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Do we have enough air?  [PDF]
V. Dorobantu
Physics , 2006,
Abstract: If only human beings would breathe the entire quantity of terrestrial air, then, at the present-day population on the Earth, one million years would exhaust that air. It seems we have enough air. Is it so?
Saving the unborn girl child: Are we doing enough?  [cached]
Pankaj Desai
International Journal of Reproduction, Contraception, Obstetrics and Gynecology , 2012, DOI: 10.5455/2320-1770.ijrcog000112
Abstract: In early part of this year film actor Amir Khan televised a hard-hitting and soul stirring series on Indian TV Channels titled “Satyameva Jayate”. It successfully showed a mirror to the society which many times didn’t like what it was seeing. As a result attempts were made to shatter the mirror rather than washing the dirty face. But the great thing about mirrors is that they always tell the truth even when shattered to pieces. One such episode covered the ills of prenatal sex determination and sex-selective abortions. It highlighted all relevant issues so well. One fact that clearly emerged was that prenatal sex determination is rampant inspite of the law and efforts to curb this evil are proving unproductive. While running through different estimates of skewed sex ratios in India one gets variable estimates. In 1992 Amartya Sen calculated that 37 million women were ‘missing’ in India. The UN in 2001 estimated that there were 44 million missing women in India. Data from the census of 2001 suggests that there are only 933 women for every 1000 men in India. This figure has just changed marginally to 941 females for every 1000 males by 2011. Whatever be the figure, one strong fact remains: inspite of the PNDT Act, inspite of so much drum-beating and even after all the resolute efforts ongoing all over the country India is losing almost 7,000 girls daily because of the traditional preference for sons which cause many people to abort female fetuses. This brings us to ponder - are we doing enough? The answer is obviously NO! Some of the main reasons for this are summarized below. [Int J Reprod Contracept Obstet Gynecol 2012; 1(1.000): 1-2]
Have we tested Lorentz invariance enough?  [PDF]
David Mattingly
Physics , 2008,
Abstract: Motivated by ideas from quantum gravity, Lorentz invariance has undergone many stringent tests over the past decade and passed every one. Since there is no conclusive reason from quantum gravity that the symmetry \textit{must} be violated at some point we should ask the questions: a) are the existing tests sufficient that the symmetry is already likely exact at the Planck scale? b) Are further tests simply blind searches for new physics without reasonable expectation of a positive signal? Here we argue that the existing tests are not quite sufficient and describe some theoretically interesting areas of existing parameterizations for Lorentz violation in the infrared that are not yet ruled out but are accessible (or almost accessible) by current experiments. We illustrate this point using a vector field model for Lorentz violation containing operators up to mass dimension six and analyzing how terrestrial experiments, neutrino observatories, and Auger results on ultra-high energy cosmic rays limit this model.
Are we getting enough sulfur in our diet?
Marcel E Nimni, Bo Han, Fabiola Cordoba
Nutrition & Metabolism , 2007, DOI: 10.1186/1743-7075-4-24
Abstract: Proteins contain between 3 and 6% of sulfur amino acids. A very small percentage of sulfur comes in the form of inorganic sulfates and other forms of organic sulfur present in foods such as garlic, onion, broccoli, etc.The minimal requirements (RDA) for all the essential amino acids have always been estimated in terms of their ability to maintain a nitrogen balance. This method asses amino acid requirements for protein synthesis, only one of the pathways that methionine follows after ingestion. To adequately evaluate the RDA for methionine, one should perform, together with a nitrogen balance a sulfur balance, something never done, neither in humans nor animals.With this in mind we decided to evaluate the dietary intake of sulfur (as sulfur amino acids) in a random population and perform sulfur balance studies in a limited number of human volunteers. Initially this was done to try and gain some information on the possible mode of action of a variety of sulfur containing compounds (chondroitin sulfate, glucosamine sulfate, and others, ) used as dietary supplements to treat diseases of the joints. Out of this study came information that suggested that a significant proportion of the population that included disproportionally the aged, may not be receiving sufficient sulfur and that these dietary supplements, were very likely exhibiting their pharmacological actions by supplying inorganic sulfur.Because of the much larger implications of sulfur metabolism, and the role that this element plays in the synthesis of a very large number of key metabolic intermediates, such as glutathione, we decided to extend this review to include a broad scope of overlapping metabolic pathways that can be affected by insufficient or marginal intake of sulfur. The hope is that such a review will encourage further research into this very important and most often neglected area of metabolism. This includes the potential to affect the initiation and progression of a large number of anomalies
Dynamic Programming and Genetic Algorithm for Business Processes Optimisation  [cached]
Mateusz Wibig
International Journal of Intelligent Systems and Applications , 2012,
Abstract: There are many business process modelling techniques, which allow to capture features of those processes, but graphical, diagrammatic models seems to be used most in companies and organizations. Although the modelling notations are more and more mature and can be used not only to visualise the process idea but also to implement it in the workflow solution and although modern software allows us to gather a lot of data for analysis purposes, there is still not much commercial used business process optimisation methods. In this paper the scheduling / optimisation method for automatic task scheduling in business processes models is described. The Petri Net model is used, but it can be easily applied to any other modelling notation, where the process is presented as a set of tasks, i.e. BPMN (Business Process Modelling Notation). The method uses Petri Nets’, business processes’ scalability and dynamic programming concept to reduce the necessary computations, by revising only those parts of the model, to which the change was applied.
