the government to accelerate the introduction of new vaccines, including the pneumococcal, second dose measles and rotavirus vaccines in Zambia. Here we present our approach, progress and lessons learned in two years of the programme. Stakeholder Engagement: Definite commitment and buy-in and sign off by the MOH were fundamental prerequisites. National and international stakeholders including the Inter Agency Coordinating Committee (ICC), GAVI Alliance, WHO, University Teaching Hospital, Paediatrics Association of Zambia, and UNICEF were engaged for stakeholder buy-in and integration. Progress made: Following successful integration, PAED was officially launched in January 2012. Preparatory work done included: Introduction and acceptance of the PAED agenda in ICC, new vaccines proposal to GAVI, resource mobilisation, Effective Vaccine Management implementation, national cold chain scale-up strategy, vaccine orientation and adapted data collection tools, health worker training, step-wise vaccine introduction to Lusaka province districts and finally national roll-out of the rotavirus vaccine immunisation. Between January 2011 and November 2013, over 270,000 vaccine doses were distributed in Lusaka province. When 94,500 infants were fully immunised, adequate preparations had been made to facilitate national launch of rotavirus immunisations countrywide on 27th November 2013. Discussion: The PAED model was successful at resource mobilization; it has demonstrated how private sector can contribute to new vaccine introduction. Lessons learned from this model can be replicated in other countries with similar need and constraints.
Adaptive simulated annealing (ASA): Lessons learned  [PDF]
Lester Ingber
Computer Science , 2000,
Abstract: Adaptive simulated annealing (ASA) is a global optimization algorithm based on an associated proof that the parameter space can be sampled much more efficiently than by using other previous simulated annealing algorithms. The author's ASA code has been publicly available for over two years. During this time the author has volunteered to help people via e-mail, and the feedback obtained has been used to further develop the code. Some lessons learned, in particular some which are relevant to other simulated annealing algorithms, are described.
Study of Light Scalars, the learned Lessons  [PDF]
N. N. Achasov
Physics , 2011,
Abstract: Attention is paid to the production mechanisms of the light scalars that reveal their nature. In the linear sigma model it is revealed the chiral shielding of the \sigma(600) meson and shown that the \sigma field is described by its four-quark component. The \pi\pi scattering amplitude is constructed taking into account the \sigma(600) and f_0(980) mesons, the chiral shielding of \sigma (600), the \sigma(600)-f_0(980) mixing, and results, obtained on the base of the chiral expansion and the Roy equations. The data agree with the four-quark nature of \sigma (600) and f_0(980). It is shown, that the kaon loop mechanism of the $\phi$ radiative decays into the light scalar mesons, which is ratified by experiment, is the four-quark transition and points to the four-quark nature of the light scalars. It is shown also, that the light scalars are produced in the two photon collisions via four-quark transitions in contrast to the classic P wave tensor q\bar q mesons, which are produced via two-quark transitions \gamma\gamma\to q\bar q, that points to the four-quark nature of the light scalar mesons, too. A programme of further investigations is laid down.
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