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Mediastinal granulocytic sarcoma
Bahar AKKAYA,Esin ?ZEL,?hsan KARADO?AN,Hüseyin BEK?Z
Türk Patoloji Dergisi , 2008,
Abstract: Granulocytic sarcoma is an unusual variant of myeloid malignancy in which there is an extramedullary tumor mass composed of myeloblasts or myeloblasts and more mature neutrophils. It rarely occurs in mediastinum and clinically may resemble a mediastinal lymphoma. We report a patient who was initially diagnosed as malignant lymphoma based on the previous biopsy specimen. The diagnosis of granulocytic sarcoma is not difficult with careful histopathologic evaluation and immunohistochemical staining.
Tuberculous Mastoiditis Presenting with Unilateral Hearing Loss,Facial Paralysis and Neck Mass
A.A. Sazegar,R. Safi-Khani
Tehran University Medical Journal , 2006,
Abstract: Background: Mycobacterium tuberculosis is a rare cause of mastoiditis, but diagnosis is often delayed, with potentially serious results. Case: We report a case of tuberculous mastoiditis with unilateral hearing loss, facial paralysis, and cervical lymph adenopathy on presentation. Conclusion: Tuberculous mastoiditis must be considered in all cases of chronic refractory mastoiditis especially in the presence of demonstrable complications such as facial paralysis, other cranial nerve palsies, and destruction of middle ear osscicles.
Granulocytic Sarcoma of the Stomach Presenting as Dysphagia during Pregnancy
Anuradha Sekaran,Santosh Darisetty,Sandeep Lakhtakia,Mohan Ramchandani,Duvuru Nageshwar Reddy
Case Reports in Gastrointestinal Medicine , 2011, DOI: 10.1155/2011/627549
Abstract: Granulocytic sarcoma also known as extramedullary myeloid sarcoma or chloroma is an uncommon manifestation of leukemia and presents as a deposit of leukemic cells outside the bone marrow. We report a case of a twenty-five-year-old pregnant woman who presented with progressive dysphagia and recurrent postprandial vomiting. Upper GI endoscopy had shown large flat laterally spread nodular lesions in the cardia and proximal body of stomach. Biopsies from the gastric lesion showed granulocytic sarcoma of the stomach. Concurrent peripheral and bone marrow picture was suggestive of acute myeloid leukemia (AML–M4). There is limited reported literature on granulocytic sarcoma of the stomach. Concurrent gastric granulocytic sarcoma involving cardia and AML in pregnancy has not been reported till date.
Granulocytic sarcoma of breast: An aleukemic presentation  [cached]
D′costa Grace,Hastak Meenal,Patil Yoganand
Indian Journal of Medical Sciences , 2007,
Abstract: Granulocytic sarcoma is a rare extramedullary tumor composed of immature myeloid cells. It is usually associated with leukemia or other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast is an uncommon site of presentation and requires a high index of suspicion for diagnosis. We report such a case in a 45-year-old female, who presented with nontender left breast lump of 6 months′ duration. A peripheral smear and bone marrow examination at that time was normal. A lumpectomy was done. An H and E diagnosis of lobular carcinoma vs. non-Hodgkin′s lymphoma was entertained. Immunostains, however, revealed myeloperoxidase, naphthol AS-D chloroacetate esterase and CD43 positivity, indicating a diagnosis of granulocytic sarcoma. It appears that early initiation of systemic AML-type chemotherapy is beneficial and may delay or avert the development of AML in bone marrow and blood. Eight months later, the patient presented with an orbital mass; bone marrow and peripheral smear involvement by AML.
Mediastinal nonleukemic granulocytic sarcoma with cardiac infiltration
Lima, Gabrielle G.;Rocha Filho, Francisco D.;Ferreira, Francisco V. A.;Linhares, Bruno L.;Pereira, Viviane C.;Freitas, Helano C.;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000400022
Abstract: we report on a case of mediastinal granulocytic sarcoma with cardiac infiltration in a young man with no evidence of leukemia involving the bone marrow or peripheral blood. diagnosis was accomplished by immuno-histochemistry with expressions of myeloperoxidase and cd99 antigens. the patient achieved clinical remission, but evolved with febrile neutropenia during chemotherapy and died. although subclinical cardiac infiltrations are commonly found at autopsy in patients with acute non-lymphoblastic leukemia, only one case of involvement of the heart with granulocytic sarcoma in the absence of bone marrow disease has been published in the literature. a diagnosis of granulocytic sarcoma should not be excluded when the biopsy of the bone marrow does not show any evidence of leukemic infiltration.