Heteroscedastic Treed Bayesian Optimisation  [PDF]
John-Alexander M. Assael,Ziyu Wang,Bobak Shahriari,Nando de Freitas
Mathematics , 2014,
Abstract: Optimising black-box functions is important in many disciplines, such as tuning machine learning models, robotics, finance and mining exploration. Bayesian optimisation is a state-of-the-art technique for the global optimisation of black-box functions which are expensive to evaluate. At the core of this approach is a Gaussian process prior that captures our belief about the distribution over functions. However, in many cases a single Gaussian process is not flexible enough to capture non-stationarity in the objective function. Consequently, heteroscedasticity negatively affects performance of traditional Bayesian methods. In this paper, we propose a novel prior model with hierarchical parameter learning that tackles the problem of non-stationarity in Bayesian optimisation. Our results demonstrate substantial improvements in a wide range of applications, including automatic machine learning and mining exploration.
Do we have enough evidence for expanding the indications of ESD for EGC?  [cached]
Hang Lak Lee,Chang Hwan Choi,Dae Young Cheung
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i21.2597
Abstract: Endoscopic submucosal dissection (ESD) is the most advanced and representative technique in the field of therapeutic endoscopy and has been used for the treatment of gastrointestinal neoplasms, including early gastric cancer. The major difference and advantage of ESD compared to existing endoscopic resection techniques, such as endoscopic mucosal resection (EMR) and polypectomy, are the width and depth of the resection. Newly developed cutting devices, distal attachable endoscopic accessories, and an advanced electrosurgical unit have helped to overcome the limitations of therapeutic endoscopy in terms of lesion size, location, presence of fibrotic scarring, and accompanying ulcers. As a result, the indications for ESD have been expanded from the classical indication for EMR and polypectomy, and there is now support for a further expansion of ESD indications. At present, the most critical factor to consider in the decision of whether to perform ESD is the probability of unexpected lymph node metastasis. The guidelines for ESD are continually being updated and debated. In this review, we discuss the strengths and weaknesses of the expanded guidelines, based on evidence found in the literature.
Formation of a Dynamic Model of Multi-criteria Optimisation of Management of Innovation Processes of Processing Enterprises of the Agro-industrial Complex Формирование динамической модели многокритериальной оптимизации управления инновационными процессами перерабатывающих предприятий АПК  [PDF]
Babenko Vitalina A.
Business Inform , 2013,
Abstract: The article studies theoretical foundations and improvement of methods of dynamic modelling of management of innovation processes of processing enterprises of the agro-industrial complex, development of a dynamic task of multi-criteria optimisation of management of innovation processes of processing enterprises and general approaches to its solution. Исследование теоретических основ и совершенствование методов динамического моделирования управления инновационными процессами перерабатывающих предприятий АПК, разработка динамической задачи многокритериальной оптимизации управления инновационными процессами перерабатывающих предприятий и общие подходы к ее решению.
Performance Evaluation and Optimisation of Industrial System in a Dynamic Maintenance
American Journal of Intelligent Systems , 2012, DOI: 10.5923/j.ajis.20120205.02
Abstract: Despite the existence of the multitude of behavioral analysis tools for industrial systems, increasingly complex, managers to date find difficulties to define maintenance strategies able to significantly improve the overall performance of companies in terms of production, quality, safety and environment. A static maintenance and not adapted to the evolution of the state system does not meet the expectations of industrialists. However, the behavior of any degradable system is closely related to the state of its components. This random influence is not always sufficiently considered for various reasons, consequently any decision making remains subjective. Our approach based on dynamic Bayesian networks (DBN) consists has the modeling of the system and the functional dependencies of its components. The results obtained then, after the introduction in the model of the most appropriate actions of maintenance show all the importance of this technique and the possible applications.
Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family  [PDF]
Saka? Dejan,Kora?evi? Goran,Pavlica Tatjana,Sekuli? Slobodan
Vojnosanitetski Pregled , 2012, DOI: 10.2298/vsp1207620s
Abstract: Background. Fabry Disease is a rare, X-chromosomal inherited lysosomal storage disease with a consequent intracellular accumulation of neutral glycosphingolipids in various tissues. This can cause skin and ocular lessions, progressive renal, cardiac or cerebrovascular disorders. If a person in a family has Fabry disease, other family members including even extended relatives, may also be at risk. Case report. We presented three cases pointed out various manifestation of Fabry disease, that illustrate a possible cause for otherwise unexplained cardiac hypertrophy and various rhythm and conduction abnormalities. Conclusion. Although most symptoms begin in childhood, various manifestations often lead to misdiagnosis and clinical diagnosis is frequently delayed for many years, even decades. Enzyme replacement therapy has become available, pointing out the importance of early diagnosis so that treatment can be initiated before irreversible organ damage.
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