Coexistence of a granulocytic sarcoma and adenocarcinoma of the rectum  [cached]
I.S. Papanikolaou, P.A. Xirou, G.H. Thomopoulou, L. Mavroyiannis, P. Georgiadou,,V. Alexopoulou, A.Ch. Lazaris .
Annals of Gastroenterology , 2007,
Abstract: SUMMARY Granulocytic sarcomas are rare extramedullary tumour-like proliferates of myelogenous precursor cells. Rarely, these tumours may de novo precede acute leukaemia or represent the initial manifestation of a blast crisis in the course of a chronic myeloproliferative disease. A case of a 53 year old male who was admitted to hospital due to intestinal bleeding combined with weight loss is reported. General examination, laboratory studies and imaging findings were nonspecific. Colonoscopy revealed a rectal polypoid mass. Microscopic pathology and immunohistochemical findings were consistent to that of a collision tumour composed of rectal adenocarcinoma arisen on a pre-existing adenomatous polyp and granulocytic sarcoma. Two months later he was readmitted to hospital and the diagnosis of acute myetoid leukaemia was established. The patient finally died due to infection. Coexistence of rectal adenocarcinoma and granulocytic sarcoma should be recognized promptly so that proper therapy is initiated, thus improving prognosis. Keywords: granulocytic sarcoma, rectal adenocarcinoma, acute myeloid leukaemia, immunohistochemistry.
Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement
Stephan Zaenker,Stefan Schweyer,Justin Hasenkamp,Lorenz Truemper,Gerald Wulf
Case Reports in Hematology , 2011, DOI: 10.1155/2011/692982
Abstract: Granulocytic sarcoma (GS) represents a rare type of extramedullar manifestation from the acute myeloid leukaemia (AML). We report the case of a patient with recurrences of AML M4eo leukaemia in the uterus and the small intestine at 3 and 5 years, respectively, after matched related peripheral blood stem cell transplantation (PBSCT). The patient underwent the withdrawal of immunosuppression, hysterectomy, and local irradiation at first relapse, as well as systemic chemotherapy and donor lymphocyte infusions at second recurrence, inducing a second and third complete remission, respectively. At year six after transplantation, the patient experienced disease progression by meningeosis leukaemia to which she succumbed despite intrathecal chemotherapy. Following allogeneic stem cell transplantation, awareness for atypical manifestations of granulocytic sarcoma appears prudent, the cellular immunotherapy should aim at immunological disease control.
Granulocytic Sarcoma as the First Sign of Acute Leukemia in Childhood  [cached]
Aalia R Sufi,Tejit Singh
Online Journal of Health & Allied Sciences , 2012,
Abstract: Acute myeloid leukemia (AML) may rarely involve the orbit as a solid tumor termed granulocytic sarcoma. This report describes the case of a child who presented with rapidly progressive unilateral proptosis and was diagnosed as rhabdomyosarcoma. However subsequent examination of the peripheral blood film revealed AML. Thus proptosis may present as the initial manifestation of AML.
Granulocytic sarcoma after stem cell transplantation in a child with biphenotypic leukemia  [PDF]
Zühre Kaya,ülker Ko?ak,Meryem Albayrak,Türkiz Gürsel
Turkish Journal of Hematology , 2009,
Abstract: Granulocytic sarcoma is an extramedullary tumor composed of leukemic blasts. Isolated granulocytic sarcoma has rarely been reported in children with leukemia undergoing allogeneic stem cell transplantation. We report a case of isolated granulocytic sarcoma arising from the pleura in an 11-year-old girl who was previously treated for biphenotypic leukemia with allogeneic stem cell transplantation. Complete resolution of the tumor was achieved after two inductions with MRC 12 protocol; however, she died of sepsis during the neutropenic period. The unusual presentation, immunophenotypic differences at diagnosis and relapse, and the management options are discussed.
Nonleukemic Granulocytic Sarcoma of Knee: A Case Report
Ibrahim Elghissassi,Hanane Inrhaoun,Hind Mrabti,Hassan Errihani
Case Reports in Medicine , 2010, DOI: 10.1155/2010/235295
Abstract: Granulocytic sarcoma (GS) is a rare extramedullary tumor composed of immature myeloid cells. It is usually associated with leukemia or other myeloproliferative disorders. It occurs very rarely without overt hematologic diseases. A 19-year-old man presented with left knee mass. Biopsy with pathological analysis showed lymphoma aspect. Immunostains yielded the diagnosis of GS with myeloperoxidase and CD43 positivity. There was no systemic manifestation of leukemia, and bone marrow biopsiy was negative for neoplastic infiltration. Chemotherapy by CHOP was efficient, and the patient remaind alive and healthy 40 months after the end of treatment. The case is discussed in the framework of the existing literature about the diagnosis, treatment, and prognosis of this very rare condition.
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